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Molecular Cancer Research, ISSN 1541-7786, 04/2017, Volume 15, Issue 4 Supplement, pp. IA13 - IA13
Journal Article
Cell Cycle, ISSN 1538-4101, 02/2011, Volume 10, Issue 3, pp. 457 - 468
Cellular senescence, an irreversible proliferation arrest evoked by stresses such as oncogene activation, telomere dysfunction, or diverse genotoxic insults,... 
Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Bacterial toxin | DNA damage response | Replication stress | Etoposide | Histone 3 trimethylated on lysine 9 | Hydroxyurea | Activated Ras oncogene | Senescence-associated heterochromatin foci
Journal Article
Nature, ISSN 0028-0836, 2015, Volume 521, Issue 7553, pp. 541 - U308
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 01/2012, Volume 19, Issue 1, pp. 5 - 7
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 06/2010, Volume 17, Issue 6, pp. 688 - 695
Germ-line mutations in breast cancer 1, early onset (BRCA1) result in predisposition to breast and ovarian cancer. BRCA1-mutated tumors show genomic... 
STEM-CELLS | GENE BRCA1 | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONDITIONAL MOUSE MODEL | DOUBLE-STRAND BREAKS | OVARIAN-CANCER | CELL BIOLOGY | GENOMIC INSTABILITY | MAMMARY-TUMORS | BIOPHYSICS | TUMOR-SUPPRESSOR | CELL-CYCLE | Embryonic Stem Cells - metabolism | Cell Proliferation | Embryonic Stem Cells - cytology | Humans | Breast Neoplasms - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Gene Deletion | Genes, BRCA2 | Female | Genes, BRCA1 | Tumor Cells, Cultured | BRCA1 Protein - deficiency | Intracellular Signaling Peptides and Proteins - genetics | DNA-Binding Proteins | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone | Breast Neoplasms - drug therapy | Mice, Knockout | BRCA1 Protein - genetics | Drug Resistance, Neoplasm - genetics | Animals | Apoptosis Regulatory Proteins | Breast Neoplasms - genetics | Cell Cycle | Breast Neoplasms - pathology | DNA Repair | BRCA2 Protein - deficiency | Mice | Mutagenesis, Insertional | DNA Damage | Mutation | Tumor Suppressor p53-Binding Protein 1 | Drug Resistance, Neoplasm - physiology | BRCA2 Protein - genetics | BRCA mutations | DNA damage | Physiological aspects | Breast cancer | Genetic aspects | Research | Health aspects | DNA repair | Risk factors | Molecular biology | Ovarian cancer | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 04/2005, Volume 434, Issue 7035, pp. 864 - 870
Journal Article
Nature, ISSN 0028-0836, 11/2006, Volume 444, Issue 7119, pp. 633 - 637
Journal Article
Nature, ISSN 0028-0836, 12/2017, Volume 552, Issue 7684, pp. 194 - 199
Journal Article
Cell Cycle, ISSN 1538-4101, 10/2012, Volume 11, Issue 20, pp. 3837 - 3850
Impaired DNA damage response pathways may create vulnerabilities of cancer cells that can be exploited therapeutically. One such selective vulnerability is the... 
predictive biomarkers | cancer treatment | DNA damage response | 53BP1 | PARP-1 inhibitor | BRCA1 | parsylation | p53 | MRN complex | synthetic lethality or viability | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Cancer treatment | Predictive biomarkers | Synthetic lethality or viability | PARsylation | STRAND BREAK REPAIR | MRE11 | DNA-DAMAGE RESPONSE | POLY(ADP-RIBOSE) POLYMERASE INHIBITION | CELL BIOLOGY | MAMMARY-TUMORS | ADP-RIBOSE POLYMERASE | IN-VITRO ASSAYS | SYNTHETIC LETHALITY | TUMOR-SUPPRESSOR | HOMOLOGOUS RECOMBINATION | Neoplasms - metabolism | Humans | DNA Repair Enzymes - genetics | Gamma Rays - therapeutic use | Gene Expression Regulation, Neoplastic | Male | Intracellular Signaling Peptides and Proteins - metabolism | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Neoplasms - genetics | BRCA1 Protein - metabolism | DNA Repair Enzymes - metabolism | Biomarkers, Tumor - metabolism | Cell Cycle Proteins - genetics | Female | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Recombinational DNA Repair - drug effects | Carcinoma - drug therapy | Genes, MDR | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Poly(ADP-ribose) Polymerase Inhibitors | Neoplasms - drug therapy | BRCA1 Protein - genetics | Drug Resistance, Neoplasm - genetics | Poly(ADP-ribose) Polymerases - metabolism | BRCA2 Protein - metabolism | Poly(ADP-ribose) Polymerases - genetics | Cell Line, Tumor | Recombinational DNA Repair - radiation effects | Biomarkers, Tumor - genetics | DNA Damage | Poly (ADP-Ribose) Polymerase-1 | Tumor Suppressor p53-Binding Protein 1 | Camptothecin - pharmacology | BRCA2 Protein - genetics | Index Medicus | Report
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 12/2013, Volume 20, Issue 12, pp. 1425 - 1433
Chromatin ubiquitylation flanking DNA double-strand breaks (DSBs), mediated by RNF8 and RNF168 ubiquitin ligases, orchestrates a two-branch pathway, recruiting... 
53BP1 RECRUITMENT | RESECTION | UBIQUITIN E3 LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | BRCA1 | CELL BIOLOGY | DAMAGE RESPONSE | REPAIR | BIOPHYSICS | HOMOLOGOUS RECOMBINATION | RAP80 | BINDING | Humans | Jumonji Domain-Containing Histone Demethylases - physiology | Oxidoreductases, N-Demethylating - physiology | Trans-Activators - chemistry | Breast Neoplasms - metabolism | DNA-Binding Proteins - metabolism | DNA Methylation | Ubiquitination | BRCA1 Protein - metabolism | DNA Breaks | Jumonji Domain-Containing Histone Demethylases - chemistry | Carrier Proteins - chemistry | Female | Tumor Cells, Cultured | Oxidoreductases, N-Demethylating - metabolism | BRCA1 Protein - chemistry | Rad51 Recombinase - metabolism | DNA-Binding Proteins - physiology | BRCA1 Protein - physiology | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Poly(ADP-ribose) Polymerase Inhibitors | Oxidoreductases, N-Demethylating - chemistry | Breast Neoplasms - genetics | Carrier Proteins - metabolism | Rad51 Recombinase - chemistry | Rad51 Recombinase - physiology | Trans-Activators - metabolism | HeLa Cells | Jumonji Domain-Containing Histone Demethylases - metabolism | Genetic markers | Care and treatment | DNA damage | Genetic aspects | Research | Identification and classification | Cancer | Proteins | Signal transduction | Chromatin | DNA repair | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2003, Volume 5, Issue 3, pp. 255 - 260
Cell cycle checkpoints are signal transduction pathways activated after DNA damage to protect genomic integrity. Dynamic spatiotemporal coordination is a... 
REPAIR | PROTEIN | MRE11 COMPLEX | KINASE CHK2 | PHOSPHORYLATION | IN-VIVO | TUMOR-SUPPRESSOR | FORKHEAD-ASSOCIATED DOMAIN | S-PHASE CHECKPOINT | P53 | CELL BIOLOGY | Cell Cycle - genetics | Phosphorylation | DNA Damage | Tumor Cells, Cultured | Cell Cycle Proteins - physiology | Humans | Physiological aspects | Cellular signal transduction | Research | DNA damage | Index Medicus
Journal Article