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index medicus (31) 31
animals (26) 26
chromatin (26) 26
gene expression (22) 22
humans (22) 22
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biochemistry & molecular biology (16) 16
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gene expression regulation (7) 7
genetics & heredity (7) 7
medicine (7) 7
microtubule-associated proteins - metabolism (7) 7
molecular biology (7) 7
promoter regions, genetic (7) 7
protein (7) 7
deoxyribonucleic acid (6) 6
developmental biology (6) 6
microtubule-associated proteins - genetics (6) 6
promoter (6) 6
transcription factors - genetics (6) 6
biology and life sciences (5) 5
bithorax complex (5) 5
cell line (5) 5
chromatin immunoprecipitation (5) 5
chromosomal proteins, non-histone - metabolism (5) 5
dna methylation (5) 5
drosophila - metabolism (5) 5
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expression (5) 5
gene regulation (5) 5
gene regulation, chromatin and epigenetics (5) 5
human genome (5) 5
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inflammation (5) 5
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lysine (5) 5
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urology (5) 5
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drosophila melanogaster - metabolism (4) 4
drosophila-bithorax complex (4) 4
epigenetic inheritance (4) 4
gene (4) 4
histones - genetics (4) 4
imprinting control region (4) 4
insulator elements - genetics (4) 4
insulator protein ctcf (4) 4
life sciences (4) 4
oligonucleotide array sequence analysis (4) 4
protein ctcf (4) 4
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1. Full Text Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles
by Walz, Susanne and Lorenzin, Francesca and Morton, Jennifer and Wiese, Katrin E and Von Eyss, Björn and Herold, Steffi and Rycak, Lukas and Dumay-Odelot, Hélène and Karim, Saadia and Bartkuhn, Marek and Roels, Frederik and Wüstefeld, Torsten and Fischer, Matthias and Teichmann, Martin and Zender, Lars and Wei, Chia-Lin and Sansom, Owen and Wolf, Elmar and Eilers, Martin
Nature, ISSN 0028-0836, 2014, Volume 511, Issue 7510, pp. 483 - 487
In mammalian cells, the MYC oncoprotein binds to thousands of promoters(1-4). During mitogenic stimulation of primary lymphocytes, MYC promotes an increase in... 
CELLS | INTEGRATION | DNA | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | C-MYC | INDUCTION | PROMOTER | BINDING | ASSOCIATION | GENOME | Humans | Transcriptome | Nuclear Proteins - metabolism | Up-Regulation - genetics | Protein Inhibitors of Activated STAT - metabolism | RNA Polymerase II - metabolism | E-Box Elements - genetics | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-myc - metabolism | Down-Regulation - genetics | Animals | Neoplasms - genetics | Kruppel-Like Transcription Factors - metabolism | Genes, myc - genetics | Cell Line, Tumor | Mice | Proto-Oncogene Proteins c-myc - genetics | Binding Sites | Gene Expression Regulation, Neoplastic - genetics | RNA sequencing | Research | Gene expression | Health aspects | Analysis | Tumors | Tumorigenesis | Binding sites | Cell adhesion & migration
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2. Full Text CTCF shapes chromatin by multiple mechanisms: the impact of 20 years of CTCF research on understanding the workings of chromatin
by Ohlsson, Rolf and Bartkuhn, Marek and Renkawitz, Rainer
Chromosoma, ISSN 0009-5915, 8/2010, Volume 119, Issue 4, pp. 351 - 360
More than 109 base pairs of the genome in higher eucaryotes are positioned in the interphase nucleus such that gene activation, gene repression, remote gene... 
Life Sciences | Human Genetics | Biochemistry, general | Developmental Biology | Eukaryotic Microbiology | Animal Genetics and Genomics | Cell Biology | RNA-POLYMERASE-II | X-INACTIVATION | IMPRINTING CONTROL REGION | ENHANCER-BLOCKING ACTIVITY | HUMAN GENOME | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | INSULATOR PROTEIN CTCF | THYROID-HORMONE RECEPTOR | BINDING-SITES | METHYLATION-FREE DOMAINS | BETA-GLOBIN LOCUS | Chromatin - ultrastructure | Genomic Imprinting | DNA-Binding Proteins - physiology | Chromosomes, Human - physiology | Humans | Nucleosomes - physiology | Cell Nucleus - physiology | Chromosomes - physiology | Repressor Proteins - physiology | Animals | Enhancer Elements, Genetic | CCCTC-Binding Factor | Chromatin - physiology | Chromosomal Proteins, Non-Histone - physiology | Zinc Fingers - physiology | Binding Sites | Cell Cycle Proteins - physiology | Chromatin - chemistry | X Chromosome Inactivation | Chromatin | DNA binding proteins | Review
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3. Full Text Insulators and domains of gene expression
by Ali, Tamer and Renkawitz, Rainer and Bartkuhn, Marek
Current Opinion in Genetics & Development, ISSN 0959-437X, 2015, Volume 37, pp. 17 - 26
The genomic organization into active and inactive chromatin domains imposes specific requirements for having domain boundaries to prohibit interference between... 
Medical Education | CCCTC-BINDING FACTOR | BITHORAX COMPLEX | CHROMATIN INSULATOR | TRANSCRIPTIONAL INSULATION | HUMAN GENOME | ENHANCER BLOCKING ACTIVITY | DROSOPHILA-MELANOGASTER | CHROMOSOMAL DOMAINS | GENETICS & HEREDITY | LONG-RANGE INTERACTIONS | BARRIER ACTIVITY | CELL BIOLOGY | Insulator Elements - genetics | Enhancer Elements, Genetic | CCCTC-Binding Factor | Humans | Gene Expression Regulation | Cell Cycle Proteins - genetics | Protein Binding | Repressor Proteins - genetics | DNA-Binding Proteins - genetics | Binding Sites | Chromatin - genetics | Chromosomal Proteins, Non-Histone - genetics | Gene expression | Chromatin | Protein binding
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4. Full Text CTCF: Insights into insulator function during development
by Herold, Martin and Bartkuhn, Marek and Renkawitz, Rainer
Development, ISSN 0950-1991, 03/2012, Volume 139, Issue 6, pp. 1045 - 1057
The genome of higher eukaryotes exhibits a patchwork of inactive and active genes. The nuclear protein CCCTC-binding factor (CTCF) when bound to insulator... 
Insulator | Cohesin | Homeotic gene | Igf2/H19 | Imprint | TRANSCRIPTIONAL INSULATION | PROTEIN CTCF | CHROMOSOMAL DOMAINS | DEVELOPMENTAL BIOLOGY | REGULATORY ELEMENTS | CHROMATIN DOMAIN BOUNDARY | ENHANCER-BLOCKING ACTIVITY | IMPRINTING CONTROL REGION | CCCTC-BINDING-FACTOR | DROSOPHILA-BITHORAX COMPLEX | GENE-EXPRESSION | Insulator Elements - genetics | Humans | Chromosomal Proteins, Non-Histone | RNA, Untranslated - genetics | Animals | Insulin-Like Growth Factor II - genetics | Enhancer Elements, Genetic | Gene Expression Regulation, Developmental | CCCTC-Binding Factor | RNA, Long Noncoding | Transcription, Genetic | Mice | Cell Cycle Proteins | Repressor Proteins - metabolism | Drosophila - genetics
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5. Full Text The chromatin insulator CTCF and the emergence of metazoan diversity
by Peter Heger and Birger Marin and Marek Bartkuhn and Einhard Schierenberg and Thomas Wiehe
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 43, pp. 17507 - 17512
The great majority of metazoans belong to bilaterian phyla. They diversified during a short interval in Earth's history known as the Cambrian explosion, ~540... 
Vertebrates | Cambrian explosion | Chromatin | Drosophila | Evolution | Genetic loci | Evolutionary genetics | Genomes | Gene expression | Binding sites | CCCTC-BINDING FACTOR | FUNCTIONAL ELEMENTS | DNA-SEQUENCES | HUMAN GENOME | EVOLUTION | PROTEIN CTCF | MULTIDISCIPLINARY SCIENCES | CAMBRIAN EXPLOSION | DROSOPHILA-BITHORAX COMPLEX | HOXC8 EARLY ENHANCER | GENE-EXPRESSION | Repressor Proteins - physiology | Multigene Family | Animals | Repressor Proteins - classification | CCCTC-Binding Factor | Phylogeny | Drosophila melanogaster - genetics | Genes, Homeobox | Microbial genetics | Physiological aspects | Research | Health aspects | Metazoa | Protein binding | Biological diversity | Biological Sciences
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6. Full Text Serpent/dGATAb regulates Laminin B1 and Laminin B2 expression during Drosophila embryogenesis
by Topfer, U and Bischoff, MC and Bartkuhn, M and Holz, A
SCIENTIFIC REPORTS, ISSN 2045-2322, 11/2019, Volume 9, Issue 1, pp. 1 - 9
Transcriptional regulation of Laminin expression during embryogenesis is a key step required for proper ECM assembly. We show, that in Drosophila the Laminin... 
GATA FACTORS | GENE | ALPHA-CHAIN | MULTIDISCIPLINARY SCIENCES | SEQUENCE | ENDODERM | DIFFERENTIATION | TRANSCRIPTION FACTOR | BINDING | BETA | WASP | Enhancers | Embryogenesis | Reporter gene | Laminin | Insects | Gene regulation | Extracellular matrix | Primordia | Gene expression | Kinases | Yolk
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7. Full Text Active promoters and insulators are marked by the centrosomal protein 190
by Bartkuhn, Marek and Herold, Martin and Saumweber, Harald and Rathke, Christina and Gilfillan, Gregor D and Becker, Peter B and Renkawitz, Rainer and Straub, Tobias and Herrmann, Mareike
The EMBO Journal, ISSN 0261-4189, 04/2009, Volume 28, Issue 7, pp. 877 - 888
For the compact Drosophila genome, several factors mediating insulator function, such as su(Hw) and dCTCF, have been identified. Recent analyses showed that... 
chromatin domains | CTCF | transcription | CP190 | chromatin insulation | Chromatin insulation | Transcription | Chromatin domains | RNA-POLYMERASE-II | NUCLEAR-ORGANIZATION | BITHORAX COMPLEX | DROSOPHILA-MELANOGASTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | GAGA FACTOR | GYPSY CHROMATIN INSULATORS | POLYCOMB COMPLEXES | GENOME-WIDE | BINDING-SITES | ENHANCER BLOCKING | Promoter Regions, Genetic | Insulator Elements - genetics | Chromosomal Proteins, Non-Histone - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Transcriptional Activation | Cell Cycle Proteins - metabolism | Nucleosomes - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Animals | CCCTC-Binding Factor | Drosophila Proteins - genetics | Genome, Insect | Nuclear Proteins - genetics | Binding Sites | Repressor Proteins - metabolism | Proteins | Insects | Molecular biology | Genomics | Binding sites
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8. Full Text Impact of human sepsis on CCCTC-binding factor associated monocyte transcriptional response of Major Histocompatibility Complex II components
by Siegler, Benedikt Hermann and Uhle, Florian and Lichtenstern, Christoph and Arens, Christoph and Bartkuhn, Marek and Weigand, Markus Alexander and Weiterer, Sebastian
PLoS ONE, ISSN 1932-6203, 09/2018, Volume 13, Issue 9, p. e0204168
Background Antigen presentation on monocyte surface to T-cells by Major Histocompatibility Complex, Class II (MHC-II) molecules is fundamental for pathogen... 
CELLS | CIITA | HLA-DR | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | SEPTIC SHOCK | DR EXPRESSION | MULTIPLE ORGAN FAILURE | CTCF | CD14 | CHROMATIN ARCHITECTURE | Flow cytometry | Chromatin | Intensive care | Immunoprecipitation | Genes | Critical care | Lymphocytes T | Genomes | Regulatory sequences | Gender | CD14 antigen | Blood | Gene sequencing | Proteins | Immunology | DNA-binding protein | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Antigen presentation | Cytokines | Inflammation | Gene expression | Ribonucleic acid--RNA | Patients | Loci | CIITA protein | Immunosuppression | CD16 antigen | Monocytes | Hospitals | Major histocompatibility complex | Epigenetics | Sepsis | Histocompatibility antigen HLA | Anesthesiology | Histocompatibility | Binding sites | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
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9. Full Text CTCF genomic binding sites in Drosophila and the organisation of the bithorax complex
by Holohan, Eimear E and Kwong, Camilla and Adryan, Boris and Bartkuhn, Marek and Herold, Martin and Renkawitz, Rainer and Russell, Steven and White, Robert
PLoS genetics, ISSN 1553-7390, 07/2007, Volume 3, Issue 7, pp. 1211 - 1222
Insulator or enhancer-blocking elements are proposed to play an important role in the regulation of transcription by preventing inappropriate enhancer/promoter... 
RESPONSE ELEMENT | ABDOMINAL-B | ENHANCER-BLOCKING ACTIVITY | METHYLATION | GENE | GENETICS & HEREDITY | INSULATOR PROTEIN CTCF | PROMOTER | MELANOGASTER | EXPRESSION | CHROMATIN DOMAIN BOUNDARY | Consensus Sequence | Genes, Insect | Oligonucleotide Array Sequence Analysis | Repressor Proteins - genetics | DNA Primers - genetics | Binding Sites - genetics | DNA - metabolism | DNA-Binding Proteins - genetics | Drosophila Proteins - metabolism | DNA - genetics | DNA-Binding Proteins - metabolism | Animals | Chromatin Immunoprecipitation | Enhancer Elements, Genetic | Base Sequence | CCCTC-Binding Factor | Models, Genetic | Drosophila - metabolism | Drosophila Proteins - genetics | Genome, Insect | Insulator Elements | Repressor Proteins - metabolism | Drosophila - genetics | Genetic aspects | Zinc finger proteins | Research | Observations | Drosophila | Binding sites (Biochemistry) | Genetics and Genomics | Vertebrates | Proteins | Insects | Deoxyribonucleic acid | DNA | Genetics | Genomes | Boundaries | Gene expression | Abdomen
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10. Full Text Sepsis induces specific changes in histone modification patterns in human monocytes
by Weiterer, Sebastian and Uhle, Florian and Lichtenstern, Christoph and Siegler, Benedikt H and Bhuju, Sabin and Jarek, Michael and Bartkuhn, Marek and Weigand, Markus A
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0121748
Background Sepsis is a global burden and the primary cause of death in intensive care units worldwide. The pathophysiological changes induced by the host's... 
MACROPHAGES | IMMUNOSUPPRESSION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | SEQUENCE | GENE-EXPRESSION | INJURY | EPIDEMIOLOGY | CARE | Promoter Regions, Genetic | Chromatin | Receptors, Interleukin-1 Type II - metabolism | Humans | Monocytes - metabolism | Receptors, Interleukin-1 Type II - genetics | Case-Control Studies | Sepsis - pathology | Chromatin Immunoprecipitation | Sepsis - metabolism | Histocompatibility Antigens Class II - metabolism | Protein Processing, Post-Translational | Histocompatibility Antigens Class II - genetics | Histones - metabolism | Cluster Analysis | Infection | Epigenetic inheritance | Health aspects | Analysis | Genomics | Enrichment | Intensive care | Immunoprecipitation | Genes | Critical care | Inflammatory response | Genomes | Kinases | Gene sequencing | Intensive care units | Next-generation sequencing | Granulocytes | Rodents | Hepatology | Acetylation | Nosocomial infections | Bioinformatics | Immune system | Immune response | Cytokines | Inflammation | RNA polymerase | Gene expression | Patients | CIITA protein | Medicine | Monocytes | Hospitals | Major histocompatibility complex | Lysine | Regulatory mechanisms (biology) | Epigenetics | Sepsis | Histocompatibility antigen HLA | Genetic engineering | Anesthesiology | Methylation | Binding sites
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11. Full Text Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer
by Kiehl, Steffen and Zimmermann, Tobias and Savai, Rajkumar and Pullamsetti, Soni S and Seeger, Werner and Bartkuhn, Marek and Dammann, Reinhard H
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 3896 - 14
Epigenetic deregulation is of importance in tumorigenesis. In particular CpG islands (CGI), are frequently hypermethylated. Here, genome-wide DNA-methylation... 
ABERRANT METHYLATION | PROMOTER HYPERMETHYLATION | DNA METHYLATION | RASSF1A | CPG ISLAND | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR GENES | BINDING PROTEINS | BREAST CANCERS | CTCF-BINDING | EXPRESSION | Lung cancer | Genes | Shores | Genomes | Tumor cell lines | Promoters | Homeobox | Gene silencing | DNA methylation | Epigenetics | Tumor suppressor genes | Tumorigenesis | CpG islands
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12. Full Text The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells
by Poppe, Michael and Wittig, Sascha and Jurida, Liane and Bartkuhn, Marek and Wilhelm, Jochen and Müller, Helmut and Beuerlein, Knut and Karl, Nadja and Bhuju, Sabin and Ziebuhr, John and Schmitz, M. Lienhard and Kracht, Michael
PLoS Pathogens, ISSN 1553-7366, 03/2017, Volume 13, Issue 3, p. e1006286
Coronavirus replication takes place in the host cell cytoplasm and triggers inflammatory gene expression by poorly characterized mechanisms. To obtain more... 
SIGNALING PATHWAYS | ACTIVATION | STRESS-RESPONSE | SARS | MICROBIOLOGY | MECHANISMS | ACUTE RESPIRATORY SYNDROME | UNFOLDED PROTEIN RESPONSE | VIROLOGY | GENE-EXPRESSION | NUCLEOCAPSID PROTEIN | STRAND RNA VIRUSES | PARASITOLOGY | Cell Line | Oligonucleotide Array Sequence Analysis | Coronavirus 229E, Human | Humans | Gene Expression Regulation | Transcriptome | Coronavirus Infections - genetics | Laser Capture Microdissection | Immunoblotting | NF-kappa B - metabolism | Chromatin Immunoprecipitation | Chromatin - physiology | Polymerase Chain Reaction | Microscopy, Fluorescence
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