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Journal for ImmunoTherapy of Cancer, ISSN 2051-1426, 02/2019, Volume 7, Issue 1, pp. 40 - 8
BackgroundSeveral predictive biomarkers are currently approved or are under investigation for the selection of patients for checkpoint blockade. Tumor PD-L1... 
Neoantigens | T cells | Checkpoint blockade | Oncogene | Predictive biomarkers | DOMAIN | PD-1 BLOCKADE | BRAF | IMMUNOLOGY | CANCER | TUMORS | ONCOLOGY | AFFINITY | AKT1 | MUTATIONS | BINDING | Medical research | Immunotherapy | Colorectal cancer | Medicine, Experimental | Genetic aspects | Lung cancer, Non-small cell | Tumors | Lymphocytes | Lung cancer | Genomics | Melanoma | Biomarkers | Ligands | Mutation | Patients | Cancer therapies
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2015, Volume 372, Issue 26, pp. 2509 - 2520
Persons with mismatch repair–deficient tumors are more likely than persons with mismatch repair–proficient tumors to benefit from pembrolizumab — which... 
MEDICINE, GENERAL & INTERNAL | COLORECTAL CARCINOMAS | ANTI-PD-L1 ANTIBODY | SAFETY | MICROSATELLITE INSTABILITY | DNA | GERMLINE MUTATIONS | PREDISPOSE | CLINICAL ACTIVITY | CANCER | LYMPHOCYTES | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Colorectal Neoplasms - genetics | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Disease-Free Survival | Neoplasm Metastasis - genetics | Neoplasm Metastasis - drug therapy | Antineoplastic Agents - adverse effects | Colorectal Neoplasms - drug therapy | DNA Mismatch Repair | Adult | Female | Adenocarcinoma - genetics | Aged | Colorectal Neoplasms - pathology | Antibody diversity | Carcinoma | Genetic disorders | Analysis | Research | Risk factors | Cancer | Tumors | Antigens | Yeast | PD-1 protein | Colorectal carcinoma | Body weight | Colorectal cancer | Autoantigens | DNA repair | Survival | Metastases | Pembrolizumab | Immune checkpoint | Immunogenicity | Mismatch repair | Death | Mutation | Genetic recombination | Cancer therapies | Drug dosages | Immune system | Medical research | Melanoma | Patients | Studies | Hypotheses | Pancreatic cancer | Epigenetics | Biomarkers | Ligands
Journal Article
Science, ISSN 0036-8075, 07/2017, Volume 357, Issue 6349, pp. 409 - 413
The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed... 
CELL LUNG-CANCER | SURVIVAL | COLORECTAL CARCINOMAS | RECEIVING NIVOLUMAB | IMMUNOTHERAPY | MICROSATELLITE INSTABILITY | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | NEOANTIGENS | CHECKPOINT BLOCKADE | LYMPHOCYTES | Neoplastic Syndromes, Hereditary - immunology | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Neoplastic Syndromes, Hereditary - mortality | Young Adult | Colorectal Neoplasms - therapy | Brain Neoplasms - immunology | DNA Mismatch Repair | Aged, 80 and over | Adult | Female | Neoplastic Syndromes, Hereditary - genetics | Brain Neoplasms - mortality | Biomarkers, Tumor - antagonists & inhibitors | Colorectal Neoplasms - mortality | Antibodies, Monoclonal, Humanized - therapeutic use | Antigens, Neoplasm - immunology | Brain Neoplasms - genetics | Disease-Free Survival | Colorectal Neoplasms - immunology | Cell Cycle Checkpoints - drug effects | Brain Neoplasms - therapy | Neoplastic Syndromes, Hereditary - therapy | T-Lymphocytes - immunology | Aged | Mutation | Programmed Cell Death 1 Receptor - immunology | Colorectal cancer | Genetic aspects | Nucleotide sequencing | Health aspects | DNA repair | Methods | Tumors | DNA sequencing | Yeast | PD-1 protein | Antibodies | Clinical trials | Genomes | Functional analysis | Lymphocytes T | Patients | Survival | Colon cancer | Immune checkpoint | Immunotherapy | Mismatch repair | Pancreatic cancer | Biomarkers | Bioindicators | Colon | Solid tumors | Genetic recombination | Repair | Cancer | Apoptosis
Journal Article
Science Translational Medicine, ISSN 1946-6234, 02/2014, Volume 6, Issue 224, pp. 224ra24 - 224ra24
The development of noninvasive methods to detect and monitor tumors continues to be a major challenge in oncology. We used digital polymerase chain... 
Humans | Middle Aged | Male | Young Adult | Neoplasm Metastasis | Neoplasms - blood | DNA, Neoplasm - blood | Neoplasms - genetics | Aged, 80 and over | Adult | Female | Aged | Neoplasms - pathology | MEDICINE, RESEARCH & EXPERIMENTAL | CELL BIOLOGY | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 09/2019
Microsatellite instability (MSI) and high tumor mutation burden (TMB-High) are promising pan-tumor biomarkers used to select patients for treatment with immune... 
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 09/2019, Volume 25, Issue 17, pp. 5250 - 5259
Purpose: Approximately 10% of patients with mismatch repair-proficient (MMRp) colorectal cancer showed clinical benefit to anti-PD-1 monotherapy (NCT01876511).... 
IMPACT | MICROENVIRONMENT | ONCOLOGY | BLOCKADE | CANCER | TH17
Journal Article
Cancer immunology research, ISSN 2326-6066, 08/2019, Volume 7, Issue 10, pp. 1574 - 1579
Mismatch-repair deficiency in solid tumors predict their response to PD-1 blockade. Based on this principle, pembrolizumab is approved as standard of care for... 
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2015, Volume 33, Issue 18_suppl, pp. LBA100 - LBA100
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2015, Volume 33, Issue 15_suppl, pp. LBA100 - LBA100
Journal Article
Neuro-Oncology, ISSN 1522-8517, 07/2014, Volume 16, Issue suppl 3, pp. iii7 - iii7
BACKGROUND: The development of minimally-invasive methods to detect and monitor tumors continues to be a major challenge in oncology. We used digital PCR-based... 
abstracts
Journal Article
Chicago Daily Tribune (1923-1963), 05/1954, p. B1
The European Golden Gloves' team, considered the finest ever to reach these shores, will leave Manhattan on the Broadway Limited tomorrow afternoon for its May... 
Newspaper Article
Chicago Daily Tribune (1923-1963), 05/1954, p. A1
Memo: John Bohr, head coach, Chicago Golden Gloves team, 
Newspaper Article
Chicago Daily Tribune (1923-1963), 04/1954, p. D1
Gosh, even Col. Russell is in training for the 17th International Golden Gloves bouts between Chicagoland's best boxers... 
Newspaper Article
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