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Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, pp. e0176855 - e0176855
Targeting epigenetic changes in diffuse intrinsic pontine glioma (DIPG) may provide a novel treatment option for patients. This report demonstrates that sodium... 
HISTONE DEACETYLASE INHIBITOR | GLIOBLASTOMA | CARBOPLATIN | ACID | BRAIN-STEM GLIOMA | ACTIVATING ACVR1 MUTATIONS | MULTIDISCIPLINARY SCIENCES | LEUKEMIA-CELLS | PHASE-I | EXPRESSION | CONVECTION-ENHANCED DELIVERY | Cell Survival - drug effects | Adjuvants, Pharmaceutic - pharmacology | Apoptosis - drug effects | Humans | Cells, Cultured | Rats | Brain Stem Neoplasms - drug therapy | Hippocampus - drug effects | Anticonvulsants - pharmacology | Valproic Acid - pharmacology | Brain Stem Neoplasms - metabolism | Glioma - metabolism | Hippocampus - metabolism | Acetylation - drug effects | Animals | Drug Repositioning - methods | Cell Line, Tumor | Histone Deacetylase Inhibitors - pharmacology | Epigenesis, Genetic - drug effects | Glioma - drug therapy | Divalproex | Complications and side effects | Gliomas | Dosage and administration | Research | Drug therapy | Valproic acid | Slopes | Brain | Cell culture | Brain stem | Estrogens | Brain cancer | Radiation | Cytotoxicity | Cerebrospinal fluid | Cancer therapies | Blood | Anticancer properties | Proteins | Learning | Alterations | Blood-brain barrier | Surgery | Biocompatibility | Genetics | Diagnosis | Acetylation | Inhibition | Deoxyribonucleic acid--DNA | Medical research | Iodides | Lymphatic leukemia | Gene expression | Survival | Discrimination | Inhibitors | Sodium | Documents | Carboplatin | Mutation | Drugs | Surgical implants | Animal models | Chromatin | Drug delivery systems | Toxicity | Leukemia | Brain tumors | Clinical trials | Neurosurgery | Antiepileptic agents | Convection | Platinum | Modulation | DNA methylation | Children | Formulations | Effectiveness | Hematology | Buildings | Breast cancer | Pharmacology | Radiation therapy | Brain research | Cell death | Epigenetics | Skull | Genetic engineering | Annexin V | Methylation | Differentiation | Apoptosis | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, pp. e56186 - e56186
Background: Despite promising early results, clinical trials involving the continuous delivery of recombinant methionyl human glial cell line-derived... 
PROTEIN | PROTECTION | NEURONS IN-VITRO | MULTIDISCIPLINARY SCIENCES | PUTAMEN | RECEPTOR | DOPAMINERGIC-NEURONS | AGED RHESUS-MONKEYS | INTRAPUTAMENAL INFUSION | BRAIN | PARKINSONS-DISEASE | Rats, Wistar | Infusion Pumps | Humans | Rats | Male | Metabolic Clearance Rate | Recombinant Proteins - pharmacokinetics | Parkinson Disease - drug therapy | Corpus Striatum - metabolism | Glial Cell Line-Derived Neurotrophic Factor - administration & dosage | Glial Cell Line-Derived Neurotrophic Factor - pharmacokinetics | Recombinant Proteins - administration & dosage | Tissue Distribution | Animals | Glial Cell Line-Derived Neurotrophic Factor - toxicity | Corpus Striatum - drug effects | Recombinant Proteins - toxicity | Neuroglia - metabolism | Neurogenesis - drug effects | Parkinson Disease - metabolism | Cell Death - drug effects | Corpus Striatum - pathology | Care and treatment | Parkinson's disease | Neuroglia | Analysis | Risk factors | Immunohistochemistry | Calcium | Synaptogenesis | Low concentrations | Toxicity | Parkinsons disease | Clinical trials | mRNA | Neurosurgery | Cerebrospinal fluid | Accumulation | Convection | Neuronal-glial interactions | Infusion | Neurotoxicity | Rodents | Neostriatum | Drug dosages | Enzyme-linked immunosorbent assay | Movement disorders | Recombinant | Medical research | Dosing | Synaptophysin | Glial cell line-derived neurotrophic factor | Translation | Medical imaging | Neurodegenerative diseases | Axonogenesis | Adapters | Glial fibrillary acidic protein | Medical treatment | Putamen | Microglia | Studies | Gliosis | Binding sites | Index Medicus
Journal Article
Fluids and Barriers of the CNS, ISSN 2045-8118, 01/2012, Volume 9, Issue 1, pp. 2 - 2
Convection-enhanced delivery (CED), a direct method for drug delivery to the brain through intraparenchymal microcatheters, is a promising strategy for... 
Nanoparticles | Solutes | Dextrans | Convection-enhanced delivery | Macrophages | Perivascular | Drugs | Drug delivery systems | Usage | Clinical trials | Management | Health aspects | Vehicles | perivascular | dextrans | solutes | macrophages | nanoparticles
Journal Article
Neuro-Oncology, ISSN 1522-8517, 06/2017, Volume 19, Issue suppl_4, pp. iv55 - iv55
Despite clinical advances, diffuse intrinsic pontine glioma (DIPG) remains universally fatal and urgently requires new treatment modalities to improve... 
Abstracts
Journal Article
Brain Pathology, ISSN 1015-6305, 03/2014, Volume 24, Issue 2, pp. 117 - 127
Journal Article
Neuro-Oncology, ISSN 1522-8517, 10/2014, Volume 16, Issue Suppl 6, pp. vi9 - vi9
INTRODUCTION: We are currently investigating CED of the platinum-based drug, carboplatin as a novel treatment strategy for high grade glioma in adults and... 
Abstracts
Journal Article
Neuro-Oncology, ISSN 1522-8517, 06/2017, Volume 19, Issue suppl_4, pp. iv55 - iv55
There is a significant need to develop new treatment strategies to improve the prognosis of DIPG patients. We have previously shown that the HDAC inhibitor,... 
Abstracts
Journal Article
by Tosun, Duygu and Schuff, Norbert and Mathis, Chester A and Jagust, William and Weiner, Michael W and Saradha, A and Abdi, Herve and Abdulkadir, Ahmed and Abeliovich, Asa and Abellan van Kan, Gabor and Abner, Erin and Acharya, Deepa and Agrusti, Antonella and Agyemang, Alex and Ahdidan, Jamila and Ahmed, Shiek and Ahn, Jae Eun and Aisen, Paul and Aksu, Yaman and Al-Akhras, Mousa and Alarcon, Marcelo and Alberca, Roman and Alexander, Gene and Alexander, Daniel and Alin, Aylin and Almeida, Fabio and Amlien, Inge and Anand, Shyam and Anderson, Dallas and Anew, Marilee and Angersbach, Steve and Anjum, Ayesha and Aoyama, Eiji and Arfanakis, Konstantinos and Armor, Tom and Arnold, Steven and Arunagiri, Vidhya and Asatryan, Albert and Ashe-McNalley, Cody and Ashiga, Hirokazu and Assareh, Arezoo and Le Page, Aurelie and Avants, Brian and Avinash, Gopal and Aviv, Richard and Awasthi, Sukrati and Ayan-Oshodi, Mosun and Babic, Tomislav and Baek, Young and Bagci, Ulas and Bai, Shuyang and Baird, Geoffrey and Baker, John and Banks, Sarah and Bard, Jonathan and Barnes, Josephine and Bartlett, Jonathan and Bartzokis, George and Barua, Neil and Bauer, Corinna and Bayley, Peter and Beck, Irene and Becker, James and Becker, J. Alex and Beckett, Laurel and Bednar, Martin and Beg, Mirza Faisal and Bek, Stephan and Belaroussi, Boubakeur and Belmokhtar, Nabil and Bernard, Charlotte and Bertram, Lars and Bhaskar, Uday and Biffi, Alessano and Bigler, Erin and Bilgic, Basar and Bishop, Courtney and Bittner, Daniel and Black, Ronald and Bogorodzki, Piotr and Bokde, Arun and Bonner-Jackson, Aaron and Boppana, Madhu and Bourgeat, Pierrick and Bowes, Mike and Bowman, DuBois and Bowman, Gene and Braskie, Meredith and Braunewell, Karl and Breitner, Joihn and Bresell, Anders and Brewer, James and Brickman, Adam and Britschgi, Markus and Broadbent, Steve and Brogren, Jacob and Brooks, David and Browndyke, Jeffrey and Brunton, Simon and Buchert, Ralph and ... and Alzheimer's Dis NeuroImaging Initi and Alzheimer's Disease NeuroImaging Initiative
Brain, ISSN 0006-8950, 2011, Volume 134, Issue Part 4, pp. 1077 - 1088
Journal Article
Practical Neurology, ISSN 1474-7758, 07/2019, p. practneurol-2019-002275
Journal Article