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Synthesis, ISSN 0039-7881, 02/2020, Volume 52, Issue 3, pp. 441 - 449
Abstract An efficient and practical synthetic protocol for the synthesis of 1,4-disubstituted pyrrolo[1,2- a ]pyrazine derivatives is described that originates... 
paper
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 11/2018, Volume 59, Issue 48, pp. 4267 - 4271
A number of cyanomethyl esters of natural/unnatural aminoacids with un-protected amino functionality were synthesized because of their synthetic and medicinal... 
Cyanomethyl | Aminoacids | Aminoacylation | tRNA analogs | N-Boc | Deprotection | ENZYMES | PDCPA | CHEMISTRY, ORGANIC | AGENTS | UBER AKTIVIERTE ESTER | Amino acids | Dioxane | Amines | Transfer RNA | Organic compounds
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, p. 2265
An X-ray crystal structure of one of our previously discovered ROR[gamma]t inverse agonists bound to the ROR[gamma]t ligand binding domain revealed that the... 
Hydrogen | Crystals | Cyclohexane | Structure | Tretinoin
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, pp. 2265 - 2269
An X-ray crystal structure of one of our previously discovered RORγt inverse agonists bound to the RORγt ligand binding domain revealed that the cyclohexane... 
Th17 | Inverse agonist | Retinoic acid-related orphan receptor gamma t | IL-17 | RORγt | AUTOIMMUNE | DESIGN | CHEMISTRY, MEDICINAL | ROR gamma t | CHEMISTRY, ORGANIC | PSORIASIS | DISCOVERY
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 11/2019, Volume 62, Issue 21, pp. 9931 - 9946
ROR gamma t is an important nuclear receptor that regulates the production of several pro-inflammatory cytokines such as IL-17 and IL-22. As a result, ROR... 
ACYL GLUCURONIDES | AUTOIMMUNE | CHEMISTRY, MEDICINAL | T(H)17 CELLS | RECEPTOR-GAMMA | REV-ERB | NUCLEAR RECEPTORS | INFLAMMATION | PROINFLAMMATORY IL-17(+) | GENE-EXPRESSION | DISCOVERY
Journal Article
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