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BIOANALYSIS, ISSN 1757-6180, 02/2019, Volume 11, Issue 3, pp. 203 - 213
Journal Article
Analytical Chemistry, ISSN 0003-2700, 01/2018, Volume 90, Issue 1, p. 866
Large molecule quantitation by LC-MS/MS commonly relies on bottom-up or so-called surrogate peptide measurements to infer the whole-molecule concentration.... 
Analytical chemistry | Molecules | Trypsin | Purification | Peptides | Reagents | Monoclonal antibodies | Affinity | Quantitation | Assaying | Mass spectrometry
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 12/2017, Volume 2017, Issue 47, pp. 7122 - 7126
Late‐stage functionalization (LSF) through C–H functionalization of drug leads is a powerful synthetic strategy for drug discovery. A key challenge in LSF is... 
C‐H activation | MS/MS | Structure elucidation | Late‐stage functionalization | C-H activation | Late-stage functionalization | ROOM-TEMPERATURE | SCOPE | ARENES | CHEMISTRY, ORGANIC | IODINATION | HALOGENATION | MASS-SPECTROMETRY | HETEROCYCLES | METABOLITE IDENTIFICATION | C-H BORYLATION | TRIFLUOROMETHYLATION | Electronic data processing | Drug discovery
Journal Article
Bioanalysis, 02/2019
The quantitation of therapeutic antibodies by MS often utilizes a surrogate peptide approach. Recent enhancements in instrumentation and sample preparation... 
Journal Article
The AAPS Journal, ISSN 1550-7416, 3/2016, Volume 18, Issue 2, pp. 519 - 527
Dried blood spot (DBS) sample collection has gained increased interest across the pharmaceutical industry as a potential alternative to plasma for... 
Biochemistry, general | Biotechnology | MK-8931 | Biomedicine | Pharmacy | population PK | Pharmacology/Toxicology | bridging | dried blood spots | Dried Blood Spot Testing - trends | Drug Industry - trends | Dried Blood Spot Testing - methods | Drug Industry - methods | Humans | Pharmaceutical industry | Alzheimer's disease
Journal Article
Rapid Communications in Mass Spectrometry, ISSN 0951-4198, 05/2007, Volume 21, Issue 9, pp. 1485 - 1496
Journal Article
Journal of Chromatography B, ISSN 1570-0232, 2004, Volume 809, Issue 1, pp. 153 - 158
Journal Article
Analytical Chemistry, ISSN 0003-2700, 01/2018, Volume 90, Issue 1, pp. 866 - 871
Large molecule quantitation by LC-MS/MS commonly relies on bottom-up or so-called surrogate peptide measurements to infer the whole-molecule concentration.... 
INTERNAL STANDARD | CHEMISTRY, ANALYTICAL | PROTEIN | QUANTIFICATION | BIOTHERAPEUTICS | IMMUNOASSAYS | GENERATION | MASS-SPECTROMETRY | STRATEGIES | PROTEOMICS | Monoclonal antibodies | Trypsin | Chemical properties | Peptides | Analysis
Journal Article
Analytical Chemistry, ISSN 0003-2700, 03/2009, Volume 81, Issue 5, p. 1881
  Chronic obstructive pulmonary disease (COPD) is characterized by the degradation of elastin, the major insoluble protein of lung tissues. The degradation of... 
Proteins | Analytical chemistry | Urine | Ion chromatography | Lungs | Chronic obstructive pulmonary disease | Mass spectrometry | Smoking
Journal Article
Bioanalysis, 07/2013, Volume 5, Issue 14, p. 1783
Merck consolidated discovery stage bioanalytical functions into the Department of Pharmacokinetics, Pharmacodynamics & Drug Metabolism in 2007. Since then... 
Automation | Efficiency | Drug Discovery | Efficiency, Organizational
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 01/2019, Volume 105, Issue 1, pp. 168 - 176
Merck & Co, Inc (Kenilworth, NJ) is investing in approaches to enrich clinical trial data and augment decision making through use of digital health... 
IMPLEMENTATION | PHARMACOLOGY & PHARMACY | ADHERENCE | Research
Journal Article
Rapid Communications in Mass Spectrometry, ISSN 0951-4198, 09/2005, Volume 19, Issue 18, pp. 2597 - 2602
The removal of bottlenecks in discovery stage metabolite identification studies is an ongoing challenge for the pharmaceutical industry. We describe the use of... 
THROUGHPUT | CHEMISTRY, ANALYTICAL | SPECTROSCOPY | ACQUISITION | RESOLUTION | BIOCHEMICAL RESEARCH METHODS | DRUG METABOLITES | DISCOVERY | VERAPAMIL | Animals | Verapamil - analysis | Microsomes, Liver - metabolism | Chromatography, Liquid | Rats | Molecular Structure | Mass Spectrometry - methods | Verapamil - metabolism | Verapamil - chemistry
Journal Article
Bioanalysis, ISSN 1757-6180, 11/2017, Volume 9, Issue 21, pp. 1633 - 1641
Aim: Preclinical pharmacokinetic studies are an essential part of modern drug development. In this work, we explored a new solution with onsite analysis using... 
miniature mass spectrometer | automatic blood sampler | preclinical pharmacokinetics | AMBIENT CONDITIONS | CHEMISTRY, ANALYTICAL | DRUG DISCOVERY | BIOCHEMICAL RESEARCH METHODS | PAPER SPRAY | IONIZATION MASS-SPECTROMETRY | QUANTITATIVE-ANALYSIS | BIOFLUID SAMPLES | ELECTROSPRAY-IONIZATION
Journal Article
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