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ChemMedChem, ISSN 1860-7179, 11/2014, Volume 9, Issue 11, p. 2516
  The Janus kinases (JAKs) are a family of cytosolic tyrosine kinases crucially involved in cytokine signaling. JAKs have been demonstrated to be valid targets... 
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2017, Volume 60, Issue 13, pp. 5290 - 5305
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2017, Volume 60, Issue 19, pp. 8027 - 8054
We recently reported 1a (skepinone-L) as a type I p38α MAP kinase inhibitor with high potency and excellent selectivity in vitro and in vivo. However, as a... 
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e95641
The fundamental role of p38 mitogen-activated protein kinases (MAPKs) in inflammation underlines their importance as therapeutic targets for various... 
ACTIVATED PROTEIN-KINASE | SCREEN | PATHWAY | MAP KINASE | MULTIDISCIPLINARY SCIENCES | CHEMOTYPES | BIOLOGICAL EVALUATION | NUCLEAR EXPORT | DIBENZOSUBERONES | DISCOVERY | STRESSES | Green Fluorescent Proteins - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Cell Survival - genetics | Protein Transport - physiology | Biological Assay - methods | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Protein Transport - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Intracellular Signaling Peptides and Proteins - genetics | Cell Survival - physiology | Protein-Serine-Threonine Kinases - metabolism | p38 mitogen-activated protein kinases | Physiological aspects | Medicine, Experimental | Medical research | Inflammation | Research | Phosphorylation | Image processing | JNK3 protein | Clinical trials | Selectivity | Drug development | Kinases | Assaying | Blood | Optimization | Proteins | Signal transduction | New combinations | Tumor necrosis factor-TNF | Content analysis | Translocation | Automation | Cytokines | MAP kinase | JNK protein | Tumor necrosis factor-α | Medical screening | Substrates | Inhibitors | Pharmacy | Cells (biology) | In vivo methods and tests | Combinatorial analysis | Binding sites
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2015, Volume 58, Issue 1, pp. 443 - 456
Journal Article
Anal. Methods, ISSN 1759-9660, 2014, Volume 6, Issue 21, pp. 8817 - 8822
Journal Article
Analytical Methods, ISSN 1759-9660, 11/2014, Volume 6, Issue 21, pp. 8817 - 8822
The availability of a robust, precise and cost-efficient test system is the prerequisite for the performance of any medicinal chemistry program, especially in... 
SPECTROSCOPY | CHEMISTRY, ANALYTICAL | FOOD SCIENCE & TECHNOLOGY | Phosphorylation | Inhibitors | Janus | Manuals | Kinases | Assaying | Standards | ELISA
Journal Article
Journal Article
Chemical Biology & Drug Design, ISSN 1747-0277, 10/2015, Volume 86, Issue 4, pp. 531 - 545
Journal Article
Journal Article
Ecology Letters, ISSN 1461-023X, 12/2011, Volume 14, Issue 12, pp. 1183 - 1190
Journal Article
Pediatric Transplantation, ISSN 1397-3142, 09/2010, Volume 14, Issue 6, pp. 715 - 721
Journal Article
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