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Pharmacology and Therapeutics, ISSN 0163-7258, 2015, Volume 146, pp. 53 - 60
The PI3K/Akt/mTOR pathway is the most frequently known activated aberrant pathway in human cancers. Pathologic activation can occur at multiple levels along... 
Isoforms | PI3K pathway | Review | PI3K inhibitors | PI3K/Akt/mTOR
Journal Article
Investigational new drugs, ISSN 0167-6997, 07/2019, pp. 1 - 9
Purposes Vactosertib is a new investigational inhibitor of activin receptor-like kinase 5. The objective of this study was to characterize vactosertib... 
Studies | Dosing | Inhibitors | Radioactive half-life | Pharmacology | Solid tumors | Pharmacokinetics | Kinases | Activin | Accumulation | Half life | Tumors
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2017, Volume 18, Issue 1, pp. 42 - 51
Journal Article
OncoTargets and therapy, ISSN 1178-6930, 2018, Volume 11, pp. 2399 - 2407
Aberrant activation of the Janus-associated kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is associated with increased malignant... 
Cytokines | Review boards | Feasibility studies | Oncology | Inflammation | Metastasis | FDA approval | Kinases | Patients | Cancer therapies | Chemotherapy | Granulocytes | Pancreatic cancer | Drug dosages | Tumors | pancreatic cancer | Janus kinase inhibitor
Journal Article
The Lancet Oncology, ISSN 1470-2045, 12/2017, Volume 18, Issue 12, pp. 1590 - 1599
Journal Article
Cancer Discovery, ISSN 2159-8274, 08/2015, Volume 5, Issue 8, pp. 850 - 860
Journal Article
by Gerstein, Hertzel C and Bosch, Jackie and Dagenais, Gilles R and Díaz, Rafael and Jung, Hyejung and Maggioni, Aldo P and Pogue, Janice and Probstfield, Jeffrey and Ramachandran, Ambady and Riddle, Matthew C and Rydén, Lars E and Yusuf, Salim and Richardson, L and Diaz, R and Johnston, P and Vige, R and Birkeland, K and Budaj, A and Cardona, E and Chazova, I and Commerford, P and Danilova, L and Davies, M and Fernando, R and Fodor, G and Gilbert, R and Gomis, R and Hâncu, N and Hanefeld, M and Hildebrandt, P and Kacerovsky-Bielesz, G and Keltai, M and Kim, J.H and Krum, H and Kültürsay, H and Lanas, F and Lewis, B.S and Lonn, E and López-Jaramillo, P and Marin-Neto, J and Marre, M and McKelvie, R and McQueen, M and Mendoza, I and Morillo, C and Pan, C and Pīrāgs, V and Profozic, V and Ratner, R and Richardson, L and Rosenstock, J and Spinas, G.A and Sreenan, S and Stoel, I and Syvänne, M and Yale, J.F and Avezum, A and Bahit, M.C and Bogaty, P and Bordeleau, L and Chacόn, C and Corson, M and Harper, W.L and Halon, D and Magloire, P and Mann, J and Pavlova, V and Punthakee, Z and Silva, J and Tsang, B and Yakubovich, N and Abdallah, A and Ahmad, S and Chandra, J and Chandra, R and Cukierman-Yaffee, T and Dyal, L and Joldersma, L and MacRae, L and MacRae, S and Malik, S and Mead, A and Pasha, F and Pazmino-Canizares, J and Pohl, K and Sakalas, A and Tyrwhitt, J and Ahuad Guerrero, R and Alebuena, A and Alvarez, N and Alzogaray, M and Amuchastegui, M and Andres, M and Angos, M and Baglivo, H and Barbieri, M and Bassi, F and Bello, F and Bono, J and Bustamante Labarta, M and ... and The ORIGIN Trial Investigators and ORIGIN Trial Investigators and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm and Centrum för klinisk forskning, Västerås
The New England Journal of Medicine, ISSN 0028-4793, 07/2012, Volume 367, Issue 4, pp. 319 - 328
In this study with a 2-by-2 factorial design, patients with cardiovascular risk factors and dysglycemia or type 2 diabetes received insulin glargine or... 
DIABETES-MELLITUS | MEDICINE, GENERAL & INTERNAL | GLYCEMIC CONTROL | THERAPY | GLARGINE | GLUCOSE CONTROL | DISEASE | RISK | PEOPLE | ENDOTHELIAL FUNCTION | BETA-CELL FUNCTION | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Cholesterol - blood | Humans | Middle Aged | Male | Incidence | Glucose Intolerance - drug therapy | Cardiovascular Diseases - epidemiology | Female | Drug Therapy, Combination | Hypoglycemia - chemically induced | Diabetes Mellitus, Type 2 - complications | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - etiology | Fasting | Blood Glucose - analysis | Double-Blind Method | Proportional Hazards Models | Hospitalization | Glucose Intolerance - complications | Insulin, Long-Acting - adverse effects | Insulin Glargine | Insulin, Long-Acting - therapeutic use | Intention to Treat Analysis | Triglycerides - blood | Fatty Acids, Omega-3 - therapeutic use | Aged | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Type 2 diabetes | Complications and side effects | Care and treatment | Insulin glargine | Patient outcomes | Causes of | Cardiovascular diseases | Risk factors | Myocardial infarction | Fees & charges | Cerebral infarction | Medical research | Stroke | Heart attacks | Statistical analysis | Diabetes mellitus | Glucose | Hypoglycemia | Fatty acids | Insulin | Glucose tolerance | Insulin resistance | Microvasculature | Diabetes | Diabetes mellitus (non-insulin dependent) | Heart diseases | Drug dosages | Cardiovascular Diseases | Insulin, Long-Acting | Blood Glucose | Triglycerides | Glucose Intolerance | Cholesterol | Life Sciences | Hypoglycemic Agents | Diabetes Mellitus, Type 2 | Fatty Acids, Omega-3 | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article