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Journal Article
Gastroenterology, ISSN 0016-5085, 2010, Volume 139, Issue 6, pp. 2170 - 2182
Background & Aims The tumor suppressor PTEN inhibits AKT2 signaling; both are aberrantly expressed in liver tumors. We investigated how PTEN and AKT2 regulate... 
Gastroenterology and Hepatology | Lipotoxic Cell Death | DDC | Mixed-Lineage Tumors | Liver Cancer Stem Cells | ALPHA-FETOPROTEIN EXPRESSION | OXIDATIVE DAMAGE | SUPPRESSOR GENE | PROTEIN-KINASE | CANCER STEM-CELLS | HEPATOCARCINOGENESIS | GROWTH | DISEASE | FATTY LIVER | HUMAN HEPATOCELLULAR-CARCINOMA | GASTROENTEROLOGY & HEPATOLOGY | Cell Line | PTEN Phosphohydrolase - genetics | Liver Neoplasms - genetics | Mice, Inbred C57BL | PTEN Phosphohydrolase - metabolism | Chemical and Drug Induced Liver Injury - genetics | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-akt - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Pyridines - toxicity | Cell Transformation, Neoplastic - genetics | Chemical and Drug Induced Liver Injury - metabolism | Mice, Mutant Strains | Liver Neoplasms - metabolism | Stem Cells - pathology | Liver Neoplasms - pathology | Signal Transduction - physiology | Mice | Cell Transformation, Neoplastic - pathology | Chemical and Drug Induced Liver Injury - pathology | Proto-Oncogene Proteins c-akt - metabolism | Gene Expression Regulation, Neoplastic - physiology | Cell Survival - physiology | Liver cancer | Platelet-derived growth factor | Growth | Cell death | Developmental biology | Liver | Pharmacy | Stem cells | Albumin | Universities and colleges | Protein kinases | Sects | Drugstores | Glycoproteins | Tumors | Liver cancer stem cells | lipotoxic cell death | mixed-lineage tumors
Journal Article
Brain Research, ISSN 0006-8993, 2008, Volume 1230, pp. 290 - 302
Abstract The blood–brain tumor barrier (BTB) significantly limits delivery of therapeutic concentrations of chemotherapy to brain tumors. A novel approach to... 
Neurology | Brain tumor | Drug transport | Drug delivery | PDE5 inhibitor | Blood–brain tumor barrier | Blood–brain barrier | Blood-brain tumor barrier | Blood-brain barrier | blood-brain barrier | SILDENAFIL | BARRIER PERMEABILITY | DOXORUBICIN | drug transport | brain tumor | blood-brain tumor barrier | BRADYKININ INFUSION | drug delivery | NEUROSCIENCES | INTRACAROTID INFUSION | NITRIC-OXIDE | VESICULAR TRANSPORT | MALIGNANT GLIOMAS | BLOOD-BRAIN | RECEPTORS | Brain Chemistry - drug effects | Capillaries - pathology | Rats, Inbred F344 | Brain Neoplasms - pathology | Phosphodiesterase 5 Inhibitors | Capillary Permeability - drug effects | Antineoplastic Agents - therapeutic use | Cyclic GMP - blood | Sulfones - pharmacology | Brain Neoplasms - metabolism | Glioma - metabolism | Neovascularization, Pathologic - pathology | Sildenafil Citrate | Glioma - pathology | Sucrose - metabolism | Female | Blood Pressure - drug effects | Tight Junctions - drug effects | Microscopy, Electron, Transmission | Triazines - pharmacology | Purines - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Rats | Imidazoles - pharmacology | Brain Neoplasms - drug therapy | Reverse Transcriptase Polymerase Chain Reaction | Piperazines - pharmacology | Tight Junctions - ultrastructure | Autoradiography | Animals | Cyclic GMP - metabolism | Survival Analysis | Vardenafil Dihydrochloride | Glioma - drug therapy | Drugs | Anti-impotence agents | Brain | Chemotherapy | Anthracyclines | Drug delivery systems | Brain tumors | Permeability | Vehicles | Cancer
Journal Article
Aging Cell, ISSN 1474-9718, 12/2013, Volume 12, Issue 6, p. 1000
  Summary Tissue regeneration diminishes with age, concurrent with declining hormone levels including growth factors such as insulin-like growth factor-1... 
Cell cycle | Aging | Insulin-like growth factors
Journal Article
Aging Cell, ISSN 1474-9718, 12/2013, Volume 12, Issue 6
Tissue regeneration diminishes with age, concurrent with declining hormone levels including growth factors such as insulin-like growth factor-1 (IGF-1). We... 
Pancreatic beta cells
Journal Article
Brain Research, ISSN 0006-8993, 2008, Volume 1227, pp. 198 - 206
Journal Article
01/2012, ISBN 1267700599
The pancreatic β-cells are responsible for producing insulin and maintaining glucose homeostasis. Loss of β-cells or their inability to compensate for insulin... 
Cellular biology | Genetics | Endocrinology
Dissertation
The open endocrinology journal, ISSN 1874-2165, 2010, Volume 4, Issue 1, pp. 23 - 32
This paper describes the biological functions of PTEN and the PTEN regulated signaling pathway in pancreatic β-cells. PTEN has been shown to regulate the... 
Journal Article
Brain Research, ISSN 0006-8993, 2008, Volume 1227, pp. 198 - 206
The blood–brain tumor barrier (BTB) significantly limits delivery of effective concentrations of chemotherapeutic drugs to brain tumors. Previous studies... 
Chemotherapy | Potassium channel | Brain tumor model | Blood–brain barrier | blood-brain barrier | GLIOMAS | POTASSIUM CHANNELS | BARRIER PERMEABILITY | brain tumor model | CEREBRAL-CIRCULATION | chemotherapy | SELECTIVE DRUG-DELIVERY | NEUROSCIENCES | BRADYKININ ANALOG | INTRACAROTID INFUSION | ENDOTHELIUM | RMP-7 | potassium channel
Journal Article
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