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PloS one, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0176139 - e0176139
Colorectal cancer (CRC) is the second leading cause of cancer death in the United States. In the metastatic setting, the majority of patients respond to... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Gene Expression - drug effects | Camptothecin - toxicity | Humans | Long Interspersed Nucleotide Elements - genetics | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Azacitidine - toxicity | Antineoplastic Agents - toxicity | ATP-Binding Cassette Transporters - genetics | Colorectal Neoplasms - drug therapy | ATP-Binding Cassette Transporters - metabolism | Colorectal Neoplasms - metabolism | Camptothecin - analogs & derivatives | Caco-2 Cells | DNA Repair - drug effects | Camptothecin - therapeutic use | HCT116 Cells | Cell Adhesion - drug effects | Mice, SCID | Irinotecan | Animals | Cell Line, Tumor | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Colorectal Neoplasms - pathology | DNA Methylation - drug effects | Azacitidine - therapeutic use | Chemotherapy | Usage | Care and treatment | Colorectal cancer | Cancer cells | Research | Cancer | Biotechnology | Colorectal carcinoma | Cytotoxicity | Oncology | Genomes | Metastasis | Cancer therapies | Synergism | DNA repair | Metastases | Cell adhesion & migration | Surgery | Cell adhesion | Xenografts | DNA methylation | Bioinformatics | Drug dosages | Deoxyribonucleic acid--DNA | Medical research | Agar | Priming | Gene expression | Medicine | Studies | Sharma, Anup | Epigenetics | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Nature reviews. Genetics, ISSN 1471-0064, 06/2002, Volume 3, Issue 6, pp. 415 - 428
Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia and include genome-wide losses of, and regional gains in, DNA... 
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | DNA Methylation | Neoplasms - genetics | Humans | Chromosome Mapping | Signal Transduction - genetics | Genome, Human | Mass Screening - methods | Index Medicus
Journal Article
by Hoadley, Katherine A and Yau, Christina and Hinoue, Toshinori and Lazar, Alexander J and Drill, Esther and Shen, Ronglai and Taylor, Alison M and Sanchez-Vega, Francisco and Schneider, Barbara G and Lawrence, Michael S and Malta, Tathiane M and Stuart, Joshua M and Laird, Peter W and Demchok, John A and Kasapi, Melpomeni and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Zhining and Yang, Liming and Zenklusen, Jean C and Zhang, Jiashan (Julia) and Chudamani, Sudha and Liu, Jia and Naresh, Rashi and Pihl, Todd and Sun, Qiang and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Getz, Gad and Heiman, David I and Lin, Pei and Noble, Michael S and Saksena, Gordon and Voet, Doug and Zhang, Hailei and Bernard, Brady and Dhankani, Varsha and Knijnenburg, Theo and Kramer, Roger and Leinonen, Kalle and Miller, Michael and Shmulevich, Ilya and Thorsson, Vesteinn and Zhang, Wei and Hegde, Apurva M and Ju, Zhenlin and Li, Jun and Liang, Han and Ling, Shiyun and Liu, Wenbin and Mills, Gordon B and Ng, Kwok-Shing and Rao, Arvind and Ryan, Michael and Zhang, Jiexin and Chakravarty, Debyani and Chatila, Walid K and de Bruijn, Ino and Gao, Jianjiong and Gross, Benjamin E and Heins, Zachary J and Kundra, Ritika and La, Konnor and Luna, Augustin and Nissan, Moriah G and Reznik, Ed and Sander, Chris and Sheridan, Robert and Sumer, S. Onur and Sun, Yichao and Wang, Jioajiao and Zhang, Hongxin and Anur, Pavana and Peto, Myron and Spellman, Paul and Benz, Christopher and Hayes, D. Neil and Parker, Joel S and Ally, Adrian and Balasundaram, Miruna and Chuah, Eric and Dhalla, Noreen and Lee, Darlene and Marra, Marco A and Mayo, Michael and Moore, Richard A and Mungall, Karen and Schein, Jacqueline E and Tam, Angela and Thiessen, Nina and Tse, Kane and Wong, Tina and Beroukhim, Rameen and Gao, Galen F and Ha, Gavin and Meyerson, Matthew and ... and The Cancer Genome Atlas Network and Cancer Genome Atlas Network
Cell (Cambridge), ISSN 0092-8674, 04/2018, Volume 173, Issue 2, pp. 291 - 304.e6
Journal Article
Oncotarget, ISSN 1949-2553, 10/2013, Volume 4, Issue 11, pp. 2067 - 2079
Journal Article
Cancer cell, ISSN 1535-6108, 05/2017, Volume 31, Issue 5, pp. 653 - 668.e7
An oncogenic role for CHD4, a NuRD component, is defined for initiating and supporting tumor suppressor gene (TSG) silencing in human colorectal cancer. CHD4... 
metastases | colorectal cancer | histone modification | double strand break | nucleosome remodeling and histone deacetylation complex | Chromodomain helicase DNA-binding protein 4 | DNA methylation | oxidative damage | DNA methyltransferase | tumor suppressor gene | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Histocompatibility Antigens - genetics | Colorectal Neoplasms - surgery | Autoantigens - metabolism | Cell Proliferation | Epigenetic Repression | Oxidative Stress | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics | Mi-2 Nucleosome Remodeling and Deacetylase Complex - metabolism | Autoantigens - genetics | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA Methylation | Neoplasm Metastasis | Transfection | RNA Interference | Time Factors | Clustered Regularly Interspaced Short Palindromic Repeats | Receptors for Activated C Kinase | Transcription, Genetic | Histocompatibility Antigens - metabolism | Genes, Tumor Suppressor | DNA Glycosylases - metabolism | Deoxyguanosine - analogs & derivatives | Colorectal Neoplasms - enzymology | Enhancer of Zeste Homolog 2 Protein - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Histone-Lysine N-Methyltransferase - genetics | Down-Regulation | HCT116 Cells | DNA Glycosylases - genetics | Gene Silencing | Kaplan-Meier Estimate | Proportional Hazards Models | Receptors, Cell Surface - metabolism | DNA (Cytosine-5-)-Methyltransferases - genetics | Disease-Free Survival | Animals | Histone-Lysine N-Methyltransferase - metabolism | Mice, Nude | Deoxyguanosine - metabolism | Mice, Inbred BALB C | DNA Damage | Colorectal Neoplasms - pathology | Tumor Suppressor Proteins | Cell Movement | Receptors, Cell Surface - genetics | Medical research | Epigenetic inheritance | Medical colleges | Chromatin | DNA damage | Genes | Colorectal cancer | Genetic transcription | Metastasis | Diseases | Gerontology | Methyltransferases | Analysis | Gastrointestinal diseases | Medicine, Experimental | Methylation | Cancer | Anopheles | Binding proteins | Protein binding | Index Medicus
Journal Article