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Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 07/2020, Volume 117, Issue 30, pp. 17785 - 17795
Poly(ADP ribose) polymerase inhibitors (PARPi) have efficacy in triple negative breast (TNBC) and ovarian cancers (OCs) harboring BRCA mutations, generating... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Sensitizing | Phenotypes | DNA damage | Homologous recombination | Adenosine diphosphate | Poly(ADP-ribose) polymerase | Homology | Genomes | Breast cancer | DNA repair | Stimulators | Signaling | Inhibitors | Ribose | DNA methyltransferase | Interferon | Mutation | Repair | Deoxyribonucleic acid--DNA | Cancer | Index Medicus
Journal Article
Cell (Cambridge), ISSN 0092-8674, 04/2020, Volume 181, Issue 2, pp. 211 - 211
Tazemetostat is the first epigenetic therapy to gain FDA approval in a solid tumor. This lysine methyltransferase inhibitor targets EZH2, the enzymatic subunit... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Antimitotic agents | Enzymes | Epigenetic inheritance | Medical colleges | Care and treatment | Sarcoma | Lysine | Antineoplastic agents | Drug approval | Index Medicus
Journal Article
Nature (London), ISSN 1476-4687, 02/2020, Volume 579, Issue 7798, pp. 284 - 290
Journal Article
Nature Cancer, ISSN 2662-1347, 01/2020, Volume 1, Issue 1, pp. 99 - 111
Despite progress in immunotherapy, identifying patients that respond has remained a challenge. Through analysis of whole-exome and targeted sequence data from... 
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 11/2019, Volume 116, Issue 45, pp. 22609 - 22618
A minority of cancers have breast cancer gene (BRCA) mutations that confer sensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis), but the role... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Carcinoma, Non-Small-Cell Lung - radiotherapy | Lung Neoplasms - drug therapy | Homologous Recombination - drug effects | DNA Modification Methylases - antagonists & inhibitors | Humans | Lung Neoplasms - metabolism | DNA Repair - radiation effects | Lung Neoplasms - radiotherapy | Male | Enzyme Inhibitors - administration & dosage | Female | Drug Therapy, Combination | Radiation, Ionizing | Lung Neoplasms - genetics | DNA Repair - drug effects | Phthalazines - administration & dosage | DNA Modification Methylases - metabolism | Homologous Recombination - radiation effects | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Antineoplastic Agents | Combined Modality Therapy | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | BRCA1 Protein - genetics | Animals | Cell Line, Tumor | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | BRCA2 Protein - genetics | Therapy | Phenotypes | Ovarian carcinoma | Lung cancer | Homologous recombination | Non-small cell lung carcinoma | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Homology | Breast cancer | Gene expression | DNA repair | Ovarian cancer | Ionizing radiation | Inhibitors | Ribose | Non-homologous end joining | Biomarkers | DNA methyltransferase | Mutation | Health risk assessment | Combinatorial analysis | Deoxyribonucleic acid--DNA | Cancer | Index Medicus | lung cancer | Biological Sciences | homologous recombination defect | nonhomologous end-joining | poly (ADP-ribose) polymerase inhibitors
Journal Article
Nature reviews. Clinical oncology, ISSN 1759-4782, 09/2019, Volume 17, Issue 2, pp. 75 - 90
Journal Article