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Journal Article
Journal of Neurotrauma, ISSN 0897-7151, 02/2010, Volume 27, Issue 2, pp. 391 - 402
Cerebrospinal fluid (CSF) adrenomedullin (ADM) levels are increased in female, but remain unchanged in male, piglets after fluid percussion injury (FPI) of the... 
Signal transduction | Plasminogen activators | Newborn | Cerebral circulation | ISCHEMIC BRAIN | CEREBROVASODILATION | signal transduction | RATS | newborn | NEUROSCIENCES | CLINICAL NEUROLOGY | CELL-DEATH | CHILDREN | MEMORY | CEREBRAL AUTOREGULATION | GENDER | plasminogen activators | cerebral circulation | AGE | CRITICAL CARE MEDICINE | Immunohistochemistry | Intracranial Pressure - drug effects | Up-Regulation | Cerebrovascular Circulation - physiology | Male | Adrenomedullin - pharmacology | Brain Injuries - metabolism | Brain Injuries - physiopathology | Brain - metabolism | Brain - blood supply | Hypotension - physiopathology | Ultrasonography, Doppler, Transcranial | Swine | Female | Animals, Newborn | Enzyme-Linked Immunosorbent Assay | Cerebrovascular Circulation - drug effects | Enzyme Inhibitors - pharmacology | Adrenomedullin - metabolism | Sex Characteristics | Extracellular Signal-Regulated MAP Kinases - biosynthesis | Intracranial Pressure - physiology | Brain - drug effects | Animals | Hypotension - metabolism | Homeostasis - physiology | Extracellular Signal-Regulated MAP Kinases - cerebrospinal fluid | Brain | Complications and side effects | Usage | Care and treatment | Peptides | Physiological aspects | Research | Cerebrospinal fluid | Health aspects | Hypotension | Risk factors | Injuries | Hogs | Pediatrics | Brain damage | Circulatory system | Index Medicus | Original
Journal Article
Circulation Research, ISSN 0009-7330, 04/2012, Volume 110, Issue 9, pp. 1202 - 1210
RATIONALE:Multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE), are inflammatory disorders of the central nervous... 
Experimental autoimmune encephalomyelitis | Autoimmune disease | Vascular inflammation | Platelets | PROGENITOR CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | autoimmune disease | platelets | LEUKOCYTE INTEGRIN MAC-1 | VESSEL WALL | IN-VITRO | experimental autoimmune encephalomyelitis | GLYCOPROTEIN IB-ALPHA | MULTIPLE-SCLEROSIS | P-SELECTIN | vascular inflammation | PERIPHERAL VASCULAR DISEASE | CENTRAL-NERVOUS-SYSTEM | INFLAMMATORY CELL RECRUITMENT | HEMATOLOGY | T-CELLS | Platelet Adhesiveness | Blood Platelets - immunology | Central Nervous System - metabolism | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Central Nervous System - immunology | Leukocytes - immunology | Membrane Glycoproteins - antagonists & inhibitors | Platelet Glycoprotein GPIb-IX Complex - metabolism | Time Factors | Platelet Glycoprotein GPIIb-IIIa Complex - metabolism | Inflammation Mediators - metabolism | Platelet Aggregation Inhibitors - pharmacology | Female | Blood Platelets - drug effects | Anti-Inflammatory Agents - pharmacology | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Cells, Cultured | Encephalomyelitis, Autoimmune, Experimental - blood | Membrane Glycoproteins - blood | Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors | Animals | Blood Platelets - metabolism | Central Nervous System - drug effects | Platelet Glycoprotein GPIb-IX Complex - antagonists & inhibitors | Leukocytes - drug effects | Mice | Index Medicus | Animal models | Multiple sclerosis | Leukocyte migration | Microscopy | Central nervous system | Glycoproteins | Inflammation | Experimental allergic encephalomyelitis | Inflammatory diseases | EAE | inflammation
Journal Article
BLOOD, ISSN 0006-4971, 01/2019, Volume 133, Issue 5, pp. 481 - 493
Inflammation and thrombosis are integrated, mutually reinforcing processes, but the interregulatory mechanisms are incompletely defined. Here, we examined the... 
RECRUITMENT | LIPOPROTEIN | PLASMINOGEN-ACTIVATOR | BLOOD-COAGULATION | INFLAMMATION | PLATELET | TISSUE | MICE | MECHANISMS | HEMATOLOGY | INNATE IMMUNITY
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 03/2009, Volume 29, Issue 3, pp. 524 - 533
We hypothesized that urokinase plasminogen activator (uPA) contributes to age-dependent early hyperemia after fluid percussion brain injury (FPI) by activating... 
Signal transduction | Plasminogen activators | Newborn | Cerebral circulation | HEAD-INJURY | TISSUE-PLASMINOGEN ACTIVATOR | RAT | TPA | signal transduction | RECEPTOR | newborn | BLOOD-FLOW | NEUROSCIENCES | CHILDREN | NEURONAL DEGENERATION | SINGLE-CHAIN UROKINASE | ENDOCRINOLOGY & METABOLISM | plasminogen activators | HEMATOLOGY | cerebral circulation | INTRACRANIAL-PRESSURE | Up-Regulation | Urokinase-Type Plasminogen Activator - physiology | Cerebral Cortex - blood supply | Cerebrovascular Circulation - physiology | Cerebral Cortex - pathology | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Male | Aging - cerebrospinal fluid | Extracellular Signal-Regulated MAP Kinases - metabolism | Brain Injuries - physiopathology | Hemodynamics - physiology | Swine | Female | Disease Models, Animal | Animals, Newborn | Cerebral Cortex - enzymology | Enzyme-Linked Immunosorbent Assay | Antibodies, Monoclonal - pharmacology | Electrophoresis, Polyacrylamide Gel | Brain Injuries - enzymology | Enzyme Inhibitors - pharmacology | Receptors, LDL - metabolism | Recombinant Proteins - pharmacology | Aging - pathology | Animals | Brain Injuries - cerebrospinal fluid | Urokinase-Type Plasminogen Activator - cerebrospinal fluid | Urokinase-Type Plasminogen Activator - biosynthesis | Aging - metabolism | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2016, Volume 291, Issue 29, pp. 15029 - 15045
Urokinase-type plasminogen activator (uPA) regulates angiogenesis and vascular permeability through proteolytic degradation of extracellular matrix and... 
SIGNAL-TRANSDUCTION | CELL-MIGRATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KRINGLE DOMAIN | NUCLEOLIN | SURFACE | SINGLE-CHAIN PROUROKINASE | EXTRACELLULAR-MATRIX | STROMAL CELLS | BINDING | CORONARY-ARTERY-DISEASE | Neovascularization, Physiologic - drug effects | Homeodomain Proteins - metabolism | Humans | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | Cell Nucleus - metabolism | Protein Binding - drug effects | HEK293 Cells | Vascular Endothelial Growth Factor A - pharmacology | Vascular Endothelial Growth Factor Receptor-1 - genetics | Endothelial Cells - metabolism | RNA, Messenger - genetics | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Mice, Knockout | Transcription Factors - metabolism | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Urokinase-Type Plasminogen Activator - metabolism | Endothelial Cells - cytology | K562 Cells | Cell Proliferation - drug effects | Cell Nucleus - drug effects | Endothelial Cells - drug effects | Index Medicus | nuclear translocation | angiogenesis | endothelial cell | VEGF Receptors | PRH | urokinase plasminogen activator | vascular endothelial growth factor (VEGF) | vascular biology | HHEX transcription factor | Cell Biology
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 02/2009, Volume 179, Issue 4, pp. 288 - 298
Journal Article
2001, ISBN 0444506691, 395
Presenting further studies in the prevention and treatment of coronary artery disease, this book brings together the knowledge accrued in the past decade... 
Autoimmunity | Immunological aspects | Pathogenesis | Atherosclerosis
eBook