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Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1857, pp. 109 - 124
RIP1 kinase plays a key role in regulating signaling pathways downstream of a number of innate immune receptors such as TNFRI and TLRs. The discovery of... 
GSK’963 | Nec-1 | Necroptosis | GSK’481 | RIP1 kinase
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2012, Volume 188, Issue 8, pp. 4023 - 4031
Ndfip1 is an adaptor for the E3 ubiquitin ligase Itch. Both Ndfip1- and Itch-deficient T cells are biased toward Th2 cytokine production. In this study, we... 
Journal Article
Nature Immunology, ISSN 1529-2908, 01/2012, Volume 13, Issue 1, p. 77
  Mice deficient in the adaptor Ndfip1 develop inflammation at sites of environmental antigen exposure. We show here that such mice had fewer inducible... 
Journal Article
Nature Immunology, ISSN 1529-2908, 01/2012, Volume 13, Issue 1, pp. 77 - 85
Mice deficient in the adaptor Ndfip1 develop inflammation at sites of environmental antigen exposure. We show here that such mice had fewer inducible... 
Journal Article
Nature Immunology, ISSN 1529-2908, 01/2012, Volume 13, Issue 1, pp. 77 - 85
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0127083
Journal Article
Immunity, ISSN 1074-7613, 10/2009, Volume 31, Issue 4, pp. 632 - 642
Cytolytic granules mediate killing of virus-infected cells by cytotoxic T lymphocytes. We show here that the granules can take long or short paths to the... 
MOLIMMUNO | CELLIMMUNO | TARGET-CELL | SUPRAMOLECULAR ACTIVATION CLUSTERS | RING JUNCTION | EFFECTOR FUNCTIONS | MICROTUBULE-ORGANIZING CENTER | CLASS-I | IMMUNOLOGY | IMMUNOLOGICAL SYNAPSE | EX-VIVO | POLARIZATION | LYMPHOCYTES-T | Calcium - metabolism | Humans | Calcium - immunology | Microtubule-Organizing Center - drug effects | Immunological Synapses - metabolism | Receptors, Antigen, T-Cell - drug effects | Signal Transduction - immunology | T-Lymphocytes, Cytotoxic - drug effects | Microtubules - metabolism | Microtubules - drug effects | Cytoplasmic Granules - metabolism | Calcium Signaling - immunology | Receptors, Antigen, T-Cell - immunology | Biological Transport - drug effects | Cell Polarity - drug effects | Cytotoxicity, Immunologic - drug effects | Ionophores - pharmacology | Microtubule-Organizing Center - metabolism | T-Lymphocytes, Cytotoxic - immunology | Cell Line | Cell Polarity - immunology | Receptors, Antigen, T-Cell - metabolism | Cytoplasmic Granules - drug effects | Microtubules - immunology | Biological Transport - immunology | Cell Degranulation - immunology | Immunological Synapses - drug effects | Microtubule-Organizing Center - immunology | Signal Transduction - drug effects | T-Lymphocytes, Cytotoxic - metabolism | Calcium Signaling - drug effects | Immunological Synapses - immunology | Ionomycin - pharmacology | Cytotoxicity, Immunologic - immunology | Cytoplasmic Granules - immunology | T-Lymphocytes, Cytotoxic - cytology | Cell Degranulation - drug effects | T cells | Ligands | T cell receptors | Peptides | Efficiency
Journal Article
Journal Article
Current Trends in Immunology, ISSN 0972-4567, 01/2013, Volume 14, pp. 57 - 64
T cells are well adapted to sense and respond to cues from their environment. Cytokine cues are particularly important when T cells are first activated. During... 
Journal Article
Current Trends in Immunology, ISSN 0972-4567, 2013, Volume 14, pp. 57 - 64
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2016, Volume 59, Issue 10, pp. 4867 - 4880
Journal Article
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2019, Volume 62, Issue 14, pp. 6482 - 6494
RIP2 kinase has been identified as a key signal transduction partner in the NOD2 pathway contributing to a variety of human pathologies, including... 
OLIGOMERIZATION DOMAIN 2 | CHEMISTRY, MEDICINAL | COLITIS | TOLL-LIKE RECEPTOR | MODEL | IDENTIFICATION | TLRS
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 8/2013, Volume 191, Issue 4
While the pathways that permit IL-2 production and the full activation of T cells upon antigen encounter are fairly well defined, the negative regulatory... 
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 4/2012, Volume 188, Issue 8, pp. 4023 - 4031
Ndfip1 is an adaptor for the E3 ubiquitin ligase Itch. Both Ndfip1- and Itch-deficient T cells are biased towards T H 2 cytokine production. Here we... 
Journal Article
Nature Immunology, ISSN 1529-2908, 01/2012, Volume 13, Issue 1, pp. 77 - 85
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2013, Volume 191, Issue 4, pp. 1536 - 1546
Journal Article
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