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by Feagan, Brian G and Sandborn, William J and Gasink, Christopher and Jacobstein, Douglas and Lang, Yinghua and Friedman, Joshua R and Blank, Marion A and Johanns, Jewel and Gao, Long-Long and Miao, Ye and Adedokun, Omoniyi J and Sands, Bruce E and Hanauer, Stephen B and Vermeire, Severine and Targan, Stephan and Ghosh, Subrata and De Villiers, Willem J and Colombel, Jean-Frederic and Tulassay, Zsolt and Seidler, Ursula and Salzberg, Bruce A and Desreumaux, Pierre and Lee, Scott D and Loftus, Edward V and Dieleman, Levinus A and Katz, Seymour and Rutgeerts, Paul and Bampton, P and Chung, A and Connor, S and Debinski, H and Leong, R and Macrae, F and Pavli, P and Sorrentino, D and van den Bogaerde, J and Vogel, W and Vogelsang, H and Louis, E and Mana, F and Zaltman, C and Aumais, G and Bernstein, C and Bressler, B and Dhalla, S and Marshall, J and Panaccione, R and Ropeleski, M and Stehlik, J and Volfova, M and Brynskov, J and Glerup, H and Abitbol-Selinger, V and Allez, M and Beaugerie, L and Bourreille, A and Cadiot, G and Dupas, J and Grimaud, J and Laharie, D and Lerebours, E and Moreau, J and Baumgart, D and Brand, S and Ebert, M and Ehehalt, R and Hasselblatt, P and Howaldt, S and Klaus, J and Krummenerl, P and Kucharzik, T and Lügering, A and Mudter, J and Preiss, J and Schreiber, S and Stallmach, A and Stein, J and Strauch, U and Salamon, A and Patchett, S and Lahat-Zok, A and Rachmilewitz, D and Annese, V and Bossa, F and Guidi, L and Kohn, A and Rocca, R and Ando, A and Ashida, T and Hanai, H and Ishida, T and Ito, H and Matsumoto, T and Motoya, S and Nakamura, S and Sameshima, Y and Suzuki, Y and Watanabe, K and Yamagami, H and Yamamoto, T and ... and UNITI-IM-UNITI Study Grp and UNITI–IM-UNITI Study Group
New England Journal of Medicine, ISSN 0028-4793, 11/2016, Volume 375, Issue 20, pp. 1946 - 1960
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2016, Volume 22, Issue 6, pp. 598 - 605
Complex interactions between the host and the gut microbiota govern intestinal homeostasis but remain poorly understood. Here we reveal a relationship between... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | ACTIVATION | ADAPTER PROTEIN CARD9 | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERLEUKIN-22 | PREVALENCE | IDENTIFICATION | IL-22 | CELL BIOLOGY | RESPONSES | INFLAMMATORY-BOWEL-DISEASE | BACTERIAL-INFECTION | Humans | Inflammatory Bowel Diseases - immunology | Middle Aged | Colitis - pathology | Colon - immunology | Male | Gene Expression Profiling | Chromatography, High Pressure Liquid | Tryptophan - metabolism | CARD Signaling Adaptor Proteins - genetics | Young Adult | Colitis - chemically induced | Interleukins - immunology | Inflammatory Bowel Diseases - genetics | Adult | Female | Colitis - immunology | Cytokines - immunology | CARD Signaling Adaptor Proteins - immunology | Colon - pathology | Gastrointestinal Microbiome - genetics | Lactobacillus - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Fecal Microbiota Transplantation | Dextran Sulfate - toxicity | Mice, Knockout | Animals | Tryptophan - immunology | Adolescent | RNA, Ribosomal, 16S - genetics | Colon - microbiology | Mice | Gastrointestinal Microbiome - immunology | Receptors, Aryl Hydrocarbon - immunology | Inflammatory bowel diseases | Microbiota (Symbiotic organisms) | Physiological aspects | Tryptophan | Development and progression | Genetic aspects | Research | Risk factors | Care and treatment | Immune response | Analysis | Dosage and administration | Colitis | Health aspects | Inflammatory bowel disease | Microorganisms | Metabolism | Digestive system | Immune system | Index Medicus | Organic chemistry | Chemical Sciences
Journal Article
by Amiot, A and Serrero, M and Peyrin‐Biroulet, L and Filippi, J and Pariente, B and Roblin, X and Buisson, A and Stefanescu, C and Trang‐Poisson, C and Altwegg, R and Marteau, P and Vaysse, T and Bourrier, A and Nancey, S and Laharie, D and Allez, M and Savoye, G and Moreau, J and Vuitton, L and Viennot, S and Aubourg, A and Pelletier, A.‐L and Bouguen, G and Abitbol, V and Gagniere, C and Bouhnik, Y and Amiot, Aurelien and Gagniere, Charlotte and Serrero, Melanie and Grimaud, Jean‐Charles and Peyrin‐Biroulet, Laurent and Zallot, Camille and Bigard, Marc‐Andre and Filippi, Jerome and Hebuterne, Xavier and Pariente, Benjamin and Nachury, Maria and Desreumaux, Pierre and Roblin, Xavier and Tedesco, Emilie and Buisson, Anthony and Bommelaer, Gilles and Stefanescu, Carmen and Bouhnik, Yoram and Boureille, Arnaud and Trang‐Poisson, Caroline and Altwegg, Romain and Marteau, Philippe and Dray, Xavier and Carbonnel, Franck and Vaysse, Thibaud and Seksik, Philippe and Beaugerie, Laurent and Cosnes, Jacques and Sokol, Harry and Landman, Cecilia and Bourrier, Anne and Nancey, Stephane and Boschetti, Gilles and Laharie, David and Poullenot, Florian and Allez, Matthieu and Gornet, Jean‐Marc and Baudry, Clautilde and Savoye, Guillaume and Moreau, Jacques and Vuitton, Lucine and Koch, Stephane and Viennot, Stephanie and Aubourg, Alexandre and Picon, Laurence and Pelletier, Anne‐Laure and Sickersen, Gaelle and Bouguen, Guillaume and Abitbol, Vered and Chaussade, Stanislas and Nahon, Stephane and Winkfield, Betsy and Brixi‐benmansour, Hedia and Gincul, Rodica and Barberis, Jean‐Christophe and Bonaz, Bruno and Michiels, Christophe and Zerbib, Franck and Beauregard, Marie Bourrier and Locher, Christophe and Davin‐Couve, Sophie and Poirette, Armelle and Guillem, Laurence and Stetiu‐Mocanu, Monica and Philippe, Beau and Beorchia, Sylvain and Al Qaddi, Jawad and GETAID and OBSERV-IBD Study Grp and OBSERV-IBD study group and the GETAID and the OBSERV-IBD study group and the GETAID
Alimentary Pharmacology & Therapeutics, ISSN 0269-2813, 08/2017, Volume 46, Issue 3, pp. 310 - 321
Journal Article
by Tadbiri, S and Peyrin‐Biroulet, L and Serrero, M and Filippi, J and Pariente, B and Roblin, X and Buisson, A and Stefanescu, C and Trang‐Poisson, C and Altwegg, R and Marteau, P and Vaysse, T and Bourrier, A and Nancey, S and Laharie, D and Allez, M and Savoye, G and Gilletta, C and Gagniere, C and Vuitton, L and Viennot, S and Aubourg, A and Pelletier, A.‐L and Bouguen, G and Abitbol, V and Fumery, M and Claudepierre, P and Bouhnik, Y and Amiot, A and Amiot, Aurelien and Gagniere, Charlotte and Serrero, Melanie and Grimaud, Jean‐Charles and Peyrin‐Biroulet, Laurent and Zallot, Camille and Bigard, Marc‐Andre and Filippi, Jerome and Hebuterne, Xavier and Pariente, Benjamin and Nachury, Maria and Desreumaux, Pierre and Roblin, Xavier and Del Tedesco, Emilie and Buisson, Anthony and Bommelaer, Gilles and Stefanescu, Carmen and Bouhnik, Yoram and Boureille, Arnaud and Trang‐Poisson, Caroline and Altwegg, Romain and Marteau, Philippe and Dray, Xavier and Carbonnel, Franck and Vaysse, Thibaud and Seksik, Philippe and Beaugerie, Laurent and Cosnes, Jacques and Sokol, Harry and Landman, Cecilia and Bourrier, Anne and Nancey, Stephane and Boschetti, Gilles and Laharie, David and Poullenot, Florian and Allez, Matthieu and Gornet, Jean‐Marc and Baudry, Clautilde and Savoye, Guillaume and Moreau, Jacques and Vuitton, Lucine and Koch, Stephane and Viennot, Stephanie and Aubourg, Alexandre and Picon, Laurence and Pelletier, Anne‐Laure and Sickersen, Gaelle and Bouguen, Guillaume and Abitbol, Vered and Chaussade, Stanislas and Fumery, Mathurin and Nahon, Stephane and Winkfield, Betsy and Brixi‐benmansour, Hedia and Gincul, Rodica and Barberis, Jean‐Christophe and Bonaz, Bruno and Michiels, Christophe and Zerbib, Franck and Bourrier de Beauregard, Marie and Locher, Christophe and Davin‐Couve, Sophie and Poirette, Armelle and Guillem, Laurence and Stetiu‐Mocanu, Monica and Philippe, Beau and Beorchia, Sylvain and Al Qaddi, Jawad and GETAID OBSERV-IBD Study Grp and GETAID OBSERV-IBD study group and the GETAID OBSERV-IBD study group
Alimentary Pharmacology & Therapeutics, ISSN 0269-2813, 02/2018, Volume 47, Issue 4, pp. 485 - 493
Journal Article
Gut, ISSN 0017-5749, 06/2017, Volume 66, Issue 6, pp. 1039 - 1048
Journal Article
by Walker, Gareth J and Harrison, James W and Heap, Graham A and Voskuil, Michiel D and Andersen, Vibeke and Anderson, Carl A and Ananthakrishnan, Ashwin N and Barrett, Jeffrey C and Beaugerie, Laurent and Bewshea, Claire M and Cole, Andy T and Cummings, Fraser R and Daly, Mark J and Ellul, Pierre and Fedorak, Richard N and Festen, Eleonora A. M and Florin, Timothy H and Gaya, Daniel R and Halfvarson, Jonas and Hart, Ailsa L and Heerasing, Neel M and Hendy, Peter and Irving, Peter and Jones, Samuel E and Koskela, Jukka and Lindsay, James O and Mansfield, John C and McGovern, Dermot and Parkes, Miles and Pollok, Richard C. G and Ramakrishnan, Subramaniam and Rampton, David S and Rivas, Manuel A and Russell, Richard K and Schultz, Michael and Sebastian, Shaji and Seksik, Philippe and Singh, Abhey and So, Kenji and Sokol, Harry and Subramaniam, Kavitha and Todd, Anthony and Annese, Vito and Weersma, Rinse K and Xavier, Ramnik and Ward, Rebecca and Weedon, Michael N and Goodhand, James R and Kennedy, Nicholas A and Ahmad, Tariq and Holden, Arthur L and Andrews, Jane and Auth, Marcus and Babu, Sathish and Bampton, Peter and Banim, Paul and Barnes, Theresa and Basude, Dharam and Beckly, John and Bell, Andy and Bell, Sally and Bhandari, Pradeep and Bloom, Stuart and Border, Dave and Bredin, Francesca and Brookes, Matthew J and Brown, Matthew and Calvert, Chris and Campbell, David and Chanchlani, Neil and Chaudhary, Basant and Chaudhary, Rakesh and Chung-Faye, Guy and Colleypriest, Ben and Connor, Susan and Cooney, Rachel and Cooper, Sheldon and Creed, Tom J and Croft, Nick and Cullen, Sue and D'Amato, Mauro and D'Inca, Renata and Dalal, Helen and Daneshmend, Tawfique K and Das, Debasish and Delaney, Michael and DeSilva, Shanika and Dhar, Anjan and Dharmasiri, Suranga and Direkze, Natalie and Dunckley, Paul and Elphick, David and Everett, Simon M and Feeney, Mark and Fell, John and Foley, Stephen and Franke, Andre and Gavin, Daniel and Gee, Ian and Ghosh, Deb and ... and IBD Pharmacogenetics Study Grp and IBD Pharmacogenetics Study Group and for the IBD Pharmacogenetics Study Group
JAMA - Journal of the American Medical Association, ISSN 0098-7484, 02/2019, Volume 321, Issue 8, pp. 753 - 761
IMPORTANCE Use of thiopurines may be limited by myelosuppression. TPMT pharmacogenetic testing identifies only 25% of at-risk patients of European ancestry.... 
MEDICINE, GENERAL & INTERNAL | S-METHYLTRANSFERASE | POLYMORPHISMS | MANAGEMENT | PREDICTOR | THERAPY | ACUTE LYMPHOBLASTIC-LEUKEMIA | SUSCEPTIBILITY | AZATHIOPRINE | MERCAPTOPURINE INTOLERANCE | CHILDREN | Haplotypes | Crohn Disease - genetics | Genome-Wide Association Study | Colitis, Ulcerative - metabolism | Humans | Methyltransferases - metabolism | Colitis, Ulcerative - genetics | Methyltransferases - genetics | Pyrophosphatases - genetics | Crohn Disease - metabolism | European Continental Ancestry Group | Male | Case-Control Studies | Methyltransferases - therapeutic use | Exome | Young Adult | Crohn Disease - drug therapy | Adolescent | Adult | Female | Leukocyte Count | Polymorphism, Single Nucleotide | Colitis, Ulcerative - drug therapy | Sequence Analysis, DNA - methods | Antimitotic agents | Complications and side effects | Inflammatory bowel diseases | Genetic variation | Myelosuppression | Dosage and administration | Genetic aspects | Research | Antineoplastic agents | Drug therapy | Health aspects | Chromosome 6 | Risk | Genomes | Chromosome deletion | Pharmacology | Gene deletion | Disease control | Patients | Inflammatory bowel disease | White blood cells | Genetic variance | Genotyping | Clonal deletion | Intestine | Deletion | Chromosome 13 | Genetic testing | Genotypes | Index Medicus | Abridged Index Medicus
Journal Article