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British Journal of Haematology, ISSN 0007-1048, 11/2014, Volume 167, Issue 3, pp. 366 - 375
Dickkopf‐1 ( DKK 1), expressed by myeloma cells, suppresses osteoblast function and plays a key role in bone disease in multiple myeloma. BHQ 880, a human... 
880 | multiple myeloma | BHQ | Phase I | skeletal‐related event | BHQ880 | Multiple myeloma | Skeletal-related event | BONE-DISEASE | DICKKOPF-1 | skeletal-related event | DKK1 | IN-VITRO | SERUM CONCENTRATIONS | OSTEOBLASTS | GROWTH | DOUBLE-BLIND | RECEPTOR-RELATED PROTEIN-5 | STEM-CELL TRANSPLANTATION | HEMATOLOGY | Recurrence | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Imidazoles - administration & dosage | Antibodies, Monoclonal - therapeutic use | Male | Neoplasm Proteins - antagonists & inhibitors | Osteolysis - etiology | Molecular Targeted Therapy | Osteolysis - drug therapy | Multiple Myeloma - drug therapy | Hypertension - chemically induced | Diphosphonates - therapeutic use | Female | Imidazoles - therapeutic use | Drug Therapy, Combination | Diphosphonates - adverse effects | Anabolic Agents - therapeutic use | Bone Density Conservation Agents - adverse effects | Multiple Myeloma - complications | Imidazoles - adverse effects | Anabolic Agents - adverse effects | Bone Resorption - drug therapy | Antibodies, Monoclonal - pharmacokinetics | Bone Density Conservation Agents - therapeutic use | Fractures, Spontaneous - etiology | Diphosphonates - administration & dosage | Spinal Cord Compression - etiology | Bone Density Conservation Agents - administration & dosage | Bone Resorption - prevention & control | Maximum Tolerated Dose | Osteolysis - blood | Anabolic Agents - administration & dosage | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Anabolic Agents - pharmacokinetics | Intercellular Signaling Peptides and Proteins - immunology | Medical research | Care and treatment | Relapse | Immunoglobulin G | Medicine, Experimental | Bones | Density | Diseases | Index Medicus
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