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Biological Psychiatry, ISSN 0006-3223, 2015, Volume 79, Issue 11, pp. 917 - 927
Abstract Background GPR88 is an orphan G protein coupled receptor highly enriched in the striatum, and previous studies have focused on GPR88 function in... 
Psychiatry | Ethological scoring of anxiety | GPR88 agonist-induced GTPγS binding | Gene clustering | Medium spiny neurons | Psychiatric disorders | Spatial learning | RECEPTOR | PROTRACTED ABSTINENCE | NEUROSCIENCES | HIPPOCAMPUS | MEMORY | GPR88 agonist-induced GTP gamma S binding | C-TERMINAL DOMAINS | STRIATOPALLIDAL NEURONS | MOUSE MODEL | SELECTIVE INTERACTIONS | OBJECT RECOGNITION | STRIATAL PLASTICITY | Naltrexone - analogs & derivatives | Receptors, Opioid, delta - metabolism | Dendrites - pathology | Male | Anxiety - drug therapy | Corpus Striatum - metabolism | Spatial Learning - physiology | Naltrexone - pharmacology | Female | Anxiety - metabolism | Corpus Striatum - pathology | Dopamine - metabolism | Dendrites - drug effects | Dendrites - metabolism | Movement Disorders - pathology | Receptors, Opioid, mu - metabolism | Mice, Inbred C57BL | Spatial Learning - drug effects | Amygdala - metabolism | Hippocampus - pathology | Amygdala - pathology | Anxiety - pathology | Mice, Knockout | Hippocampus - metabolism | Movement Disorders - metabolism | Animals | Receptors, G-Protein-Coupled - deficiency | Narcotic Antagonists - pharmacology | Serotonin - metabolism | Receptors, G-Protein-Coupled - genetics | Movement Disorders - drug therapy | Neurosciences | G proteins | Anxiety | Brain research | Genetic transcription | Neurons | Life Sciences | Human health and pathology | Other | Psychiatrics and mental health | medium spiny neurons | spatial learning | gene clustering | ethological scoring of anxiety | psychiatric disorders
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2018, Volume 175, Issue 14, pp. 2750 - 2769
The endogenous opioid system is well known to relieve pain and underpin the rewarding properties of most drugs of abuse. Among opioid receptors, the μ receptor... 
Animals | Receptors, Opioid, mu - metabolism | Social Behavior | Autism Spectrum Disorder - metabolism | Humans | Receptors, Opioid, mu - genetics | Reward | Life Sciences | Neurons and Cognition | Psychology and behavior | Themed Section | Review
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2009, Volume 4, Issue 5, pp. e5425 - e5425
Background: GPCRs regulate a remarkable diversity of biological functions, and are thus often targeted for drug therapies. Stimulation of a GPCR by an... 
NEUROPATHIC PAIN | MORPHINE-TOLERANCE | DESENSITIZATION | MULTIDISCIPLINARY SCIENCES | PROTEIN-COUPLED RECEPTORS | SPINAL-CORD | CHRONIC INFLAMMATION | KNOCKOUT MICE | ENDOCYTOSIS | MEMBRANE TRAFFICKING | Phosphorylation | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | Piperidines - pharmacology | Pain - drug therapy | Receptors, Opioid, delta - genetics | Neurons - physiology | Behavior, Animal - drug effects | Benzamides - pharmacology | Cell Membrane - metabolism | Green Fluorescent Proteins - chemistry | Neurons - drug effects | Green Fluorescent Proteins - metabolism | Receptors, Opioid, delta - chemistry | Biological Transport, Active - drug effects | Cells, Cultured | Behavior, Animal - physiology | Mice, Transgenic | Recombinant Fusion Proteins - chemistry | Piperazines - pharmacology | Animals | Pain - physiopathology | Recombinant Fusion Proteins - genetics | Ligands | Protein Conformation | Mice | In Vitro Techniques | Receptors, Opioid, delta - agonists | Receptors, Opioid, delta - physiology | Physiological aspects | G proteins | Analysis | Neurophysiology | Membrane proteins | G protein-coupled receptors | Fluorescence | Nervous system | Biodiversity | Cell surface | Complexity | Proteins | Receptors | Biological effects | Pain | Rodents | Physiology | Protein transport | Localization | Pain perception | Desensitization | Narcotics | Neurons | Inflammation | Opioid receptors (type delta) | Studies | Analgesia | Internalization | Regulation | Mutation | Receptor mechanisms | Life Sciences | Biochemistry, Molecular Biology
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e74706
Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by... 
NEUROPATHIC PAIN | MESSENGER-RNA EXPRESSION | RELATIVE CONTRIBUTION | DELTA | MULTIDISCIPLINARY SCIENCES | DORSAL-ROOT GANGLIA | SPINAL-CORD | INFLAMMATORY PAIN | MORPHINE-INDUCED ANALGESIA | SENSORY NEURONS | RAT MODEL | Posterior Horn Cells - drug effects | Posterior Horn Cells - metabolism | Analgesics, Opioid - pharmacology | Male | Receptors, Opioid, mu - agonists | Pain - genetics | Pain - drug therapy | Gene Deletion | Nociception - drug effects | Female | Gene Order | Gene Targeting | Gene Expression | Morphine - pharmacology | Enkephalin, Ala-MePhe-Gly- - pharmacology | Receptors, Opioid, mu - metabolism | Gene Knockout Techniques | Constipation - chemically induced | Mice, Knockout | Analgesia | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Protein Binding | NAV1.8 Voltage-Gated Sodium Channel - metabolism | Mice | Receptors, Opioid, mu - genetics | Pain Measurement | Morphine - adverse effects | NAV1.8 Voltage-Gated Sodium Channel - genetics | Sensory Thresholds - drug effects | Morphine | Care and treatment | Pain | RNA | Neurons | Analysis | Drugs | Neurosciences | Animal models | Spinal cord | Chemical stimuli | Opioid receptors (type mu) | Fentanyl | Nervous system | Opiates | mRNA | Mental depression | Receptors | Dorsal root ganglia | Analgesics | Drug tolerance | Sensory neurons | Sodium channels (voltage-gated) | Constipation | Pain perception | Narcotics | Cloning | Nausea | Pharmacology | Inflammation | Addictions | Ganglia | Medicine | Brain research
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