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Immunity, ISSN 1074-7613, 09/2017, Volume 47, Issue 3, pp. 566 - 581.e9
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a... 
Alzheimer’s disease | multiple sclerosis | transcriptional regulation | neurodegeneration | TREM2 | APOE | amyotrophic lateral sclerosis | microglia | Alzheimer's disease | GENE-EXPRESSION SIGNATURE | ACTIVATION | MULTIPLE-SCLEROSIS | ALZHEIMERS-DISEASE | MOUSE MODEL | MACROPHAGE | MICE | IMMUNOLOGY | DEFICIENCY | APOLIPOPROTEIN-E | CELL-DEATH | Microglia - metabolism | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Humans | Cerebral Cortex - pathology | Transcriptome | Apoptosis - genetics | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Phagocytosis - genetics | Neurodegenerative Diseases - immunology | Apolipoproteins E - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Microglia - immunology | Superoxide Dismutase-1 - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Female | Neurons - metabolism | Disease Models, Animal | Gene Targeting | Plaque, Amyloid - pathology | Signal Transduction | Gene Expression Regulation | Phagocytosis - immunology | Immune Tolerance | Mice, Transgenic | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Mice, Knockout | Encephalomyelitis, Autoimmune, Experimental | Phenotype | Animals | Apoptosis - immunology | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Superoxide Dismutase-1 - genetics | Plaque, Amyloid - metabolism | Mice | Alzheimer Disease - genetics | Transforming Growth Factor beta - metabolism | Receptors, Immunologic - metabolism | Cluster Analysis | Nervous system diseases | Multiple sclerosis | Neurons | Analysis | Amyotrophic lateral sclerosis | Genetic aspects | Genetic transcription | Apolipoproteins | Brain | Animal models | Myeloid cells | Disease | Transcription | Neurodegenerative diseases | Genes | Homeostasis | Microglia | Neurological diseases | Proteins | Molecular modelling | Restoration | Neurodegeneration | Apolipoprotein E | Rodents | β-Amyloid | Plaques | Phagocytosis | Apoptosis
Journal Article
GLIA, ISSN 0894-1491, 09/2015, Volume 63, Issue 9, pp. 1606 - 1620
The functional diversity and molecular adaptations of reactive microglia in the chronically inflamed central nervous system (CNS) are poorly understood. We... 
phagocytosis | CELL GENE-THERAPY | SPINAL-CORD | MULTIFUNCTIONAL PROTEIN-2 | AMYOTROPHIC-LATERAL-SCLEROSIS | X-LINKED ADRENOLEUKODYSTROPHY | NEUROSCIENCES | FUNCTIONAL PEROXISOMES | neuroinflammation | multifunctional protein 2 | mTOR | peroxisomes | CENTRAL-NERVOUS-SYSTEM | MICE | microglia | EXPRESSION | Enzymes | Oxidation-reduction reaction | Gene expression | Analysis | Oxidation
Journal Article
Molecular Imaging and Biology, ISSN 1536-1632, 2/2018, Volume 20, Issue 1, pp. 94 - 102
Journal Article
MOLECULAR IMAGING AND BIOLOGY, ISSN 1536-1632, 06/2018, Volume 20, Issue 3, pp. 354 - 355
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s11307-018-1173-3 
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Receptors, GABA | Microglia
Journal Article
Frontiers in cellular neuroscience, ISSN 1662-5102, 2018, Volume 12, p. 136
It is becoming evident that microglia, the resident immune cells of the central nervous system (CNS), are active contributors in neurological disorders.... 
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 5/2019, Volume 56, Issue 5, pp. 3175 - 3192
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 09/2019, Volume 203, Issue 6, pp. 1650 - 1664
IgD(-)CD27(-) double negative (DN) B cells with proinflammatory characteristics are abnormally elevated in a proportion of multiple sclerosis (MS) patients. In... 
OCRELIZUMAB | POPULATION | MEMORY | CLONAL EXPANSION | SUBSETS | V-H GENES | AUTOREACTIVITY | IMMUNOLOGY | CEREBROSPINAL-FLUID | T-BET | EXPRESSION
Journal Article
JOURNAL OF NEUROINFLAMMATION, ISSN 1742-2094, 03/2019, Volume 16, Issue 1
BackgroundMicroglia play a central role in most neurological disorders, but the impact of microgliosis on brain environment and clinical functions is not fully... 
Immune response | MULTIFUNCTIONAL PROTEIN-2 | IMMUNOLOGY | IL-34 | NEUROSCIENCES | Microglia | LANGERHANS CELLS | DEGENERATION | Facial nerve axotomy | MAINTENANCE | Peroxisomes | Conditional mouse model | ROLES | DYNAMICS | Oxidation | Behavior | EXPRESSION | INSIGHTS | Immunohistochemistry | Enzymes | Nervous system diseases | Neurons | Analysis | Oxidation-reduction reaction | Neurophysiology
Journal Article
Brain Behavior and Immunity, ISSN 0889-1591, 01/2020, Volume 83, pp. 180 - 191
•The present study reports a new microglia-specific reporter model (Tmem119-tdTomato knockin mice).•TMEM119-tdTomato is expressed only in CNS but not in... 
CELLS | PSYCHIATRY | ALZHEIMERS-DISEASE | MACROPHAGES | TMEM119 | IMMUNOLOGY | IDENTIFICATION | NEUROSCIENCES
Journal Article
Steroids, ISSN 0039-128X, 07/2015, Volume 99, Issue Pt B, pp. 172 - 177
[Display omitted] •Measurement of oxysterols and cholestenoic acids in mouse CSF by LC–MS.•Major cholesterol metabolites in mouse CSF are 7α-hydroxylated... 
Brain | Bile acid | LC–MS | Derivatisation | LC-MS | METABOLITES | CELL-MIGRATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | 27-HYDROXYCHOLESTEROL | ELIMINATION | X RECEPTOR LIGANDS | Cholestenes - chemistry | Cholesterol - analogs & derivatives | Cholestenes - blood | Sterols - chemistry | Cholesterol - blood | Cholestenes - cerebrospinal fluid | Male | Hydroxycholesterols - cerebrospinal fluid | Sterols - blood | Cholesterol - chemistry | Tandem Mass Spectrometry | Animals | Sterols - cerebrospinal fluid | Female | Mice | Enzymes - metabolism | Cholesterol - cerebrospinal fluid | LXRs, liver X receptors | RIC, reconstructed ion chromatograms | 3β-HCA, 3β-hydroxycholest-5-enoic acid | EADSA, enzyme assisted derivatisation for sterol analysis | 7αH,3O-CA, 7α-hydroxy-3-oxocholest-4-enoic acid | 7α,25-diHC, 7α,25-dihydroxycholesterol (cholest-5-ene-3β,7α,25-triol) | 7-OC, 7-oxocholesterol (3β-hydroxycholest-5-en-7-one) | 3β,7α-diHCA, 3β,7α-dihydroxycholest-5-enoic acid | LC–MSn, liquid chromatography–tandem mass spectrometry | GP, Girard P | CNS, central nervous system | 7α,24-diHCO, 7α,24-dihydroxycholest-4-en-3-one | LIT, linear ion trap | 26-HC, (25R)26-hydroxcholesterol,(cholest-5-en-3β,(25R)26-diol) | BBB, blood brain barrier | SPE, solid phase extraction | CYP, cytochrome P450 | 22R-HCO, 22R-hydroxycholest-4-en-3-one | CSF, cerebrospinal fluid
Journal Article