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Infectious diseases and therapy, ISSN 2193-8229, 06/2019, Volume 8, Issue 2, pp. 301 - 306
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 26, pp. 2773 - 2774
In this issue of Blood, Harbort et al identify a novel role for DNA damage responses in the regulation of cytokine production and cell death of activated... 
HEMATOLOGY | ATM | DISEASE | Respiratory Burst - physiology | Apoptosis - physiology | Ataxia Telangiectasia Mutated Proteins - metabolism | Enzyme Activation - physiology | Neutrophils - metabolism | Humans | Inside
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 04/2019, Volume 19, Issue 4, pp. 231 - 242
DNA damage occurs on exposure to genotoxic agents and during physiological DNA transactions. DNA double-strand breaks (DSBs) are particularly dangerous lesions... 
B-CELLS | ALLELIC EXCLUSION | GENOMIC STABILITY | SPI-C | T-CELL-RECEPTOR | V(D)J RECOMBINATION | GENE-EXPRESSION | CLASS-SWITCH RECOMBINATION | IMMUNOLOGY | GERMINAL-CENTER | STRAND BREAKS ACTIVATE | DNA damage | Analysis | Immune response | Cell activation | Genotoxicity | Cell cycle | Kinases | Lesions | Damage | DNA repair | Deoxyribonucleic acid--DNA | Genotoxic chemicals | Immune system
Journal Article
Advances in Immunology, ISSN 0065-2776, 01/2012, Volume 116, pp. 175 - 204
Lymphocytes traverse functionally discrete stages as they develop into mature B and T cells. This development is directed by cues from a variety of different... 
Integration | Transcription | DNA damage | V(D)J recombination | Lymphocytes T | Cell surface | Lymphocytes B | Cell cycle | Development | Ataxia telangiectasia | Ataxia telangiectasia mutated protein | Endonuclease | Apoptosis
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 1269 - 1269
Abstract Hematopoietic stem cells (HSC) persist throughout life by undergoing extensive self-renewal divisions while maintaining an undifferentiated state. The... 
Journal Article
Blood, ISSN 0006-4971, 10/2018, Volume 132, Issue 17, pp. 1737 - 1749
The Primary Immune Deficiency Treatment Consortium (PIDTC) performed a retrospective analysis of 662 patients with severe combined immunodeficiency (SCID) who... 
CRITERIA | SEVERE COMBINED IMMUNODEFICIENCY | BONE-MARROW-TRANSPLANTATION | DISEASE | HCT | EXPERIENCE | COHORT | STEM-CELL TRANSPLANTATION | HEMATOLOGY | RECONSTITUTION | Plenary Paper | 100
Journal Article
Journal Article
Nature, ISSN 0028-0836, 01/2011, Volume 469, Issue 7329, pp. 245 - 250
Journal Article
The Journal of Immunology, ISSN 0022-1767, 11/2019, p. ji1900539
Journal Article
2012, Advances in Immunology, ISBN 9780123943002, Volume 116, 30
Book Chapter
Journal of Experimental Medicine, ISSN 0022-1007, 02/2013, Volume 210, Issue 2, pp. 233 - 239
Allelic exclusion is enforced through the ability of antigen receptor chains expressed from one allele to signal feedback inhibition of V-to-(D)J recombination... 
MEDICINE, RESEARCH & EXPERIMENTAL | MDC1 | B-CELL-DEVELOPMENT | LIGHT-CHAIN | GENES | TRANSCRIPTION | V(D)J RECOMBINATION | DOUBLE-STRAND BREAKS | ATM | MECHANISMS | IMMUNOLOGY | INTERLEUKIN-7 | Homeodomain Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Mice, 129 Strain | RNA, Messenger - metabolism | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Cell Cycle Proteins - immunology | Base Sequence | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Gene Rearrangement, B-Lymphocyte, Light Chain | Intracellular Signaling Peptides and Proteins - genetics | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - immunology | Signal Transduction | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Immunoglobulin kappa-Chains - metabolism | Tumor Suppressor Proteins - immunology | Mice, Knockout | Histones - deficiency | Immunoglobulin kappa-Chains - genetics | Animals | B-Lymphocytes - immunology | Histones - genetics | Models, Biological | Alleles | Protein-Serine-Threonine Kinases - immunology | Mice | Histones - metabolism | Brief Definitive Report
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 3307 - 3307
Acute myeloid leukemia (AML) accounts for 18% of pediatric leukemias. For high-risk AML, standard treatment includes multi-agent chemotherapy followed... 
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2011, Volume 108, Issue 5, p. 2022
Lymphocyte antigen receptor gene assembly occurs through the process of V(D)J recombination, which is initiated when the RAG endonuclease introduces DNA DSBs... 
Proteins | Antigens | Immunology | Lymphocytes | Genes | Kinases | Chromosomes | Deoxyribonucleic acid--DNA
Journal Article
The Journal of experimental medicine, ISSN 0022-1007, 10/2018, Volume 215, Issue 10, pp. 2586 - 2599
B cell progenitors require paracrine signals such as interleukin-7 (IL-7) provided by bone marrow stromal cells for proliferation and survival. Yet, how B... 
MEDICINE, RESEARCH & EXPERIMENTAL | COMBINED IMMUNODEFICIENCY | LYMPHOPOIESIS | PRE-B | HEMATOPOIETIC STEM-CELLS | WHIM-SYNDROME | IMMUNOLOGY | MOUSE BONE-MARROW | STROMAL CELLS | EXPRESSION | CXCR4 DESENSITIZATION | STRAND BREAKS ACTIVATE | 315 | 304
Journal Article
Biology of Blood and Marrow Transplantation, ISSN 1083-8791, 2016, Volume 23, Issue 3, pp. S227 - S227
Journal Article