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1. Full Text Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias (vol 10, e1004606, 2014)
by Beecham, GW
PLOS GENETICS, ISSN 1553-7390, 11/2014, Volume 10, Issue 11
GENETICS & HEREDITY
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2. Full Text Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
by Lambert, Jean-Charles and Ibrahim-Verbaas, Carla A and Harold, Denise and Naj, Adam C and Sims, Rebecca and Bellenguez, Céline and Jun, Gyungah and DeStefano, Anita L and Bis, Joshua C and Beecham, Gary W and Grenier-Boley, Benjamin and Russo, Giancarlo and Thornton-Wells, Tricia A and Jones, Nicola and Smith, Albert V and Chouraki, Vincent and Thomas, Charlene and Ikram, M. Arfan and Zelenika, Diana and Vardarajan, Badri N and Kamatani, Yoichiro and Lin, Chiao-Feng and Gerrish, Amy and Schmidt, Helena and Kunkle, Brian and Fiévet, Nathalie and Amouyel, Philippe and Pasquier, Florence and Deramecourt, Vincent and De Bruijn, Renee F.A.G and Amin, Najaf and Hofman, Albert and Van Duijn, Cornelia M and Dunstan, Melanie L and Hollingworth, Paul and Owen, Michael J and O'Donovan, Michael C and Jones, Lesley and Holmans, Peter A and Moskvina, Valentina and Williams, Julie and Baldwin, Clinton and Farrer, Lindsay A and Choi, Seung-Hoan and Lunetta, Kathryn L and Fitzpatrick, Annette L and Harris, Tamara B and Psaty, Bruce M and Gilbert, John R and Hamilton-Nelson, Kara L and Martin, Eden R and Kunkle, Brian and Haines, Jonathan L and Gudnason, Vilmundur and Jonsson, Palmi V and Eiriksdottir, Gudny and Bihoreau, Marie-Thérèse and Lathrop, Mark and Valladares, Otto and Cantwell, Laura B and Wang, Li-San and Schellenberg, Gerard D and Ruiz, Agustin and Boada, Mercè and Reitz, Christiane and Mayeux, Richard and Ramirez, Alfredo and Maier, Wolfgang and Hanon, Olivier and Kukull, Walter A and Buxbaum, Joseph D and Campion, Dominique and Wallon, David and Hannequin, Didier and Crane, Paul K and Larson, Eric B and Becker, Tim and Cruchaga, Carlos and Goate, Alison M and Craig, David and Johnston, Janet A and Mc-Guinness, Bernadette and Todd, Stephen and Passmore, Peter and Berr, Claudine and Ritchie, Karen and Lopez, Oscar L and De Jager, Philip L and Evans, Denis and Lovestone, Simon and Proitsi, Petroula and Powell, John F and Letenneur, Luc and Barberger-Gateau, Pascale and Dufouil, Carole and Dartigues, Jean-François and Morón, Francisco J and Rubinsztein, David C and St. George-Hyslop, Peter and Sleegers, Kristel and ... and EADI and CHARGE and ADGC and GERAD and Cohorts for Heart and Aging Research in Genomic Epidemiology and Genetic and Environmental Risk in Alzheimer's Disease and Alzheimer's Disease Genetic Consortium and European Alzheimer's Disease Initiative (EADI) and Alzheimer's Disease Genetic Consortium (ADGC) and Genetic and Environmental Risk in Alzheimer's Disease (GERAD) and Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) and Stockholms universitet and Centrum för forskning om äldre och åldrande (ARC), (tills m KI) and Samhällsvetenskapliga fakulteten
Nature Genetics, ISSN 1061-4036, 12/2013, Volume 45, Issue 12, pp. 1452 - 1458
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this... 
GENOTYPES | COMMON VARIANTS | IMPUTATION | GENETIC RISK | SEQUENCE | GENETICS & HEREDITY | NEURONS | RECEPTOR | MUTATIONS | CD33 | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease | Humans | Middle Aged | Male | Genetic Loci | Genome-Wide Association Study - statistics & numerical data | Case-Control Studies | Age of Onset | Aged, 80 and over | Alzheimer Disease - epidemiology | Female | Aged | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Cohort Studies | Quantitative trait loci | Genetic aspects | Research | Genetic susceptibility | Alzheimer's disease | Identification and classification | Genealogy | Genomics | Genes | Quality control | Aging | Genomes | Alzheimers disease | Health risk assessment | Meta-analysis | Genetik | Biological Sciences | Genetics | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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3. Full Text Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias
by Beecham, Gary W and Hamilton, Kara and Naj, Adam C and Martin, Eden R and Huentelman, Matt and Myers, Amanda J and Corneveaux, Jason J and Hardy, John and Vonsattel, Jean-Paul and Younkin, Steven G and Bennett, David A and De Jager, Philip L and Larson, Eric B and Crane, Paul K and Kamboh, M. Ilyas and Kofler, Julia K and Mash, Deborah C and Duque, Linda and Gilbert, John R and Gwirtsman, Harry and Buxbaum, Joseph D and Kramer, Patricia and Dickson, Dennis W and Farrer, Lindsay A and Frosch, Matthew P and Ghetti, Bernardino and Haines, Jonathan L and Hyman, Bradley T and Kukull, Walter A and Mayeux, Richard P and Pericak-Vance, Margaret A and Schneider, Julie A and Trojanowski, John Q and Reiman, Eric M and Schellenberg, Gerard D and Montine, Thomas J and ADGC and Alzheimer's Disease Genetics Consortium (ADGC) and the Alzheimer's Disease Genetics Consortium (ADGC)
PLoS Genetics, ISSN 1553-7390, 09/2014, Volume 10, Issue 9, p. e1004606
Alzheimer's disease (AD) and related dementias are a major public health challenge and present a therapeutic imperative for which we need additional insight... 
COMMON VARIANTS | DIAGNOSIS | PROTEIN | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | RISK | EPHA1 | CD33 | CD2AP | ATP Binding Cassette Transporter, Subfamily G, Member 1 | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Dementia - diagnosis | Chromosome Mapping | Hippocampus - pathology | Chromosomes, Human, Pair 9 | Case-Control Studies | Alzheimer Disease - diagnosis | Dementia - etiology | Hippocampus - metabolism | Plaque, Amyloid | Phenotype | ATP-Binding Cassette Transporters - genetics | Chromosomes, Human, Pair 18 | N-Acetylgalactosaminyltransferases - genetics | Brain - pathology | Alzheimer Disease - genetics | Odds Ratio | Quantitative Trait Loci | Genetic research | Genetic aspects | Alzheimer's disease | Dementia | Medical research | Pathogenesis | Neuropathology | Religious orders | Colleges & universities | Science | Genomes | Brain research | Councils | Aging | Genetics | Alzheimers disease | Health risk assessment | Public health
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4. Full Text Genome-wide Association Study Implicates a Chromosome 12 Risk Locus for Late-Onset Alzheimer Disease
by Beecham, Gary W and Martin, Eden R and Li, Yi-Ju and Slifer, Michael A and Gilbert, John R and Haines, Jonathan L and Pericak-Vance, Margaret A
The American Journal of Human Genetics, ISSN 0002-9297, 01/2009, Volume 84, Issue 1, pp. 35 - 43
Only polymorphisms have been consistently associated with the risk of late-onset Alzheimer disease (LOAD), but they represent only a minority of the underlying... 
TYPE-4 ALLELE | TESTS | LR11/SORLA EXPRESSION | LINKAGE PHASE | CANDIDATE GENES | GENETICS & HEREDITY | HAPLOTYPE | BIPOLAR DISORDER | FAMILY-BASED ASSOCIATION | SORL1 | APOLIPOPROTEIN-E | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Middle Aged | Male | Risk | Aged, 80 and over | Female | Aged | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Genome, Human | Chromosomes, Human, Pair 12 - genetics | Logistic regression | Analysis | Genetic aspects | Single nucleotide polymorphisms | Research | Alzheimer's disease | Genetic polymorphisms | Studies | Regression analysis | Alzheimers disease | Chromosomes | Genomics | Polymorphism
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5. Full Text Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
by Naj, Adam C and Jun, Gyungah and Beecham, Gary W and Wang, Li-San and Vardarajan, Badri Narayan and Buros, Jacqueline and Gallins, Paul J and Buxbaum, Joseph D and Jarvik, Gail P and Crane, Paul K and Larson, Eric B and Bird, Thomas D and Boeve, Bradley F and Graff-Radford, Neill R and De Jager, Philip L and Evans, Denis and Schneider, Julie A and Carrasquillo, Minerva M and Ertekin-Taner, Nilufer and Younkin, Steven G and Cruchaga, Carlos and Kauwe, John S. K and Nowotny, Petra and Kramer, Patricia and Hardy, John and Huentelman, Matthew J and Myers, Amanda J and Barmada, Michael M and Demirci, F Yesim and Baldwin, Clinton T and Green, Robert C and Rogaeva, Ekaterina and George-Hyslop, Peter St and Arnold, Steven E and Barber, Robert and Beach, Thomas and Bigio, Eileen H and Bowen, James D and Boxer, Adam and Burke, James R and Cairns, Nigel J and Carlson, Chris S and Carney, Regina M and Carroll, Steven L and Chui, Helena C and Clark, David G and Corneveaux, Jason and Cotman, Carl W and Cummings, Jeffrey L and Decarli, Charles and Dekosky, Steven T and Diaz-Arrastia, Ramon and Dick, Malcolm and Dickson, Dennis W and Ellis, William G and Faber, Kelley M and Fallon, Kenneth B and Farlow, Martin R and Ferris, Steven and Frosch, Matthew P and Galasko, Douglas R and Ganguli, Mary and Gearing, Marla and Geschwind, Daniel H and Ghetti, Bernardino and Gilbert, John R and Gilman, Sid and Giordani, Bruno and Glass, Jonathan D and Growdon, John H and Hamilton, Ronald L and Harrell, Lindy E and Head, Elizabeth and Honig, Lawrence S and Hulette, Christine M and Hyman, Bradley T and Jicha, Gregory A and Jin, Lee-Way and Johnson, Nancy and Karlawish, Jason and Karydas, Anna and Kaye, Jeffrey A and Kim, Ronald and Koo, Edward H and Kowall, Neil W and Lah, James J and Levey, Allan I and Lieberman, Andrew P and Lopez, Oscar L and MacK, Wendy J and Marson, Daniel C and Martiniuk, Frank and Mash, Deborah C and Masliah, Eliezer and McCormick, Wayne C and McCurry, Susan M and McDavid, Andrew N and McKee, Ann C and Mesulam, Marsel and Miller, Bruce L and ...
Nature Genetics, ISSN 1061-4036, 05/2011, Volume 43, Issue 5, pp. 436 - 443
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design... 
POPULATION | IDENTIFIES VARIANTS | METAANALYSIS | GENE | GENETICS & HEREDITY | RISK | LOCI | APOE | MISSENSE MUTATIONS | GENOME-WIDE ASSOCIATION | APOLIPOPROTEIN-E | Genetic Predisposition to Disease | Genome-Wide Association Study | Multigene Family | Cytoskeletal Proteins - genetics | Membrane Proteins - genetics | Humans | Databases, Genetic | Male | Antigens, CD - genetics | Antigens, Differentiation, Myelomonocytic - genetics | Genetic Variation | Receptor, EphA1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Age of Onset | Aged, 80 and over | Female | Aged | Polymorphism, Single Nucleotide | Sialic Acid Binding Ig-like Lectin 3 | Alzheimer Disease - genetics | Cohort Studies | Conferences, meetings and seminars | Alzheimer's disease | Medical societies | Studies | Medical research | Genomes | Statistical methods | Alzheimers disease | Independent sample | Meta-analysis
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6. Full Text Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
by Sims, Rebecca and Van Der Lee, Sven J and Naj, Adam C and Bellenguez, Céline and Badarinarayan, Nandini and Jakobsdottir, Johanna and Kunkle, Brian W and Boland, Anne and Raybould, Rachel and Bis, Joshua C and Martin, Eden R and Grenier-Boley, Benjamin and Heilmann-Heimbach, Stefanie and Chouraki, Vincent and Kuzma, Amanda B and Sleegers, Kristel and Vronskaya, Maria and Ruiz, Agustin and Graham, Robert R and Olaso, Robert and Hoffmann, Per and Grove, Megan L and Vardarajan, Badri N and Hiltunen, Mikko and Nöthen, Markus M and White, Charles C and Hamilton-Nelson, Kara L and Epelbaum, Jacques and Maier, Wolfgang and Choi, Seung-Hoan and Beecham, Gary W and Dulary, Cécile and Herms, Stefan and Smith, Albert V and Funk, Cory C and Derbois, Céline and Forstner, Andreas J and Ahmad, Shahzad and Li, Hongdong and Bacq, Delphine and Harold, Denise and Satizabal, Claudia L and Valladares, Otto and Squassina, Alessio and Thomas, Rhodri and Brody, Jennifer A and Qu, Liming and Sánchez-Juan, Pascual and Morgan, Taniesha and Wolters, Frank J and Zhao, Yi and Garcia, Florentino Sanchez and Denning, Nicola and Fornage, Myriam and Malamon, John and Naranjo, Maria Candida Deniz and Majounie, Elisa and Mosley, Thomas H and Dombroski, Beth and Wallon, David and Lupton, Michelle K and Dupuis, Josée and Whitehead, Patrice and Fratiglioni, Laura and Medway, Christopher and Jian, Xueqiu and Mukherjee, Shubhabrata and Keller, Lina and Brown, Kristelle and Lin, Honghuang and Cantwell, Laura B and Panza, Francesco and McGuinness, Bernadette and Moreno-Grau, Sonia and Burgess, Jeremy D and Solfrizzi, Vincenzo and Proitsi, Petra and Adams, Hieab H and Allen, Mariet and Seripa, Davide and Pastor, Pau and Cupples, L Adrienne and Price, Nathan D and Hannequin, Didier and Frank-García, Ana and Levy, Daniel and Chakrabarty, Paramita and Caffarra, Paolo and Giegling, Ina and Beiser, Alexa S and Giedraitis, Vilmantas and Hampel, Harald and Garcia, Melissa E and Wang, Xue and Lannfelt, Lars and Mecocci, Patrizia and Eiriksdottir, Gudny and Crane, Paul K and Pasquier, Florence and Boccardi, Virginia and ... and EADI and GERAD PERADES and ARUKConsortium and CHARGE and ADGC and GERAD/PERADES, CHARGE, ADGC, EADI and ARUK Consortium and Stockholms universitet and Centrum för forskning om äldre och åldrande (ARC), (tills m KI) and Samhällsvetenskapliga fakulteten
Nature Genetics, ISSN 1061-4036, 09/2017, Volume 49, Issue 9, pp. 1373 - 1384
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174... 
COMMON VARIANTS | IDENTIFIES VARIANTS | METAANALYSIS | GENOTYPE IMPUTATION | LOW-FREQUENCY | SUSCEPTIBILITY | GENETICS & HEREDITY | RISK | LOCI | WAVE2 COMPLEX | GENOME-WIDE ASSOCIATION | Amino Acid Sequence | Microglia - metabolism | Genetic Predisposition to Disease - genetics | Gene Frequency | Humans | Immunity, Innate - genetics | Genotype | Gene Expression Profiling | Case-Control Studies | Linkage Disequilibrium | Membrane Glycoproteins - genetics | Sequence Homology, Amino Acid | Exome - genetics | Protein Interaction Maps - genetics | Adaptor Proteins, Signal Transducing - genetics | Phospholipase C gamma - genetics | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Odds Ratio | Receptors, Immunologic - genetics | Immune response | Genetic variation | Physiological aspects | Development and progression | Genetic aspects | Research | Alzheimer's disease | Neurodegenerative diseases | Genes | Genomics | Health risks | Innate immunity | Genomes | Disease control | Immunity | Microglia | Proteins | Studies | Consortia | DNA microarrays | Genotyping | Gene frequency | DNA methylation | Alzheimers disease | Protein interaction | Bioinformatics | Genotypes | Immune system | Biological Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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7. Full Text Genome-Wide Association Study Confirms SNPs in SNCA and the MAPT Region as Common Risk Factors for Parkinson Disease
by Edwards, Todd L and Scott, William K and Almonte, Cherylyn and Burt, Amber and Powell, Eric H and Beecham, Gary W and Wang, Liyong and Zuchner, Stephan and Konidari, Ioanna and Wang, Gaofeng and Singer, Carlos and Nahab, Fatta and Scott, Burton and Stajich, Jeffrey M and Pericak-Vance, Margaret and Haines, Jonathan and Vance, Jeffery M and Martin, Eden R
Annals of Human Genetics, ISSN 0003-4800, 03/2010, Volume 74, Issue 2, pp. 97 - 109
Summary Parkinson disease (PD) is a chronic neurodegenerative disorder with a cumulative prevalence of greater than one per thousand. To date three independent... 
Parkinson disease | microtubule associated protein tau | alpha-synuclein | association study | MITOCHONDRIAL-DNA POLYMORPHISMS | MULTILOCUS GENOTYPE DATA | TAU-GENE | NEUROPATHOLOGIC CRITERIA | LINKAGE DISEQUILIBRIUM | NORWEGIAN POPULATION | GENETICS & HEREDITY | LEWY BODIES | PROGRESSIVE SUPRANUCLEAR PALSY | CORTICOBASAL DEGENERATION | Genome-Wide Association Study | tau Proteins - genetics | Humans | tau Proteins - metabolism | Parkinson Disease - metabolism | Polymorphism, Single Nucleotide | alpha-Synuclein - genetics | Parkinson Disease - genetics | alpha-Synuclein - metabolism | Association study | Alpha-Synuclein | Microtubule associated protein tau | Medical research | Parkinson's disease | Genomics | Medicine, Experimental | Genomes | Research | Risk factors | Prevalence studies (Epidemiology) | Alpha-synuclein
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8. Full Text Meta‐analysis of Parkinson's Disease: Identification of a novel locus, RIT2
by Pankratz, Nathan and Beecham, Gary W and DeStefano, Anita L and Dawson, Ted M and Doheny, Kimberly F and Factor, Stewart A and Hamza, Taye H and Hung, Albert Y and Hyman, Bradley T and Ivinson, Adrian J and Krainc, Dmitri and Latourelle, Jeanne C and Clark, Lorraine N and Marder, Karen and Martin, Eden R and Mayeux, Richard and Ross, Owen A and Scherzer, Clemens R and Simon, David K and Tanner, Caroline and Vance, Jeffery M and Wszolek, Zbigniew K and Zabetian, Cyrus P and Myers, Richard H and Payami, Haydeh and Scott, William K and Foroud, Tatiana and PD GWAS Consortium and and the PD GWAS Consortium
Annals of Neurology, ISSN 0364-5134, 03/2012, Volume 71, Issue 3, pp. 370 - 384
Objective: Genome-wide association (GWAS) methods have identified genes contributing to Parkinson's disease (PD); we sought to identify additional genes... 
RISK-FACTORS | VARIANTS | GENETICS | CALMODULIN | SUSCEPTIBILITY | SEQUENCE | HAPLOTYPES | ALPHA-SYNUCLEIN | NEUROSCIENCES | CLINICAL NEUROLOGY | GENOME-WIDE ASSOCIATION | SNCA | Glycoproteins - genetics | Humans | Genetic Loci - genetics | Parkinson Disease - diagnosis | Parkinson Disease - epidemiology | Polymorphism, Single Nucleotide - genetics | Parkinson Disease - genetics | Genome-Wide Association Study - methods | Nerve Tissue Proteins - genetics
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