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science & technology (22) 22
life sciences & biomedicine (21) 21
animals (20) 20
life sciences (19) 19
obesity (15) 15
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[sdv.mhep.heg]life sciences [q-bio]/human health and pathology/hépatology and gastroenterology (8) 8
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dose-response relationship, drug (3) 3
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foods, foodstuffs, or non-alcoholic beverages, not covered bysubclasses a23b - a23j (3) 3
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[ sdv.mhep.heg ] life sciences [q-bio]/human health and pathology/hépatology and gastroenterology (2) 2
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Journal Article
Journal of hepatology, ISSN 0168-8278, 04/2011, Volume 54, Issue 4, pp. 773 - 794
Numerous investigations have shown that mitochondrial dysfunction is a major mechanism of drug-induced liver injury, which involves the parent drug or a... 
Gastroenterology and Hepatology | Drugs | Obesity | Oxidative stress | Mitochondria | Cell death | Lipids | Hepatotoxicity | Steatosis | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Carbohydrate Metabolism - drug effects | Reactive Oxygen Species - metabolism | Mitochondria, Liver - metabolism | Humans | Leptin - metabolism | Oxidative Phosphorylation - drug effects | Adipose Tissue - metabolism | Adiponectin - metabolism | Hepatitis C - complications | Cell Death - drug effects | Fatty Acids - metabolism | Chemical and Drug Induced Liver Injury - etiology | Diabetes Mellitus, Type 2 - complications | Genetic Predisposition to Disease | Fatty Liver - metabolism | Oxidation-Reduction | Obesity - complications | Insulin Resistance | Mitochondrial Membrane Transport Proteins - drug effects | Chemical and Drug Induced Liver Injury - genetics | Mitochondria, Liver - drug effects | Animals | Chemical and Drug Induced Liver Injury - metabolism | Models, Biological | Lipid Metabolism - drug effects | Alcoholic Intoxication - complications | Genome, Mitochondrial | Adipose Tissue - drug effects | Energy Metabolism - drug effects | Fatty Liver - etiology | Divalproex | Liver diseases | Thiols | Liver | Cytochrome P-450 | Mitochondrial DNA | Triglycerides | Stavudine | Permeability | Valproic acid | Fatty acids | Cells | Carnitine | Metabolites | Glutathione transferase | Acetaminophen | Physiological aspects | DNA polymerases | Health aspects | Zidovudine | Index Medicus | Reactive Oxygen Species | Fatty Acids | Adiponectin | Mitochondria, Liver | Life Sciences | Mitochondrial Membrane Transport Proteins | Cell Death | Diabetes Mellitus, Type 2 | Adipose Tissue | Alcoholic Intoxication | Hépatology and Gastroenterology | Oxidative Phosphorylation | Carbohydrate Metabolism | Lipid Metabolism | Drug-Induced Liver Injury | Fatty Liver | Human health and pathology | Energy Metabolism | Leptin | Hepatitis C
Journal Article
ISSN 0003-2654, 10/2016, Volume 141, Issue 22, pp. 6259 - 6269
... Lardjane, d Thibault Cavey, c,e,f Bruno Turlin, c,e,g Alain Fautrel, c,h Karima Begriche, c,e Valérie Monbet, i,j Bernard Fromenty, c,e Patricia Leroyer, c,e Pascal... 
Journal Article
Journal Article
Clinics and research in hepatology and gastroenterology, ISSN 2210-7401, 06/2020
Acetaminophen (APAP) hepatotoxicity is mediated by N-acetyl-p-benzoquinone imine (NAPQI), a highly toxic metabolite generated by cytochrome P450 2E1 (CYP2E1).... 
Index Medicus | Life Sciences | Medication | Human health and pathology | Hépatology and Gastroenterology | Pharmaceutical sciences
Journal Article