International Archives of Allergy and Immunology, ISSN 1018-2438, 09/2004, Volume 135, Issue 1, pp. 30 - 35
Background: The pathogenesis of late asthmatic reactions after allergen challenge in contrast to isolated early responses is incompletely understood. Recently,...
Original Paper | Antioxidants | Allergen challenge | Glutathione | Induced sputum | INDIVIDUALS | OXIDATIVE STRESS | ALLERGY | antioxidants | glutathione | INFLAMMATION | induced sputum | NITRIC-OXIDE | IMMUNOLOGY | allergen challenge | DEFICIENCY | S-Nitrosothiols - immunology | Allergens - adverse effects | Glutathione Disulfide - immunology | Humans | Breath Tests | Administration, Inhalation | Male | Glutathione Disulfide - analysis | Eosinophils - immunology | Nitric Oxide - analysis | Glutathione - immunology | S-Nitrosothiols - analysis | Sputum - chemistry | Allergens - administration & dosage | Sputum - immunology | Allergens - immunology | Time Factors | Glutathione - analysis | Asthma - immunology | Adult | Asthma - etiology | Measurement | Immunology | Comparative analysis | Allergies | Asthma
Original Paper | Antioxidants | Allergen challenge | Glutathione | Induced sputum | INDIVIDUALS | OXIDATIVE STRESS | ALLERGY | antioxidants | glutathione | INFLAMMATION | induced sputum | NITRIC-OXIDE | IMMUNOLOGY | allergen challenge | DEFICIENCY | S-Nitrosothiols - immunology | Allergens - adverse effects | Glutathione Disulfide - immunology | Humans | Breath Tests | Administration, Inhalation | Male | Glutathione Disulfide - analysis | Eosinophils - immunology | Nitric Oxide - analysis | Glutathione - immunology | S-Nitrosothiols - analysis | Sputum - chemistry | Allergens - administration & dosage | Sputum - immunology | Allergens - immunology | Time Factors | Glutathione - analysis | Asthma - immunology | Adult | Asthma - etiology | Measurement | Immunology | Comparative analysis | Allergies | Asthma
Journal Article
Pflege Zeitschrift, ISSN 0945-1129, 2005, Volume 58, Issue 9, pp. 576 - 579
Journal Article
Pflege Zeitschrift, ISSN 0945-1129, 10/2004, Volume 57, Issue 10, p. 715
Behavior Therapy | Electric Stimulation Therapy - nursing | Nursing Homes | Humans | Cooperative Behavior | Urinary Incontinence - nursing | Biofeedback, Psychology | Treatment Outcome | Combined Modality Therapy | Homes for the Aged | Nursing, Team | Incontinence Pads | Physical Therapy Modalities - nursing | Aged | Toilet Training
Journal Article
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, ISSN 1081-1206, 12/2007, Volume 99, Issue 6, p. 555
Indacaterol is a novel, inhaled, once-daily beta2-agonist. To investigate the safety and tolerability of indacaterol at doses of 400 and 800 microg/d....
Indans - adverse effects | Asthma - physiopathology | Double-Blind Method | Drug Administration Schedule | Forced Expiratory Volume - drug effects | Humans | Middle Aged | Electrocardiography - drug effects | Male | Asthma - drug therapy | Heart Rate - drug effects | Quinolones - administration & dosage | Quinolones - adverse effects | Asthma - blood | Adolescent | Adrenergic beta-Agonists - administration & dosage | Adult | Female | Potassium - blood | Aged | Indans - administration & dosage | Blood Glucose - metabolism | Child | Adrenergic beta-Agonists - adverse effects
Indans - adverse effects | Asthma - physiopathology | Double-Blind Method | Drug Administration Schedule | Forced Expiratory Volume - drug effects | Humans | Middle Aged | Electrocardiography - drug effects | Male | Asthma - drug therapy | Heart Rate - drug effects | Quinolones - administration & dosage | Quinolones - adverse effects | Asthma - blood | Adolescent | Adrenergic beta-Agonists - administration & dosage | Adult | Female | Potassium - blood | Aged | Indans - administration & dosage | Blood Glucose - metabolism | Child | Adrenergic beta-Agonists - adverse effects
Journal Article
Annals of Allergy, Asthma & Immunology, ISSN 1081-1206, 12/2007, Volume 99, Issue 6, pp. 555 - 561
Background: Indacaterol is a novel, inhaled, once-daily beta sub(2)-agonist. Objective: To investigate the safety and tolerability of indacaterol at doses of...
Journal Article
International Archives of Allergy and Immunology, ISSN 1018-2438, 09/2003, Volume 132, Issue 1, pp. 76 - 81
Background: In patients with allergic rhinitis, bronchial hyperresponsiveness (BHR) and airway inflammation may increase during pollen exposure. BHR can be...
Original Paper | Grass pollen | Adenosine-5′-monophosphate | Allergic rhinitis | Methacholine | Sputum | Airway hyperresponsiveness | airway hyperresponsiveness | BRONCHIAL HYPERRESPONSIVENESS | PROVOCATION | EOSINOPHILS | MARKERS | sputum | IMMUNOLOGY | grass pollen | EXERCISE | adenosine-5 '-monophosphate | CHALLENGE | ADENOSINE 5'-MONOPHOSPHATE | PC20 | ALLERGY | INFLAMMATION | ASTHMA | allergic rhinitis | methacholine | Poaceae - immunology | Sputum - cytology | Bronchial Hyperreactivity - immunology | Cell Count | Humans | Middle Aged | Male | Pollen - immunology | Eosinophils - immunology | Bronchial Hyperreactivity - blood | Rhinitis, Allergic, Seasonal - immunology | Sputum - drug effects | Forced Expiratory Volume - immunology | Methacholine Chloride - pharmacology | Rhinitis, Allergic, Seasonal - blood | Statistics, Nonparametric | Adult | Female | Adenosine Monophosphate - pharmacology | Bronchoconstrictor Agents - pharmacology | Seasons
Original Paper | Grass pollen | Adenosine-5′-monophosphate | Allergic rhinitis | Methacholine | Sputum | Airway hyperresponsiveness | airway hyperresponsiveness | BRONCHIAL HYPERRESPONSIVENESS | PROVOCATION | EOSINOPHILS | MARKERS | sputum | IMMUNOLOGY | grass pollen | EXERCISE | adenosine-5 '-monophosphate | CHALLENGE | ADENOSINE 5'-MONOPHOSPHATE | PC20 | ALLERGY | INFLAMMATION | ASTHMA | allergic rhinitis | methacholine | Poaceae - immunology | Sputum - cytology | Bronchial Hyperreactivity - immunology | Cell Count | Humans | Middle Aged | Male | Pollen - immunology | Eosinophils - immunology | Bronchial Hyperreactivity - blood | Rhinitis, Allergic, Seasonal - immunology | Sputum - drug effects | Forced Expiratory Volume - immunology | Methacholine Chloride - pharmacology | Rhinitis, Allergic, Seasonal - blood | Statistics, Nonparametric | Adult | Female | Adenosine Monophosphate - pharmacology | Bronchoconstrictor Agents - pharmacology | Seasons
Journal Article
Pflege Zeitschrift, ISSN 0945-1129, 2004, Volume 57, Issue 10, pp. 715 - 719
Journal Article
Annals of Allergy, Asthma & Immunology, ISSN 1081-1206, 2007, Volume 99, Issue 6, pp. 555 - 561
Indacaterol is a novel, inhaled, once-daily β -agonist. To investigate the safety and tolerability of indacaterol at doses of 400 and 800 μg/d. Randomized,...
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 04/2007, Volume 63, Issue 4, pp. 451 - 458
Aims The aim of these first-in-human studies was to investigate the tolerability and the pharmacokinetics of bimosiamose disodium (TBC1269Z) administered by...
pharmacokinetics | Phase I trial | inhalation | bimosiamose | selectin | safety and tolerability | Bimosiamose | Safety and tolerability | Selectin | Pharmacokinetics | Inhalation | CHEMOKINES | CELL-ADHESION | IN-VITRO ANALYSIS | CHALLENGE | MOLECULE SELECTIN INHIBITOR | INFLAMMATION | ASTHMA | PHARMACOLOGY & PHARMACY | AIRWAY HYPERRESPONSIVENESS | DIFFERENT NEBULIZERS | ANTAGONISTS | Mannose - analogs & derivatives | Nasopharyngeal Diseases - drug therapy | Humans | Middle Aged | Administration, Inhalation | Male | Hexanes - adverse effects | Cell Adhesion | Mannose - adverse effects | Nasopharyngeal Diseases - blood | Mannose - pharmacokinetics | Adult | Hexanes - pharmacokinetics | Nasopharyngeal Diseases - diagnosis
pharmacokinetics | Phase I trial | inhalation | bimosiamose | selectin | safety and tolerability | Bimosiamose | Safety and tolerability | Selectin | Pharmacokinetics | Inhalation | CHEMOKINES | CELL-ADHESION | IN-VITRO ANALYSIS | CHALLENGE | MOLECULE SELECTIN INHIBITOR | INFLAMMATION | ASTHMA | PHARMACOLOGY & PHARMACY | AIRWAY HYPERRESPONSIVENESS | DIFFERENT NEBULIZERS | ANTAGONISTS | Mannose - analogs & derivatives | Nasopharyngeal Diseases - drug therapy | Humans | Middle Aged | Administration, Inhalation | Male | Hexanes - adverse effects | Cell Adhesion | Mannose - adverse effects | Nasopharyngeal Diseases - blood | Mannose - pharmacokinetics | Adult | Hexanes - pharmacokinetics | Nasopharyngeal Diseases - diagnosis
Journal Article
Lung, ISSN 0341-2040, 12/2004, Volume 182, Issue 6, pp. 369 - 377
Oxidative stress associated with increased presence of neutrophils is an important feature of inflammatory airways diseases like asthma or chronic obstructive...
Antiinflammatory drugs | Pneumology/Respiratory System | Medicine & Public Health | Piclamilast | Neutrophils | phosphodiesterase inhibitors | Asthma | COPD | Phosphodiesterase inhibitors | RESPIRATORY BURST | DEXAMETHASONE | GLUCOCORTICOIDS | asthma | PERIPHERAL-BLOOD | piclamilast | HUMAN-NEUTROPHILS | RESPIRATORY SYSTEM | DISEASE | antiinflammatory drugs | ALVEOLAR MACROPHAGES | PDE4 INHIBITOR | neutrophils | ROFLUMILAST | INDEXES | Sputum - cytology | Humans | Middle Aged | Phosphodiesterase Inhibitors - pharmacology | Male | Pulmonary Disease, Chronic Obstructive - pathology | Prednisolone - pharmacology | Respiratory Burst - drug effects | Theophylline - pharmacology | Adult | Female | Benzamides - pharmacology | Pyridines - pharmacology | Asthma - pathology | Oxidation | Protease inhibitors | Disease | Pulmonary arteries
Antiinflammatory drugs | Pneumology/Respiratory System | Medicine & Public Health | Piclamilast | Neutrophils | phosphodiesterase inhibitors | Asthma | COPD | Phosphodiesterase inhibitors | RESPIRATORY BURST | DEXAMETHASONE | GLUCOCORTICOIDS | asthma | PERIPHERAL-BLOOD | piclamilast | HUMAN-NEUTROPHILS | RESPIRATORY SYSTEM | DISEASE | antiinflammatory drugs | ALVEOLAR MACROPHAGES | PDE4 INHIBITOR | neutrophils | ROFLUMILAST | INDEXES | Sputum - cytology | Humans | Middle Aged | Phosphodiesterase Inhibitors - pharmacology | Male | Pulmonary Disease, Chronic Obstructive - pathology | Prednisolone - pharmacology | Respiratory Burst - drug effects | Theophylline - pharmacology | Adult | Female | Benzamides - pharmacology | Pyridines - pharmacology | Asthma - pathology | Oxidation | Protease inhibitors | Disease | Pulmonary arteries
Journal Article
Annals of Allergy, Asthma & Immunology, ISSN 1081-1206, 2004, Volume 92, Issue 4, pp. 459 - 463
Oxidative stress is involved in the pathogenesis of allergic inflammatory diseases, such as rhinitis and asthma. Glutathione is a vital intracellular and...
INDIVIDUALS | IDIOPATHIC PULMONARY FIBROSIS | HEALTHY-CHILDREN | FLUID | ALLERGY | NITRIC-OXIDE | EXACERBATIONS | LOWER RESPIRATORY-TRACT | IMMUNOLOGY | DEFICIENCY | ATOPY | Severity of Illness Index | Asthma - metabolism | Eosinophils - metabolism | Glutathione - metabolism | Humans | Middle Aged | Glutathione Disulfide - metabolism | Sputum - metabolism | Sputum - chemistry | Asthma - blood | Adolescent | Adult | Neutrophils - metabolism
INDIVIDUALS | IDIOPATHIC PULMONARY FIBROSIS | HEALTHY-CHILDREN | FLUID | ALLERGY | NITRIC-OXIDE | EXACERBATIONS | LOWER RESPIRATORY-TRACT | IMMUNOLOGY | DEFICIENCY | ATOPY | Severity of Illness Index | Asthma - metabolism | Eosinophils - metabolism | Glutathione - metabolism | Humans | Middle Aged | Glutathione Disulfide - metabolism | Sputum - metabolism | Sputum - chemistry | Asthma - blood | Adolescent | Adult | Neutrophils - metabolism
Journal Article
SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, ISSN 1124-0490, 06/2003, Volume 20, Issue 2, pp. 138 - 143
Background: Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology. Biopsy and bronchoalveolar lavage studies have shown, that accumulation of...
RESPIRATORY-TRACT | UNKNOWN CAUSE | AIRWAY INFLAMMATION | INCREASES | INDUCTION | BRONCHOALVEOLAR LAVAGE | INTERSTITIAL LUNG-DISEASES | GLUTATHIONE | RESPIRATORY SYSTEM | pulmonary fibrosis | induced sputum | cytokines | TNF-ALPHA | neutrophils | MODULATION | Sputum - cytology | Cross-Sectional Studies | Neutrophil Activation | Granulocyte-Macrophage Colony-Stimulating Factor - analysis | Humans | Middle Aged | Biomarkers - analysis | Pulmonary Fibrosis - immunology | Male | Inflammation | Interleukin-8 - analysis | Sputum - immunology | Adult | Female | Aged | Intercellular Adhesion Molecule-1 - analysis | Pulmonary fibrosis | Cytokines | Neutrophils | Induced sputum
RESPIRATORY-TRACT | UNKNOWN CAUSE | AIRWAY INFLAMMATION | INCREASES | INDUCTION | BRONCHOALVEOLAR LAVAGE | INTERSTITIAL LUNG-DISEASES | GLUTATHIONE | RESPIRATORY SYSTEM | pulmonary fibrosis | induced sputum | cytokines | TNF-ALPHA | neutrophils | MODULATION | Sputum - cytology | Cross-Sectional Studies | Neutrophil Activation | Granulocyte-Macrophage Colony-Stimulating Factor - analysis | Humans | Middle Aged | Biomarkers - analysis | Pulmonary Fibrosis - immunology | Male | Inflammation | Interleukin-8 - analysis | Sputum - immunology | Adult | Female | Aged | Intercellular Adhesion Molecule-1 - analysis | Pulmonary fibrosis | Cytokines | Neutrophils | Induced sputum
Journal Article
Journal of Heart and Lung Transplantation, ISSN 1053-2498, 2001, Volume 20, Issue 11, pp. 1144 - 1151
Background: Chronic transplant rejection is characterized by progressive narrowing of small airways caused by matrix remodeling and fibrosis....
ALLOGRAFT-REJECTION | CARDIAC & CARDIOVASCULAR SYSTEMS | HUMAN NEUTROPHILS | TRANSPLANTATION | MATRIX METALLOPROTEINASES | BRONCHIOLITIS OBLITERANS SYNDROME | RESPIRATORY SYSTEM | GELATINASE-B | IN-VIVO | MATRIX-METALLOPROTEINASE-9 | ASTHMA | TNF-ALPHA | UP-REGULATION | Airway Obstruction - etiology | Graft Rejection - enzymology | Sputum - cytology | Humans | Middle Aged | Matrix Metalloproteinase 9 - analysis | Immunoenzyme Techniques | Tumor Necrosis Factor-alpha - analysis | Sputum - chemistry | Lung Transplantation | Tissue Inhibitor of Metalloproteinase-1 - analysis | Airway Obstruction - enzymology | Adolescent | Adult | Interleukin-10 - analysis | Postoperative Complications
ALLOGRAFT-REJECTION | CARDIAC & CARDIOVASCULAR SYSTEMS | HUMAN NEUTROPHILS | TRANSPLANTATION | MATRIX METALLOPROTEINASES | BRONCHIOLITIS OBLITERANS SYNDROME | RESPIRATORY SYSTEM | GELATINASE-B | IN-VIVO | MATRIX-METALLOPROTEINASE-9 | ASTHMA | TNF-ALPHA | UP-REGULATION | Airway Obstruction - etiology | Graft Rejection - enzymology | Sputum - cytology | Humans | Middle Aged | Matrix Metalloproteinase 9 - analysis | Immunoenzyme Techniques | Tumor Necrosis Factor-alpha - analysis | Sputum - chemistry | Lung Transplantation | Tissue Inhibitor of Metalloproteinase-1 - analysis | Airway Obstruction - enzymology | Adolescent | Adult | Interleukin-10 - analysis | Postoperative Complications
Journal Article
08/2010, Progress in Respiratory Research, ISBN 9783805595667, Volume 39, 5
Book Chapter
Pulmonary pharmacology & therapeutics, ISSN 1094-5539, 2007, Volume 20, Issue 6, p. 740
In patients with chronic obstructive pulmonary disease (COPD) classified as moderate onwards, Global Initiative for Chronic Obstructive Lung Disease (GOLD)...
Indans - adverse effects | Follow-Up Studies | Forced Expiratory Volume - drug effects | Humans | Middle Aged | Male | Indans - therapeutic use | Dose-Response Relationship, Drug | Heart Rate - drug effects | Quinolones - adverse effects | Time Factors | Quinolones - therapeutic use | Adrenergic beta-Agonists - administration & dosage | Electrocardiography | Adult | Female | Blood Pressure - drug effects | Indans - administration & dosage | Adrenergic beta-Agonists - therapeutic use | Adrenergic beta-Agonists - adverse effects | Severity of Illness Index | Double-Blind Method | Administration, Inhalation | Blood Glucose - drug effects | Quinolones - administration & dosage | Potassium - blood | Aged | Nebulizers and Vaporizers | Pulmonary Disease, Chronic Obstructive - drug therapy
Indans - adverse effects | Follow-Up Studies | Forced Expiratory Volume - drug effects | Humans | Middle Aged | Male | Indans - therapeutic use | Dose-Response Relationship, Drug | Heart Rate - drug effects | Quinolones - adverse effects | Time Factors | Quinolones - therapeutic use | Adrenergic beta-Agonists - administration & dosage | Electrocardiography | Adult | Female | Blood Pressure - drug effects | Indans - administration & dosage | Adrenergic beta-Agonists - therapeutic use | Adrenergic beta-Agonists - adverse effects | Severity of Illness Index | Double-Blind Method | Administration, Inhalation | Blood Glucose - drug effects | Quinolones - administration & dosage | Potassium - blood | Aged | Nebulizers and Vaporizers | Pulmonary Disease, Chronic Obstructive - drug therapy
Journal Article
Annals of Allergy, Asthma & Immunology, ISSN 1081-1206, 2005, Volume 95, Issue 2, pp. 197 - 203
Airway hyperresponsiveness and inflammation can be noninvasively studied by bronchial provocation using direct (histamine) or indirect (adenosine...
METHACHOLINE CHALLENGE | ALLERGY | AIRWAY INFLAMMATION | LUNG-FUNCTION | ALLERGIC RHINITIS | ASTHMA | INDUCED BRONCHOCONSTRICTION | RELEASE | IMMUNOLOGY | MAST-CELL | NONASTHMATIC SUBJECTS | 5'-MONOPHOSPHATE | Asthma - diagnosis | Sputum - cytology | Cell Count | Humans | Neutrophils - drug effects | Bronchial Provocation Tests | Neutrophils - immunology | Male | Adenosine Monophosphate - immunology | Histamine - immunology | Rhinitis, Allergic, Seasonal - diagnosis | Interleukin-8 - analysis | Rhinitis, Allergic, Seasonal - immunology | Cross-Over Studies | Sputum - immunology | Peroxidase - analysis | Asthma - immunology | Adult | Female | Leukotriene B4 - analysis
METHACHOLINE CHALLENGE | ALLERGY | AIRWAY INFLAMMATION | LUNG-FUNCTION | ALLERGIC RHINITIS | ASTHMA | INDUCED BRONCHOCONSTRICTION | RELEASE | IMMUNOLOGY | MAST-CELL | NONASTHMATIC SUBJECTS | 5'-MONOPHOSPHATE | Asthma - diagnosis | Sputum - cytology | Cell Count | Humans | Neutrophils - drug effects | Bronchial Provocation Tests | Neutrophils - immunology | Male | Adenosine Monophosphate - immunology | Histamine - immunology | Rhinitis, Allergic, Seasonal - diagnosis | Interleukin-8 - analysis | Rhinitis, Allergic, Seasonal - immunology | Cross-Over Studies | Sputum - immunology | Peroxidase - analysis | Asthma - immunology | Adult | Female | Leukotriene B4 - analysis
Journal Article
Chest, ISSN 0012-3692, 03/2003, Volume 123, Issue 3, pp. 778 - 783
Neutrophilic inflammation is a major feature of COPD. Induced sputum is increasingly used to monitor inflammatory airway diseases. Although short-term...
repeatability | induced sputum | interleukin-8 | neutrophils | COPD | soluble intercellular adhesion molecule
repeatability | induced sputum | interleukin-8 | neutrophils | COPD | soluble intercellular adhesion molecule
Journal Article
Pflege Zeitschrift, ISSN 0945-1129, 02/2005, Volume 58, Issue 2, p. suppl 2
Counselling plays an important role in different fields of activities within different professions. This study of the "Institut für Medizin-/Pflegepädagogik...
Clinical Competence | Health Promotion - organization & administration | Humans | Nurse-Patient Relations | Cooperative Behavior | Counseling - education | Curriculum | Nurse's Role - psychology | Counseling - organization & administration | Education, Nursing - organization & administration | Health Behavior | Germany
Clinical Competence | Health Promotion - organization & administration | Humans | Nurse-Patient Relations | Cooperative Behavior | Counseling - education | Curriculum | Nurse's Role - psychology | Counseling - organization & administration | Education, Nursing - organization & administration | Health Behavior | Germany
Journal Article
Pflege Zeitschrift, ISSN 0945-1129, 2005, Volume 58, Issue 2, p. 6
Journal Article
Nurse Education Today, ISSN 0260-6917, 2006, Volume 26, Issue 3, pp. 183 - 190
This article describes current and future tendencies in the development of curriculum planning for health care professions in Germany, using the example of...
Curriculum | Competency model | Midwifery education | Professional analysis | Health care industry | Nursing | Universities and colleges | Analysis | Health planning
Curriculum | Competency model | Midwifery education | Professional analysis | Health care industry | Nursing | Universities and colleges | Analysis | Health planning
Journal Article
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