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The New England Journal of Medicine, ISSN 0028-4793, 11/2015, Volume 373, Issue 21, pp. 2048 - 2058
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, p. e0154097
ALS-8112 is the parent molecule of ALS-8176, a first-in-class nucleoside analog prodrug effective in the clinic against respiratory syncytial virus (RSV)... 
SYSTEM | REPLICATION | MECHANISM | MULTIDISCIPLINARY SCIENCES | DRUGS | L PROTEIN | INFECTION | PRIMER | HIV-1 REVERSE-TRANSCRIPTASE | VESICULAR STOMATITIS-VIRUS | RESPIRATORY SYNCYTIAL VIRUS | Niacinamide - analogs & derivatives | DNA-Directed RNA Polymerases - antagonists & inhibitors | Epithelial Cells - drug effects | Humans | Viral Proteins - metabolism | RNA, Viral - antagonists & inhibitors | RNA, Viral - genetics | Recombinant Proteins - metabolism | Antiviral Agents - pharmacology | Gene Expression | Cytidine Triphosphate - pharmacology | RNA, Viral - biosynthesis | Viral Proteins - genetics | Viral Proteins - antagonists & inhibitors | DNA-Directed RNA Polymerases - genetics | Recombinant Proteins - genetics | Benzazepines - pharmacology | Drug Synergism | Point Mutation | Drug Resistance, Viral - genetics | Epithelial Cells - virology | Cell Line, Tumor | Cytidine Triphosphate - analogs & derivatives | Niacinamide - pharmacology | DNA-Directed RNA Polymerases - metabolism | Drug Combinations | Respiratory syncytial virus | Research | Gene mutations | Analysis | RNA polymerases | Risk factors | L protein | Cross-resistance | Amino acids | Viruses | Infections | RNA polymerase | Drug resistance | Ribonucleic acid--RNA | DNA-directed RNA polymerase | RNA-directed RNA polymerase | P protein | Polymerase | Hepatitis | Discrimination | Inhibitors | Antiviral activity | Nucleosides | Mutation | Inhibition | Cytidine triphosphate--CTP | Pharmaceutical industry | Nucleoside analogs | RNA | Cytidine triphosphate | Ribonucleic acid | CTP
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2015, Volume 58, Issue 4, pp. 1862 - 1878
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2015, Volume 59, Issue 12, pp. 7504 - 7516
Journal Article
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 02/2019, Volume 74, Issue 2, pp. 442 - 452
Abstract Background Respiratory syncytial virus (RSV) causes high morbidity, with mortality rates approaching or exceeding that of influenza in adult and... 
BRONCHIOLITIS | INFECTIOUS DISEASES | QUANTIFICATION | INFLUENZA | MICROBIOLOGY | MODEL | HOSPITALIZATION | INCREASED RISK | INFANTS | PHARMACOLOGY & PHARMACY | UPDATED GUIDANCE | YOUNG-CHILDREN | PALIVIZUMAB PROPHYLAXIS
Journal Article
Antiviral Research, ISSN 0166-3542, 07/2017, Volume 143, pp. 151 - 161
Journal Article
PLoS Pathogens, ISSN 1553-7366, 06/2015, Volume 11, Issue 6
  Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections, yet no vaccines or effective therapeutics are available. ALS-8176 is a... 
Hydrogen bonds | Funding | Mortality | Viruses | Infections | RNA polymerase | Pharmaceutical industry | Viral infections
Journal Article
Cytokine, ISSN 1043-4666, 09/2013, Volume 63, Issue 3, p. 304
Type 1 interferons (IFN) have been shown to be efficacious against many viruses. However, a significant drawback is the short duration of exposure. We have... 
Amyotrophic lateral sclerosis
Journal Article