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FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 08/2019, Volume 10, p. 1973
Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first step in the kynurenine pathway of tryptophan (Trp) degradation that produces several biologically... 
tryptophan metabolism | KYNURENINE PATHWAY | aryl hydrocarbon (Ah) receptor | TOLERANCE | AHR | IMMUNOLOGY | nuclear coactivator 7 (NCOA7) | CANCER | immune regulation | TRYPTOPHAN CATABOLISM | GENE | REGULATORY T-CELLS | SUPERFAMILY | BINDING | dendritic cell | IDO EXPRESSION | Tryptophan | Research | Dendritic cells | T cells | Immune system
Journal Article
Nature Immunology, ISSN 1529-2908, 09/2011, Volume 12, Issue 9, pp. 870 - 878
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 511, Issue 7508, pp. 184 - 190
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2008, Volume 105, Issue 52, pp. 20828 - 20833
Despite their common ability to activate intracellular signaling through CD80/CD86 molecules, cytotoxic T lymphocyte antigen 4 (CTLA-4)-Ig and CD28-Ig bias the... 
T lymphocytes | Messenger RNA | Reactivity | Dendritic cells | Cytokines | Antibodies | Catabolism | Physiological regulation | Immunity | Skin tests | CD28-Ig | Tryptophan catabolism | IL-6 | CD80/86 signaling | SOCS proteins | ACTIVATION | MULTIDISCIPLINARY SCIENCES | COMPETENT DENDRITIC CELLS | CUTTING EDGE | RESPONSES | REJECTION | IN-VIVO | REGULATORY T-CELLS | IMMUNE REGULATION | tryptophan catabolism | NF-KAPPA-B | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Antigens, CD - immunology | B7-2 Antigen - genetics | B7-1 Antigen - genetics | Immune Tolerance - physiology | Dendritic Cells - immunology | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Antigens, CD - genetics | Antigens, CD - metabolism | CD28 Antigens - metabolism | CD28 Antigens - genetics | Mice, Inbred DBA | B7-2 Antigen - immunology | Proteasome Endopeptidase Complex - immunology | Interleukin-6 - genetics | B7-1 Antigen - immunology | Suppressor of Cytokine Signaling Proteins - immunology | Suppressor of Cytokine Signaling Proteins - genetics | Mice, Transgenic | B7-1 Antigen - metabolism | CD28 Antigens - immunology | Ubiquitination - immunology | CTLA-4 Antigen | Proteasome Endopeptidase Complex - genetics | B7-2 Antigen - metabolism | Suppressor of Cytokine Signaling 3 Protein | Animals | Amino Acid Motifs - immunology | Dendritic Cells - enzymology | Interleukin-6 - immunology | Interleukin-6 - biosynthesis | Dendritic Cells - cytology | Mice | Proteasome Endopeptidase Complex - metabolism | Amino Acid Motifs - genetics | Suppressor of Cytokine Signaling Proteins - biosynthesis | Ubiquitination - genetics | Cellular signal transduction | Research | T cells | Properties | Biological Sciences | CD80 | 86 signaling
Journal Article
Nature Medicine, ISSN 1078-8956, 05/2007, Volume 13, Issue 5, pp. 579 - 586
Journal Article
Nature Immunology, ISSN 1529-2908, 11/2002, Volume 3, Issue 11, pp. 1097 - 1101
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a critical role in peripheral tolerance. However, regulatory pathways initiated by the interactions... 
ALLOGRAFT-REJECTION | DENDRITIC CELLS | INTERFERON-GAMMA | INDOLEAMINE 2,3-DIOXYGENASE | IN-VIVO | T-CELL ACTIVATION | MICE | IMMUNOLOGY | NF-KAPPA-B | CARDIAC ALLOGRAFTS | EXPRESSION | Recombinant Fusion Proteins - pharmacology | Male | NF-kappa B - metabolism | Tryptophan - metabolism | Trans-Activators - physiology | Immunoconjugates - pharmacology | Isoantigens - immunology | p38 Mitogen-Activated Protein Kinases | DNA-Binding Proteins - physiology | NF-kappa B - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Antigens, Differentiation - physiology | Mice, Knockout | CTLA-4 Antigen | Dendritic Cells - classification | STAT1 Transcription Factor | Cells, Cultured - metabolism | Mice | Mice, Inbred BALB C | Antigens, CD | Immunoconjugates - toxicity | Diabetes Mellitus, Experimental - surgery | Kynurenine - biosynthesis | Recombinant Fusion Proteins - therapeutic use | Abatacept | Immune Tolerance - immunology | Immunoglobulin G - pharmacology | Islets of Langerhans Transplantation | Dendritic Cells - drug effects | Dendritic Cells - metabolism | Immune Tolerance - drug effects | B7-1 Antigen - immunology | Mice, Inbred C57BL | Interferon-gamma - physiology | B7-1 Antigen - metabolism | Enzyme Activation - drug effects | Transplantation, Homologous - immunology | Graft Enhancement, Immunologic | Peptides - pharmacology | Gene Expression Regulation - drug effects | Tryptophan Oxygenase - metabolism | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Antigen Presentation - drug effects | Pyridines - pharmacology | Graft Survival - drug effects | Interferon-gamma - biosynthesis
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 06/2006, Volume 176, Issue 11, pp. 6752 - 6761
Tryptophan catabolism is a tolerogenic effector system in regulatory T cell function, yet the general mechanisms whereby tryptophan catabolism affects T cell... 
IMMUNE-RESPONSE | INHIBITION | DENDRITIC CELLS | NONOBESE DIABETIC MICE | TRANSCRIPTION FACTOR FOXP3 | INDOLEAMINE 2,3-DIOXYGENASE | IN-VIVO | PERIPHERAL TOLERANCE | PROLIFERATION | IMMUNOLOGY | ANTIGEN | T-Lymphocyte Subsets - immunology | T-Lymphocytes, Regulatory - metabolism | CD8-Positive T-Lymphocytes - pathology | Coculture Techniques | Protein-Serine-Threonine Kinases | Receptors, Antigen, T-Cell - antagonists & inhibitors | Tryptophan - metabolism | Interleukin-10 - physiology | Receptors, Antigen, T-Cell - biosynthesis | T-Lymphocytes, Regulatory - immunology | Forkhead Transcription Factors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Female | Mice, Inbred DBA | Kynurenine - metabolism | Forkhead Transcription Factors - biosynthesis | Receptors, Interleukin-2 - biosynthesis | Kynurenine - pharmacology | Cells, Cultured | Transforming Growth Factor beta - physiology | Receptors, Interleukin-2 - metabolism | Immunophenotyping | Mice, Transgenic | Mice, SCID | Antigens, Differentiation - physiology | Mice, Knockout | CTLA-4 Antigen | Membrane Proteins - biosynthesis | Animals | T-Lymphocyte Subsets - pathology | Membrane Proteins - antagonists & inhibitors | Down-Regulation - immunology | T-Lymphocyte Subsets - metabolism | Protein Kinases - physiology | Resting Phase, Cell Cycle - immunology | Tryptophan - physiology | Mice, Inbred NOD | Mice | CD8-Positive T-Lymphocytes - immunology | Antigens, CD
Journal Article
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, p. 1852
CpG-rich oligodeoxynucleotides activate the immune system, leading to innate and acquired immune responses. The immune-stimulatory effects of CpG-rich... 
PLASMACYTOID DENDRITIC CELLS | IMMUNOSUPPRESSIVE PATHWAY | ACTIVATION | INDOLEAMINE 2,3-DIOXYGENASE IDO | INDUCE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | NF-KAPPA-B | TRYPTOPHAN CATABOLISM | CUTTING EDGE | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Immunomodulation - drug effects | Membrane Glycoproteins - metabolism | Humans | Interferon Regulatory Factors - metabolism | Pneumonia - pathology | NF-kappa B - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Antigens, CD - metabolism | Interleukin-23 - genetics | Signal Transduction - immunology | Interleukin-23 - metabolism | Interferon Type I - metabolism | Pneumonia - immunology | Dendritic Cells - drug effects | Dendritic Cells - metabolism | Immune Tolerance - drug effects | Skin Tests | Toll-Like Receptor 3 - metabolism | Aspergillosis, Allergic Bronchopulmonary - pathology | Toll-Like Receptor 4 - metabolism | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism | Gene Expression Regulation - drug effects | Animals | Transforming Growth Factor beta - genetics | Signal Transduction - drug effects | Aspergillosis, Allergic Bronchopulmonary - immunology | Mice | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Transforming Growth Factor beta - metabolism
Journal Article
Journal of Immunology, ISSN 0022-1767, 2008, Volume 181, Issue 8, pp. 5194 - 5198
CD8(-) and CD8(+) dendritic cells (DCs) are distinct subsets of mouse splenic accessory cells with opposite but flexible programs of Ag presentation, leading... 
GROWTH-FACTOR-BETA | ACTIVATION | MECHANISM | TOLERANCE | INDOLEAMINE 2,3-DIOXYGENASE | REGULATORY T-CELLS | RECEPTOR | IMMUNOLOGY | SUPPRESSION | TRYPTOPHAN CATABOLISM | TGF-BETA-1 | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Dendritic Cells - immunology | NF-kappa B - immunology | NF-kappa B - metabolism | Autocrine Communication - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Enzyme Activation - immunology | Phosphatidylinositol 3-Kinases - immunology | Proto-Oncogene Proteins c-akt - genetics | Signal Transduction - immunology | Transforming Growth Factor beta1 - immunology | Autocrine Communication - immunology | Proto-Oncogene Proteins c-akt - metabolism | Dendritic Cells - metabolism | Transforming Growth Factor beta1 - pharmacology | Immune Tolerance - drug effects | Antigen Presentation - genetics | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Enzyme Activation - drug effects | Autocrine Communication - genetics | CD8 Antigens - immunology | Phosphatidylinositol 3-Kinases - genetics | CD8 Antigens - metabolism | Animals | Proto-Oncogene Proteins c-akt - immunology | NF-kappa B - genetics | Signal Transduction - drug effects | CD8 Antigens - genetics | Immune Tolerance - genetics | Antigen Presentation - drug effects | Dendritic Cells - cytology | Mice | Enzyme Activation - genetics
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 01/2017, Volume 21, Issue 1, pp. 165 - 176
Journal Article