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Microbes and infection, ISSN 1286-4579, 06/2019
Protein phosphorylation is known to be one of the keystones of signal sensing and transduction in all living organisms. Once thought to be essentially confined... 
Journal Article
PLoS Pathogens, ISSN 1553-7366, 05/2017, Volume 13, Issue 5, p. e1006399
Journal Article
Journal of structural biology, ISSN 1047-8477, 08/2019
Mycobacterial KGD, the thiamine diphosphate (ThDP)-dependent E1o component of the 2-oxoglutarate dehydrogenase complex (OGDHC), is known to undergo significant... 
Journal Article
The FEBS Journal, ISSN 1742-464X, 02/2017, Volume 284, Issue 4, pp. 602 - 614
Journal Article
The FEBS Journal, ISSN 1742-464X, 02/2017, Volume 284, Issue 4, pp. 602 - 614
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2014, Volume 457, Issue 3, pp. 425 - 434
alpha-Ketoacid dehydrogenases are large multi-enzyme machineries that orchestrate the oxidative decarboxylation of alpha-ketoacids with the concomitant... 
X-ray crystallography | Mycobacterium | Decarboxylase | Bacterial metabolism | Enzyme catalysis | Protein dynamics | Dehydrogenase | decarboxylase | 2-OXOGLUTARATE DEHYDROGENASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein dynamics | ESCHERICHIA-COLI | KETOACID DEHYDROGENASE | enzyme catalysis | dehydrogenase | CRYSTALLOGRAPHIC SNAPSHOTS | bacterial metabolism | INDIVIDUAL STEPS | E1 COMPONENT | PYRUVATE DECARBOXYLASE | DEHYDROGENASE MULTIENZYME COMPLEX | THIAMIN DIPHOSPHATE | Adipates - metabolism | Ketoglutarate Dehydrogenase Complex - chemistry | Molecular Conformation | Bacterial Proteins - chemistry | Ketoglutarate Dehydrogenase Complex - metabolism | Carboxy-Lyases - genetics | Ketoglutarate Dehydrogenase Complex - genetics | Ketoglutaric Acids - chemistry | Aldehyde-Ketone Transferases - genetics | Carboxy-Lyases - metabolism | Ketoglutaric Acids - metabolism | Mycobacterium smegmatis - enzymology | Peptide Fragments - genetics | Recombinant Proteins - metabolism | Aldehyde-Ketone Transferases - metabolism | Catalytic Domain | Peptide Fragments - metabolism | Biocatalysis | Bacterial Proteins - genetics | Protein Refolding | Adipates - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Carboxy-Lyases - chemistry | Peptide Fragments - chemistry | Decarboxylation | Mutant Proteins - chemistry | Aldehyde-Ketone Transferases - chemistry | Bacterial Proteins - metabolism | Molecular Docking Simulation | Protein Processing, Post-Translational | Amino Acid Substitution
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 2008, Volume 1784, Issue 1, pp. 193 - 202
Reversible protein phosphorylation is a major regulation mechanism of fundamental biological processes, not only in eukaryotes but also in bacteria. A growing... 
Protein phosphatases | Drug design | Mycobacterium tuberculosis | Ser/Thr protein phosphorylation | Protein kinases | 2-COMPONENT SIGNAL-TRANSDUCTION | MEDIATED INTERACTIONS | drug design | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein kinases | mycobacterium tuberculosis | FHA DOMAIN | TYROSINE-PHOSPHATASE | SUBSTRATE RECOGNITION | CELL-DIVISION | BIOPHYSICS | BACILLUS-SUBTILIS | STRUCTURAL BASIS | protein phosphatases | SERINE/THREONINE KINASE | Phosphorylation | Signal Transduction | Humans | Phosphoprotein Phosphatases - metabolism | Virulence | Protein-Serine-Threonine Kinases - genetics | Crystallography, X-Ray | Phosphoprotein Phosphatases - antagonists & inhibitors | Mycobacterium tuberculosis - pathogenicity | Animals | Protein Kinase Inhibitors - therapeutic use | Mycobacterium tuberculosis - enzymology | Tuberculosis - drug therapy | Mycobacterium tuberculosis - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Bacterial Proteins - metabolism | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | Protein-Serine-Threonine Kinases - metabolism | Antitubercular Agents - therapeutic use | Mycobacterium tuberculosis - genetics | Phosphoprotein Phosphatases - chemistry | Quantitative Methods | Protein-Serine-Threonine Kinases | Bacterial Proteins | Life Sciences | Protein Kinase Inhibitors | Tuberculosis | Antitubercular Agents | Computer Science | Bioinformatics | Phosphoprotein Phosphatases
Journal Article