X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
chemistry, medicinal (47) 47
humans (47) 47
index medicus (36) 36
structure-activity relationship (34) 34
animals (19) 19
alzheimer's disease (18) 18
drug design (18) 18
derivatives (17) 17
biochemistry & molecular biology (16) 16
molecular structure (16) 16
models, molecular (15) 15
alzheimer disease - drug therapy (14) 14
cell line, tumor (13) 13
cholinesterase inhibitors - chemical synthesis (13) 13
cholinesterase inhibitors - chemistry (12) 12
dose-response relationship, drug (11) 11
drug discovery3003 pharmaceutical science (10) 10
inhibitors (10) 10
acetylcholinesterase - metabolism (9) 9
chemistry, organic (9) 9
organic chemistry (9) 9
alzheimers-disease (8) 8
antineoplastic agents - chemistry (8) 8
antineoplastic agents - pharmacology (8) 8
ligands (8) 8
mice (8) 8
molecular docking simulation (8) 8
pharmacology (8) 8
acetylcholinesterase - chemistry (7) 7
acetylcholinesterase inhibitors (7) 7
alzheimer’s disease (7) 7
analysis (7) 7
binding sites (7) 7
breast-cancer (7) 7
cancer (7) 7
cholinesterase inhibitors - pharmacology (7) 7
drug discovery (7) 7
drug screening assays, antitumor (7) 7
in-vitro (7) 7
molecular medicine (7) 7
neuroprotection (7) 7
pharmacology & pharmacy (7) 7
activation (6) 6
amyloid beta-peptides - metabolism (6) 6
antineoplastic agents - chemical synthesis (6) 6
apoptosis (6) 6
aromatase inhibitors - chemical synthesis (6) 6
aromatase inhibitors - chemistry (6) 6
beta-amyloid aggregation (6) 6
butyrylcholinesterase - metabolism (6) 6
coumarins - chemistry (6) 6
curcumin (6) 6
design (6) 6
drugs (6) 6
enzyme (6) 6
enzyme inhibitors - pharmacology (6) 6
flavone acetic-acid (6) 6
highly potent (6) 6
imidazoles - chemical synthesis (6) 6
imidazoles - chemistry (6) 6
imidazoles - pharmacology (6) 6
in vitro techniques (6) 6
natural products (6) 6
neurodegenerative diseases (6) 6
oxidative stress (6) 6
steroid 17-alpha-hydroxylase - antagonists & inhibitors (6) 6
aggregation (5) 5
alzheimer disease - metabolism (5) 5
amyloid beta-peptides - chemistry (5) 5
amyloid precursor protein secretases - antagonists & inhibitors (5) 5
benzophenone (5) 5
biological evaluation (5) 5
butyrylcholinesterase (5) 5
butyrylcholinesterase - chemistry (5) 5
cell proliferation - drug effects (5) 5
cell survival - drug effects (5) 5
cells (5) 5
cholinesterase inhibitors (5) 5
coumarins - chemical synthesis (5) 5
curcumin - chemistry (5) 5
cytochromes p450 (5) 5
discovery (5) 5
enzyme inhibitors (5) 5
enzyme inhibitors - chemical synthesis (5) 5
enzyme inhibitors - chemistry (5) 5
female (5) 5
magnetic resonance spectroscopy (5) 5
nf-y (5) 5
oligomers (5) 5
ovarian-carcinoma cells (5) 5
potent (5) 5
xanthenes - chemical synthesis (5) 5
xanthenes - chemistry (5) 5
xanthenes - pharmacology (5) 5
xanthones - chemical synthesis (5) 5
xanthones - chemistry (5) 5
xanthones - pharmacology (5) 5
acetylcholinesterase (4) 4
aldosterone synthase inhibitors (4) 4
amyloid precursor protein secretases - metabolism (4) 4
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 8, p. 1DUMMY
Alzheimer’s disease still represents an untreated multifaceted pathology, and drugs able to stop or reverse its progression are urgently needed. In this paper,... 
Antioxidants | Neuroprotection | Chalcones | Alzheimer’s disease | Cholinesterase inhibitors | Oligomers | Neurotoxicity | Benzofuran | Lead compounds | Neuroprotective agents | Cholinesterase | chalcones | cholinesterase inhibitors | antioxidants | neuroprotection
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e53664
Background: The activation of autophagy has been extensively described as a pro-survival strategy, which helps to keep cells alive following deprivation of... 
NF-Y | SIGNALING PATHWAYS | IN-VITRO | ACTIVATION | INDUCED APOPTOSIS | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | ENDOPLASMIC-RETICULUM STRESS | BCL-2 FAMILY-MEMBERS | UP-REGULATION | Cell Survival - drug effects | Curcumin - analogs & derivatives | Endoplasmic Reticulum Stress - drug effects | Curcumin - chemistry | HCT116 Cells | Humans | Curcumin - pharmacology | Tumor Suppressor Protein p53 - metabolism | Mitochondria - metabolism | Enzyme Activation - drug effects | Colonic Neoplasms - ultrastructure | Mitochondria - ultrastructure | Autophagy - drug effects | Drug Synergism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | Colonic Neoplasms - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Colonic Neoplasms - enzymology | Cell Death - drug effects | Cell Cycle - drug effects | Drug Screening Assays, Antitumor | Cytochrome c | Colon cancer | Analysis | Cancer cells | Biochemistry | Tumor proteins | Apoptosis | Cytochrome | Cell proliferation | Bcl-2 protein | p53 Protein | Colorectal cancer | Fluorescence | Cytotoxicity | Kinases | Autophagy | Proteins | Signal transduction | Mitochondria | Rodents | Cell cycle | Nutrients | Curcumin | Colon | Growth factors | Stresses | Deprivation | Cell survival | RNA-mediated interference | Mortality | Caspase | Pharmacology | Electron microscopy | Stress | Caspase-7 | Cell death | Endoplasmic reticulum | Vacuoles | Phagocytosis | Cytoplasm | Cancer
Journal Article
Journal Article
Molecules, ISSN 1420-3049, 11/2018, Volume 23, Issue 12, p. 3088
As a follow-up to our previous studies on differently substituted 1,4-dihydropyridines endowed with a peculiar cardiac selectivity, in this paper, a small... 
Lidoflazine | Xanthone | Calcium channels | Hybrid compounds | 1,4-dihydropyridine | MEDICINAL CHEMISTRY | CALCIUM-CHANNELS | lidoflazine | calcium channels | BIOCHEMISTRY & MOLECULAR BIOLOGY | 1,4-DIHYDROPYRIDINE SCAFFOLD | STORY | CHEMISTRY, MULTIDISCIPLINARY | hybrid compounds | xanthone
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2016, Volume 59, Issue 13, pp. 6387 - 6406
The modulation of the endocannabinoid system is emerging as a viable avenue for the treatment of neurodegeneration, being involved in neuroprotective and... 
Journal Article
Anti-Cancer Agents in Medicinal Chemistry, ISSN 1871-5206, 2014, Volume 14, Issue 1, pp. 54 - 65
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2015, Volume 25, Issue 14, pp. 2804 - 2808
Journal Article
Journal Article
Journal Article