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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 10, pp. 2550 - 2555
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 4, pp. 1243 - 1248
The creation of effective bioscavengers as a pretreatment for exposure to nerve agents is a challenging medical objective. We report a recombinant method using... 
Enzymes | Organic chemistry | Toxicity | Nerves | Plasma stability | Poisoning | Biochemistry | Pharmacokinetics | Dosage | Blood plasma | organophosphate | POLYSIALIC ACIDS | pesticide | MULTIDISCIPLINARY SCIENCES | CIRCULATORY STABILITY | HYDROLYSIS | TOXICITY | EQUINE SERUM BUTYRYLCHOLINESTERASE | IMMUNOGENICITY | PEPTIDES | ACETYLCHOLINESTERASE | PHARMACOKINETICS | Russian VX | mass spectrometry | SARIN | N-acetylneuraminic acid | Butyrylcholinesterase - genetics | Cricetulus | Humans | Molecular Sequence Data | Male | Recombinant Proteins - pharmacokinetics | Organothiophosphorus Compounds - antagonists & inhibitors | Sialic Acids - chemistry | Butyrylcholinesterase - chemistry | Organothiophosphorus Compounds - toxicity | Neuroprotective Agents - pharmacokinetics | Neuroprotective Agents - administration & dosage | CHO Cells | Amino Acid Sequence | Cricetinae | Neuroprotective Agents - chemistry | Butyrylcholinesterase - pharmacokinetics | Models, Molecular | Recombinant Proteins - chemistry | Butyrylcholinesterase - administration & dosage | Recombinant Proteins - genetics | Lethal Dose 50 | Recombinant Proteins - administration & dosage | Animals | Mice | Mice, Inbred BALB C | Chemical Warfare Agents - toxicity | Nerve gas | Peptides | Cholinesterases | Physiological aspects | Chemical reactions | Research | Mass spectrometry | Health aspects | Methods | Biological Sciences
Journal Article
FASEB Journal, ISSN 0892-6638, 05/2015, Volume 29, Issue 5, pp. 1901 - 1913
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 06/2019, Volume 33, Issue 6, pp. 6852 - 6866
A majority of thousands of intracellular mammalian proteins are recognized by proteasome only being conjugated with ubiquitin (Ub), representing a universal... 
RECOGNITION | PHOSPHORYLATION | proteasome recognition | BIOCHEMISTRY & MOLECULAR BIOLOGY | ORNITHINE-DECARBOXYLASE | myelin basic protein | PA28 ALPHA | CELL BIOLOGY | MYELIN BASIC-PROTEIN | PA28 | DISTINCT MECHANISMS | 11S | MULTIPLE-SCLEROSIS | direct proteasomal signal | BIOLOGY | DEGRADATION | REG regulatory subunit | ubiquitin-independent degradation | CELL | 20S PROTEASOMES
Journal Article
Biotechnology Letters, ISSN 0141-5492, 7/2016, Volume 38, Issue 7, pp. 1173 - 1180
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e20991
B cells play an important role in the pathogenesis of both systemic and organ-specific autoimmune diseases. Autoreactive B cells not only produce... 
RHEUMATOID-ARTHRITIS | AUTOANTIBODIES | IN-VITRO | PROTEIN | AUTOIMMUNE-DISEASES | MULTIDISCIPLINARY SCIENCES | DEPENDENT TRANSLATION | DEPLETION | MAMMALIAN MESSENGER-RNAS | T-CELLS | LYMPHOCYTES | Ribonucleases - genetics | Cricetulus | Humans | Cell Death - immunology | Antibodies, Monoclonal - therapeutic use | Epitopes - immunology | Antibodies, Monoclonal - immunology | Autoimmune Diseases - drug therapy | CHO Cells | Cell Line | Cricetinae | Antibodies, Monoclonal - pharmacology | Autoimmune Diseases - immunology | Proto-Oncogene Proteins c-myc - immunology | Recombinant Proteins - genetics | Spleen - cytology | B-Lymphocytes - drug effects | Animals | B-Lymphocytes - immunology | Recombinant Proteins - immunology | Ribonucleases - immunology | Autoantigens - immunology | Hybridomas - immunology | Mice | Mice, Inbred BALB C | Proto-Oncogene Proteins c-myc - genetics | Autoimmunity | Autoantibodies | Analysis | Immunoglobulin G | Genetically modified organisms | Monoclonal antibodies | Autoantigens | Genetic engineering | B cells | T cells | Immunity | Antigenic determinants | Cell culture | Therapy | Toxicity | Pathogenesis | c-Myc protein | Clinical trials | Cytotoxicity | Lymphocytes T | Biology | Myc protein | Pseudomonas | Legibility | Epidemiology | Cancer therapies | Proteins | E coli | Lymphocytes | Splenocytes | Catalysis | Targeted cancer therapy | Killing | Antigens | Barnase | Cytokines | Medical treatment | Melanoma | Shiga-like toxin | T cell receptors | Inflammation | Diseases | Immunotoxins | Chemistry | Side effects | Depletion | Mutagenesis | Lymphocytes B | Rheumatoid arthritis | Cell lines | CD20 antigen | Toxins | Autoimmune diseases | Apoptosis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2006, Volume 103, Issue 2, pp. 281 - 286
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 38, pp. 15954 - 15959
Igs offer a versatile template for combinatorial and rational design approaches to the de novo creation of catalytically active proteins. We have used a... 
Enzymes | Molecules | Reactivity | Active sites | Phosphonic acids | Antibodies | Ligands | Esters | Kinetics | Catalysis | Catalytic antibodies | Insecticide | Organophosphate hydrolysis | Crystal structure | BUTYRYLCHOLINESTERASE | STRUCTURAL PLASTICITY | MULTIDISCIPLINARY SCIENCES | insecticide | SITE-DIRECTED MUTAGENESIS | organophosphate hydrolysis | EVOLUTION | INHIBITION | AFFINITY | catalytic antibodies | PHOSPHONATE ESTERS | ENZYMES | crystal structure | BINDING | Complementarity Determining Regions - genetics | Antibodies - metabolism | Cricetulus | Antibodies - chemistry | Humans | Immunoglobulin Variable Region - chemistry | Immunoglobulin Variable Region - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Immunoglobulin Light Chains - chemistry | Immunoglobulin Light Chains - genetics | Thermodynamics | Spectrometry, Mass, Electrospray Ionization | Complementarity Determining Regions - chemistry | Complementarity Determining Regions - metabolism | CHO Cells | Recombinant Proteins - metabolism | Amino Acid Sequence | Cricetinae | Models, Molecular | Recombinant Proteins - chemistry | Binding Sites - genetics | Immunoglobulin Light Chains - metabolism | Proteins - genetics | Algorithms | Animals | Proteins - metabolism | Protein Binding | Antibodies - genetics | Calorimetry | Immunoglobulin Variable Region - genetics | Protein Conformation | Mutation | Proteins - chemistry | Physiological aspects | Research | Immunoglobulin G | Biological Sciences
Journal Article