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The Lancet Infectious Diseases, ISSN 1473-3099, 05/2019, Volume 19, Issue 5, pp. e149 - e161
In the past 5–10 years, Venezuela has faced a severe economic crisis, precipitated by political instability and declining oil revenue. Public health provision... 
INFECTIOUS DISEASES | BOLIVAR STATE | CHIKUNGUNYA | VIRUS | CHAGAS-DISEASE | MALARIA | INFECTION | SIFONTES | MAYARO | EPIDEMIC | MUNICIPALITY | Disease transmission | Vector-borne diseases | Epidemics | Malaria | Mortality | Dengue | Viral diseases | Viruses | Infections | Zika virus | Political factors | Epidemiology | Vectors (Biology) | Tropical diseases | Incidence | Surveillance | Parasitic diseases | Politics | Chagas' disease | Children | Public health
Journal Article
Journal Article
PLoS ONE, 06/2015, Volume 10, Issue 6
Src family non-receptor tyrosine kinases play a prominent role in multiple cellular processes, including: cell proliferation, differentiation, cell survival,... 
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2015, Volume 472, Issue 2, pp. 195 - 204
The activity of calmodulin (CaM) is modulated not only by oscillations in the cytosolic concentration of free Ca2+, but also by its phosphorylation status. In... 
Tyrosine kinase | Phospho-(Tyr)-calmodulin | Calcium | Calmodulin | Epidermal growth factor receptor | CELLS | DOMAIN | calcium | PHOSPHORYLATION | epidermal growth factor receptor | BIOCHEMISTRY & MOLECULAR BIOLOGY | tyrosine kinase | MECHANISMS | calmodulin | CANCER-THERAPY | EGFR | phospho-(Tyr)-calmodulin | CALMODULIN-BINDING PROTEIN | PURIFICATION | Calmodulin - genetics | Receptor, Epidermal Growth Factor - genetics | Phosphorylation | Humans | Male | Calmodulin - isolation & purification | Receptor, Epidermal Growth Factor - metabolism | Cell Membrane - metabolism | Binding Sites | Mutant Proteins - antagonists & inhibitors | Peptide Fragments - genetics | Recombinant Proteins - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Peptide Fragments - metabolism | Calmodulin - metabolism | Rats | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Receptor, Epidermal Growth Factor - chemistry | Receptor, Epidermal Growth Factor - isolation & purification | Nerve Tissue Proteins - metabolism | Cell Membrane - enzymology | Peptide Fragments - chemistry | Tyrosine - metabolism | Animals | Nerve Tissue Proteins - isolation & purification | Proto-Oncogene Proteins pp60(c-src) - genetics | Proto-Oncogene Proteins pp60(c-src) - metabolism | Cell Line, Tumor | Ligands | Protein Processing, Post-Translational | Calmodulin - antagonists & inhibitors | Sus scrofa | Amino Acid Substitution
Journal Article
by Felip, E and Carcereny, E and Barlesi, F and Gandhi, L and Sequist, L. V and Kim, S.-W and Groen, H. J. M and Besse, B and Kim, D.-W and Smit, E and Akimov, M and Avsar, E and Bailey, S and Ofosu-Appiah, W and Garon, E. B and Gettinger, S and Weiss, G. J and Salgia, R and Bazhenova, L and Narasimhan, N. I and Dorer, D. J and Rivera, V. M and Zhang, J and Clackson, T and Haluska, F and Shaw, A. T and Camidge, D. R and Sharma, S and Tan, D. S. W and Kim, D and De Pas, T and Vansteenkiste, J. F and Santoro, A and Liu, G and Goldwasser, M and Dai, D and Boral, A. L and Mehra, R and Nishio, M and Kiura, K and Nakagawa, K and Seto, T and Inoue, A and Maemondo, M and Hida, T and Harada, M and Yoshioka, H and Tamura, T and Munster, P and van der Noll, R and Voest, E and Specht, J and Werner, T. L and Dees, E. C and Tan, A. R and Daud, A and Schellens, J and Lolkema, M. P and Griffin, M and Agarwal, N and Falchook, G. S and Kleha, J. F and Durante, M and Smith, D. A and Adams, L and Greshock, J and Morris, S. R and Kurzrock, R and Elez, E and Tabernero, J and Prudkin, L and Agarwal, S and Han, M and Credi, M and Yin, W and Kuriyama, N and Baselga, J and Hong, D. S and Amin, H. M and Fu, S and Piha-Paul, S. A and Klevesath, M. B and Jego, V and Johne, A and Stinchi, S and Cohen, E. E. W and Elisei, R and Schlumberger, M. J and Muller, S. P and Schoffski, P and Brose, M and Shah, M and Miles, D. R and Nguyen, L. T and Sherman, S and Soria, J and Hollebecque, A and Massard, C and Deutsch, E and Varga, A and ...
Annals of Oncology, ISSN 0923-7534, 09/2012, Volume 23, Issue suppl 9, pp. ix152 - ix174
Journal Article
by Gravis, G and Fizazi, K and Joly Lobbedez, F and Oudard, S and Priou, F and Latorzeff, I and Delva, R and Krakowski, I and Laguerre, B and Rolland, F and Theodore, C and Deplanque, G and Ferrero, J. M and Pouessel, D and Mourey, L and Beuzeboc, P and Zanetta, S and Esterni, B and Habibian, M and Soulie, M and Ryan, C. J and Morris, M and Molina, A and Piulats, J. R and De Souza, P and Li, J and Kheoh, T and de Bono, J. S and Larson, S and Griffin, T and Matheny, S and Naini, V and Scher, H. I and Small, E and Basch, E and Logothetis, C. J and Rathkopf, D. E and Smith, M. R and Mainwaring, P. N and Hao, Y and Li, S and Meyers, M and Cleeland, C and Saad, F and Sternberg, C. N and Miller, K and Mulders, P and Chi, K and Hirmand, M and Rathkopf, D and Corn, P. G and Mukherji, D and Harzstark, A. L and Sartor, O. A and Smith, D. C and Tunariu, N and Sweeney, C and Parker, C and Coleman, R. E and Nilsson, S and Vogelzang, N and Lloyd, A. J and Staudacher, K and van Gool, R and Sartor, A. O and Taplin, M and Armstrong, A. J and Selby, B and Yu, E. Y and Ellard, S and Hotte, S. J and Gingerich, J. R and Joshua, A. M and Gleave, M. E and Sonpavde, G and Pond, G. R and Galsky, M. D and Wood, B. A and Wang, S and Paolini, J and Lechuga, M and Michaelson, M. D and Liede, A and Gunther, O and Bennett, B and Wong, S and Pezaro, C and Omlin, A. G and Sandhu, S and Bianchini, D and Cassidy, A. M and Maier, G and Olmos, D and Attard, G and Dixit, S and Tito, J and Afzal, P and Wolff, J. M and Gedamke, M and Li, C and ...
Annals of Oncology, ISSN 0923-7534, 09/2012, Volume 23, Issue suppl 9, pp. ix294 - ix318
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2006, Volume 49, Issue 3, pp. 892 - 899
There is no effective treatment for the prevalent chronic form of Chagas' disease in Latin America. Its causative agent, the protozoan parasite Trypanosoma... 
Journal Article
PLOS ONE, ISSN 1932-6203, 07/2019, Volume 14, Issue 7, p. e0219311
Journal Article
Investigational New Drugs, ISSN 0167-6997, 6/2014, Volume 32, Issue 3, pp. 489 - 499
Purpose Amplification or over-expression of the mitotic Aurora A kinase (AAK) has been reported in several heme-lymphatic malignancies. MLN8237 (alisertib) is... 
Novel antitumor agent | Medicine & Public Health | Aurora A kinase inhibitor | MLN8237 | Oncology | Cell cycle mechanisms of anticancer drug action | Pharmacology/Toxicology | Phase I-III Leukemia and lymphomas | APOPTOSIS | B ACTIVITY | INSTABILITY | RESPONSE CRITERIA | ALISERTIB MLN8237 | INCREASES | TARGETING AURORA | OVEREXPRESSION | ONCOLOGY | GROWTH | PHARMACOLOGY & PHARMACY | A KINASE | Humans | Middle Aged | Neoplasm Recurrence, Local - drug therapy | Male | Antineoplastic Agents - administration & dosage | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Protein Kinase Inhibitors - adverse effects | Aurora Kinase A - antagonists & inhibitors | Aurora Kinase A - metabolism | Multiple Myeloma - drug therapy | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Aurora Kinase A - genetics | Lymphoma, Non-Hodgkin - drug therapy | Protein Kinase Inhibitors - pharmacokinetics | Azepines - adverse effects | Neoplasm Recurrence, Local - metabolism | Pyrimidines - administration & dosage | Lymphoma, Non-Hodgkin - genetics | Multiple Myeloma - metabolism | Protein Kinase Inhibitors - administration & dosage | Maximum Tolerated Dose | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Lymphoma, Non-Hodgkin - metabolism | Pyrimidines - adverse effects | Pyrimidines - pharmacokinetics | Neoplasm Recurrence, Local - genetics | Aged | Azepines - pharmacokinetics | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Azepines - administration & dosage | Multiple Myeloma - genetics | Antimitotic agents | Complications and side effects | Chronic lymphocytic leukemia | Care and treatment | Dosage and administration | Genetic aspects | Research | Antineoplastic agents | Pharmacokinetics | Inhibitor drugs | Statistical analysis | Research & development--R&D | Clinical trials | Patients | Cancer therapies | Pharmaceuticals | Index Medicus | Phase I Studies
Journal Article