Oral Oncology, ISSN 1368-8375, 2013, Volume 49, Issue 8, pp. 747 - 752
Summary Induction chemotherapy prior to planned definitive local therapy for head and neck squamous cell carcinoma has been studied for at least three decades...
Otolaryngology | Hematology, Oncology and Palliative Medicine | Neo-adjuvant chemotherapy | Sequential | Platinum | Combined treatments | Larynx preservation | Taxanes | Cetuximab | RANDOMIZED-TRIAL | ADVANCED LARYNGEAL-CANCER | RADIATION-THERAPY | PHASE-III TRIAL | ALTERNATING CHEMOTHERAPY | ORGAN PRESERVATION | CISPLATIN | ONCOLOGY | DENTISTRY, ORAL SURGERY & MEDICINE | LOCALLY ADVANCED HEAD | CARCINOMA | CONCURRENT CHEMORADIOTHERAPY | Head and Neck Neoplasms - radiotherapy | Carcinoma, Squamous Cell - drug therapy | Humans | Head and Neck Neoplasms - drug therapy | Carcinoma, Squamous Cell - surgery | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Carcinoma, Squamous Cell - radiotherapy | Head and Neck Neoplasms - surgery | Chemotherapy | Squamous cell carcinoma | Nuclear radiation | Cancer
Otolaryngology | Hematology, Oncology and Palliative Medicine | Neo-adjuvant chemotherapy | Sequential | Platinum | Combined treatments | Larynx preservation | Taxanes | Cetuximab | RANDOMIZED-TRIAL | ADVANCED LARYNGEAL-CANCER | RADIATION-THERAPY | PHASE-III TRIAL | ALTERNATING CHEMOTHERAPY | ORGAN PRESERVATION | CISPLATIN | ONCOLOGY | DENTISTRY, ORAL SURGERY & MEDICINE | LOCALLY ADVANCED HEAD | CARCINOMA | CONCURRENT CHEMORADIOTHERAPY | Head and Neck Neoplasms - radiotherapy | Carcinoma, Squamous Cell - drug therapy | Humans | Head and Neck Neoplasms - drug therapy | Carcinoma, Squamous Cell - surgery | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Carcinoma, Squamous Cell - radiotherapy | Head and Neck Neoplasms - surgery | Chemotherapy | Squamous cell carcinoma | Nuclear radiation | Cancer
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2008, Volume 359, Issue 11, pp. 1116 - 1127
This randomized trial of the treatment of advanced head and neck cancer tested the efficacy of adding cetuximab, an antibody against the epidermal growth...
GROWTH-FACTOR RECEPTOR | SINGLE-AGENT | MEDICINE, GENERAL & INTERNAL | ONCOLOGY-GROUP | CISPLATIN | RECURRENT | COPY NUMBER | SQUAMOUS-CELL CARCINOMA | PHASE-II MULTICENTER | FLUOROURACIL | ANTIBODY CETUXIMAB | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | Cisplatin - administration & dosage | Antibodies, Monoclonal, Humanized | Carcinoma, Squamous Cell - mortality | Fluorouracil - administration & dosage | Female | Cetuximab | Neutropenia - chemically induced | Head and Neck Neoplasms - drug therapy | Kaplan-Meier Estimate | Anemia - chemically induced | Carboplatin - administration & dosage | Thrombocytopenia - chemically induced | Disease Progression | Carcinoma, Squamous Cell - drug therapy | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Carcinoma, Squamous Cell - secondary | Aged | Head and Neck Neoplasms - mortality | Drug therapy | Chemotherapy | Index Medicus | Abridged Index Medicus
GROWTH-FACTOR RECEPTOR | SINGLE-AGENT | MEDICINE, GENERAL & INTERNAL | ONCOLOGY-GROUP | CISPLATIN | RECURRENT | COPY NUMBER | SQUAMOUS-CELL CARCINOMA | PHASE-II MULTICENTER | FLUOROURACIL | ANTIBODY CETUXIMAB | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | Cisplatin - administration & dosage | Antibodies, Monoclonal, Humanized | Carcinoma, Squamous Cell - mortality | Fluorouracil - administration & dosage | Female | Cetuximab | Neutropenia - chemically induced | Head and Neck Neoplasms - drug therapy | Kaplan-Meier Estimate | Anemia - chemically induced | Carboplatin - administration & dosage | Thrombocytopenia - chemically induced | Disease Progression | Carcinoma, Squamous Cell - drug therapy | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Carcinoma, Squamous Cell - secondary | Aged | Head and Neck Neoplasms - mortality | Drug therapy | Chemotherapy | Index Medicus | Abridged Index Medicus
Journal Article
The Lancet, ISSN 0140-6736, 11/2019, Volume 394, Issue 10212, pp. 1915 - 1928
Pembrolizumab is active in head and neck squamous cell carcinoma (HNSCC), with programmed cell death ligand 1 (PD-L1) expression associated with improved...
Chemotherapy | Squamous cell carcinoma | Metastasis | Analysis | Cancer | Medical research | 5-Fluorouracil | Mortality | Oncology | Survival | Metastases | Population (statistical) | Pembrolizumab | Hypotheses | Randomization | Motivation | Platinum | Cell death | PD-L1 protein | Population | Head and neck cancer | Ligands | Larynx | Safety | Apoptosis
Chemotherapy | Squamous cell carcinoma | Metastasis | Analysis | Cancer | Medical research | 5-Fluorouracil | Mortality | Oncology | Survival | Metastases | Population (statistical) | Pembrolizumab | Hypotheses | Randomization | Motivation | Platinum | Cell death | PD-L1 protein | Population | Head and neck cancer | Ligands | Larynx | Safety | Apoptosis
Journal Article
The Lancet, ISSN 0140-6736, 01/2019, Volume 393, Issue 10167, pp. 156 - 167
There are few effective treatment options for patients with recurrent or metastatic head-and-neck squamous cell carcinoma. Pembrolizumab showed antitumour...
CRITERIA | TRIAL | MEDICINE, GENERAL & INTERNAL | NIVOLUMAB | CANCER | CHEMOTHERAPY | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Docetaxel - adverse effects | Humans | Middle Aged | Squamous Cell Carcinoma of Head and Neck - pathology | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | Cetuximab - therapeutic use | Cetuximab - adverse effects | Docetaxel - administration & dosage | Antibodies, Monoclonal, Humanized - administration & dosage | Squamous Cell Carcinoma of Head and Neck - drug therapy | Female | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Drug Administration Schedule | Head and Neck Neoplasms - drug therapy | Kaplan-Meier Estimate | Disease Progression | Head and Neck Neoplasms - pathology | Methotrexate - adverse effects | Squamous Cell Carcinoma of Head and Neck - secondary | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cetuximab - administration & dosage | Methotrexate - administration & dosage | Aged | Methotrexate | Squamous cell carcinoma | Metastasis | Therapy | Toxicity | Perforation | Clinical trials | Oncology | Cancer therapies | Metastases | Skin cancer | Anticancer properties | Pembrolizumab | Randomization | Motivation | Platinum | Neck | Safety | Medical treatment | Fatigue | Hypothyroidism | Survival | Patients | Chemotherapy | Interactive systems | Large intestine | Head and neck cancer | Ligands | Tumors
CRITERIA | TRIAL | MEDICINE, GENERAL & INTERNAL | NIVOLUMAB | CANCER | CHEMOTHERAPY | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Docetaxel - adverse effects | Humans | Middle Aged | Squamous Cell Carcinoma of Head and Neck - pathology | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | Cetuximab - therapeutic use | Cetuximab - adverse effects | Docetaxel - administration & dosage | Antibodies, Monoclonal, Humanized - administration & dosage | Squamous Cell Carcinoma of Head and Neck - drug therapy | Female | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Drug Administration Schedule | Head and Neck Neoplasms - drug therapy | Kaplan-Meier Estimate | Disease Progression | Head and Neck Neoplasms - pathology | Methotrexate - adverse effects | Squamous Cell Carcinoma of Head and Neck - secondary | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cetuximab - administration & dosage | Methotrexate - administration & dosage | Aged | Methotrexate | Squamous cell carcinoma | Metastasis | Therapy | Toxicity | Perforation | Clinical trials | Oncology | Cancer therapies | Metastases | Skin cancer | Anticancer properties | Pembrolizumab | Randomization | Motivation | Platinum | Neck | Safety | Medical treatment | Fatigue | Hypothyroidism | Survival | Patients | Chemotherapy | Interactive systems | Large intestine | Head and neck cancer | Ligands | Tumors
Journal Article
Head & Neck, ISSN 1043-3074, 12/2018, Volume 40, Issue 12, pp. 2648 - 2656
Background We evaluated the impact of center expertise, in terms of number of patients treated, on the overall survival (OS) and progression‐free survival...
treatment expertise | referral centers | HNCC | survival | SURGERY | MANAGEMENT | INSTITUTION | FACILITIES | INTENSITY | IMPROVED SURVIVAL | ALTERNATING CHEMOTHERAPY | HOSPITAL VOLUME | OTORHINOLARYNGOLOGY | SQUAMOUS-CELL CARCINOMA | LOCALLY ADVANCED HEAD | RADIOTHERAPY | Squamous cell carcinoma | Cell survival | Clinical trials | Data processing | Head and neck cancer | Radiation therapy | Neck | Patients
treatment expertise | referral centers | HNCC | survival | SURGERY | MANAGEMENT | INSTITUTION | FACILITIES | INTENSITY | IMPROVED SURVIVAL | ALTERNATING CHEMOTHERAPY | HOSPITAL VOLUME | OTORHINOLARYNGOLOGY | SQUAMOUS-CELL CARCINOMA | LOCALLY ADVANCED HEAD | RADIOTHERAPY | Squamous cell carcinoma | Cell survival | Clinical trials | Data processing | Head and neck cancer | Radiation therapy | Neck | Patients
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2016, Volume 34, Issue 15_suppl, pp. 6022 - 6022
Journal Article
Supportive Care in Cancer, ISSN 0941-4355, 9/2012, Volume 20, Issue 9, pp. 2141 - 2147
To date, the specific role of “in-field” crusting exudation on pain and on activity of daily living (ADL) in head and neck cancer (HNSCC) patients undergoing...
Pain Medicine | Radiodermatitis | Rehabilitation Medicine | Nursing | Medicine & Public Health | Skin toxicity | Oncology | Head and neck cancer | Nursing Management/Nursing Research | Chemoradiotherapy and cetuximab | PLUS CETUXIMAB | DERMATOLOGICAL TOXICITIES | RADIATION | THERAPY | ONCOLOGY | INFLAMMATION | HEALTH CARE SCIENCES & SERVICES | SQUAMOUS-CELL CARCINOMA | ALTERNATING RADIOTHERAPY | REHABILITATION | QUALITY-OF-LIFE | SKIN | CONCURRENT CETUXIMAB | Radiodermatitis - pathology | Severity of Illness Index | Humans | Head and Neck Neoplasms - drug therapy | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Activities of Daily Living | Antibodies, Monoclonal, Humanized | Head and Neck Neoplasms - radiotherapy | Pain - physiopathology | Pain - etiology | Cetuximab | Radiodermatitis - physiopathology | Exudates and Transudates | Chemotherapy | Pain | Head & neck cancer | Radiation therapy | Dermatitis
Pain Medicine | Radiodermatitis | Rehabilitation Medicine | Nursing | Medicine & Public Health | Skin toxicity | Oncology | Head and neck cancer | Nursing Management/Nursing Research | Chemoradiotherapy and cetuximab | PLUS CETUXIMAB | DERMATOLOGICAL TOXICITIES | RADIATION | THERAPY | ONCOLOGY | INFLAMMATION | HEALTH CARE SCIENCES & SERVICES | SQUAMOUS-CELL CARCINOMA | ALTERNATING RADIOTHERAPY | REHABILITATION | QUALITY-OF-LIFE | SKIN | CONCURRENT CETUXIMAB | Radiodermatitis - pathology | Severity of Illness Index | Humans | Head and Neck Neoplasms - drug therapy | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Activities of Daily Living | Antibodies, Monoclonal, Humanized | Head and Neck Neoplasms - radiotherapy | Pain - physiopathology | Pain - etiology | Cetuximab | Radiodermatitis - physiopathology | Exudates and Transudates | Chemotherapy | Pain | Head & neck cancer | Radiation therapy | Dermatitis
Journal Article
Critical Reviews in Oncology and Hematology, ISSN 1040-8428, 2015, Volume 96, Issue 1, pp. 167 - 182
Highlights • Baseline assessment (successively, during CRT, at least weekly) and preventive recommendations. • Topical steroidal agents. • Dressings and...
Hematology, Oncology and Palliative Medicine | Chemotherapy | Skin toxicity | EGFRi | Head and neck cancer | Biodermatitis | Radiotherapy | Cetuximab | ACUTE RADIATION DERMATITIS | INTENSITY-MODULATED RADIOTHERAPY | RANDOMIZED CONTROLLED-TRIAL | CLINICAL-PRACTICE GUIDELINES | ONCOLOGY GROUP RTOG | PATIENTS RECEIVING RADIOTHERAPY | COLLAGEN VASCULAR-DISEASES | ONCOLOGY | INDUCED MOIST DESQUAMATION | SQUAMOUS-CELL CARCINOMA | III DOUBLE-BLIND | HEMATOLOGY | Dermatitis - etiology | Dermatitis - therapy | Chemoradiotherapy - adverse effects | Humans | Risk Factors | Head and Neck Neoplasms - therapy | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Pruritus - etiology | Consensus | Cetuximab - adverse effects | Cancer patients | Care and treatment | Skin | Cancer | Index Medicus
Hematology, Oncology and Palliative Medicine | Chemotherapy | Skin toxicity | EGFRi | Head and neck cancer | Biodermatitis | Radiotherapy | Cetuximab | ACUTE RADIATION DERMATITIS | INTENSITY-MODULATED RADIOTHERAPY | RANDOMIZED CONTROLLED-TRIAL | CLINICAL-PRACTICE GUIDELINES | ONCOLOGY GROUP RTOG | PATIENTS RECEIVING RADIOTHERAPY | COLLAGEN VASCULAR-DISEASES | ONCOLOGY | INDUCED MOIST DESQUAMATION | SQUAMOUS-CELL CARCINOMA | III DOUBLE-BLIND | HEMATOLOGY | Dermatitis - etiology | Dermatitis - therapy | Chemoradiotherapy - adverse effects | Humans | Risk Factors | Head and Neck Neoplasms - therapy | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Pruritus - etiology | Consensus | Cetuximab - adverse effects | Cancer patients | Care and treatment | Skin | Cancer | Index Medicus
Journal Article
Tumori, ISSN 0300-8916, 07/2008, Volume 94, Issue 4, p. suppl 26
Humans | Endpoint Determination - methods | Antineoplastic Agents - therapeutic use | Evidence-Based Medicine | Remission Induction | Randomized Controlled Trials as Topic | Radiation-Sensitizing Agents - therapeutic use | Disease-Free Survival | Medical Oncology | Taxoids - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Chemotherapy, Adjuvant | Radiotherapy, Adjuvant | Endpoint Determination - trends
Journal Article
Tumori, ISSN 0300-8916, 07/2008, Volume 94, Issue 4, pp. 26 - 29
Journal Article
The Oncologist, ISSN 1083-7159, 01/2016, Volume 21, Issue 1, pp. 59 - 71
Background. Platinum‐based concurrent chemoradiation (CCRT) improves locoregional control and overall survival of locoregionally advanced (LA) squamous cell...
Chemotherapy | Gemcitabine | Toxicity | Radiation | Head and neck cancer | Oncology | Radiotherapy | Concomitant chemoradiotherapy | Neoplasms | REDUCE SWALLOWING DYSFUNCTION | INDUCTION CHEMOTHERAPY | CONCURRENT RADIOTHERAPY | FOLLOW-UP | OF-THE-ART | RADIATION-THERAPY | CISPLATIN | III RANDOMIZED-TRIAL | PHASE-I TRIAL | SQUAMOUS-CELL CARCINOMA | Neoplasm Recurrence, Local - radiotherapy | Carcinoma, Squamous Cell - pathology | Humans | Head and Neck Neoplasms - drug therapy | Neoplasm Recurrence, Local - drug therapy | Carcinoma, Squamous Cell - radiotherapy | Head and Neck Neoplasms - pathology | Neoplasm Recurrence, Local - pathology | Radiation-Sensitizing Agents - therapeutic use | Head and Neck Neoplasms - radiotherapy | Deoxycytidine - therapeutic use | Squamous Cell Carcinoma of Head and Neck | Carcinoma, Squamous Cell - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Deoxycytidine - analogs & derivatives | Radiotherapy, Intensity-Modulated | Head and Neck Cancers
Chemotherapy | Gemcitabine | Toxicity | Radiation | Head and neck cancer | Oncology | Radiotherapy | Concomitant chemoradiotherapy | Neoplasms | REDUCE SWALLOWING DYSFUNCTION | INDUCTION CHEMOTHERAPY | CONCURRENT RADIOTHERAPY | FOLLOW-UP | OF-THE-ART | RADIATION-THERAPY | CISPLATIN | III RANDOMIZED-TRIAL | PHASE-I TRIAL | SQUAMOUS-CELL CARCINOMA | Neoplasm Recurrence, Local - radiotherapy | Carcinoma, Squamous Cell - pathology | Humans | Head and Neck Neoplasms - drug therapy | Neoplasm Recurrence, Local - drug therapy | Carcinoma, Squamous Cell - radiotherapy | Head and Neck Neoplasms - pathology | Neoplasm Recurrence, Local - pathology | Radiation-Sensitizing Agents - therapeutic use | Head and Neck Neoplasms - radiotherapy | Deoxycytidine - therapeutic use | Squamous Cell Carcinoma of Head and Neck | Carcinoma, Squamous Cell - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Deoxycytidine - analogs & derivatives | Radiotherapy, Intensity-Modulated | Head and Neck Cancers
Journal Article
Tumori, 08/2019, p. 300891619868289
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease often presenting at an already advanced stage. Cisplatin chemoradiotherapy is the...
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2016, Volume 71, pp. 34 - 42
Abstract Background No evidence exists to recommend a specific chemotherapy regimen in young breast cancer patients. We performed a pooled analysis of two...
Hematology, Oncology and Palliative Medicine | Treatment-induced amenorrhoea | Premenopausal patients | Breast cancer | Dose-dense chemotherapy | AMENORRHEA | TRIALS | METAANALYSIS | MANAGEMENT | CONSENSUS | ONCOLOGY | RECOMMENDATIONS | ANTHRACYCLINE | OUTCOMES | YOUNG-WOMEN | FERTILITY CONCERNS | Premenopause | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Breast Neoplasms - drug therapy | Cyclophosphamide - adverse effects | Cyclophosphamide - therapeutic use | Dose-Response Relationship, Drug | Fluorouracil - therapeutic use | Fluorouracil - adverse effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Epirubicin - therapeutic use | Adult | Female | Chemotherapy, Adjuvant | Amenorrhea - chemically induced | Epirubicin - adverse effects | Care and treatment | Cancer patients | Analysis | Oncology, Experimental | Menopause | Adjuvant treatment | Clinical trials | Research | Epidemiology | Cancer
Hematology, Oncology and Palliative Medicine | Treatment-induced amenorrhoea | Premenopausal patients | Breast cancer | Dose-dense chemotherapy | AMENORRHEA | TRIALS | METAANALYSIS | MANAGEMENT | CONSENSUS | ONCOLOGY | RECOMMENDATIONS | ANTHRACYCLINE | OUTCOMES | YOUNG-WOMEN | FERTILITY CONCERNS | Premenopause | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Breast Neoplasms - drug therapy | Cyclophosphamide - adverse effects | Cyclophosphamide - therapeutic use | Dose-Response Relationship, Drug | Fluorouracil - therapeutic use | Fluorouracil - adverse effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Epirubicin - therapeutic use | Adult | Female | Chemotherapy, Adjuvant | Amenorrhea - chemically induced | Epirubicin - adverse effects | Care and treatment | Cancer patients | Analysis | Oncology, Experimental | Menopause | Adjuvant treatment | Clinical trials | Research | Epidemiology | Cancer
Journal Article