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2013, ISBN 9781461478546
Web Resource
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 795 - 795
Abstract Deletion of chromosome 20q [del(20q)] is a common chromosomal abnormality associated with myeloid neoplasms including myeloproliferative neoplasms... 
Journal Article
Molecular metabolism, 09/2019, Volume 27, p. 83
Given the worldwide epidemics of obesity and type 2 diabetes, novel antidiabetic and appetite-suppressing drugs are urgently needed. Adipocytes play a central... 
Journal Article
08/2013, 2013, ISBN 1461478545, 279
This volume highlights many aspects of PTP function in the context of metabolism. It covers the identification of new phosphatases that are involved in... 
Regulation | Metabolism | Physiological effect | Protein-tyrosine phosphatase | Life Sciences | Protein Science | Biochemistry, general | Endocrinology | Biomedicine general
eBook
Journal Article
Journal of Obesity, ISSN 2090-0708, 2012, Volume 2012, p. 926857
The protein tyrosine phosphatase PTP1B is a negative regulator of both insulin and leptin signaling and is involved in the control of glucose homeostasis and... 
Review
Journal Article
Journal Article
American Journal of Physiology, ISSN 0193-1849, 09/2012, Volume 303, Issue 5, p. E644
  Leptin regulates energy balance through central circuits that control food intake and energy expenditure, including proopiomelanocortin (POMC) neurons. POMC... 
Proteins | Obesity | Peptides | Bioenergetics | Neurons | Rodents | Physiology
Journal Article
American Journal of Physiology, ISSN 0193-1849, 08/2012, Volume 303, Issue 4, p. E496
  Leptin receptor (LepRb) signaling in the hindbrain is required for energy balance control. Yet the specific hindbrain neurons and the behavioral processes... 
Signal transduction | Diet | Neurons | T cell receptors | Pharmacology
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2011, Volume 438, Issue 2, pp. 369 - 378
Obesity is associated with induction of the ER (endoplasmic reticulum)-stress response signalling and insulin resistance. PTP1B (protein tyrosine phosphatase... 
Obesity | Insulin resistance | Endoplasmic reticulum (ER) stress | Metabolic syndrome | Protein tyrosine phosphatase 1B (PTP1B) | OXIDATIVE STRESS | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein tyrosine phosphatase 1B (PTP1B) | endoplasmic reticulum (ER) stress | INSULIN SENSITIVITY | metabolic syndrome | SIGNAL-TRANSDUCTION | GLUCOSE-HOMEOSTASIS | LEPTIN ACTION | IN-VIVO | GENE-EXPRESSION | BINDING PROTEIN-1 | insulin resistance | HEPATIC STEATOSIS | obesity | Organ Specificity - drug effects | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Liver - pathology | Liver - enzymology | Humans | Protein Transport - drug effects | RNA, Messenger - metabolism | X-Box Binding Protein 1 | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | Endoplasmic Reticulum - pathology | Organ Specificity - genetics | Cell Nucleus - metabolism | Liver - drug effects | Endoplasmic Reticulum - drug effects | Gene Deletion | Eukaryotic Initiation Factor-2 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Stress, Physiological - drug effects | Homeostasis - drug effects | Protein-Serine-Threonine Kinases - metabolism | Endoribonucleases - metabolism | RNA, Messenger - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - deficiency | Regulatory Factor X Transcription Factors | Hep G2 Cells | Obesity - pathology | Transcription Factors - metabolism | Activating Transcription Factor 6 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Animals | Signal Transduction - drug effects | Tunicamycin - pharmacology | Lipid Metabolism - drug effects | Glucose - metabolism | Thapsigargin - pharmacology | Mice | Obesity - enzymology | Cell Nucleus - drug effects | ER stress | PTP1B
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2010, Volume 16, Issue 2, pp. 237 - 237
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2010, Volume 16, Issue 2, pp. 237 - 237
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2010, Volume 16, Issue 2, p. 237
Journal Article
Journal Article
Cell Metabolism, ISSN 1550-4131, 11/2011, Volume 14, Issue 5, pp. 684 - 699
Journal Article