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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2012, Volume 109, Issue 15, pp. E869 - E878
IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that culminate in the sequence-specific splicing of the Xbp1 mRNA and in the... 
High-throughput screening | 8-formyl-umbelliferone | Aldehydes | Reversible covalent inhibitor | Unfolded protein response | reversible covalent inhibitor | ACTIVATION | UNFOLDED-PROTEIN RESPONSE | ER-STRESS | MULTIDISCIPLINARY SCIENCES | high-throughput screening | KINASE | IRE1-ALPHA | TRANSCRIPTION FACTOR XBP-1 | ENDOPLASMIC-RETICULUM STRESS | CELL-SURVIVAL | unfolded protein response | aldehydes | IRE1 | TRANSMEMBRANE PROTEIN | Humans | Coumarins - chemistry | Endoribonucleases - antagonists & inhibitors | RNA, Messenger - metabolism | Ribonucleases - metabolism | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Ribonucleases - antagonists & inhibitors | Proteolysis - drug effects | Protein Binding - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Membrane Proteins - metabolism | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | RNA Splicing - drug effects | Endoribonucleases - metabolism | RNA, Messenger - genetics | Regulatory Factor X Transcription Factors | Coumarins - pharmacology | Transcription Factors - metabolism | Secretory Pathway - drug effects | Animals | Membrane Proteins - antagonists & inhibitors | Endoplasmic Reticulum Stress | Schiff Bases - chemistry | Mice | Schiff Bases - metabolism | Biological Sciences | PNAS Plus
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 17693 - 10
Pooled CRISPR-Cas9 knock out screens provide a valuable addition to the methods available for novel drug target identification and validation. However, where... 
SYSTEM | VULNERABILITIES | ACTIVATION | BACTERIA | ARCHAEA | REPRESSION | SEQUENCE-SPECIFIC CONTROL | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | KNOCKOUT | EXPRESSION | CRISPR | Transcription | Gene regulation | Genomes | Nuclease | Drug resistance | Deoxyribonucleic acid--DNA
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 04/2013, Volume 201, Issue 2, p. 337
  Interfering with disulfide bond formation impedes protein folding and promotes endoplasmic reticulum (ER) stress. Due to limitations in measurement... 
Protein folding | Homeostasis | Mammals | Cells
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2012, Volume 109, Issue 15, p. E869
IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that culminate in the sequence-specific splicing of the Xbp1 mRNA and in the... 
Proteins | Molecules | Membranes | Ribonucleic acid--RNA | Cells
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2012, Volume 109, Issue 15, pp. 5559 - 5560
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14_Supplement, pp. 2059 - 2059
Some cancers lack clearly druggable driver mutations and might also have too few neo-antigen generating mutations to provoke a tumor-specific immune response,... 
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 2059 - 2059
Journal Article
Scientific Reports, ISSN 2045-2322, 08/2016, Volume 6, Issue 1, p. 31782
Components of the type II CRISPR-Cas complex in bacteria have been used successfully in eukaryotic cells to facilitate rapid and accurate cell line... 
SYSTEM | BACTERIA | CRISPR/CAS9 | ARCHAEA | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | GENES
Journal Article