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Scientific reports, ISSN 2045-2322, 01/2020, Volume 10, Issue 1, pp. 1453 - 10
Atrial Fibrillation (AF) is the most common cardiac arrhythmia. Its pathogenesis is complex and poorly understood. Whole exome sequencing of Danish families... 
Cardiac arrhythmia | Arrhythmia | Nonsense mutation | Stop codon | Genetic diversity | Gene expression | Gene deletion | Risk factors | Fibrillation | Clonal deletion | Chlorides | ClC-2 protein | Ventricle
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 06/2019, Volume 10
Background and Purpose: Prolongation of cardiac action potentials is considered antiarrhythmic in the atria but can be proarrhythmic in ventricles if the... 
Atrial fibrillation | Dofetilide | Ondansetron | AP14145 | QT prolongation | dofetilide | ondansetron | arrhythmia (heart rhythm disorders)
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2015, Volume 112, Issue 18, pp. 5714 - 5719
Polyunsaturated fatty acids (PUFAs) affect cardiac excitability. Kv7.1 and the beta-subunit KCNE1 form the cardiac I-Ks channel that is central for cardiac... 
Kv7.1 | Antiarrhythmic | KCNE1 | KCNQ1 | I Ks | MULTIDISCIPLINARY SCIENCES | antiarrhythmic | DEATH | I-Ks | TRIAL | VOLTAGE SENSOR | LONG QT SYNDROME | GATED ION CHANNELS | FISH-OIL | KCNQ1 POTASSIUM CHANNELS | K+ CHANNEL | MODULATION | Clinical Medicine | Kv7.1; KCNQ1; KCNE1; I-Ks; antiarrhythmic | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 16218 - 9
Optically pumped magnetometers are becoming a promising alternative to cryogenically-cooled superconducting magnetometers for detecting and imaging biomagnetic... 
DIAGNOSIS | MAGNETIC-FIELD | ARRAY | FETAL | MAGNETOENCEPHALOGRAPHY | MULTIDISCIPLINARY SCIENCES | Heart | Neuroimaging | Body temperature | Spatial discrimination | Electrocardiography | Cesium | Paraffin
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, pp. e103402 - e103402
Mitochondrial potassium channels have been implicated in myocardial protection mediated through pre-/postconditioning. Compounds that open the Ca2+-and... 
PROTEIN-KINASE-A | HEART | PERMEABILITY TRANSITION PORE | CYTOCHROME-C-OXIDASE | ATP CHANNELS | INNER MITOCHONDRIAL-MEMBRANE | MULTIDISCIPLINARY SCIENCES | CA2+-ACTIVATED K+ CHANNELS | RAT VENTRICULAR MYOCYTES | CARDIOPROTECTION | POTASSIUM CHANNEL | Large-Conductance Calcium-Activated Potassium Channels - metabolism | Mitochondria, Heart - metabolism | Reactive Oxygen Species - metabolism | Tetrazoles - pharmacology | Muscle, Skeletal - metabolism | Thiourea - pharmacology | Membrane Potential, Mitochondrial - drug effects | Cell Hypoxia | Oxidative Phosphorylation - drug effects | Large-Conductance Calcium-Activated Potassium Channels - chemistry | Muscle Fibers, Skeletal - ultrastructure | Myocardium - metabolism | Large-Conductance Calcium-Activated Potassium Channels - genetics | Indoles - pharmacology | Reperfusion Injury - metabolism | Disease Models, Animal | Myocytes, Cardiac - cytology | Reperfusion Injury - pathology | Mice, Inbred C57BL | Ischemic Preconditioning | Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - metabolism | Mice, Knockout | Animals | Myocytes, Cardiac - drug effects | Energy Metabolism | Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - genetics | Myocytes, Cardiac - metabolism | Mice | Thiourea - analogs & derivatives | Ischemia | Mitochondrial DNA | Potassium channels | Cytochrome | Heart | Oxidative metabolism | Biochemistry | Potassium channels (calcium-gated) | Proteins | Toxicology | Mitochondria | Physiology | Potassium channels (voltage-gated) | Anoxia | Limiting factors | Calcium channels (voltage-gated) | Gene expression | Electron microscopy | Metabolism | Survival | Resistance | Pharmacy | Myocardium | Hypoxia | Conductance | Oxygenation | Preconditioning | Cardiac arrhythmia | Reactive oxygen species | Phosphorylation | Calcium | Science | Channels | Reperfusion | Immunology | Rodents | Heart diseases | Injuries | Cell survival | Muscles | Cardiomyocytes | Pharmacology | Permeability | Transmission electron microscopy | Oxidative phosphorylation | Infarction | Ventricle | Respiration | Potassium | Calcium ions | Index Medicus | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Reperfusion Injury | Genes | Medicine/Technology | Medicinska och farmaceutiska grundvetenskaper | Medicin/Teknik
Journal Article
eLife, ISSN 2050-084X, 09/2016, Volume 5, Issue 2016
About 300 loss-of-function mutations in the IKs channel have been identified in patients with Long QT syndrome and cardiac arrhythmia. How specific mutations... 
Taurine | Arrhythmia | Channel gating | Cardiomyocytes | Fluorometry | Molecular modelling | Voltage | Long QT syndrome | Mutation | Sensors | Gating | Heart diseases | Potassium
Journal Article
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 3/2009, Volume 457, Issue 5, pp. 979 - 988
Activation of the large-conductance Ca2+-activated K+ channel (BK) in the cardiac inner mitochondrial membrane has been suggested to protect the heart against... 
Ischemia–reperfusion injury | Mitochondria | Biomedicine | Cardioprotection | Human Physiology | Potassium channels | BK channels | Ischemia-reperfusion injury | NS1619 | SMOOTH-MUSCLE | PHYSIOLOGY | NS-1619 | Proteins | Ischemia | Calcium
Journal Article
Journal Article
Journal Article
Obesity, ISSN 1930-7381, 05/2013, Volume 21, Issue 5, pp. 985 - 992
Objective: Tesofensine is a novel triple monoamine reuptake inhibitor which is in development for the treatment of obesity. Preclinical and clinical data... 
MONOAMINE REUPTAKE INHIBITOR | NUTRITION & DIETETICS | METABOLISM | OBESE-PATIENTS | PREDICTORS | IN-VIVO | OVERWEIGHT | ENDOCRINOLOGY & METABOLISM | WEIGHT-LOSS | METOPROLOL | SIBUTRAMINE | FOOD | Antihypertensive Agents - pharmacology | Appetite Depressants - adverse effects | Benzoates - therapeutic use | Metoprolol - pharmacology | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Cardiovascular Diseases - prevention & control | Sympathomimetics - pharmacology | Anti-Obesity Agents - adverse effects | Male | Appetite Depressants - therapeutic use | Angiotensin II Type 1 Receptor Blockers - pharmacology | Anti-Obesity Agents - therapeutic use | Dose-Response Relationship, Drug | Heart Rate - drug effects | Bridged Bicyclo Compounds, Heterocyclic - adverse effects | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Blood Pressure - drug effects | Benzimidazoles - therapeutic use | Sympathomimetics - adverse effects | Sympathomimetics - therapeutic use | Cardiovascular Diseases - etiology | Appetite Depressants - pharmacology | Appetite - drug effects | Metoprolol - therapeutic use | Energy Intake - drug effects | Antihypertensive Agents - therapeutic use | Rats, Sprague-Dawley | Feeding Behavior - drug effects | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Obesity - prevention & control | Benzoates - pharmacology | Benzimidazoles - pharmacology | Anti-Obesity Agents - pharmacology | Obesity | Automation | Statistical analysis | Dopamine | Nuclear magnetic resonance--NMR | Telemetry | Abdomen | Heart rate | Weight control | Rodents | Monitoring systems | Software | Drug dosages | Food
Journal Article
Pacing and clinical electrophysiology : PACE, ISSN 0147-8389, 01/2020
The slow delayed rectifier potassium current I is crucial for the repolarization of the cardiac action potential. It is conducted by the voltage-gated channel... 
Journal Article