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FRONTIERS IN PHARMACOLOGY, ISSN 1663-9812, 04/2019, Volume 10, p. 347
Reduction of the opioid analgesia in diabetic neuropathic pain (DNP) results from mu-opioid receptor (MOR) reserve reduction. Herein, we examined the... 
opioid efficacy | 14-O-methylmorphine-6-O-sulfate | SPINAL-CORD | RECEPTOR | MODEL | morphine | neuropathic pain | IN-VITRO | INDUCED RESPIRATORY DEPRESSION | fentanyl | NEURONS | PHARMACOLOGY & PHARMACY | ANTINOCICEPTIVE EFFICACY | diabetes | CHRONIC NONCANCER PAIN | AGONIST | Analgesia | Diabetic neuropathies
Journal Article
Journal Article
Frontiers in Systems Neuroscience, ISSN 1662-5137, 2009, Volume 3
Journal Article
Pharmacological Reports, ISSN 1734-1140, 01/2011, Volume 63, Issue 1, pp. 235 - 236
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 08/2017, Volume 8, Issue 8, pp. 858 - 863
In this work we enhanced the ring lipophilicity of biphalin introducing a xylene moiety, thus obtaining three cyclic regioisomers. Novel compounds have similar... 
antinociception | Biphalin | CLIPS technology | xylene bridge | opioids | CHEMISTRY, MEDICINAL | DELTA-OPIOID RECEPTORS | MORPHINE | PEPTIDE
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 04/2017, Volume 8, Issue 4, pp. 449 - 454
D-Pen(2),D-Pen(5) enkephalin (DPDPE) is one of the most selective synthetic peptide agonists targeting the delta-opioid receptor. Three cyclic analogues of... 
peptides | antinociception | DPDPE | Opioids | xylene bridge | PROFILES | DESIGN | CHEMISTRY, MEDICINAL | DELTA | CONFORMATIONS | NITRIC-OXIDE | INFLAMMATORY PAIN | SCAFFOLDS | CYCLIZATION
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2008, Volume 51, Issue 1, pp. 173 - 177
Journal Article
British journal of pharmacology, ISSN 0007-1188, 07/2019
The concept of opioid ligands biased toward the G protein pathway with minimal recruitment of β-arrestin-2 has become a promising approach for the development... 
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 09/2014, Volume 5, Issue 9, pp. 1032 - 1036
Two novel opioid analogues have been designed by substituting the native d-Ala residues in position 2,2' of biphalin with two residues of d-penicillamine or... 
biphalin | dimeric opioid peptides | Analgesics | cyclic analogues | CHEMISTRY, MEDICINAL | CIS-4-AMINO-L-PROLINE RESIDUE | RECEPTOR AGONISTS | HIGH-AFFINITY | LINEAR ENDOMORPHIN-2 ANALOGS | ANALGESIC ACTIVITY | OPIOID PEPTIDE | LIGANDS | BIOLOGICAL EVALUATION | DICARBA-ANALOGS | ENKEPHALIN ANALOGS
Journal Article
MedChemComm, ISSN 2040-2503, 07/2019, Volume 10, Issue 7, pp. 1187 - 1191
Journal Article
Croatian Medical Journal, ISSN 0353-9504, 2016, Volume 57, Issue 2, pp. 100 - 109
To assess the effect of 17β-estradiol pretreatment on the function and expression of α2- adrenergic receptors (ARs) subtypes in late pregnancy in rats.... 
Pregnancy | Receptors, Adrenergic, alpha-2 - drug effects | Animals | Rats | Female | Male | Adrenergic alpha-2 Receptor Antagonists - pharmacology | Rats, Sprague-Dawley | Estradiol - pharmacology | Obstetric Labor, Premature - physiopathology | Uterine Contraction - drug effects | RECOOP for Common Mechanisms of Disease
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2013, Volume 68, pp. 167 - 177
Endomorphin-2 [Tyr-Pro-Phe-Phe-NH ] and DAMGO [Tyr-D-Ala-Gly-(N-Me)Phe-Gly-ol] are natural (EM2) and synthetic (DAMGO) opioid peptides both selective for μ... 
Endomorphins | Nociception | Analgesics | DAMGO | Tail flick | Opioid | Hot plate
Journal Article