genesis, ISSN 1526-954X, 08/2018, Volume 56, Issue 8, pp. e23217 - n/a
Summary The neuropeptide, melanin concentrating hormone (MCH), and its G protein‐coupled receptor, melanin concentrating hormone receptor 1 (Mchr1), are...
median eminence | arcuate nucleus | nucleus accumbens | hypothalamus | paraventricular nucleus | SYSTEM | MEMORY RETENTION | DEVELOPMENTAL BIOLOGY | DEFICIENT MICE | BODY-WEIGHT | OBESITY | MCH | GENETICS & HEREDITY | NEURONS | RAT-BRAIN | RECEPTOR 1 ANTAGONIST | Signal Transduction | Melanins - physiology | Mice, Transgenic | Neuropeptides - metabolism | Tamoxifen | Brain - physiology | Melanins - metabolism | Pituitary Hormones - physiology | Hypothalamic Hormones - physiology | Integrases | Brain - metabolism | Animals | Hypothalamus - metabolism | Hypothalamic Hormones - metabolism | Pituitary Hormones - metabolism | Models, Animal | Receptors, Somatostatin - physiology | Mice | Neurons - metabolism | Receptors, Somatostatin - metabolism | Brain | Animal behavior | Neurons | Genetic engineering | Hormones | Kidney diseases | G proteins | Free radicals (Chemistry) | Membrane proteins | Neurophysiology | Phenotypes | Feeding behavior | Transgenic mice | Hypothalamus | Recombinase | Cre recombinase | Bacterial artificial chromosomes | Feeding | Nucleus accumbens | Proteins | Signal transduction | Signaling | Sleep | Addiction | Melanin-concentrating hormone | Rodents | Reinforcement | Constitutive models | Anxiety | Melanin | Technology Report | Technology Reports
median eminence | arcuate nucleus | nucleus accumbens | hypothalamus | paraventricular nucleus | SYSTEM | MEMORY RETENTION | DEVELOPMENTAL BIOLOGY | DEFICIENT MICE | BODY-WEIGHT | OBESITY | MCH | GENETICS & HEREDITY | NEURONS | RAT-BRAIN | RECEPTOR 1 ANTAGONIST | Signal Transduction | Melanins - physiology | Mice, Transgenic | Neuropeptides - metabolism | Tamoxifen | Brain - physiology | Melanins - metabolism | Pituitary Hormones - physiology | Hypothalamic Hormones - physiology | Integrases | Brain - metabolism | Animals | Hypothalamus - metabolism | Hypothalamic Hormones - metabolism | Pituitary Hormones - metabolism | Models, Animal | Receptors, Somatostatin - physiology | Mice | Neurons - metabolism | Receptors, Somatostatin - metabolism | Brain | Animal behavior | Neurons | Genetic engineering | Hormones | Kidney diseases | G proteins | Free radicals (Chemistry) | Membrane proteins | Neurophysiology | Phenotypes | Feeding behavior | Transgenic mice | Hypothalamus | Recombinase | Cre recombinase | Bacterial artificial chromosomes | Feeding | Nucleus accumbens | Proteins | Signal transduction | Signaling | Sleep | Addiction | Melanin-concentrating hormone | Rodents | Reinforcement | Constitutive models | Anxiety | Melanin | Technology Report | Technology Reports
Journal Article
FRONTIERS IN CELLULAR NEUROSCIENCE, ISSN 1662-5102, 06/2019, Volume 13, p. 266
Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons...
SYSTEM | ALPHA-MSH | LOCALIZATION | smoothened | primary neuronal cultures | leptin | hedgehog signaling | NEUROSCIENCES | PRIMARY CILIUM | DISRUPTION | INTRAFLAGELLAR | melanin concentrating hormone receptor 1 | SAG | NEURONS | cilia | MELANIN-CONCENTRATING HORMONE | RECEPTORS | hypothalamus | SONIC-HEDGEHOG | Obesity | Research | Neurons | Cilia and ciliary motion | Health aspects | Hyperphagia | Brain | Cells | Appetite | Animal models | Feeding behavior | G protein-coupled receptors | Menopause | Nervous system | Neuropeptides | Proopiomelanocortin | Hypothalamus | Gene expression | Proteins | Signal transduction | Molecular modelling | Melanin-concentrating hormone | Hedgehog protein | Leptin | Endorphins | Satiety | Localization | Melanin | Cilia
SYSTEM | ALPHA-MSH | LOCALIZATION | smoothened | primary neuronal cultures | leptin | hedgehog signaling | NEUROSCIENCES | PRIMARY CILIUM | DISRUPTION | INTRAFLAGELLAR | melanin concentrating hormone receptor 1 | SAG | NEURONS | cilia | MELANIN-CONCENTRATING HORMONE | RECEPTORS | hypothalamus | SONIC-HEDGEHOG | Obesity | Research | Neurons | Cilia and ciliary motion | Health aspects | Hyperphagia | Brain | Cells | Appetite | Animal models | Feeding behavior | G protein-coupled receptors | Menopause | Nervous system | Neuropeptides | Proopiomelanocortin | Hypothalamus | Gene expression | Proteins | Signal transduction | Molecular modelling | Melanin-concentrating hormone | Hedgehog protein | Leptin | Endorphins | Satiety | Localization | Melanin | Cilia
Journal Article
Methods in Cell Biology, ISSN 0091-679X, 01/2016, Volume 132, pp. 35 - 54
In the last decade highly conserved cellular appendages called cilia have enjoyed a renewed interest from basic, biomedical scientists, and clinicians alike....
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2016, Volume 1454, pp. 203 - 214
Neuroscientists have been captivated by cilia ever since these slender, microtubule-based projections on the cell body were found to play critical roles in...
Acetylated α-tubulin | ACIII | Cilia-GFP | Arl13b | Molecular Imaging - methods | Neurons - metabolism | Animals | Humans | Staining and Labeling | Cilia - metabolism
Acetylated α-tubulin | ACIII | Cilia-GFP | Arl13b | Molecular Imaging - methods | Neurons - metabolism | Animals | Humans | Staining and Labeling | Cilia - metabolism
Journal Article
Current Biology, ISSN 0960-9822, 07/2009, Volume 19, Issue 13, pp. R526 - R535
Respect for the primary cilium has undergone a remarkable renaissance over the past decade, and it is now thought to be an essential regulator of numerous...
INTRAFLAGELLAR TRANSPORT PROTEINS | MCKUSICK-KAUFMAN-SYNDROME | PHOTORECEPTOR OUTER SEGMENTS | POLYCYSTIC KIDNEY-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BARDET-BIEDL-SYNDROME | PLANAR CELL POLARITY | BASAL BODY PROTEOME | SENSORY ORGANELLE | POSSESS PRIMARY CILIA | SONIC-HEDGEHOG | CELL BIOLOGY | Animals | Olfactory Receptor Neurons - cytology | Sensation - physiology | Photoreceptor Cells - cytology | Humans | Cilia - ultrastructure | Hedgehog Proteins - metabolism | Signal Transduction - physiology | Mechanotransduction, Cellular - physiology | Wnt Proteins - metabolism | Cilia - metabolism | Proteins
INTRAFLAGELLAR TRANSPORT PROTEINS | MCKUSICK-KAUFMAN-SYNDROME | PHOTORECEPTOR OUTER SEGMENTS | POLYCYSTIC KIDNEY-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BARDET-BIEDL-SYNDROME | PLANAR CELL POLARITY | BASAL BODY PROTEOME | SENSORY ORGANELLE | POSSESS PRIMARY CILIA | SONIC-HEDGEHOG | CELL BIOLOGY | Animals | Olfactory Receptor Neurons - cytology | Sensation - physiology | Photoreceptor Cells - cytology | Humans | Cilia - ultrastructure | Hedgehog Proteins - metabolism | Signal Transduction - physiology | Mechanotransduction, Cellular - physiology | Wnt Proteins - metabolism | Cilia - metabolism | Proteins
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2014, Volume 111, Issue 28, p. 10335
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2008, Volume 105, Issue 11, pp. 4242 - 4246
Primary cilia are ubiquitous cellular appendages that provide important yet not well understood sensory and signaling functions. Ciliary dysfunction underlies...
Brain | Obesity | Receptors | Signaling proteins | Neurons | Bardet Biedl syndrome | Antibodies | Photoreceptors | Mice | Cilia | Type III adenylyl cyclase | Neuronal cilia | Somatostatin receptor 3 | Melanin-concentrating hormone receptor 1 | type III adenylyl cyclase | neuronal cilia | CYSTIC KIDNEY-DISEASE | MEMBRANE | MULTIDISCIPLINARY SCIENCES | TRANSPORT | DISRUPTION | melanin-concentrating hormone receptor 1 | MICE LEADS | SOMATOSTATIN | CELLS ANTENNA | somatostatin receptor 3 | MELANIN-CONCENTRATING HORMONE | obesity | Bardet-Biedl Syndrome - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Cells, Cultured | Mutation - genetics | Cilia - metabolism | Mice, Knockout | Proteins - genetics | Animals | Proteins - metabolism | Bardet-Biedl Syndrome - genetics | Receptors, Somatostatin - metabolism | Microtubule-Associated Proteins - deficiency | Hormone receptors | Physiology, Pathological | Cilia and ciliary motion | Bardet-Biedl syndrome | Research | G proteins | Somatostatin | Properties | Biological Sciences
Brain | Obesity | Receptors | Signaling proteins | Neurons | Bardet Biedl syndrome | Antibodies | Photoreceptors | Mice | Cilia | Type III adenylyl cyclase | Neuronal cilia | Somatostatin receptor 3 | Melanin-concentrating hormone receptor 1 | type III adenylyl cyclase | neuronal cilia | CYSTIC KIDNEY-DISEASE | MEMBRANE | MULTIDISCIPLINARY SCIENCES | TRANSPORT | DISRUPTION | melanin-concentrating hormone receptor 1 | MICE LEADS | SOMATOSTATIN | CELLS ANTENNA | somatostatin receptor 3 | MELANIN-CONCENTRATING HORMONE | obesity | Bardet-Biedl Syndrome - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Cells, Cultured | Mutation - genetics | Cilia - metabolism | Mice, Knockout | Proteins - genetics | Animals | Proteins - metabolism | Bardet-Biedl Syndrome - genetics | Receptors, Somatostatin - metabolism | Microtubule-Associated Proteins - deficiency | Hormone receptors | Physiology, Pathological | Cilia and ciliary motion | Bardet-Biedl syndrome | Research | G proteins | Somatostatin | Properties | Biological Sciences
Journal Article
Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, 2017, Volume 9, Issue 7, p. a028217
The ciliopathies Bardet-Biedl syndrome and Alstrom syndrome cause obesity. How ciliary dysfunction leads to obesity has remained mysterious, partly because of...
MICE LEADS | FOOD-INTAKE | BARDET-BIEDL-SYNDROME | BODY-MASS INDEX | SYNDROME PROTEINS | ADIPOCYTE DIFFERENTIATION | MELANIN-CONCENTRATING HORMONE | ALSTROM-SYNDROME | LEPTIN RESISTANCE | ADIPOGENIC DIFFERENTIATION | CELL BIOLOGY | Cilia - physiology | Satiety Response | Animals | Alstrom Syndrome - physiopathology | Energy Metabolism | Bardet-Biedl Syndrome - pathology | Humans | Alstrom Syndrome - pathology | Mice | Bardet-Biedl Syndrome - physiopathology | Obesity - genetics | Obesity - pathology | PERSPECTIVES | 010
MICE LEADS | FOOD-INTAKE | BARDET-BIEDL-SYNDROME | BODY-MASS INDEX | SYNDROME PROTEINS | ADIPOCYTE DIFFERENTIATION | MELANIN-CONCENTRATING HORMONE | ALSTROM-SYNDROME | LEPTIN RESISTANCE | ADIPOGENIC DIFFERENTIATION | CELL BIOLOGY | Cilia - physiology | Satiety Response | Animals | Alstrom Syndrome - physiopathology | Energy Metabolism | Bardet-Biedl Syndrome - pathology | Humans | Alstrom Syndrome - pathology | Mice | Bardet-Biedl Syndrome - physiopathology | Obesity - genetics | Obesity - pathology | PERSPECTIVES | 010
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2013, Volume 110, Issue 19, p. 7796
Although primary cilia are well established as important sensory and signaling structures, their function in most tissues remains unknown. Obesity is a...
Genotype & phenotype | Obesity | Rodents | Mutation | Drug resistance
Genotype & phenotype | Obesity | Rodents | Mutation | Drug resistance
Journal Article
Journal of Comparative Neurology, ISSN 0021-9967, 12/2007, Volume 505, Issue 5, pp. 562 - 571
Solitary primary cilia project from nearly every cell type in the human body. These organelles are considered to have important sensory and signaling...
somatostatin receptor 3 | neuronal cilia | glial cilia | serotonin receptor 6 | choroid plexus | Choroid plexus | Glial cilia | Serotonin receptor 6 | Neuronal cilia | Somatostatin receptor 3 | ANTIBODIES | NERVOUS-SYSTEM | TISSUE | SENSORY ORGANELLE | NEUROSCIENCES | ZOOLOGY | CELLS ANTENNA | RECEPTORS | Biomarkers - metabolism | Rabbits | Brain - cytology | Age Factors | Choroid Plexus - metabolism | Antibodies | Adenylyl Cyclases - metabolism | Isoenzymes - immunology | Astrocytes - ultrastructure | Brain - metabolism | Choroid Plexus - cytology | Animals | Isoenzymes - metabolism | Mice, Inbred Strains - metabolism | Fluorescent Antibody Technique | Adenylyl Cyclases - immunology | Cilia - enzymology | Mice | Astrocytes - metabolism
somatostatin receptor 3 | neuronal cilia | glial cilia | serotonin receptor 6 | choroid plexus | Choroid plexus | Glial cilia | Serotonin receptor 6 | Neuronal cilia | Somatostatin receptor 3 | ANTIBODIES | NERVOUS-SYSTEM | TISSUE | SENSORY ORGANELLE | NEUROSCIENCES | ZOOLOGY | CELLS ANTENNA | RECEPTORS | Biomarkers - metabolism | Rabbits | Brain - cytology | Age Factors | Choroid Plexus - metabolism | Antibodies | Adenylyl Cyclases - metabolism | Isoenzymes - immunology | Astrocytes - ultrastructure | Brain - metabolism | Choroid Plexus - cytology | Animals | Isoenzymes - metabolism | Mice, Inbred Strains - metabolism | Fluorescent Antibody Technique | Adenylyl Cyclases - immunology | Cilia - enzymology | Mice | Astrocytes - metabolism
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 04/2008, Volume 19, Issue 4, pp. 1540 - 1547
Primary cilia are sensory organelles present on most mammalian cells. The functions of cilia are defined by the signaling proteins localized to the ciliary...
3RD INTRACELLULAR LOOP | CYSTIC KIDNEY-DISEASE | NEURONAL CILIA | CELLS ANTENNA | 5-HYDROXYTRYPTAMINE(2A) RECEPTOR | MELANIN-CONCENTRATING HORMONE | SENSORY ORGANELLE | INTRAFLAGELLAR TRANSPORT | 5-HT6 RECEPTORS | PRIMARY CILIUM | CELL BIOLOGY | Consensus Sequence | Receptors, G-Protein-Coupled - metabolism | Humans | Molecular Sequence Data | Green Fluorescent Proteins - genetics | Kidney Tubules, Collecting - cytology | Receptors, Serotonin - genetics | Recombinant Fusion Proteins - metabolism | Receptors, Somatostatin - genetics | Receptors, Somatostatin - chemistry | Receptors, Somatostatin - metabolism | Amino Acid Sequence | Cell Line | Green Fluorescent Proteins - metabolism | Mutagenesis, Site-Directed | Binding Sites - genetics | Receptors, Serotonin - chemistry | Recombinant Fusion Proteins - chemistry | Cilia - metabolism | Receptors, Serotonin - metabolism | Sequence Homology, Amino Acid | Kidney Tubules, Collecting - metabolism | Animals | Recombinant Fusion Proteins - genetics | Mice | Receptors, G-Protein-Coupled - genetics | Receptors, G-Protein-Coupled - chemistry | Index Medicus
3RD INTRACELLULAR LOOP | CYSTIC KIDNEY-DISEASE | NEURONAL CILIA | CELLS ANTENNA | 5-HYDROXYTRYPTAMINE(2A) RECEPTOR | MELANIN-CONCENTRATING HORMONE | SENSORY ORGANELLE | INTRAFLAGELLAR TRANSPORT | 5-HT6 RECEPTORS | PRIMARY CILIUM | CELL BIOLOGY | Consensus Sequence | Receptors, G-Protein-Coupled - metabolism | Humans | Molecular Sequence Data | Green Fluorescent Proteins - genetics | Kidney Tubules, Collecting - cytology | Receptors, Serotonin - genetics | Recombinant Fusion Proteins - metabolism | Receptors, Somatostatin - genetics | Receptors, Somatostatin - chemistry | Receptors, Somatostatin - metabolism | Amino Acid Sequence | Cell Line | Green Fluorescent Proteins - metabolism | Mutagenesis, Site-Directed | Binding Sites - genetics | Receptors, Serotonin - chemistry | Recombinant Fusion Proteins - chemistry | Cilia - metabolism | Receptors, Serotonin - metabolism | Sequence Homology, Amino Acid | Kidney Tubules, Collecting - metabolism | Animals | Recombinant Fusion Proteins - genetics | Mice | Receptors, G-Protein-Coupled - genetics | Receptors, G-Protein-Coupled - chemistry | Index Medicus
Journal Article
ASSAY and Drug Development Technologies, ISSN 1540-658X, 10/2009, Volume 7, Issue 5, p. 530
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 03/2011, Volume 22, Issue 6, pp. 806 - 816
The primary cilium is an evolutionarily conserved dynamic organelle important for regulating numerous signaling pathways, and, as such, mutations disrupting...
RENAL EPITHELIAL-CELLS | HUMAN SYNCYTIOTROPHOBLAST | CHLAMYDOMONAS-REINHARDTII | POLYCYSTIC KIDNEY-DISEASE | FLAGELLAR LENGTH | GLYCOGEN-SYNTHASE KINASE-3 | ALPHA-TUBULIN | IMMUNOLOGICAL DETECTION | INTRAFLAGELLAR TRANSPORT | CATION CHANNEL FUNCTION | CELL BIOLOGY | Cyclic AMP-Dependent Protein Kinases - metabolism | Paclitaxel - pharmacology | Tubulin Modulators - pharmacology | Humans | Actins - metabolism | Cilia - metabolism | Microtubules - metabolism | Tubulin - metabolism | Animals | Microtubules - drug effects | Cilia - ultrastructure | Cytoskeleton - metabolism | Cytosol - metabolism | Mice | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors
RENAL EPITHELIAL-CELLS | HUMAN SYNCYTIOTROPHOBLAST | CHLAMYDOMONAS-REINHARDTII | POLYCYSTIC KIDNEY-DISEASE | FLAGELLAR LENGTH | GLYCOGEN-SYNTHASE KINASE-3 | ALPHA-TUBULIN | IMMUNOLOGICAL DETECTION | INTRAFLAGELLAR TRANSPORT | CATION CHANNEL FUNCTION | CELL BIOLOGY | Cyclic AMP-Dependent Protein Kinases - metabolism | Paclitaxel - pharmacology | Tubulin Modulators - pharmacology | Humans | Actins - metabolism | Cilia - metabolism | Microtubules - metabolism | Tubulin - metabolism | Animals | Microtubules - drug effects | Cilia - ultrastructure | Cytoskeleton - metabolism | Cytosol - metabolism | Mice | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 19, pp. 7796 - 7801
Although primary cilia are well established as important sensory and signaling structures, their function in most tissues remains unknown. Obesity is a feature...
Obesity | Phenotypes | Neurons | Food intake | Bardet Biedl syndrome | Arcuate nucleus | Mice | Food consumption | Cilia | Vehicles | DEFECTS | INTRAFLAGELLAR | CIRCADIAN-RHYTHMS | MULTIDISCIPLINARY SCIENCES | BARDET-BIEDL-SYNDROME | SYNDROME PROTEINS | CELL-SIZE | DIET-INDUCED OBESITY | WEIGHT | PRIMARY CILIA | SONIC-HEDGEHOG | Body Composition | Temperature | Cilia - pathology | Signal Transduction | Leptin - metabolism | Feeding Behavior | Mice, Transgenic | Motor Activity | Obesity - genetics | Obesity - metabolism | Obesity - pathology | Phenotype | Animals | Bardet-Biedl Syndrome - pathology | Bardet-Biedl Syndrome - genetics | Mice, Obese | Neurons - metabolism | Mutation | Disease Models, Animal | Gene mutations | Leptin | Physiological aspects | Genetic aspects | Research | Health aspects | Biological Sciences
Obesity | Phenotypes | Neurons | Food intake | Bardet Biedl syndrome | Arcuate nucleus | Mice | Food consumption | Cilia | Vehicles | DEFECTS | INTRAFLAGELLAR | CIRCADIAN-RHYTHMS | MULTIDISCIPLINARY SCIENCES | BARDET-BIEDL-SYNDROME | SYNDROME PROTEINS | CELL-SIZE | DIET-INDUCED OBESITY | WEIGHT | PRIMARY CILIA | SONIC-HEDGEHOG | Body Composition | Temperature | Cilia - pathology | Signal Transduction | Leptin - metabolism | Feeding Behavior | Mice, Transgenic | Motor Activity | Obesity - genetics | Obesity - metabolism | Obesity - pathology | Phenotype | Animals | Bardet-Biedl Syndrome - pathology | Bardet-Biedl Syndrome - genetics | Mice, Obese | Neurons - metabolism | Mutation | Disease Models, Animal | Gene mutations | Leptin | Physiological aspects | Genetic aspects | Research | Health aspects | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e106576
It has been known for decades that neurons throughout the brain possess solitary, immotile, microtubule based appendages called primary cilia. Only recently...
LOCALIZATION | DEFECTS | OBESITY | NEURONAL CILIA | MEMBRANE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | POLARIS | BIEDL-SYNDROME PROTEINS | RECEPTORS | INTRAFLAGELLAR TRANSPORT | Neurons - pathology | Depression - pathology | Humans | Cerebral Cortex - pathology | Hippocampus - pathology | Schizophrenia - pathology | Depression - genetics | Cerebral Cortex - metabolism | Cilia - metabolism | Cilia - genetics | Mice, Knockout | Neurogenesis - genetics | Fear | Hippocampus - metabolism | Animals | Maze Learning | Schizophrenia - genetics | Bardet-Biedl Syndrome - pathology | Tumor Suppressor Proteins - genetics | Bardet-Biedl Syndrome - genetics | Mice | Neurons - metabolism | Hippocampus - growth & development | Physiological aspects | Brain | Analysis | Neurophysiology | Neurosciences | Mental disorders | Memory | Cognitive ability | Schizophrenia | Biology | Bardet-Biedl syndrome | Mental depression | Gene deletion | Neurogenesis | Defects | Proteins | Learning | Clonal deletion | Rodents | Deletion | Behavior | Appendages | Cilia | Neurons | Cortex | Pattern recognition | Object recognition | Maze learning | Mutants | Fear conditioning | Brain research | Hippocampus
LOCALIZATION | DEFECTS | OBESITY | NEURONAL CILIA | MEMBRANE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | POLARIS | BIEDL-SYNDROME PROTEINS | RECEPTORS | INTRAFLAGELLAR TRANSPORT | Neurons - pathology | Depression - pathology | Humans | Cerebral Cortex - pathology | Hippocampus - pathology | Schizophrenia - pathology | Depression - genetics | Cerebral Cortex - metabolism | Cilia - metabolism | Cilia - genetics | Mice, Knockout | Neurogenesis - genetics | Fear | Hippocampus - metabolism | Animals | Maze Learning | Schizophrenia - genetics | Bardet-Biedl Syndrome - pathology | Tumor Suppressor Proteins - genetics | Bardet-Biedl Syndrome - genetics | Mice | Neurons - metabolism | Hippocampus - growth & development | Physiological aspects | Brain | Analysis | Neurophysiology | Neurosciences | Mental disorders | Memory | Cognitive ability | Schizophrenia | Biology | Bardet-Biedl syndrome | Mental depression | Gene deletion | Neurogenesis | Defects | Proteins | Learning | Clonal deletion | Rodents | Deletion | Behavior | Appendages | Cilia | Neurons | Cortex | Pattern recognition | Object recognition | Maze learning | Mutants | Fear conditioning | Brain research | Hippocampus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2014, Volume 111, Issue 28, pp. 10335 - 10340
Most central neurons in the mammalian brain possess an appendage called a primary cilium that projects from the soma into the extracellular space. The...
Brain | Sex hormones | Receptors | Neurons | Male animals | Mice | Hypothalamus | Female animals | Genotypes | Cilia | Electrophysiology | Neuronal primary cilia | GPR54 | MOUSE-BRAIN | LOCALIZATION | MULTIDISCIPLINARY SCIENCES | neuronal primary cilia | 5-HT6 RECEPTORS | CEREBRAL-CORTEX | LUTEINIZING-HORMONE | electrophysiology | PROTEIN-COUPLED-RECEPTORS | DISEASE | BARDET-BIEDL-SYNDROME | HYPOGONADOTROPIC HYPOGONADISM | HYPOTHALAMUS | Cell Line | Receptors, G-Protein-Coupled - metabolism | Gonadotropin-Releasing Hormone - genetics | Reproduction - physiology | Male | Mice, Transgenic | Neurons - cytology | Sexual Maturation - physiology | Kisspeptins - metabolism | Nerve Tissue Proteins - genetics | Cilia - metabolism | Cilia - genetics | Nerve Tissue Proteins - metabolism | Kisspeptins - genetics | Animals | Gonadotropin-Releasing Hormone - metabolism | Female | Signal Transduction - physiology | Neurons - metabolism | Receptors, G-Protein-Coupled - genetics | Receptors, Kisspeptin-1 | Physiological aspects | Protein research | Cellular signal transduction | Research | Peptides | Cilia and ciliary motion | Biological Sciences
Brain | Sex hormones | Receptors | Neurons | Male animals | Mice | Hypothalamus | Female animals | Genotypes | Cilia | Electrophysiology | Neuronal primary cilia | GPR54 | MOUSE-BRAIN | LOCALIZATION | MULTIDISCIPLINARY SCIENCES | neuronal primary cilia | 5-HT6 RECEPTORS | CEREBRAL-CORTEX | LUTEINIZING-HORMONE | electrophysiology | PROTEIN-COUPLED-RECEPTORS | DISEASE | BARDET-BIEDL-SYNDROME | HYPOGONADOTROPIC HYPOGONADISM | HYPOTHALAMUS | Cell Line | Receptors, G-Protein-Coupled - metabolism | Gonadotropin-Releasing Hormone - genetics | Reproduction - physiology | Male | Mice, Transgenic | Neurons - cytology | Sexual Maturation - physiology | Kisspeptins - metabolism | Nerve Tissue Proteins - genetics | Cilia - metabolism | Cilia - genetics | Nerve Tissue Proteins - metabolism | Kisspeptins - genetics | Animals | Gonadotropin-Releasing Hormone - metabolism | Female | Signal Transduction - physiology | Neurons - metabolism | Receptors, G-Protein-Coupled - genetics | Receptors, Kisspeptin-1 | Physiological aspects | Protein research | Cellular signal transduction | Research | Peptides | Cilia and ciliary motion | Biological Sciences
Journal Article