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by Gibbs, David L and Brown, Scott D and Ou Yang, Tai-Hsien and Porta-Pardo, Eduard and Gao, Galen F and Plaisier, Christopher L and Ziv, Elad and Sivakumar, I.K. Ashok and Gentles, Andrew J and Malhotra, Raunaq and Farshidfar, Farshad and Colaprico, Antonio and Parker, Joel S and Mose, Lisle E and Vo, Nam Sy and Liu, Jianfang and Dhankani, Varsha and Reynolds, Sheila M and Cherniack, Andrew D and Anastassiou, Dimitris and Bedognetti, Davide and Mokrab, Younes and Rao, Arvind and Hu, Hai and Noushmehr, Houtan and Pedamallu, Chandra Sekhar and Bullman, Susan and Lamb, Andrew and Zhou, Wanding and Choueiri, Toni K and Weinstein, John N and Guinney, Justin and Rabkin, Charles S and Lazar, Alexander J and Serody, Jonathan S and Vincent, Benjamin G and Demchok, John A and Kasapi, Melpomeni and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Zhining and Yang, Liming and Zenklusen, Jean C and Zhang, Jiashan (Julia) and Chudamani, Sudha and Naresh, Rashi and Pihl, Todd and Sun, Qiang and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Gehlenborg, Nils and Getz, Gad and Heiman, David I and Lawrence, Michael S and Meier, Sam and Noble, Michael S and Saksena, Gordon and Voet, Doug and Zhang, Hailei and Chambwe, Nyasha and Knijnenburg, Theo and Kramer, Roger and Leinonen, Kalle and Miller, Michael and Zhang, Wei and Akbani, Rehan and Broom, Bradley M and Hegde, Apurva M and Kanchi, Rupa S and Liang, Han and Ling, Shiyun and Liu, Wenbin and Lu, Yiling and Mills, Gordon B and Ng, Kwok-Shing and Ryan, Michael and Zhang, Jiexin and Abeshouse, Adam and Chakravarty, Debyani and Chatila, Walid K and de Bruijn, Ino and Gross, Benjamin E and Heins, Zachary J and La, Konnor and Ladanyi, Marc and Ochoa, Angelica and Phillips, Sarah M and Reznik, Ed and Sander, Chris and Sumer, S. Onur and Wang, Jioajiao and Zhang, Hongxin and Anur, Pavana and Stuart, Joshua M and Wong, Christopher K and Hayes, D. Neil and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Immunity (Cambridge, Mass.), ISSN 1074-7613, 04/2018, Volume 48, Issue 4, pp. 812 - 830.e14
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across... 
tumor immunology | immunotherapy | cancer genomics | integrative network analysis | immuno-oncology | tumor microenvironment | immune subtypes | immunomodulatory | Immunology | Infectious Diseases | Immunology and Allergy | Life Sciences & Biomedicine | Science & Technology | Transforming Growth Factor beta - immunology | Prognosis | Humans | Middle Aged | Th1-Th2 Balance - physiology | Male | Neoplasms - classification | Wound Healing - immunology | Young Adult | Transforming Growth Factor beta - genetics | Neoplasms - genetics | Neoplasms - immunology | Interferon-gamma - immunology | Adolescent | Aged, 80 and over | Adult | Female | Aged | Interferon-gamma - genetics | Wound Healing - genetics | Genomics - methods | Child | Macrophages - immunology | Cell proliferation | Cluster analysis | Transcription | Copy number | p53 Protein | Lung cancer | Genomics | Aneuploidy | Lymphocytes T | Genomes | Cell interactions | Macrophages | Immunotherapy | DNA methylation | miRNA | Deoxyribonucleic acid--DNA | Immune system | Medical research | Wound healing | Immunomodulation | Stockholders | Inflammation | T cell receptors | Communications networks | Gene expression | White blood cells | Inventors | Medical prognosis | γ-Interferon | Mutation | Cancer | Tumors | Index Medicus | Immune Subtypes | Integrative Network Analysis | Cancer Genomics | Immuno-oncology | Tumor immunology
Journal Article
by Sokolov, Artem and Gentles, Andrew J and Burzykowski, Tomasz and Poisson, Laila and Weinstein, John N and Huelsken, Joerg and Omberg, Larsson and Colaprico, Antonio and Czerwińska, Patrycja and Mazurek, Sylwia and Krasnitz, Alex and Godwin, Andrew K and Lazar, Alexander J and Stuart, Joshua M and Hoadley, Katherine A and Laird, Peter W and Noushmehr, Houtan and Wiznerowicz, Maciej and Demchok, John A and Kasapi, Melpomeni and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Zhining and Yang, Liming and Zenklusen, Jean C and Zhang, Jiashan (Julia) and Chudamani, Sudha and Liu, Jia and Naresh, Rashi and Pihl, Todd and Sun, Qiang and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Getz, Gad and Heiman, David I and Lawrence, Michael S and Lin, Pei and Meier, Sam and Noble, Michael S and Saksena, Gordon and Voet, Doug and Zhang, Hailei and Bernard, Brady and Chambwe, Nyasha and Dhankani, Varsha and Knijnenburg, Theo and Kramer, Roger and Liu, Yuexin and Miller, Michael and Reynolds, Sheila and Thorsson, Vesteinn and Zhang, Wei and Hegde, Apurva M and Ju, Zhenlin and Korkut, Anil and Li, Jun and Ling, Shiyun and Liu, Wenbin and Lu, Yiling and Mills, Gordon B and Abeshouse, Adam and Chakravarty, Debyani and Chatila, Walid K and de Bruijn, Ino and Gao, Jianjiong and Gross, Benjamin E and Heins, Zachary J and Kundra, Ritika and La, Konnor and Ladanyi, Marc and Luna, Augustin and Nissan, Moriah G and Ochoa, Angelica and Sander, Chris and Sun, Yichao and Zhang, Hongxin and Anur, Pavana and Peto, Myron and Spellman, Paul and Benz, Christopher and Yau, Christina and Hayes, D. Neil and Parker, Joel S and Balasundaram, Miruna and Bowlby, Reanne and Brooks, Denise and Carlsen, Rebecca and Dhalla, Noreen and Holt, Robert and Jones, Steven J.M and Kasaian, Katayoon and Lee, Darlene and Ma, Yussanne and Mayo, Michael and Mungall, Andrew J and Mungall, Karen and ... and The Cancer Genome Atlas Research Network and Cancer Genome Atlas Res Network
Cell (Cambridge), ISSN 0092-8674, 04/2018, Volume 173, Issue 2, pp. 338 - 354.e15
Cancer progression involves the gradual loss of a differentiated phenotype and acquisition of progenitor and stem-cell-like features. Here, we provide novel... 
pan-cancer | genomic | stemness | epigenomic | dedifferentiation | cancer stem cells | machine learning | The Cancer Genome Atlas | Biochemistry, Genetics and Molecular Biology(all) | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Index Medicus
Journal Article
by Amos, Christopher I and Dennis, Joe and Wang, Zhaoming and Byun, Jinyoung and Schumacher, Fredrick R and Gayther, Simon A and Casey, Graham and Hunter, David J and Sellers, Thomas A and Gruber, Stephen B and Dunning, Alison M and Michailidou, Kyriaki and Fachal, Laura and Doheny, Kimberly and Spurdle, Amanda B and Li, Yafang and Xiao, Xiangjun and Romm, Jane and Pugh, Elizabeth and Coetzee, Gerhard A and Hazelett, Dennis J and Bojesen, Stig E and Caga-Anan, Charlisse and Haiman, Christopher A and Kamal, Ahsan and Luccarini, Craig and Tessier, Daniel and Vincent, Daniel and Bacot, François and Van Den Berg, David J and Nelson, Stefanie and Demetriades, Stephen and Goldgar, David E and Couch, Fergus J and Forman, Judith L and Giles, Graham G and Conti, David V and Bickeböller, Heike and Risch, Angela and Waldenberger, Melanie and Brüske-Hohlfeld, Irene and Hicks, Belynda D and Ling, Hua and McGuffog, Lesley and Lee, Andrew and Kuchenbaecker, Karoline and Soucy, Penny and Manz, Judith and Cunningham, Julie M and Butterbach, Katja and Kote-Jarai, Zsofia and Kraft, Peter and FitzGerald, Liesel and Lindström, Sara and Adams, Marcia and McKay, James D and Phelan, Catherine M and Benlloch, Sara and Kelemen, Linda E and Brennan, Paul and Riggan, Marjorie and O'Mara, Tracy A and Shen, Hongbing and Shi, Yongyong and Thompson, Deborah J and Goodman, Marc T and Nielsen, Sune F and Berchuck, Andrew and Laboissiere, Sylvie and Schmit, Stephanie L and Shelford, Tameka and Edlund, Christopher K and Taylor, Jack A and Field, John K and Park, Sue K and Offit, Kenneth and Thomassen, Mads and Schmutzler, Rita and Ottini, Laura and Hung, Rayjean J and Marchini, Jonathan and Amin Al Olama, Ali and Peters, Ulrike and Eeles, Rosalind A and Seldin, Michael F and Gillanders, Elizabeth and Seminara, Daniela and Antoniou, Antonis C and Pharoah, Paul D.P and Chenevix-Trench, Georgia and Chanock, Stephen J and Simard, Jacques and Easton, Douglas F
Cancer epidemiology, biomarkers & prevention, ISSN 1538-7755, 01/2017, Volume 26, Issue 1, pp. 126 - 135
Journal Article
by Wang, Zehua and Zhang, Min and Guo, Weiwei and Wu, Zhiyuan and Wang, Yue and Xie, Wen and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Yang, Liming and Zenklusen, Jean C and Zhang, Jiashan (Julia) and Chudamani, Sudha and Naresh, Rashi and Sun, Qiang and Wan, Yunhu and Wu, Ye and Frazer, Scott and Heiman, David I and Kim, Jaegil and Lin, Pei and Meier, Sam and Noble, Michael S and Saksena, Gordon and Voet, Doug and Zhang, Hailei and Bernard, Brady and Chambwe, Nyasha and Dhankani, Varsha and Knijnenburg, Theo and Kramer, Roger and Leinonen, Kalle and Liu, Yuexin and Miller, Michael and Reynolds, Sheila and Shmulevich, Ilya and Thorsson, Vesteinn and Zhang, Wei and Hegde, Apurva M and Ju, Zhenlin and Li, Jun and Liang, Han and Ling, Shiyun and Liu, Wenbin and Lu, Yiling and Mills, Gordon B and Ng, Kwok-Shing and Rao, Arvind and Ryan, Michael and Zhang, Jiexin and Abeshouse, Adam and Chakravarty, Debyani and Chatila, Walid K and Bruijn, Inode and Gao, Jianjiong and Gross, Benjamin E and Heins, Zachary J and Kundra, Ritika and La, Konnor and Ladanyi, Marc and Luna, Augustin and Nissan, Moriah G and Phillips, Sarah M and Sanchez-Vega, Francisco and Sander, Chris and Schultz, Nikolaus and Sumer, S. Onur and Taylor, Barry S and Zhang, Hongxin and Anur, Pavana and Peto, Myron and Spellman, Paul and Benz, Christopher and Stuart, Joshua M and Yau, Christina and Hayes, D. Neil and Parker, Joel S and Wilkerson, Matthew D and Ally, Adrian and Balasundaram, Miruna and Bowlby, Reanne and Brooks, Denise and Carlsen, Rebecca and Chuah, Eric and Dhalla, Noreen and Holt, Robert and Jones, Steven J.M and Kasaian, Katayoon and Lee, Darlene and Ma, Yussanne and Marra, Marco A and Mayo, Michael and Mungall, Andrew J and Mungall, Karen and Robertson, A. Gordon and Sipahimalani, Payal and Tam, Angela and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network
Cancer cell, ISSN 1535-6108, 04/2018, Volume 33, Issue 4, pp. 706 - 720.e9
We characterized the epigenetic landscape of genes encoding long noncoding RNAs (lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to... 
TCGA pan-cancer | MYC | CIMP | LOC284930 | long noncoding RNA | breast cancer | ENSG00000224271 | EPIC1 | P21 | Oncology | Cancer Research | Cell Biology | Life Sciences & Biomedicine | Science & Technology | Index Medicus
Journal Article
The lancet oncology, ISSN 1470-2045, 04/2012, Volume 13, Issue 4, pp. 385 - 394
Journal Article