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index medicus (14) 14
animals (8) 8
mice (7) 7
oligonucleotides (7) 7
oligonucleotides - chemistry (6) 6
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structure (4) 4
structure-activity relationship (4) 4
base sequence (3) 3
biochemistry & molecular biology (3) 3
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expression (3) 3
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affinity (2) 2
alpha-l-lna (2) 2
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apoptosis (2) 2
argonaute2 paz domain (2) 2
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base pairing (2) 2
crystal structure (2) 2
drug carriers (2) 2
duplex stability (2) 2
duplexes (2) 2
fluorine (2) 2
hydrogen (2) 2
in-vitro (2) 2
lna (2) 2
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mechanisms (2) 2
messenger-rna (2) 2
molecular biology (2) 2
molecular conformation (2) 2
molecular structure (2) 2
nucleosides - chemistry (2) 2
oligodeoxyribonucleotides, antisense - administration & dosage (2) 2
oligodeoxyribonucleotides, antisense - chemistry (2) 2
oligodeoxyribonucleotides, antisense - pharmacokinetics (2) 2
oligonucleotides - chemical synthesis (2) 2
oligonucleotides - pharmacology (2) 2
oxygen - chemistry (2) 2
pten phosphohydrolase - genetics (2) 2
recognition (2) 2
residues (2) 2
reverse transcriptase polymerase chain reaction (2) 2
rna (2) 2
rna splicing (2) 2
rna, messenger - biosynthesis (2) 2
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scavenger receptors, class b - genetics (2) 2
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thermal stability (2) 2
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1. Full Text Widespread recognition of 5′ splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides
by Roca, Xavier and Akerman, Martin and Gaus, Hans and Berdeja, Andrés and Bennett, C. Frank and Krainer, Adrian R
Genes and Development, ISSN 0890-9369, 05/2012, Volume 26, Issue 10, pp. 1098 - 1109
An established paradigm in pre-mRNA splicing is the recognition of the 5' splice site (5'ss) by canonical base-pairing to the 5' end of U1 small nuclear RNA... 
Alternative splicing | 5′ splice site | U1 small nuclear RNA | Splicing mutation | Base-pairing register | Bulged nucleotide | bulged nucleotide | 5 ' splice site | alternative splicing | base-pairing register | CRYSTAL-STRUCTURE | DEVELOPMENTAL BIOLOGY | U2 SNRNA | THERMODYNAMIC PARAMETERS | SINGLE NUCLEOTIDE | U6 SNRNA | 5'-SPLICE SITES | CELL BIOLOGY | IN-VITRO | MESSENGER-RNA | COMPARATIVE GENOMICS | GENETICS & HEREDITY | splicing mutation | SMALL NUCLEAR RNAS | Ribonucleotides - chemistry | Alternative Splicing | Base Pairing | RNA Splice Sites - genetics | RNA, Small Nuclear - genetics | Humans | Transcriptome | RNA, Small Nuclear - chemistry | HeLa Cells | Nucleic Acid Conformation | Messenger RNA | Research | Nucleotides | Gene mutations | RNA splicing | Research Paper
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2. Full Text Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′O-Methoxyethyl and 2′,4′-Constrained 2′O-Ethyl Nucleic Acid Analogues
by Seth, Punit P and Vasquez, Guillermo and Allerson, Charles A and Berdeja, Andres and Gaus, Hans and Kinberger, Garth A and Prakash, Thazha P and Migawa, Michael T and Bhat, Balkrishen and Swayze, Eric E
The Journal of Organic Chemistry, ISSN 0022-3263, 03/2010, Volume 75, Issue 5, pp. 1569 - 1581
We have recently shown that combining the structural elements of 2′O-methoxyethyl (MOE) and locked nucleic acid (LNA) nucleosides yielded a series of... 
NUCLEOSIDE SYNTHESES | OLIGODEOXYNUCLEOTIDES | POTENCY | STABILITY | CHEMISTRY, ORGANIC | ENA | RIBONUCLEOSIDES | DEPROTECTION | ANTISENSE OLIGONUCLEOTIDES | LNA | CYTOSINE
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3. Full Text Fully 2‘-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA
by Allerson, Charles R and Sioufi, Namir and Jarres, Russell and Prakash, Thazha P and Naik, Nishant and Berdeja, Andres and Wanders, Lisa and Griffey, Richard H and Swayze, Eric E and Bhat, Balkrishen
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2005, Volume 48, Issue 4, pp. 901 - 904
We have identified a small interfering RNA (siRNA) motif, consisting entirely of 2‘-O-methyl and 2‘-fluoro nucleotides, that displays enhanced plasma stability... 
ARGONAUTE2 PAZ DOMAIN | SYNTHETIC SIRNAS | CHEMISTRY, MEDICINAL | GENE | ANTISENSE DRUGS | MICE | ENZYME COMPLEX | MAMMALIAN-CELLS | BINDING | PHOSPHOROTHIOATE OLIGONUCLEOTIDES | DROSOPHILA | Oligonucleotides - chemistry | RNA, Small Interfering - genetics | Phosphoric Monoester Hydrolases - genetics | Drug Stability | Humans | Structure-Activity Relationship | Reverse Transcriptase Polymerase Chain Reaction | Oligonucleotides - chemical synthesis | Drug Carriers | RNA, Small Interfering - chemistry | RNA, Messenger - biosynthesis | Phosphatidylethanolamines | Animals | Transfection | Oligonucleotides - pharmacology | PTEN Phosphohydrolase | Phosphoric Monoester Hydrolases - biosynthesis | Tumor Suppressor Proteins - genetics | RNA, Messenger - chemistry | Mice | HeLa Cells | Tumor Suppressor Proteins - biosynthesis
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4. Full Text TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues-a comparative study of oligonucleotide length, design and chemistry
by Murray, Sue and Ittig, Damian and Koller, Erich and Berdeja, Andres and Chappell, Alfred and Prakash, Thazha P and Norrbom, Michaela and Swayze, Eric E and Leumann, Christian J and Seth, Punit P
Nucleic Acids Research, ISSN 0305-1048, 07/2012, Volume 40, Issue 13, pp. 6135 - 6143
We report the evaluation of 20-, 18-, 16- and 14-mer phosphorothioate (PS)-modified tricycloDNA (tcDNA) gapmer antisense oligonucleotides (ASOs) in T-m, cell... 
SR-BI | INHIBITION | CHOLESTEROL | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SHOW IMPROVED POTENCY | MECHANISMS | IDENTIFICATION | ANTISENSE OLIGONUCLEOTIDES | EXPRESSION | NUCLEIC-ACIDS | Molecular Biology
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5. Full Text Comparison of Duplex Stabilizing Properties of 2′-Fluorinated Nucleic Acid Analogues with Furanose and Non-Furanose Sugar Rings
by Østergaard, Michael E and Dwight, Timothy and Berdeja, Andres and Swayze, Eric E and Jung, Michael E and Seth, Punit P
The Journal of Organic Chemistry, ISSN 0022-3263, 09/2014, Volume 79, Issue 18, pp. 8877 - 8881
We compare the duplex stabilizing properties of 2′-fluorinated nucleic acid analogues with furanose and non-furanose ring systems and dissect the relative... 
AFFINITY | HAIRPIN | CRYSTAL-STRUCTURE | RESISTANCE | CHEMISTRY, ORGANIC | HYBRID DUPLEXES | SIRNAS | STRUCTURAL-PROPERTIES | ANTISENSE PROPERTIES | COMPLEMENTARY RNA | OLIGONUCLEOTIDES | Base Pairing | Carbohydrates - chemistry | Nucleic Acids - chemistry | Molecular Conformation | Ribose - chemistry | Molecular Structure | Carbohydrate Conformation | Nucleic Acid Conformation | RNA - chemistry | Chemical properties | Research | Furanoses | Structure | Hydration (Chemistry) | Fluorine
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6. Full Text Human Dicer Binds Short Single-strand and Double-strand RNA with High Affinity and Interacts with Different Regions of the Nucleic Acids
by Walt F. Lima and Heather Murray and Josh G. Nichols and Hongjiang Wu and Hong Sun and Thazha P. Prakash and Andres R. Berdeja and Hans J. Gaus and Stanley T. Crooke
Journal of Biological Chemistry, ISSN 0021-9258, 01/2009, Volume 284, Issue 4, pp. 2535 - 2548
Human Dicer is an integral component of the RNA interference pathway. Dicer processes premicro-RNA and double-strand RNA to, respectively, mature micro-RNA and... 
ARGONAUTE2 PAZ DOMAIN | OLIGONUCLEOTIDE DUPLEXES | CAENORHABDITIS-ELEGANS | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | C-ELEGANS | MAMMALIAN-CELLS | EXPRESSION | RIBONUCLEASE | INTERFERING-RNA | RNA-Binding Proteins - genetics | Ribonuclease III - genetics | Ribonuclease III - metabolism | Humans | Gene Silencing | Substrate Specificity | Chromatography, High Pressure Liquid | RNA - chemistry | Spectrometry, Mass, Electrospray Ionization | Base Sequence | Models, Genetic | HeLa Cells | RNA-Binding Proteins - metabolism | RNA - metabolism
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7. Full Text An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA
by Seth, Punit P and Allerson, Charles R and Berdeja, Andres and Siwkowski, Andrew and Pallan, Pradeep S and Gaus, Hans and Prakash, Thazha P and Watt, Andrew T and Egli, Martin and Swayze, Eric E and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Journal of the American Chemical Society, ISSN 0002-7863, 10/2010, Volume 132, Issue 42, pp. 14942 - 14950
We show for the first time that it is possible to obtain LNA-like (Locked Nucleic Acid 1) binding affinity and biological activity with carbocyclic LNA (cLNA)... 
LDL CHOLESTEROL | DUPLEX STABILITY | IN-VITRO | NUCLEOSIDE ANALOGS | RNA | LOCKED NUCLEIC-ACID | CRYSTAL-STRUCTURE | SHOW IMPROVED POTENCY | ANTISENSE OLIGONUCLEOTIDES | 2'-MODIFIED OLIGONUCLEOTIDES | CHEMISTRY, MULTIDISCIPLINARY | Alkenes - chemistry | PTEN Phosphohydrolase - genetics | Nucleic Acid Hybridization | Animals | Nucleic Acids - chemistry | RNA, Messenger - genetics | Oxygen - chemistry | Models, Molecular | Crystallography, X-Ray | Mice | Structure-Activity Relationship | Analysis | Oligonucleotides | Chemical properties | Ring formation (Chemistry) | Nucleic acids | Structure | Carbenes | Index Medicus | ANIMALS | NUCLEOSIDES | STABILITY | 08 HYDROGEN | CRYSTAL STRUCTURE | HYBRIDIZATION | TOXICITY | MATERIALS SCIENCE | IN VIVO | NUCLEIC ACIDS | OLIGONUCLEOTIDES | OXYGEN | HYDROGEN | AFFINITY | DNA | SYNTHESIS | ATOMS | RADICALS | POLARIZATION | RESIDUES | CYCLIZATION
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8. Full Text Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages
by Wan, W. Brad and Migawa, Michael T and Vasquez, Guillermo and Murray, Heather M and Nichols, Josh G and Gaus, Hans and Berdeja, Andres and Lee, Sam and Hart, Christopher E and Lima, Walt F and Swayze, Eric E and Seth, Punit P
Nucleic Acids Research, ISSN 0305-1048, 12/2014, Volume 42, Issue 22, pp. 13456 - 13468
Bicyclic oxazaphospholidine monomers were used to prepare a series of phosphorothioate (PS)modified gapmer antisense oligonucleotides (ASOs) with control of... 
RAT-LIVER | SR-BI | SCAVENGER RECEPTOR | MESSENGER-RNA | HUMAN RNASE H1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | HETERODUPLEX SUBSTRATE | APOLIPOPROTEIN-B | INHIBITOR | STEREOCONTROLLED SYNTHESIS | RNA/DNA HYBRID | Temperature | Oligonucleotides, Antisense - pharmacology | Stereoisomerism | Cells, Cultured | Oligonucleotides, Antisense - chemistry | Oligonucleotides, Antisense - metabolism | Animals | Oligonucleotides, Antisense - chemical synthesis | Single-Strand Specific DNA and RNA Endonucleases - metabolism | Mice | Phosphorothioate Oligonucleotides - chemistry | Fungal Proteins - metabolism | Ribonuclease H - metabolism | Chemical Biology and Nucleic Acid Chemistry
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9. Full Text Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides
by Egli, Martin and Pallan, Pradeep S and Allerson, Charles R and Prakash, Thazha P and Berdeja, Andres and Yu, Jinghua and Lee, Sam and Watt, Andrew and Gaus, Hans and Bhat, Balkrishen and Swayze, Eric E and Seth, Punit P
Journal of the American Chemical Society, ISSN 0002-7863, 10/2011, Volume 133, Issue 41, pp. 16642 - 16649
The synthesis, biophysical, structural, and biological properties of both isomers of 3′-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified... 
ANA | ANALOGS | STABILITY | SHOW IMPROVED POTENCY | DEGRADATION | MECHANISMS | DUPLEXES | CHEMISTRY, MULTIDISCIPLINARY | FLUORIDES | LNA | D-ALTRITOL NUCLEOSIDES | Oligonucleotides - chemistry | Nucleic Acids - chemistry | Stereoisomerism | Molecular Conformation | Sugar Alcohols - chemistry | Models, Molecular | RNA - chemistry | Analysis | Oligonucleotides | Crystals | Nucleic acids | Chemical properties | Research | Structure | Hydrogen bonding | Index Medicus
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10. Full Text Structure and nuclease resistance of 2′,4′-constrained 2′-O-methoxyethyl (cMOE) and 2′-O-ethyl (cEt) modified DNAs
by Pallan, Pradeep S and Allerson, Charles R and Berdeja, Andres and Seth, Punit P and Swayze, Eric E and Prakash, Thazha P and Egli, Martin
Chemical Communications, ISSN 1359-7345, 08/2012, Volume 48, Issue 66, pp. 8195 - 8197
Combining the structural elements of the second generation 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications... 
ACID LNA | NUCLEOSIDE ANALOGS | CRYSTAL-STRUCTURE | STABILITY | DUPLEXES | ANTISENSE OLIGONUCLEOTIDES | CHEMISTRY, MULTIDISCIPLINARY | Models, Molecular | DNA - chemistry | Nucleosides - chemistry | Oligoribonucleotides - chemistry | Deoxyribonucleases - chemistry | Antisense oligonucleotides
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11. Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides
by Roca, Xavier and Akerman, Martin and Gaus, Hans and Berdeja, Andres and Bennett, CFrank and Krainer, Adrian R
Genes & Development, ISSN 0890-9369, 05/2012, Volume 26, Issue 10, pp. 1098 - 1109
An established paradigm in pre-mRNA splicing is the recognition of the 5' splice site (5'ss) by canonical base-pairing to the 5' end of U1 small nuclear RNA... 
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12. Full Text Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway
by Lee, Sang-il and Boyle, David L and Berdeja, Andres and Firestein, Gary S
Arthritis Research and Therapy, ISSN 1478-6354, 02/2012, Volume 14, Issue 1, pp. R38 - R38
Introduction: The c-Jun N-terminal kinase (JNK) is a key regulator of matrix metalloproteinase (MMP) and cytokine production in rheumatoid arthritis (RA) and... 
Anti-sense oligonucleotide | Mitogen-activated protein kinase kinase 7 | C-Jun N-terminal kinase | Rheumatoid arthritis | RHEUMATOID-ARTHRITIS | APOPTOSIS | JNK | ANTISENSE | MAP KINASES | RHEUMATOLOGY | MKK7 | OLIGONUCLEOTIDES | SIGNAL-TRANSDUCTION | GENE-EXPRESSION | SYNOVIOCYTES | MAP Kinase Kinase 7 - genetics | Synovitis - metabolism | Ankle Joint - metabolism | Phosphorylation | Injections, Intravenous | Synovial Membrane - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | Interleukin-1beta - genetics | Gene Knockdown Techniques | MAP Kinase Kinase 7 - metabolism | Arthritis, Rheumatoid - metabolism | MAP Kinase Signaling System - genetics | Time Factors | JNK Mitogen-Activated Protein Kinases - genetics | Synovitis - genetics | Severity of Illness Index | Gene Expression | Ankle Joint - pathology | Matrix Metalloproteinase 13 - genetics | Mice, Inbred C57BL | Reverse Transcriptase Polymerase Chain Reaction | Synovial Membrane - metabolism | Blotting, Western | Arthritis, Rheumatoid - pathology | Arthritis, Rheumatoid - genetics | Animals | Oligonucleotides, Antisense - genetics | Oligonucleotides, Antisense - administration & dosage | Mice | Development and progression | Drug targeting | Models | Research | Metalloproteins | c-Jun N-terminal kinases
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13. Full Text Structure and nuclease resistance of 2,4-constrained 2-O-methoxyethyl (cMOE) and 2-O-ethyl (cEt) modified DNAsElectronic supplementary information (ESI) available: Nuclease resistances (Table S1), crystallization experiments, data collection and refinement parameter summary (Table S2), and illustrations of overall structures, quality of the electron density (Fig. S1), and origins of nuclease resistance (Fig. S2). See DOI: 10.1039/c2cc32286b
by Pallan, Pradeep S and Allerson, Charles R and Berdeja, Andres and Seth, Punit P and Swayze, Eric E and Prakash, Thazha P and Egli, Martin
ISSN 1359-7345, 7/2012, Volume 48, Issue 66, pp. 8195 - 8197
Combining the structural elements of the second generation 2- O -methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications... 
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14. Full Text Structure and nuclease resistance of 2;#8242;,4;#8242;-constrained 2;#8242;-O-methoxyethyl (cMOE) and 2;#8242;-O-ethyl (cEt) modified DNAs
by Pallan, Pradeep S and Allerson, Charles R and Berdeja, Andres and Seth, Punit P and Swayze, Eric E and Prakash, Thazha P and Egli, Martin and and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
ChemComm, ISSN 1359-7345, 04/2012, Volume 48, Issue 66
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15. Full Text Configuration of the 5′-Methyl Group Modulates the Biophysical and Biological Properties of Locked Nucleic Acid (LNA) Oligonucleotides
by Seth, Punit P and Allerson, Charles R and Siwkowski, Andrew and Vasquez, Guillermo and Berdeja, Andres and Migawa, Michael T and Gaus, Hans and Prakash, Thazha P and Bhat, Balkrishen and Swayze, Eric E
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2010, Volume 53, Issue 23, pp. 8309 - 8318
As part of a program aimed at exploring the structure− activity relationships of 2′,4′-bridged nucleic acid (BNA) containing antisense oligonucleotides (ASOs),... 
RNASE-H | DUPLEX STABILITY | CHEMISTRY, MEDICINAL | ANALOGS | CRYSTAL-STRUCTURE | DNA | SHOW IMPROVED POTENCY | TORSION ANGLES | SIRNA DELIVERY | ANTISENSE OLIGONUCLEOTIDES | PAIRING PROPERTIES | Nuclear Magnetic Resonance, Biomolecular | Oligonucleotides - chemistry | Structure-Activity Relationship | Biophysics | Oligonucleotides - pharmacology
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16. Full Text Replacing the 2′-oxygen with an exocyclic methylene group reverses the stabilization effects of α-l-LNA
by Seth, Punit P and Allerson, Charles R and Berdeja, Andres and Swayze, Eric E
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2011, Volume 21, Issue 1, pp. 588 - 591
The synthesis and hybridization properties of an α- -LNA analog where the 2′-oxygen atom is replaced with an exocyclic methylene group is reported. Contrary to... 
α-l-LNA | cLNA | Methylene-cLNA | Thermal stability | Oligonucleotides | RNASE-H | CHEMISTRY, MEDICINAL | NUCLEOSIDE ANALOGS | RECOGNITION | LOCKED NUCLEIC-ACID | STABILITY | CHEMISTRY, ORGANIC | TOXICITY | PHOSPHATE | CARBA-LNAS | alpha-L-LNA | 2'-AMINO-ALPHA-L-LNA | METATHESIS | Oligonucleotides - chemistry | Nucleic Acid Conformation | Transition Temperature | Oxygen - chemistry
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17. Full Text Synthesis and biophysical characterization of R-6′-Me-α- l-LNA modified oligonucleotides
by Seth, Punit P and Yu, Jinghua and Allerson, Charles R and Berdeja, Andres and Swayze, Eric E
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2011, Volume 21, Issue 4, pp. 1122 - 1125
The synthesis and biophysical properties of -6′-Me-α- -LNA, which has a methyl group in the ( ) configuration on the 2′,4′-bridging substituent of α- -LNA, is... 
R-6′-Me-α- l-LNA | α- l-LNA | Thermal stability | Oligonucleotides | α-l-LNA | R-6′-Me-α-l-LNA | RNASE-H | CHEMISTRY, MEDICINAL | RECOGNITION | ANALOGS | LOCKED NUCLEIC-ACID | NUCLEOSIDES | CHEMISTRY, ORGANIC | R-6`-Me-alpha-L-LNA | NMR | L-RIBO | alpha-L-LNA | DNA | 2'-AMINO-ALPHA-L-LNA | Oligonucleotides - chemistry | Stereoisomerism | Base Sequence | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Nucleic Acid Conformation | Transition Temperature | Oligonucleotides - chemical synthesis | Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis
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18. Full Text TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry
by Murray, Sue and Ittig, Damian and Koller, Erich and Berdeja, Andres and Chappell, Alfred and Prakash, Thazha P and Norrbom, Michaela and Swayze, Eric E and Leumann, Christian J and Seth, Punit P
Nucleic acids research, 07/2012, Volume 40, Issue 13, p. 6135
We report the evaluation of 20-, 18-, 16- and 14-mer phosphorothioate (PS)-modified tricycloDNA (tcDNA) gapmer antisense oligonucleotides (ASOs) in T(m), cell... 
Cell Line | Oligodeoxyribonucleotides, Antisense - administration & dosage | Liver - metabolism | Male | Scavenger Receptors, Class B - genetics | RNA, Messenger - metabolism | Tissue Distribution | Animals | Mice | Mice, Inbred BALB C | Scavenger Receptors, Class B - metabolism | Oligodeoxyribonucleotides, Antisense - chemistry | Oligodeoxyribonucleotides, Antisense - pharmacokinetics
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19. Full Text Replacing the 2'-oxygen with an exocyclic methylene group reverses the stabilization effects of [alpha]-l-LNA
by Seth, Punit P and Allerson, Charles R and Berdeja, Andres and Swayze, Eric E
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2011, Volume 21, Issue 1, p. 588
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20. Full Text Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3;#8242;-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides
by Egli, Martin and Pallan, Pradeep S and Allerson, Charles R and Prakash, Thazha P and Berdeja, Andres and Yu, Jinghua and Lee, Sam and Watt, Andrew and Gaus, Hans and Bhat, Balkrishen and Swayze, Eric E and Seth, Punit P and and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
J. Am. Chem. Soc, ISSN 0002-7863, 03/2012, Volume 133, Issue (41) ; 10, 2011
The synthesis, biophysical, structural, and biological properties of both isomers of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified... 
ANIMALS | SACCHAROSE | MONOMERS | RNA | STABILITY | ADENOSINE | PYRIMIDINES | 08 HYDROGEN | CRYSTAL STRUCTURE | THYMINE | NUCLEIC ACIDS | OLIGONUCLEOTIDES | HYDROGEN | ORIGIN | DNA | GENES | LIVER | ISOMERS | SYNTHESIS | ATOMS | FLUORINE | RESIDUES
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