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The Journal of Organic Chemistry, ISSN 0022-3263, 03/2010, Volume 75, Issue 5, pp. 1569 - 1581
We have recently shown that combining the structural elements of 2′O-methoxyethyl (MOE) and locked nucleic acid (LNA) nucleosides yielded a series of... 
NUCLEOSIDE SYNTHESES | OLIGODEOXYNUCLEOTIDES | POTENCY | STABILITY | CHEMISTRY, ORGANIC | ENA | RIBONUCLEOSIDES | DEPROTECTION | ANTISENSE OLIGONUCLEOTIDES | LNA | CYTOSINE
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 07/2012, Volume 40, Issue 13, pp. 6135 - 6143
We report the evaluation of 20-, 18-, 16- and 14-mer phosphorothioate (PS)-modified tricycloDNA (tcDNA) gapmer antisense oligonucleotides (ASOs) in T-m, cell... 
SR-BI | INHIBITION | CHOLESTEROL | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SHOW IMPROVED POTENCY | MECHANISMS | IDENTIFICATION | ANTISENSE OLIGONUCLEOTIDES | EXPRESSION | NUCLEIC-ACIDS | Molecular Biology
Journal Article
Journal Article
Chemical Communications, ISSN 1359-7345, 08/2012, Volume 48, Issue 66, pp. 8195 - 8197
Combining the structural elements of the second generation 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications... 
ACID LNA | NUCLEOSIDE ANALOGS | CRYSTAL-STRUCTURE | STABILITY | DUPLEXES | ANTISENSE OLIGONUCLEOTIDES | CHEMISTRY, MULTIDISCIPLINARY | Models, Molecular | DNA - chemistry | Nucleosides - chemistry | Oligoribonucleotides - chemistry | Deoxyribonucleases - chemistry | Antisense oligonucleotides
Journal Article
Genes & Development, ISSN 0890-9369, 05/2012, Volume 26, Issue 10, pp. 1098 - 1109
An established paradigm in pre-mRNA splicing is the recognition of the 5' splice site (5'ss) by canonical base-pairing to the 5' end of U1 small nuclear RNA... 
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 02/2012, Volume 14, Issue 1, pp. R38 - R38
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2010, Volume 53, Issue 23, pp. 8309 - 8318
As part of a program aimed at exploring the structure− activity relationships of 2′,4′-bridged nucleic acid (BNA) containing antisense oligonucleotides (ASOs),... 
RNASE-H | DUPLEX STABILITY | CHEMISTRY, MEDICINAL | ANALOGS | CRYSTAL-STRUCTURE | DNA | SHOW IMPROVED POTENCY | TORSION ANGLES | SIRNA DELIVERY | ANTISENSE OLIGONUCLEOTIDES | PAIRING PROPERTIES | Nuclear Magnetic Resonance, Biomolecular | Oligonucleotides - chemistry | Structure-Activity Relationship | Biophysics | Oligonucleotides - pharmacology
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2011, Volume 21, Issue 1, pp. 588 - 591
The synthesis and hybridization properties of an α- -LNA analog where the 2′-oxygen atom is replaced with an exocyclic methylene group is reported. Contrary to... 
α-l-LNA | cLNA | Methylene-cLNA | Thermal stability | Oligonucleotides | RNASE-H | CHEMISTRY, MEDICINAL | NUCLEOSIDE ANALOGS | RECOGNITION | LOCKED NUCLEIC-ACID | STABILITY | CHEMISTRY, ORGANIC | TOXICITY | PHOSPHATE | CARBA-LNAS | alpha-L-LNA | 2'-AMINO-ALPHA-L-LNA | METATHESIS | Oligonucleotides - chemistry | Nucleic Acid Conformation | Transition Temperature | Oxygen - chemistry
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2011, Volume 21, Issue 1, p. 588
Journal Article
J. Am. Chem. Soc, ISSN 0002-7863, 03/2012, Volume 133, Issue (41) ; 10, 2011
The synthesis, biophysical, structural, and biological properties of both isomers of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified... 
ANIMALS | SACCHAROSE | MONOMERS | RNA | STABILITY | ADENOSINE | PYRIMIDINES | 08 HYDROGEN | CRYSTAL STRUCTURE | THYMINE | NUCLEIC ACIDS | OLIGONUCLEOTIDES | HYDROGEN | ORIGIN | DNA | GENES | LIVER | ISOMERS | SYNTHESIS | ATOMS | FLUORINE | RESIDUES
Journal Article
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