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1. Full Text Paediatric rheumatology in 2017: Child-centred research is the key to progress
by Beresford, Michael W and Ramanan, Athimalaipet V
Nature Reviews Rheumatology, ISSN 1759-4790, 02/2018, Volume 14, Issue 2, pp. 69 - 70
Severity of Illness Index | Adalimumab - therapeutic use | Standard of Care | Humans | Treatment Outcome | Clinical Trials as Topic | Methotrexate - therapeutic use | Drug Therapy, Combination | Child | Arthritis, Juvenile - pathology | Arthritis, Juvenile - drug therapy | Practice Guidelines as Topic | Pediatrics | Care and treatment | Arthritis | Research | Children | Methotrexate | Evidence-based medicine | Diseases
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2. Full Text The human glomerular endothelial cells are potent pro-inflammatory contributors in an in vitro model of lupus nephritis
by Dimou, Paraskevi and Wright, Rachael D and Budge, Kelly L and Midgley, Angela and Satchell, Simon C and Peak, Matthew and Beresford, Michael W
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 8348 - 17
Juvenile-onset lupus nephritis (LN) affects up to 80% of juvenile-onset systemic lupus erythematosus patients (JSLE). As the exact role of human renal... 
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3. Full Text Methodology of clinical trials for rare diseases
by Tudur Smith, Catrin and Williamson, Paula R and Beresford, Michael W
Best Practice and Research: Clinical Rheumatology, ISSN 1521-6942, 2014, Volume 28, Issue 2, pp. 247 - 262
Evidence from clinical trials, ideally using randomisation and allocation concealment, is essential for informing clinical decisions regarding the benefits and... 
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4. Full Text Juvenile Idiopathic Arthritis
: New Insights into Classification, Measures of Outcome, and Pharmacotherapy
by Beresford, Michael W
Pediatric Drugs, ISSN 1174-5878, 6/2011, Volume 13, Issue 3, pp. 161 - 173
Significant advances have taken place in recent years in our understanding of the aetiopathogenesis, anagement, and clinical outcome of juvenile idiopathic... 
Pharmacotherapy | Pediatrics | Internal Medicine | Medicine & Public Health | Disease-modifying-antirheumatics, therapeutic use | Methotrexate, therapeutic use | Research-and-development | Interleukin-1-receptor-antagonist, therapeutic use | Abatacept, therapeutic use | Tocilizumab, therapeutic use | Adalimumab, therapeutic use | Infliximab, therapeutic use | Anakinra, therapeutic use | Etanercept, therapeutic use | Juvenile-rheumatoid-arthritis, treatment | Canakinumab, therapeutic use | Children | Corticosteroids, therapeutic use | RHEUMATOID-ARTHRITIS | ONSET STILL-DISEASE | FACTOR-ALPHA BLOCKERS | DOUBLE-BLIND | TERM-FOLLOW-UP | PRELIMINARY DEFINITION | PEDIATRICS | PHARMACOLOGY & PHARMACY | QUALITY-OF-LIFE | PLACEBO-CONTROLLED TRIAL | PEDIATRIC RHEUMATOLOGY | INTRAARTICULAR TRIAMCINOLONE HEXACETONIDE | Complications and side effects | Patient outcomes | Antiarthritic agents | Arthritis | Dosage and administration | Diagnosis | Drug therapy | Risk factors
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5. Full Text Introduction
by Cleary, Gavin and Beresford, Michael W and Foster, Helen
Rheumatology, ISSN 1462-0324, 02/2011, Volume 50, Issue 1, p. i1
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6. Full Text Clinical predictors of proteinuric remission following an LN flare - evidence from the UK JSLE cohort study
by Smith, Eve M.D and Yin, Peng and Jorgensen, Andrea L and Beresford, Michael W and UK JSLE Study Grp and UK JSLE Study Group and on behalf of the UK JSLE Study Group
Pediatric Rheumatology, ISSN 1546-0096, 02/2018, Volume 16, Issue 1, pp. 14 - 9
Background: Proteinuria is a well-known risk factor for progression of renal dysfunction in a variety of chronic kidney diseases. In adult-onset Systemic Lupus... 
JSLE | Prognosis | Lupus nephritis | Juvenile-onset systemic lupus erythematosus | Active LN | Proteinuria | ANTI-C1Q ANTIBODIES | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ADULT-ONSET | RHEUMATOLOGY | GLOMERULAR-FILTRATION-RATE | ALL-CAUSE | EUROPEAN WORKSHOP | RHEUMATOLOGY RESEARCH | CONSENSUS-STUDY-GROUP | DISEASE-ACTIVITY INDEX | CHILDHOOD-ONSET | PEDIATRICS | Regression (Disease) | Nephritis | Research | Pediatric research
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7. Full Text Introduction
by Pilkington, Clarissa and Beresford, Michael W and Foster, Helen and Walsh, Jo
Rheumatology (United Kingdom), ISSN 1462-0324, 12/2012, Volume 51, Issue 12, p. viii1
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8. Full Text PP6. Felty’s syndrome in rheumatoid factor positive polyarticular juvenile idiopathic arthritis: the role of rituximab
by Brown, Laura E and Sampath, Sunil and Ryan, Fiona and Pain, Clare E and McCann, Liza J and Cleary, Gavin and Beresford, Michael W and Baildam, Eileen M
Rheumatology, ISSN 1462-0324, 05/2015, Volume 54, Issue suppl_2, pp. ii7 - ii7
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9. Full Text Adalimumab plus Methotrexate for Uveitis in Juvenile Idiopathic Arthritis
by Ramanan, Athimalaipet V and Dick, Andrew D and Jones, Ashley P and McKay, Andrew and Williamson, Paula R and Compeyrot-Lacassagne, Sandrine and Hardwick, Ben and Hickey, Helen and Hughes, Dyfrig and Woo, Patricia and Benton, Diana and Edelsten, Clive and Beresford, Michael W and SYCAMORE Study Grp and SYCAMORE Study Group
The New England Journal of Medicine, ISSN 0028-4793, 04/2017, Volume 376, Issue 17, pp. 1637 - 1646
In a randomized trial, children with uveitis associated with juvenile idiopathic arthritis who were taking a stable dose of methotrexate were significantly... 
MEDICINE, GENERAL & INTERNAL | THERAPY | EFFICACY | VALIDATION | PRELIMINARY DEFINITION | ALPHA | AGENTS | DISEASE-ACTIVITY | Uveitis - etiology | Double-Blind Method | Uveitis - drug therapy | Humans | Child, Preschool | Male | Methotrexate - therapeutic use | Adalimumab - adverse effects | Arthritis, Juvenile - drug therapy | Adalimumab - therapeutic use | Anti-Inflammatory Agents - adverse effects | Time Factors | Adolescent | Arthritis, Juvenile - complications | Intention to Treat Analysis | Anti-Inflammatory Agents - therapeutic use | Female | Drug Therapy, Combination | Child | Antirheumatic Agents - therapeutic use | Usage | Care and treatment | Patient outcomes | Juvenile arthritis | Uveitis | Dosage and administration | Drug therapy, Combination | Adalimumab | Methotrexate | Drug therapy | Adolescence | Nomenclature | Body weight | Standardization | Arthritis | Tumor necrosis factor-α | Patients | Monoclonal antibodies | Tumor necrosis factor-TNF | Children | Drug dosages
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10. Full Text Juvenile-onset systemic lupus erythematosus: how to diagnose and manage
by Oni, Louise and Thorbinson, Colin and Beresford, Michael W
Paediatrics and Child Health, ISSN 1751-7222, 2015, Volume 25, Issue 12, pp. 555 - 560
Abstract Systemic lupus erythematosus (SLE) is the prototypic autoimmune disorder, characterised by auto-antibody production against nuclear antigens.... 
Pediatrics | JSLE | diagnosis | systemic lupus erythematosus | management | juvenile-onset systemic lupus erythematosus | Systemic lupus erythematosus | Diagnosis | Management | Juvenile-onset systemic lupus erythematosus | Lupus erythematosus | Care and treatment | Risk factors
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11. Full Text P40 S100A8/A9 and S100A12 may be biomarkers for juvenile-onset systemic lupus erythematosus
by Donohue, Sean Joseph and Midgley, Angela and Bruce, Ian and Beresford, Michael W and Hedrich, Christian M
Rheumatology, ISSN 1462-0324, 10/2019, Volume 58, Issue Supplement_4
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12. Full Text Characterization of Human Disease Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1
by Crow, Y.J and Chase, D.S and Schmidt, J.L and Szynkiewicz, M and Forte, G.M.A and Gornall, H.L and Oojageer, A and Anderson, B and Pizzino, A and Helman, G and Abdel-Hamid, M.S and Abdel-Salam, G.M and Ackroyd, S and Aeby, A and Agosta, G and Albin, C and Allon-Shalev, S and Arellano, M and Ariaudo, G and Aswani, V and Babul-Hirji, R and Baildam, E.M and Bahi-Buisson, N and Bailey, K.M and Barnerias, C and Barth, M and Battini, R and Beresford, M.W and Bernard, G and Bianchi, M and de Villemeur, T.B and Blair, E.M and Bloom, M and Burlina, A.B and Carpanelli, M.L and Carvalho, D.R and Castro-Gago, M and Cavallini, A and Cereda, C and Chandler, K.E and Chitayat, D.A and Collins, A.E and Corcoles, C.S and Cordeiro, N.J.V and Crichiutti, G and Dabydeen, L and Dale, R.C and D'Arrigo, S and De Goede, C.G.E.L and de Laet, C and De Waele, L.M.H and Denzler, I and Desguerre, I and Devriendt, K and Di Rocco, M and Fahey, M.C and Fazzi, E and Ferrie, C.D and Figueiredo, A and Gener, B and Goizet, C and Gowrinathan, N.R and Gowrishankar, K and Hanrahan, D and Isidor, B and Kara, L and Khan, N and King, M.D and Kirk, E.P and Kumar, R and Lagae, L and Lanieu, P and Lauffer, H and Laugel, V and La Piana, R and Lim, M.J and Lin, J.P.S.M and Linnankivi, T and Mackay, M.T and Marom, D.R and Lourenco, C.M and McKee, S.A and Moroni, I and Morton, J.E.V and Moutard, M.L and Murray, K and Nabbout, R and Nampoothiri, S and Nunez-Enamorado, N and Oades, P.J and Olivieri, I and Ostergaard, J.R and Perez-Duenas, B and Prendiville, J.S and Ramesh, V and Rasmussen, M and Regal, L and Ricci, F and Rio, M and Knaap, M and ...
American Journal of Medical Genetics Part A, ISSN 1552-4825, 2015, Volume 167, Issue 2, pp. 296 - 312
Aicardi-Goutières syndrome is an inflammatory disease occurring due to mutations in any of TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR or IFIH1. We... 
spastic paraparesis | type I interferon | bilateral striatal necrosis | interferon signature | Aicardi–Goutières syndrome | Interferon signature | Bilateral striatal necrosis | Spastic paraparesis | Type I interferon | Aicardi-Goutières syndrome | SYSTEMIC-LUPUS-ERYTHEMATOSUS | BASAL GANGLIA | ENCEPHALOPATHY | AICARDI-GOUTIERES-SYNDROME | INTERFERON-ALPHA | GENE | Aicardi-Goutieres syndrome | DNA EXONUCLEASE TREX1 | GENETICS & HEREDITY | CLASSIFICATION-SYSTEM | VASCULOPATHY | CALCIFICATIONS | Interferons - cerebrospinal fluid | Genetic Association Studies | Adenosine Deaminase - genetics | Humans | SAM Domain and HD Domain-Containing Protein 1 | Genotype | Monomeric GTP-Binding Proteins - genetics | Phosphoproteins - genetics | Pterins - cerebrospinal fluid | Interferon-Induced Helicase, IFIH1 | DEAD-box RNA Helicases - genetics | Phenotype | Interferons - blood | Autoimmune Diseases of the Nervous System - genetics | Nervous System Malformations - diagnosis | Exodeoxyribonucleases - genetics | Mutation | Nervous System Malformations - genetics | Autoimmune Diseases of the Nervous System - diagnosis | Ribonuclease H - genetics | Glaucoma | Mortality | Skin diseases | Genetic aspects | Hypothyroidism | Biological response modifiers | Index Medicus
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13. Full Text 29. Lupus and You: Developing a workshop for young people with lupus and their families
by Wilson, Emily and Lythgoe, Hanna and Smith, Eve and Preston, Jenny and Beresford, Michael W
Rheumatology, ISSN 1462-0324, 12/2017, Volume 56, Issue suppl_7
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14. Full Text 30. Using a pre-clinic screening tool to support young people with lupus in prioritising issues for discussion in clinic appointments
by Wilson, Emily and Etheridge, Jody and Smith, Eve and Beresford, Michael W
Rheumatology, ISSN 1462-0324, 12/2017, Volume 56, Issue suppl_7
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15. Full Text Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type i interferon signaling
by Rice, Gillian I and Del Toro Duany, Yoandris and Jenkinson, Emma M and Forte, Gabriella M. A and Anderson, Beverley H and Ariaudo, Giada and Bader-Meunier, Brigitte and Baildam, Eileen M and Battini, Roberta and Beresford, Michael W and Casarano, Manuela and Chouchane, Mondher and Cimaz, Rolando and Collins, Abigail E and Cordeiro, Nuno J. V and Dale, Russell C and Davidson, Joyce E and De Waele, Liesbeth and Desguerre, Isabelle and Faivre, Laurence and Fazzi, Elisa and Isidor, Bertrand and Lagae, Lieven and Latchman, Andrew R and Lebon, Pierre and Li, Chumei and Livingston, John H and Lourenço, Charles M and Mancardi, Maria Margherita and Masurel-Paulet, Alice and McInnes, Iain B and Menezes, Manoj P and Mignot, Cyril and O'Sullivan, James and Orcesi, Simona and Picco, Paolo P and Riva, Enrica and Robinson, Robert A and Rodriguez, Diana and Salvatici, Elisabetta and Scott, Christiaan and Szybowska, Marta and Tolmie, John L and Vanderver, Adeline and Vanhulle, Catherine and Vieira, Jose Pedro and Webb, Kate and Whitney, Robyn N and Williams, Simon G and Wolfe, Lynne A and Zuberi, Sameer M and Hur, Sun and Crow, Yanick J
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 5, pp. 503 - 509
The type I interferon system is integral to human antiviral immunity. However, inappropriate stimulation or defective negative regulation of this system can... 
AICARDI-GOUTIERES-SYNDROME | DYSCHROMATOSIS SYMMETRICA HEREDITARIA | LUPUS | AUTOIMMUNITY | TREX1 | GENETICS & HEREDITY | DISORDERS | MICE | MDA5 FILAMENTS | DSRNA RECOGNITION | EXPRESSION SIGNATURE | Nervous System Malformations - immunology | Humans | Models, Molecular | Molecular Sequence Data | Signal Transduction - genetics | Interferon Type I - immunology | Mutation - genetics | Sequence Analysis, DNA | Interferon-Induced Helicase, IFIH1 | Microsatellite Repeats - genetics | Autoimmune Diseases of the Nervous System - immunology | DEAD-box RNA Helicases - genetics | Exome - genetics | Phenotype | Analysis of Variance | Base Sequence | Autoimmune Diseases of the Nervous System - genetics | HEK293 Cells | Electrophoretic Mobility Shift Assay | Nervous System Malformations - genetics | Spectrum Analysis | DEAD-box RNA Helicases - chemistry | Real-Time Polymerase Chain Reaction | Cell receptors | Gene mutations | Interferon | Genetic aspects | Genetic regulation | Health aspects | Proteins | Studies | Genotype & phenotype | Hospitals | Biomedical research | Disease | Womens health | Pathogenesis | Families & family life | Genomes | Mutation
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16. Full Text Protein Kinase Cδ Deficiency Causes Mendelian Systemic Lupus Erythematosus With B Cell‐Defective Apoptosis and Hyperproliferation
by Belot, Alexandre and Kasher, Paul R and Trotter, Eleanor W and Foray, Anne‐Perrine and Debaud, Anne‐Laure and Rice, Gillian I and Szynkiewicz, Marcin and Zabot, Marie‐Therese and Rouvet, Isabelle and Bhaskar, Sanjeev S and Daly, Sarah B and Dickerson, Jonathan E and Mayer, Josephine and O'Sullivan, James and Juillard, Laurent and Urquhart, Jill E and Fawdar, Shameem and Marusiak, Anna A and Stephenson, Natalie and Waszkowycz, Bohdan and W. Beresford, Michael and Biesecker, Leslie G and C. M. Black, Graeme and René, Céline and Eliaou, Jean‐François and Fabien, Nicole and Ranchin, Bruno and Cochat, Pierre and Gaffney, Patrick M and Rozenberg, Flore and Lebon, Pierre and Malcus, Christophe and Crow, Yanick J and Brognard, John and Bonnefoy, Nathalie
Arthritis & Rheumatism, ISSN 0004-3591, 08/2013, Volume 65, Issue 8, pp. 2161 - 2171
Systemic lupus erythematosus (SLE) is a prototype autoimmune disease that is assumed to occur via a complex interplay of environmental and genetic factors.... 
Lupus Erythematosus, Systemic - enzymology | Cell Proliferation | Humans | Hyperplasia | Protein Kinase C-delta - deficiency | Immune Tolerance | Male | Mutation, Missense | Protein Kinase C-delta - immunology | Genetic Variation | Young Adult | Homozygote | B-Lymphocytes - immunology | Lupus Erythematosus, Systemic - genetics | Adolescent | Adult | Female | Polymorphism, Single Nucleotide | B-Lymphocytes - pathology | Child | Lupus Erythematosus, Systemic - pathology | Protein Kinase C-delta - genetics | B-Lymphocytes - metabolism | Apoptosis | Life Sciences | Microbiology and Parasitology | Immunology | Bacteriology | Virology
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17. Full Text Podocytes contribute, and respond, to the inflammatory environment in lupus nephritis
by Wright, Rachael D and Beresford, Michael W
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 12/2018, Volume 315, Issue 6, pp. F1683 - F1694
Lupus nephritis (LN) affects up to 80% of juvenile onset systemic lupus erythematosus patients, leading to end stage renal failure requiring dialysis or... 
Biomarkers | Podocytes | Effacement | Inflammation | Lupus nephritis | RECRUITMENT | PHYSIOLOGY | M-CSF | biomarkers | URINARY-EXCRETION | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | VEGF-A | ERYTHEMATOSUS | DISEASE-ACTIVITY | inflammation | podocytes | effacement | MURINE LUPUS | UROLOGY & NEPHROLOGY | lupus nephritis | EXPRESSION
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18. Full Text Urine biomarkers in juvenile-onset SLE nephritis
by Watson, Louise and Beresford, Michael W
Pediatric Nephrology, ISSN 0931-041X, 3/2013, Volume 28, Issue 3, pp. 363 - 374
Over 80 % of patients with juvenile-onset systemic lupus erythematosus will have renal involvement compared to 40 % with adult-onset disease. Up to 44 % of... 
NGAL | Pediatrics | Nephritis | Biomarker | Systemic lupus erythematosus | MCP1 | Medicine & Public Health | TGF-β | ANTI-C1Q ANTIBODIES | SYSTEMIC-LUPUS-ERYTHEMATOSUS | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | GELATINASE-ASSOCIATED LIPOCALIN | CYTOKINE GENE-EXPRESSION | INITIAL VALIDATION | GLOMERULAR-FILTRATION-RATE | TGF-beta | MESSENGER-RNA | DISEASE-ACTIVITY INDEX | CHILDHOOD-ONSET | UROLOGY & NEPHROLOGY | PEDIATRICS | Predictive Value of Tests | Biomarkers - urine | Lupus Nephritis - genetics | Urinalysis | Humans | Immunosuppressive Agents - therapeutic use | Lupus Nephritis - drug therapy | Treatment Outcome | Genetic Markers | Disease Progression | Kidney Function Tests | Animals | Time Factors | Age of Onset | Lupus Nephritis - urine | Lupus Nephritis - epidemiology | Child | Early Diagnosis | Lupus Nephritis - diagnosis | Care and treatment | Usage | Diagnosis | Biological markers | Risk factors
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