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Nature Chemical Biology, ISSN 1552-4450, 08/2015, Volume 11, Issue 8, pp. 611 - 617
The current predominant therapeutic paradigm is based on maximizing drug-receptor occupancy to achieve clinical benefit. This strategy, however, generally... 
CHIMERIC MOLECULES | CHEMICAL PROTEOMICS | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESTROGEN-RECEPTOR-ALPHA | KINASE INHIBITORS | CARD15 MUTATIONS | BLAU-SYNDROME | ABSOLUTE QUANTIFICATION | LIGASE COMPLEX | CELL-DEATH | Neoplasm Transplantation | Small Molecule Libraries - pharmacology | Receptors, Estrogen - metabolism | Humans | Ubiquitin - metabolism | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Breast Neoplasms - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Ubiquitination | MCF-7 Cells | Proteolysis | Female | Antineoplastic Agents - pharmacology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Neoplasm Proteins - genetics | Binding Sites | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Biocatalysis | Receptors, Estrogen - genetics | Models, Molecular | Receptors, Estrogen - antagonists & inhibitors | Ubiquitin - genetics | Breast Neoplasms - drug therapy | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Protein Binding | Mice | Proteasome Endopeptidase Complex - metabolism | Proteins | Molecular biology | Biocatalysts | Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 12/2018, Volume 564, Issue 7736, pp. 439 - 443
Journal Article
Advanced Functional Materials, ISSN 1616-301X, 08/2018, Volume 28, Issue 32, pp. 1801946 - n/a
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 6 - 6
Journal Article
Surgical Endoscopy, ISSN 0930-2794, 4/2017, Volume 31, Issue 4, pp. 1785 - 1795
Journal Article
Gynecologic Oncology, ISSN 0090-8258, 12/2018, Volume 151, Issue 3, pp. 449 - 452
To compare clinical outcomes of patients diagnosed with low-risk gestational trophoblastic neoplasia (GTN) receiving intramuscular methotrexate 50 mg total... 
Chemotherapy resistance | Methotrexate | Low-risk | Gestational trophoblastic neoplasia | Medicine, Experimental | Medical research | Chemotherapy | Body weight | Cancer | Index Medicus
Journal Article
Lancet, The, ISSN 0140-6736, 2012, Volume 380, Issue 9847, pp. 1059 - 1065
Journal Article