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multiple myeloma - genetics (78) 78
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Leukemia, ISSN 0887-6924, 08/2019
The canonical plasma cell marker CD138 (syndecan-1) is highly expressed on the myeloma cell surface, but its functional role in vivo is unclear, as well as the... 
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2015, Volume 21, Issue 17 Supplement, pp. IA25 - IA25
Journal Article
Science Translational Medicine, ISSN 1946-6234, 2019, Volume 11, Issue 494, p. eaau9087
Osteolytic lesions in multiple myeloma are caused by osteoclast-mediated bone resorption and reduced bone formation. A unique feature of myeloma is a failure... 
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2012, Volume 122, Issue 10, pp. 3456 - 3463
Multiple myeloma is a monoclonal tumor of plasma cells, and its development is preceded by a premalignant tumor with which it shares genetic abnormalities,... 
LIGHT-CHAIN RATIO | MEDICINE, RESEARCH & EXPERIMENTAL | RAS MUTATIONS | BONE-MARROW | GENE-EXPRESSION | PLASMA-CELL LEUKEMIA | MONOCLONAL GAMMOPATHY | KAPPA-B PATHWAY | FLOW-CYTOMETRY | UNDETERMINED SIGNIFICANCE MGUS | INDEPENDENT RISK-FACTOR | Precancerous Conditions - etiology | Translocation, Genetic | Monoclonal Gammopathy of Undetermined Significance - genetics | Humans | Neoplasm Proteins - physiology | Tumor Microenvironment | Oncogene Proteins, Fusion - physiology | Cyclin D1 - physiology | Neoplastic Stem Cells - pathology | Precancerous Conditions - pathology | Osteoclasts - physiology | Neoplasm Proteins - genetics | Retinoblastoma Protein - physiology | Stem Cell Niche | Genes, Retinoblastoma | Genes, bcl-1 | Monoclonal Gammopathy of Undetermined Significance - etiology | Immunophenotyping | Signal Transduction - genetics | Precancerous Conditions - genetics | Disease Progression | Drug Resistance, Neoplasm - genetics | Multiple Myeloma - etiology | Multiple Myeloma - pathology | Monoclonal Gammopathy of Undetermined Significance - pathology | Cell Transformation, Neoplastic | Models, Biological | Oncogene Proteins, Fusion - genetics | Signal Transduction - physiology | Bone Remodeling | Immunoglobulin Heavy Chains - genetics | Multiple Myeloma - genetics | Immunoglobulins | Gene mutations | Multiple myeloma | Physiological aspects | Genetic aspects | Research | Health aspects | Risk factors | Review Series
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 4480 - 4480
Abstract Background and Aims. Despite the fact that the myeloma mutational landscape was elucidated several years ago, there are yet no approved precision... 
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 415 - 415
Abstract A genetic rearrangement of the MYC locus, resulting in dysregulated expression of MYC, is the most common mutation in human multiple myeloma (MM). The... 
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 4458 - 4458
Abstract Monoclonal gammopathies, including multiple myeloma (MM), represent a group of plasma cell (PC) disorders that comprise of mostly incurable... 
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 3018 - 3018
Journal Article
Cell, ISSN 0092-8674, 2011, Volume 146, Issue 6, pp. 904 - 917
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 5489 - 5489
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 21, pp. 1850 - 1850
Abstract Deletions of chromosome 13 occur in about 50% of multiple myeloma (MM) patients, with monosomy being the most common (85%), and small interstitial... 
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 09/2005, Volume 23, Issue 26, pp. 6333 - 6338
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2012, Volume 122, Issue 10, p. 3456
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2012, Volume 122, Issue 10, pp. 3456 - 3456
Multiple myeloma is a monoclonal tumor of plasma cells, and its development is preceded by a premalignant tumor with which it shares genetic abnormalities,... 
Journal Article
International Journal of Hematology, ISSN 0925-5710, 3/2013, Volume 97, Issue 3, pp. 313 - 323
Multiple myeloma is divided into two distinct genetic subtypes based on chromosome content. Hyperdiploid myeloma is characterized by multiple trisomies of... 
Prognosis | Treatment | Medicine & Public Health | Hematology | Pathogenesis | Multiple myeloma | Oncology | Genetics | INTERGROUPE FRANCOPHONE | PROGNOSTIC-FACTOR | RAS MUTATIONS | GENE-EXPRESSION | UNDETERMINED SIGNIFICANCE | TOTAL THERAPY 3 | MONOCLONAL GAMMOPATHY | KAPPA-B PATHWAY | STEM-CELL TRANSPLANTATION | HEMATOLOGY | HISTONE METHYLTRANSFERASE | Translocation, Genetic | United States - epidemiology | ras Proteins - genetics | Trisomy | Cell Proliferation | Multiple Myeloma - mortality | Humans | Antineoplastic Agents - therapeutic use | Pyrazines - therapeutic use | Boronic Acids - therapeutic use | Incidence | Immunoglobulin M - metabolism | ras Proteins - biosynthesis | Multiple Myeloma - drug therapy | Proto-Oncogene Proteins c-myc - biosynthesis | Gene Expression Regulation, Neoplastic - genetics | Immunoglobulin M - genetics | Bortezomib | Chromosomes, Human - genetics | Risk Factors | Survival Rate | Chromosomes, Human - metabolism | Multiple Myeloma - metabolism | Disease-Free Survival | Multiple Myeloma - pathology | Animals | Proto-Oncogene Proteins B-raf - biosynthesis | Proto-Oncogene Proteins B-raf - genetics | Sex Factors | Cyclin D - biosynthesis | Proto-Oncogene Proteins c-myc - genetics | Somatic Hypermutation, Immunoglobulin - genetics | Cyclin D - genetics | Multiple Myeloma - genetics | Immunoglobulins | Genetic transcription | Genes
Journal Article
Mayo Clinic Proceedings, ISSN 0025-6196, 2013, Volume 88, Issue 4, pp. 360 - 376
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 4629 - 4629
Abstract Introduction: Hematologic response (HR) particularly complete response (CR) is critical in patients (pts) with AL since it improves overall survival... 
Journal Article
Nature, ISSN 0028-0836, 02/2011, Volume 470, Issue 7332, pp. 124 - 129
Journal Article