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PLoS Genetics, ISSN 1553-7390, 12/2007, Volume 3, Issue 12, pp. 2381 - 2394
Protein Phosphatase type 2A (PP2A) represents a family of holoenzyme complexes with diverse biological activities. Specific holoenzyme complexes are thought to... 
SIGNAL-TRANSDUCTION | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | SERINE/THREONINE PHOSPHATASE | N-TERMINAL KINASE | GENETICS & HEREDITY | FAMILY KINASES | MIDDLE TUMOR-ANTIGEN | ADENOVIRUS E4ORF4 PROTEIN | OKADAIC ACID | TYROSINE-PHOSPHATASE | Genetics and Genomics | In Vitro | Mammals | Homo (human)
Journal Article
The EMBO Journal, ISSN 0261-4189, 09/1994, Volume 13, Issue 17, pp. 4080 - 4086
The product of the c‐myc proto‐oncogene, c‐Myc, is a sequence‐specific DNA binding protein with an N‐terminal transactivation domain and a C‐terminal DNA... 
pRb | p107 | c-Myc | Transactivation | TRANSFORMATION | PRB | DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACTIVATES TRANSCRIPTION | C-MYC | P107 | CELL BIOLOGY | ADENOVIRUS E1A PROTEINS | PHASE | TRANSACTIVATION | RETINOBLASTOMA GENE-PRODUCT | E2F | CELL-CYCLE | EXPRESSION | BINDING
Journal Article
Journal Article
Physical Review C - Nuclear Physics, ISSN 0556-2813, 11/2011, Volume 84, Issue 5
Journal Article
by Woudt, Sjoukje H. S and de Greeff, Sabine C and Schoffelen, Annelot F and Vlek, Anne L. M and Bonten, Marc J. M and Cohen Stuart, J. W. T and Weersink, A. J. L and Vandenbroucke-Grauls, C. M. J. E and Visser, C. E and van Ogtrop, M. L and Kaersenhout, D. J and Scholing, M and van Hees, B. C and van Keulen, P. H. J and Kluytmans, J. A. J. W and Kraan, E. M and Mattsson, E. E and Sebens, F. W and de Jong, E and Frénay, H. M. E and Maraha, B and van Griethuysen, A. J and Silvis, W and Demeulemeester, A and Wintermans, B. B and van Trijp, M and Ott, A and Arends, J. P and Kampinga, G. A and Veenendaal, D and Hol, C and de Brauwer, E. I. G. B and Stals, F. S and Bakker, L. J and Dorigo-Zetsma, J. W and Ridwan, B and van Zeijl, J. H and Bernards, A. T and Erkens-Hulshof, S and de Jongh, B. M and Vlaminckx, B. J. M and Nabuurs-Franssen, M. H and Kuipers, S and Diederen, B. M. W and Melles, D. C and van Rijn, M and Dinant, S and Pontesilli, O and de Man, P and Vaessen, N and Leversteijn-van Hall, M. A and van Elzakker, E. P. M and Muller, A. E and Renders, N. H and van Dam, D. W and Buiting, A. G. M and Vlek, A. L. M and Deege, M. P. D and Frakking, F. N. J and Overdevest, I. T. M. A and Bosboom, R. W and Trienekens, T and Voorn, G. P and Ruijs, G. J. H. M and Wolfhagen, M. J. H. M and Alblas, J and Altorf-van der Kuil, W and Blijboom, L and Groenendijk, S and van Heereveld, J and Hertroys, R and Monen, J. C and Notermans, D. W and Reuland, E. A and van Triest, M. I and Wielders, C. C. H and Infectious Diseases Surveillance Information System–Antimicrobial Resistance (ISIS-AR) Study Group
Clinical infectious diseases, ISSN 1058-4838, 2018, Volume 66, Issue 11, pp. 1651 - 1657
Background Direct health effects of antibiotic resistance are difficult to assess. We quantified the risk of recurrent bacteremia associated with resistance.... 
recurrent bacteremia | antibiotic resistance | population attributable effect | acquired antibiotic resistance | and Commentaries
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2015, Volume 25, Issue 4, pp. 445 - 458
Recurrent inactivating mutations in components of SWI/SNF chromatin-remodeling complexes have been identified across cancer types, supporting their roles as... 
ALK | 抑制剂 | 控制 | 肿瘤抑制 | 表皮生长因子 | 非小细胞肺癌 | MET | EGFR | Signal Transduction | Carcinoma, Non-Small-Cell Lung | Humans | Proto-Oncogene Proteins c-met | Chromosomal Proteins, Non-Histone | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Quinazolines | Lung Neoplasms | Receptor Protein-Tyrosine Kinases | EGFR signaling | Polycomb Repressive Complex 1 | Cell Line, Tumor | Mutation | drug resistance | RNAi screening | DNA-Binding Proteins | Receptor, Epidermal Growth Factor | SMARCE1 | Drug resistance | SWI/SNF | ACTIVATION | BRAF(V600E) INHIBITION | GERM-LINE | REMODELING GENE ARID1A | SOMATIC MUTATIONS | CELL BIOLOGY | SMALL-CELL CARCINOMA | HYPERCALCEMIC TYPE | RESISTANCE | DIFFERENTIATION | HSNF5/INI1 | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Lung Neoplasms - pathology | Polycomb Repressive Complex 1 - biosynthesis | Chromosomal Proteins, Non-Histone - biosynthesis | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Quinazolines - administration & dosage | Gene Expression Regulation, Neoplastic - drug effects | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Receptor, Epidermal Growth Factor - biosynthesis | Carcinoma, Non-Small-Cell Lung - genetics | Proto-Oncogene Proteins c-met - antagonists & inhibitors | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Proto-Oncogene Proteins c-met - genetics | Drug Resistance, Neoplasm - genetics | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - drug therapy | DNA-Binding Proteins - biosynthesis | Drug Resistance, Neoplasm - drug effects | Index Medicus | SWI | SNF | Original
Journal Article
Journal Article
Genome Medicine, ISSN 1756-994X, 11/2018, Volume 10, Issue 1, pp. 90 - 13
BACKGROUND: Mutations in KRAS are frequent in human cancer, yet effective targeted therapeutics for these cancers are still lacking. Attempts to drug the MEK... 
Humans | Proto-Oncogene Proteins p21(ras)/genetics | MAP Kinase Kinase Kinases/antagonists & inhibitors | Endoribonucleases/genetics | Unfolded Protein Response | Protein-Serine-Threonine Kinases/genetics | Proto-Oncogene Proteins c-jun/genetics | Pyrimidinones/pharmacology | Antineoplastic Agents/pharmacology | Benzimidazoles/pharmacology | Endoplasmic Reticulum Stress | HEK293 Cells | Cell Line, Tumor | Pyridones/pharmacology | Protein Kinase Inhibitors/pharmacology | Colonic Neoplasms/drug therapy | Yeasts/genetics | ERN1 | JUN | MEK inhibitor | Colon cancer | JNK | Ire1 | COMPLEX | ACTIVATION | XBP1 MESSENGER-RNA | IDENTIFICATION | GENOME | RUNX2 | COP1 | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | C-JUN | SERINE/THREONINE KINASE | Colonic Neoplasms - genetics | Endoribonucleases - genetics | MAP Kinase Kinase Kinases - genetics | Proto-Oncogene Proteins c-jun - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Colonic Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - genetics | Yeasts - genetics | Benzimidazoles - pharmacology | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | MAP Kinase Kinase Kinases - antagonists & inhibitors | Pyridones - pharmacology | Immune response | Gene mutations | Clinical trials | Genetic aspects | Stress (Physiology) | Research | Endoplasmic reticulum | Yeast | Colorectal carcinoma | Colorectal cancer | Genomes | Drug development | Kinases | Genetic screening | K-Ras protein | Proteins | Signal transduction | Gene disruption | Protein folding | Colon | Sensors | CRISPR | Ploidy | Tumor cells | TAK1 protein | MEK inhibitors | Tumor cell lines | Gene expression | Cell lines | Mutation
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article