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Nature, ISSN 0028-0836, 04/2019, Volume 568, Issue 7753, pp. 458 - 458
Journal Article
Cancer Research, ISSN 0008-5472, 09/2011, Volume 71, Issue 18 Supplement, pp. IA26 - IA26
Journal Article
Nature, ISSN 0028-0836, 2002, Volume 418, Issue 6900, pp. 823 - 823
Most, if not all, human tumours develop through a succession of genetic and epigenetic changes that confer increasingly neoplastic (cancer-like)... 
Neoplasm Metastasis - genetics | Clone Cells - pathology | Neoplasms - genetics | Models, Biological | Cell Division | Humans | Neoplasms - pathology | Disease Progression | Apoptosis | Cell division | Mutation | Tumors | Index Medicus
Journal Article
Nature medicine, ISSN 1078-8956, 2015, Volume 21, Issue 11, pp. 1350 - 1356
Journal Article
The EMBO Journal, ISSN 0261-4189, 05/2018, Volume 37, Issue 10, pp. e99386 - n/a
Cellular senescence is a natural safeguard against cancer. Pharmacologically, it can be induced by drugs that inhibit the CDK 4/6 kinases such as palbociclib,... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Pyridines | Piperazines | Humans | Proteome | Breast Neoplasms | Cyclin-Dependent Kinase 4 | Proteasome Endopeptidase Complex | Drugs | Senescence | Pharmacology | Kinases | Cyclin-dependent kinase 4 | Cancer | Index Medicus | Views | Post-translational Modifications, Proteolysis & Proteomics | Molecular Biology of Disease
Journal Article
Cancer Discovery, ISSN 2159-8274, 2014, Volume 4, Issue 4, pp. 392 - 393
KIF1B is a candidate tumor-suppressor gene in neuroblastoma whose function is to mediate apoptosis when nerve growth factor becomes limiting in the developing... 
NEURONAL APOPTOSIS | PHEOCHROMOCYTOMA | ONCOLOGY | Animals | Humans | Neuroblastoma - genetics | Nerve Growth Factor - genetics | DEAD-box RNA Helicases - metabolism | Neoplasm Proteins - metabolism | Kinesin - metabolism | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 10/2012, Volume 151, Issue 3, pp. 465 - 468
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2012, Volume 18, Issue 10_Supplement, pp. IA13 - IA13
Unresponsiveness to therapy remains a significant problem in the treatment of cancer, also with the new classes of cancer drugs. In my laboratory, we use... 
Journal Article
2012, ISBN 364216482X, Volume 2, 3
Reference