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by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Toxicon, ISSN 0041-0101, 12/2016, Volume 123, pp. S61 - S61
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 2017, Volume 591, Issue 22, p. 3781
Botulinum neurotoxins are highly toxic substances and are all encoded together with one of two alternative gene clusters, the HA or the OrfX gene cluster. Very... 
Biological Sciences | Naturvetenskap | Biokemi och molekylärbiologi | TULIP | Biologiska vetenskaper | Biochemistry and Molecular Biology | Natural Sciences | X-ray | gene cluster | botulinum neurotoxin | Crystallography
Journal Article
Protein Science, ISSN 0961-8368, 05/2009, Volume 18, Issue 5, pp. 1121 - 1127
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2012, Volume 109, Issue 35, pp. 13990 - 13995
Journal Article
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2018, Volume 114, Issue 3, pp. 90a - 90a
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1541 - 17
The NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as mRNA processing. Although highly conserved throughout all organisms, their... 
HMTH1 PROTEIN | MOTIF 2 | OXIDATIVE STRESS | HUMAN MTH1 | MESSENGER-RNA | OXIDIZED FORMS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | GENETIC INTERACTION | HUMAN MUTT HOMOLOG | PROTEIN HYDROLYZES | A549 Cells | Cell Line | Multigene Family | Pyrophosphatases - classification | Humans | Gene Expression Regulation, Neoplastic | Pyrophosphatases - genetics | Substrate Specificity | Gene Expression Profiling - methods | Phylogeny | Gene Regulatory Networks | Gene Expression Regulation, Enzymologic | Pyrophosphatases - metabolism | MCF-7 Cells | RNA Interference | Cell Line, Tumor | Hydrolase | Nucleotide sequence | mRNA processing | Redundancy | Homeostasis | Epistasis | Gene expression | Metabolism | Tissues | Substrates | Proteins | Cell cycle | Crystal structure | Cancer | Index Medicus | NUDT4 protein | phylogenetic tree | NUDT21 protein | Medical and Health Sciences | Nudix hydrolase | NUDT6 protein | functional genomics | DNA content | enzyme structure | enzyme activity | NUDT8 protein | protein | upregulation | cancer cell line | protein expression | algorithm | NUDT14 protein | colorectal cancer | cancer tissue | Medicinsk bioteknologi | gene silencing | melanoma | human cell | NUDT17 protein | biochemical composition | NUDT12 protein | Medical Biotechnology | NUDT10 protein | NUDT19 protein | metabolism | gene expression | unclassified drug | NUDT5 protein | sequence alignment | Medicin och hälsovetenskap | NUDT22 protein | tissue microarray | Article | NUDT1 protein | NUDT7 protein | NUDT20 protein | NUDT16 protein | gene interaction | immunohistochemistry | human | enzyme | cell survival | human tissue | cell cycle | NUDT13 protein | breast cancer | NUDT11 protein | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | homeostasis | A-549 cell line | controlled study | cancer | cell cycle regulation
Journal Article
FEBS Letters, ISSN 0014-5793, 10/2010, Volume 584, Issue 20, pp. 4373 - 4373
Shortly after our publication, Dr. Gavin Thomas informed usthat four proteins (BugD, BugE, Bug27 and TT1099), belonging tothe TAXI and TTT families of... 
Journal Article