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1. Full Text Protective CD8 + T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation
by Ewer, Katie J and O'Hara, Geraldine A and Duncan, Christopher J. A and Collins, Katharine A and Sheehy, Susanne H and Reyes-Sandoval, Arturo and Goodman, Anna L and Edwards, Nick J and Elias, Sean C and Halstead, Fenella D and Longley, Rhea J and Rowland, Rosalind and Poulton, Ian D and Draper, Simon J and Blagborough, Andrew M and Berrie, Eleanor and Moyle, Sarah and Williams, Nicola and Siani, Loredana and Folgori, Antonella and Colloca, Stefano and Sinden, Robert E and Lawrie, Alison M and Cortese, Riccardo and Gilbert, Sarah C and Nicosia, Alfredo and Hill, Adrian V. S
Nature Communications, ISSN 2041-1723, 11/2013, Volume 4, Issue 1, p. 2836
Induction of antigen-specific CD8(+) T cells offers the prospect of immunization against many infectious diseases, but no subunit vaccine has induced CD8(+) T... 
NONHUMAN-PRIMATES | PRIME-BOOST IMMUNIZATION | MEDIATED PROTECTION | POLYMERASE-CHAIN-REACTION | VACCINIA VIRUS ANKARA | DNA VACCINES | RHESUS-MONKEYS | MULTIDISCIPLINARY SCIENCES | INFLUENZA-VIRUS | NAIVE ADULTS | PHASE 2A TRIAL | Adenoviruses, Simian - immunology | Malaria, Falciparum - prevention & control | Humans | Middle Aged | Male | Leukocytes, Mononuclear | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Vaccinia virus - genetics | Vaccinia virus - immunology | Adenoviruses, Simian - genetics | Young Adult | Immunization, Secondary | Plasmodium falciparum - genetics | Malaria Vaccines - immunology | Adult | Female | Immunization | Genetic Vectors - immunology | Antibodies, Protozoan - immunology | Genetic Vectors - genetics | Malaria, Falciparum - parasitology | Animals | Malaria Vaccines - administration & dosage | Interferon-gamma - immunology | Adolescent | Malaria, Falciparum - immunology | CD8-Positive T-Lymphocytes - immunology | Immunity, Cellular | Protozoan Proteins - immunology | Malaria Vaccines - genetics
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2. Full Text A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA
by Ewer, Katie and Rampling, Tommy and Venkatraman, Navin and Bowyer, Georgina and Wright, Danny and Wright, Edward and Lambe, Teresa and Imoukhuede, Egeruan B and Payne, Ruth and Fehling, Sarah Katharina and Strecker, Thomas and Biedenkopf, Nadine and Krähling, Verena and Tully, Claire M and Edwards, Nick J and Bentley, Emma M and Samuel, Dhanraj and Labbé, Geneviève and Jin, Jing and Gibani, Malick and Minhinnick, Alice and Wilkie, Morven and Poulton, Ian and Lella, Natalie and Roberts, Rachel and Hartnell, Felicity and Bliss, Carly and Sierra-Davidson, Kailan and Powlson, Jonathan and Berrie, Eleanor and Tedder, Richard and Roman, Francois and De Ryck, Iris and Nicosia, Alfredo and Sullivan, Nancy J and Stanley, Daphne A and Mbaya, Olivier T and Ledgerwood, Julie E and Schwartz, Richard M and Siani, Loredana and Colloca, Stefano and Folgori, Antonella and Di Marco, Stefania and Cortese, Riccardo and Becker, Stephan and Graham, Barney S and Koup, Richard A and Levine, Myron M and Volkmann, Ariane and Chaplin, Paul and Pollard, Andrew J and Draper, Simon J and Ballou, W. Ripley and Lawrie, Alison and Gilbert, Sarah C and Hill, Adrian V.S
The New England Journal of Medicine, ISSN 0028-4793, 04/2016, Volume 374, Issue 17, pp. 1635 - 1646
In this phase 1 study involving 76 healthy volunteers in England, a single dose of a monovalent chimpanzee adenovirus vaccine elicited immune responses to... 
T-Lymphocytes - physiology | Adenoviruses, Simian - immunology | Hemorrhagic Fever, Ebola - prevention & control | Humans | Middle Aged | B-Lymphocytes - physiology | Ebola Vaccines - administration & dosage | Male | Pan troglodytes | Antibodies, Viral - blood | Ebolavirus - immunology | Young Adult | Animals | Immunization, Secondary | Adult | Ebola Vaccines - immunology | Female | Hemorrhagic Fever, Ebola - immunology | Immunity, Cellular | Vaccinia | Cytokines - blood | Ebola virus | Research | T cells | Adenoviruses | Immunization | CD8 antigen | Vaccination | Antibodies | Outbreaks | Lymphocytes T | Vaccines | Monkeys & apes | Studies | Stomatitis | Lymphocytes B | Virions
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3. Full Text Vaccine-elicited Human T Cells Recognizing Conserved Protein Regions Inhibit HIV-1
by Borthwick, Nicola and Ahmed, Tina and Ondondo, Beatrice and Hayes, Peter and Rose, Annie and Ebrahimsa, Umar and Hayton, Emma-Jo and Black, Antony and Bridgeman, Anne and Rosario, Maximillian and Hill, Adrian VS and Berrie, Eleanor and Moyle, Sarah and Frahm, Nicole and Cox, Josephine and Colloca, Stefano and Nicosia, Alfredo and Gilmour, Jill and McMichael, Andrew J and Dorrell, Lucy and Hanke, Tomáš
Molecular Therapy, ISSN 1525-0016, 02/2014, Volume 22, Issue 2, pp. 464 - 475
Virus diversity and escape from immune responses are the biggest challenges to the development of an effective vaccine against HIV-1. We hypothesized that... 
MEDICINE, RESEARCH & EXPERIMENTAL | EFFICACY | STEP TRIAL | INDUCTION | GAG | ESCAPE | RESPONSES | REPLICATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PLASMID DNA | GENETICS & HEREDITY | IMMUNODEFICIENCY-VIRUS TYPE-1 | INFECTION | T-Lymphocyte Subsets - immunology | Epitope Mapping | HIV Infections - prevention & control | Vaccines, DNA - genetics | Humans | Middle Aged | AIDS Vaccines - immunology | Vaccines, DNA - immunology | pol Gene Products, Human Immunodeficiency Virus - immunology | Molecular Sequence Data | Male | Young Adult | HIV Infections - immunology | T-Cell Antigen Receptor Specificity - immunology | Adult | Female | Conserved Sequence - immunology | Epitopes, T-Lymphocyte - immunology | Amino Acid Sequence | Cells, Cultured | Virus Replication - immunology | HIV-1 - genetics | Epitopes, T-Lymphocyte - chemistry | HIV-1 - immunology | Adolescent | AIDS Vaccines - genetics | T-Lymphocytes - immunology | gag Gene Products, Human Immunodeficiency Virus - immunology | Original
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4. Full Text Haemopoietic stem-cell transplantation with antibody-based minimal-intensity conditioning: a phase 1/2 study
by Straathof, Karin C, MRCPCH and Rao, Kanchan, MRCPCH and Eyrich, Matthias, MD and Hale, Geoff, PhD and Bird, Prudence, PhD and Berrie, Eleanor, PhD and Brown, Lucinda and Adams, Stuart, PhD and Schlegel, Paul G, FRCP and Goulden, Nicholas, FRCPCH and Gaspar, H Bobby, Prof and Gennery, Andrew R, MD and Landais, Paul, MD and Davies, EG, FRCPCH and Brenner, Malcolm K, Prof and Veys, Paul A, FRCPCH and Amrolia, Persis Jal, Dr
Lancet, The, ISSN 0140-6736, 2009, Volume 374, Issue 9693, pp. 912 - 920
Summary Background Stem-cell transplantation can cure primary immunodeficiencies. However, in patients with pre-existing organ toxicity, patients younger than... 
Internal Medicine | TOTAL-BODY IRRADIATION | REDUCED-INTENSITY | MEDICINE, GENERAL & INTERNAL | SEVERE COMBINED IMMUNODEFICIENCY | BONE-MARROW-TRANSPLANTATION | IMMUNE RECONSTITUTION | DYSKERATOSIS-CONGENITA | DNA-LIGASE IV | ACUTE MYELOID-LEUKEMIA | MONOCLONAL-ANTIBODIES | NONMALIGNANT DISEASES | Antibodies, Neoplasm - therapeutic use | Graft vs Host Disease - epidemiology | Follow-Up Studies | Humans | Immunosuppressive Agents - therapeutic use | Child, Preschool | Antibodies, Monoclonal - therapeutic use | Infant | Male | Cyclophosphamide - therapeutic use | Transplantation Conditioning - mortality | Antibodies, Monoclonal, Humanized | Hematopoietic Stem Cell Transplantation - adverse effects | Female | Transplantation Conditioning - adverse effects | Transplantation Conditioning - methods | Graft vs Host Disease - etiology | Immunologic Deficiency Syndromes - therapy | Kaplan-Meier Estimate | Rats | Treatment Outcome | Vidarabine - analogs & derivatives | Alemtuzumab | Vidarabine - therapeutic use | Transplantation Chimera | Leukocyte Common Antigens - antagonists & inhibitors | Disease-Free Survival | Animals | Graft vs Host Disease - prevention & control | Hematopoietic Stem Cell Transplantation - methods | Immunologic Factors - therapeutic use | Care and treatment | Usage | Patient outcomes | Immunodeficiency | Stem cells | Transplantation | Children | Health aspects | Diseases | Bone marrow | Medical research | Transplants & implants | Mortality | Metabolic disorders | Index Medicus | Abridged Index Medicus
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5. Full Text Clinical Assessment of a Recombinant Simian Adenovirus ChAd63: A Potent New Vaccine Vector
by Geraldine A. O'Hara and Christopher J. A. Duncan and Katie J. Ewer and Katharine A. Collins and Sean C. Elias and Fenella D. Halstead and Anna L. Goodman and Nick J. Edwards and Arturo Reyes-Sandoval and Prudence Bird and Rosalind Rowland and Susanne H. Sheehy and Ian D. Poulton and Claire Hutchings and Stephen Todryk and Laura Andrews and Antonella Folgori and Eleanor Berrie and Sarah Moyle and Alfredo Nicosia and Stefano Colloca and Riccardo Cortese and Loredana Siani and Alison M. Lawrie and Sarah C. Gilbert and Adrian V. S. Hill
The Journal of Infectious Diseases, ISSN 0022-1899, 3/2012, Volume 205, Issue 5, pp. 772 - 781
Background. Vaccine development in human Plasmodium falciparum malaria has been hampered by the exceptionally high levels of CD8⁺ T cells required for... 
T lymphocytes | Vaccinia virus | Volunteerism | Immunization | Immune response | Malaria | Vaccination | Adenoviruses | Enzyme linked immunospot assay | Immunity | VIRUSES | LIVER-STAGE MALARIA | INFECTIOUS DISEASES | PROTECTION | EFFICACY | VOLUNTEERS | CIRCUMSPOROZOITE PROTEIN | SPOROZOITES | MICROBIOLOGY | IMMUNOLOGY | VIRUS ANKARA | PRIME-BOOST IMMUNIZATION | PLASMODIUM-BERGHEI | T-CELLS | Interleukin-2 - metabolism | Tumor Necrosis Factor-alpha - metabolism | Adenoviruses, Simian - immunology | Humans | CD4-Positive T-Lymphocytes - metabolism | Vaccines, DNA - immunology | Epitopes | Interferon-gamma - metabolism | Vaccines, DNA - administration & dosage | Adenoviruses, Simian - genetics | Animals | Flow Cytometry | Malaria Vaccines - administration & dosage | Malaria Vaccines - adverse effects | Vaccines, DNA - adverse effects | Malaria Vaccines - immunology | Malaria, Falciparum - immunology | CD8-Positive T-Lymphocytes - metabolism | Antibodies, Neutralizing - blood | Protozoan Proteins - immunology | Major and Brief Reports
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6. Full Text Insulin Needs after CD3-Antibody Therapy in New-Onset Type 1 Diabetes
by Keymeulen, Bart and Vandemeulebroucke, Evy and Ziegler, Anette G and Mathieu, Chantal and Kaufman, Leonard and Hale, Geoff and Gorus, Frans and Goldman, Michel and Walter, Markus and Candon, Sophie and Schandene, Liliane and Crenier, Laurent and De Block, Christophe and Seigneurin, Jean-Marie and De Pauw, Pieter and Pierard, Denis and Weets, Ilse and Rebello, Peppy and Bird, Pru and Berrie, Eleanor and Frewin, Mark and Waldmann, Herman and Bach, Jean-François and Pipeleers, Daniel and Chatenoud, Lucienne
The New England Journal of Medicine, ISSN 0028-4793, 06/2005, Volume 352, Issue 25, pp. 2598 - 2608
This multicenter, phase 2, placebo-controlled trial involved the use of a humanized antibody — ChAglyCD3 — directed against CD3 in the treatment of new-onset... 
MEDICINE, GENERAL & INTERNAL | ANTI-CD3 MONOCLONAL-ANTIBODY | CD3 ANTIBODY | PREVENTION | IMMUNOSUPPRESSIVE PROPERTIES | MELLITUS | PHASE-I | INTERVENTION | MODULATION | SELF-TOLERANCE | REMISSION | Hypoglycemic Agents - therapeutic use | Herpesviridae - isolation & purification | Islets of Langerhans - drug effects | Blood Glucose - analysis | Autoantibodies - blood | Humans | Immunoglobulin G - therapeutic use | Islets of Langerhans - immunology | Male | Diabetes Mellitus, Type 1 - drug therapy | Immunoglobulin G - adverse effects | C-Peptide - biosynthesis | Diabetes Mellitus, Type 1 - blood | Adolescent | CD3 Complex - immunology | Islets of Langerhans - physiopathology | Adult | Female | Diabetes Mellitus, Type 1 - immunology | Glucose Clamp Technique | Child | Insulin - therapeutic use | Diabetes | Glucose | Peptides | Insulin | Patients
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7. Full Text ChAd63-MVA–vectored Blood-stage Malaria Vaccines Targeting MSP1 and AMA1: Assessment of Efficacy Against Mosquito Bite Challenge in Humans
by Sheehy, Susanne H and Duncan, Christopher JA and Elias, Sean C and Choudhary, Prateek and Biswas, Sumi and Halstead, Fenella D and Collins, Katharine A and Edwards, Nick J and Douglas, Alexander D and Anagnostou, Nicholas A and Ewer, Katie J and Havelock, Tom and Mahungu, Tabitha and Bliss, Carly M and Miura, Kazutoyo and Poulton, Ian D and Lillie, Patrick J and Antrobus, Richard D and Berrie, Eleanor and Moyle, Sarah and Gantlett, Katherine and Colloca, Stefano and Cortese, Riccardo and Long, Carole A and Sinden, Robert E and Gilbert, Sarah C and Lawrie, Alison M and Doherty, Tom and Faust, Saul N and Nicosia, Alfredo and Hill, Adrian VS and Draper, Simon J
Molecular Therapy, ISSN 1525-0016, 12/2012, Volume 20, Issue 12, pp. 2355 - 2368
The induction of cellular immunity, in conjunction with antibodies, may be essential for vaccines to protect against blood-stage infection with the human... 
APICAL MEMBRANE ANTIGEN-1 | MEDICINE, RESEARCH & EXPERIMENTAL | PROTECTION | PARASITE GROWTH | ANTIBODY | IN-VITRO | PHASE | POLYMERASE-CHAIN-REACTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PLASMODIUM-FALCIPARUM | IMMUNE-RESPONSES | GENETICS & HEREDITY | T-CELLS | Orthopoxvirus - immunology | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Pan troglodytes - virology | Humans | Culicidae - pathogenicity | Adenoviruses, Simian - genetics | Animals | Flow Cytometry | Malaria Vaccines - administration & dosage | Merozoite Surface Protein 1 - immunology | Malaria, Falciparum - immunology | Culicidae - parasitology | Malaria Vaccines - therapeutic use | Original
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8. Full Text Phase ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors
by Sheehy, Susanne H and Duncan, Christopher J. A and Elias, Sean C and Biswas, Sumi and Collins, Katharine A and O'Hara, Geraldine A and Halstead, Fenella D and Ewer, Katie J and Mahungu, Tabitha and Spencer, Alexandra J and Miura, Kazutoyo and Poulton, Ian D and Dicks, Matthew D. J and Edwards, Nick J and Berrie, Eleanor and Moyle, Sarah and Colloca, Stefano and Cortese, Riccardo and Gantlett, Katherine and Long, Carole A and Lawrie, Alison M and Gilbert, Sarah C and Doherty, Tom and Nicosia, Alfredo and Hill, Adrian V. S and Draper, Simon J
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e31208
Background: Traditionally, vaccine development against the blood-stage of Plasmodium falciparum infection has focused on recombinant protein-adjuvant... 
APICAL MEMBRANE ANTIGEN-1 | NATURAL IMMUNE-RESPONSES | VIRUS ANKARA | PRIME-BOOST IMMUNIZATION | IN-VITRO | MEROZOITE SURFACE PROTEIN-1 | BIOLOGY | ADJUVANT VACCINES | RHESUS-MACAQUES | PARASITE GROWTH | MALARIA VACCINE | Immunization | Antigens, Protozoan - immunology | Antibodies, Protozoan - immunology | Humans | Middle Aged | Male | Enzyme-Linked Immunospot Assay | Plasmodium falciparum - immunology | Vaccinia virus - genetics | Genetic Vectors - genetics | Life Cycle Stages | Adenoviruses, Simian - genetics | Young Adult | Antibodies, Neutralizing - immunology | Animals | Interferon-gamma - immunology | Malaria Vaccines - adverse effects | Adolescent | Malaria Vaccines - immunology | Malaria, Falciparum - immunology | Adult | Female | T-Lymphocytes - immunology | Plasmodium falciparum - growth & development | Antigens | Medical research | Immune response | Malaria | Immunoglobulin G | Clinical trials | Vaccines | B cells | T cells | Recombinant proteins | Mediation | Infection | Plasmodium falciparum | Genetic vectors | Adenoviruses | Medicine, Experimental | Product development | Health aspects | Laboratories | CD8 antigen | Antibodies | Viruses | Lymphocytes T | Infections | Parasites | Apical membrane antigen 1 | Immunity | Blood | Proteins | Developmental stages | Lymphocytes | Coding | Peripheral blood mononuclear cells | Drug dosages | Recombinant | Formulations | Vector-borne diseases | Phenotypes | Immunoglobulins | Effectiveness | Immune response (cell-mediated) | Vectors | Vectors (Biology) | Immune response (humoral) | CD4 antigen | Medicine | Hospitals | Infectious diseases | Immunogenicity | Alleles | Adults
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9. Full Text Phase Ia Clinical Evaluation of the Plasmodium falciparum Blood-stage Antigen MSP1 in ChAd63 and MVA Vaccine Vectors
by Sheehy, Susanne H and Duncan, Christopher JA and Elias, Sean C and Collins, Katharine A and Ewer, Katie J and Spencer, Alexandra J and Williams, Andrew R and Halstead, Fenella D and Moretz, Samuel E and Miura, Kazutoyo and Epp, Christian and Dicks, Matthew DJ and Poulton, Ian D and Lawrie, Alison M and Berrie, Eleanor and Moyle, Sarah and Long, Carole A and Colloca, Stefano and Cortese, Riccardo and Gilbert, Sarah C and Nicosia, Alfredo and Hill, Adrian VS and Draper, Simon J
Molecular Therapy, ISSN 1525-0016, 12/2011, Volume 19, Issue 12, pp. 2269 - 2276
Efficacy trials of antibody-inducing protein-in-adjuvant vaccines targeting the blood-stage malaria parasite have so far shown disappointing results. The... 
APICAL MEMBRANE ANTIGEN-1 | MEDICINE, RESEARCH & EXPERIMENTAL | RHESUS-MONKEYS | ADENOVIRAL VECTORS | PROTECTIVE IMMUNITY | IN-VITRO | MEROZOITE SURFACE PROTEIN-1 | T-CELL RESPONSES | MEDIATED-IMMUNITY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | MALARIA VACCINES | ADJUVANT VACCINES | Malaria, Falciparum - therapy | Humans | Vaccination | Merozoite Surface Protein 1 - genetics | Male | Macaca mulatta | Genetic Vectors - therapeutic use | Plasmodium falciparum - immunology | Vaccinia virus - genetics | CD4-Positive T-Lymphocytes - immunology | Young Adult | Malaria, Falciparum - blood | Flow Cytometry | Immunoglobulin G - immunology | Plasmodium falciparum - genetics | Adenoviridae - genetics | Adult | Female | Enzyme-Linked Immunosorbent Assay | Adjuvants, Immunologic | Antibodies, Protozoan - immunology | Merozoite Surface Protein 1 - blood | Blotting, Western | Animals | Merozoite Surface Protein 1 - immunology | Fluorescent Antibody Technique | Malaria, Falciparum - immunology | Immunologic Memory | Mice | Immunity, Cellular | Original
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10. Full Text A phase Ia study to assess the safety and immunogenicity of new malaria vaccine candidates ChAd63 CS administered alone and with MVA CS
by De Barra, Eoghan and Hodgson, Susanne H and Ewer, Katie J and Bliss, Carly M and Hennigan, Kerrie and Collins, Ann and Berrie, Eleanor and Lawrie, Alison M and Gilbert, Sarah C and Nicosia, Alfredo and McConkey, Samuel J and Hill, Adrian V. S
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, p. e115161
Background: Plasmodium falciparum (P. falciparum) malaria remains a significant cause of mortality and morbidity throughout the world. Development of an... 
VIRUS ANKARA | LIVER-STAGE MALARIA | PRIME-BOOST IMMUNIZATION | PROTECTIVE IMMUNITY | PLASMODIUM CIRCUMSPOROZOITE PROTEIN | FALCIPARUM-MALARIA | MULTIDISCIPLINARY SCIENCES | FOWLPOX STRAIN FP9 | PROTRACTED PROTECTION | NAIVE ADULTS | CD8(+) T-CELLS | Adenoviruses, Simian - immunology | Immunoglobulin G - blood | Humans | Middle Aged | Protozoan Proteins - genetics | Viral Vaccines - adverse effects | Viral Vaccines - administration & dosage | Adenoviruses, Simian - genetics | Malaria Vaccines - administration & dosage | Malaria Vaccines - adverse effects | Adolescent | Malaria Vaccines - immunology | Adult | Female | Viral Vaccines - immunology | Protozoan Proteins - immunology | Medical research | Immune response | Malaria | Malaria vaccine | Mortality | Clinical trials | B cells | Vaccines | T cells | Plasmodium falciparum | Genetic vectors | Adenoviruses | Medicine, Experimental | Health aspects | CD8 antigen | Immunoglobulin G | Erythrocytes | Viruses | Lymphocytes T | Infections | Parasites | Impact analysis | Proteins | Lymphocytes | Peripheral blood mononuclear cells | Enzyme-linked immunosorbent assay | Circumsporozoite protein | Vector-borne diseases | Antigens | Immunoglobulins | Priming | College campuses | Morbidity | CD4 antigen | Studies | Immunogenicity | Adults | Economic impact
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