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1. Full Text Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial
by Folegatti, Pedro M and Bittaye, Mustapha and Flaxman, Amy and Lopez, Fernando Ramos and Bellamy, Duncan and Kupke, Alexandra and Mair, Catherine and Makinson, Rebecca and Sheridan, Jonathan and Rohde, Cornelius and Halwe, Sandro and Jeong, Yuji and Park, Young-Shin and Kim, Jae-Ouk and Song, Manki and Boyd, Amy and Tran, Nguyen and Silman, Daniel and Poulton, Ian and Datoo, Mehreen and Marshall, Julia and Themistocleous, Yrene and Lawrie, Alison and Roberts, Rachel and Berrie, Eleanor and Becker, Stephan and Lambe, Teresa and Hill, Adrian and Ewer, Katie and Gilbert, Sarah
The Lancet infectious diseases, ISSN 1473-3099, 07/2020, Volume 20, Issue 7, pp. 816 - 826
Life Sciences & Biomedicine | Infectious Diseases | Science & Technology | Medical research | HIV antibodies | Vaccination | Medicine, Experimental | Product development | Monkeys | Vaccines | Coronaviruses | Biological response modifiers | Hepatitis C | Health aspects | Funding | Immunoglobulin G | Clinical trials | Antibodies | Viruses | Lymphocytes T | Security | Middle East respiratory syndrome | Hepatitis | Randomization | Human immunodeficiency virus--HIV | Safety | Hepatitis B virus | Public health | Enzyme-linked immunosorbent assay | Antigens | Immunization | Hepatitis B surface antigen | Health risks | Glycoproteins | Constraining | Pregnancy | Spikes | Immunogenicity | Respiratory diseases | γ-Interferon | Interferon | Hepatitis C virus | Index Medicus
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2. Full Text Vaccine-elicited Human T Cells Recognizing Conserved Protein Regions Inhibit HIV-1
by Borthwick, Nicola and Ahmed, Tina and Ondondo, Beatrice and Hayes, Peter and Rose, Annie and Ebrahimsa, Umar and Hayton, Emma-Jo and Black, Antony and Bridgeman, Anne and Rosario, Maximillian and Hill, Adrian VS and Berrie, Eleanor and Moyle, Sarah and Frahm, Nicole and Cox, Josephine and Colloca, Stefano and Nicosia, Alfredo and Gilmour, Jill and McMichael, Andrew J and Dorrell, Lucy and Hanke, Tomáš
Molecular therapy, ISSN 1525-0016, 02/2014, Volume 22, Issue 2, pp. 464 - 475
Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | T-Lymphocyte Subsets - immunology | Epitope Mapping | HIV Infections - prevention & control | Vaccines, DNA - genetics | Humans | Middle Aged | AIDS Vaccines - immunology | Vaccines, DNA - immunology | pol Gene Products, Human Immunodeficiency Virus - immunology | Molecular Sequence Data | Male | Young Adult | HIV Infections - immunology | T-Cell Antigen Receptor Specificity - immunology | Adult | Female | Conserved Sequence - immunology | Epitopes, T-Lymphocyte - immunology | Amino Acid Sequence | Cells, Cultured | Virus Replication - immunology | HIV-1 - genetics | Epitopes, T-Lymphocyte - chemistry | HIV-1 - immunology | Adolescent | AIDS Vaccines - genetics | T-Lymphocytes - immunology | gag Gene Products, Human Immunodeficiency Virus - immunology | Index Medicus | Original
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3. Full Text Protective CD8 + T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation
by Ewer, Katie J and O'Hara, Geraldine A and Duncan, Christopher J. A and Collins, Katharine A and Sheehy, Susanne H and Reyes-Sandoval, Arturo and Goodman, Anna L and Edwards, Nick J and Elias, Sean C and Halstead, Fenella D and Longley, Rhea J and Rowland, Rosalind and Poulton, Ian D and Draper, Simon J and Blagborough, Andrew M and Berrie, Eleanor and Moyle, Sarah and Williams, Nicola and Siani, Loredana and Folgori, Antonella and Colloca, Stefano and Sinden, Robert E and Lawrie, Alison M and Cortese, Riccardo and Gilbert, Sarah C and Nicosia, Alfredo and Hill, Adrian V. S
Nature communications, ISSN 2041-1723, 11/2013, Volume 4, Issue 1, pp. 2836 - 2836
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Adenoviruses, Simian - immunology | Malaria, Falciparum - prevention & control | Humans | Middle Aged | Male | Leukocytes, Mononuclear | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Vaccinia virus - genetics | Vaccinia virus - immunology | Adenoviruses, Simian - genetics | Young Adult | Immunization, Secondary | Plasmodium falciparum - genetics | Malaria Vaccines - immunology | Adult | Female | Immunization | Genetic Vectors - immunology | Antibodies, Protozoan - immunology | Genetic Vectors - genetics | Malaria, Falciparum - parasitology | Animals | Malaria Vaccines - administration & dosage | Interferon-gamma - immunology | Adolescent | Malaria, Falciparum - immunology | CD8-Positive T-Lymphocytes - immunology | Immunity, Cellular | Protozoan Proteins - immunology | Malaria Vaccines - genetics | Index Medicus
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4. Full Text Haemopoietic stem-cell transplantation with antibody-based minimal-intensity conditioning: a phase 1/2 study
by Straathof, Karin C, MRCPCH and Rao, Kanchan, MRCPCH and Eyrich, Matthias, MD and Hale, Geoff, PhD and Bird, Prudence, PhD and Berrie, Eleanor, PhD and Brown, Lucinda and Adams, Stuart, PhD and Schlegel, Paul G, FRCP and Goulden, Nicholas, FRCPCH and Gaspar, H Bobby, Prof and Gennery, Andrew R, MD and Landais, Paul, MD and Davies, EG, FRCPCH and Brenner, Malcolm K, Prof and Veys, Paul A, FRCPCH and Amrolia, Persis Jal, Dr
The Lancet (British edition), ISSN 0140-6736, 2009, Volume 374, Issue 9693, pp. 912 - 920
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Bone marrow, stem cells transplantation. Graft versus host reaction | Transfusions. Complications. Transfusion reactions. Cell and gene therapy | Antibodies, Neoplasm - therapeutic use | Graft vs Host Disease - epidemiology | Follow-Up Studies | Humans | Immunosuppressive Agents - therapeutic use | Child, Preschool | Antibodies, Monoclonal - therapeutic use | Infant | Male | Cyclophosphamide - therapeutic use | Transplantation Conditioning - mortality | Antibodies, Monoclonal, Humanized | Hematopoietic Stem Cell Transplantation - adverse effects | Female | Transplantation Conditioning - adverse effects | Transplantation Conditioning - methods | Graft vs Host Disease - etiology | Immunologic Deficiency Syndromes - therapy | Kaplan-Meier Estimate | Rats | Treatment Outcome | Vidarabine - analogs & derivatives | Alemtuzumab | Vidarabine - therapeutic use | Transplantation Chimera | Leukocyte Common Antigens - antagonists & inhibitors | Disease-Free Survival | Animals | Graft vs Host Disease - prevention & control | Hematopoietic Stem Cell Transplantation - methods | Immunologic Factors - therapeutic use | Care and treatment | Usage | Patient outcomes | Immunodeficiency | Stem cells | Transplantation | Children | Health aspects | Diseases | Bone marrow | Medical research | Transplants & implants | Mortality | Metabolic disorders | Index Medicus | Abridged Index Medicus
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5. Full Text Insulin Needs after CD3-Antibody Therapy in New-Onset Type 1 Diabetes
by Keymeulen, Bart and Vandemeulebroucke, Evy and Ziegler, Anette G and Mathieu, Chantal and Kaufman, Leonard and Hale, Geoff and Gorus, Frans and Goldman, Michel and Walter, Markus and Candon, Sophie and Schandene, Liliane and Crenier, Laurent and De Block, Christophe and Seigneurin, Jean-Marie and De Pauw, Pieter and Pierard, Denis and Weets, Ilse and Rebello, Peppy and Bird, Pru and Berrie, Eleanor and Frewin, Mark and Waldmann, Herman and Bach, Jean-François and Pipeleers, Daniel and Chatenoud, Lucienne
The New England journal of medicine, ISSN 0028-4793, 06/2005, Volume 352, Issue 25, pp. 2598 - 2608
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Hypoglycemic Agents - therapeutic use | Herpesviridae - isolation & purification | Islets of Langerhans - drug effects | Blood Glucose - analysis | Autoantibodies - blood | Humans | Immunoglobulin G - therapeutic use | Islets of Langerhans - immunology | Male | Diabetes Mellitus, Type 1 - drug therapy | Immunoglobulin G - adverse effects | C-Peptide - biosynthesis | Diabetes Mellitus, Type 1 - blood | Adolescent | CD3 Complex - immunology | Islets of Langerhans - physiopathology | Adult | Female | Diabetes Mellitus, Type 1 - immunology | Glucose Clamp Technique | Child | Insulin - therapeutic use | Diabetes | Glucose | Peptides | Insulin | Patients | Index Medicus | Abridged Index Medicus
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6. Full Text Clinical Assessment of a Recombinant Simian Adenovirus ChAd63: A Potent New Vaccine Vector
by Geraldine A. O'Hara and Christopher J. A. Duncan and Katie J. Ewer and Katharine A. Collins and Sean C. Elias and Fenella D. Halstead and Anna L. Goodman and Nick J. Edwards and Arturo Reyes-Sandoval and Prudence Bird and Rosalind Rowland and Susanne H. Sheehy and Ian D. Poulton and Claire Hutchings and Stephen Todryk and Laura Andrews and Antonella Folgori and Eleanor Berrie and Sarah Moyle and Alfredo Nicosia and Stefano Colloca and Riccardo Cortese and Loredana Siani and Alison M. Lawrie and Sarah C. Gilbert and Adrian V. S. Hill
The Journal of infectious diseases, ISSN 0022-1899, 3/2012, Volume 205, Issue 5, pp. 772 - 781
T lymphocytes | Vaccinia virus | Volunteerism | Immunization | Immune response | Malaria | Vaccination | Adenoviruses | Enzyme linked immunospot assay | Immunity | VIRUSES | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Miscellaneous | Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) | Infectious diseases | Applied microbiology | Biological and medical sciences | Medical sciences | Virology | Interleukin-2 - metabolism | Tumor Necrosis Factor-alpha - metabolism | Adenoviruses, Simian - immunology | Humans | CD4-Positive T-Lymphocytes - metabolism | Vaccines, DNA - immunology | Epitopes | Interferon-gamma - metabolism | Vaccines, DNA - administration & dosage | Adenoviruses, Simian - genetics | Animals | Flow Cytometry | Malaria Vaccines - administration & dosage | Malaria Vaccines - adverse effects | Vaccines, DNA - adverse effects | Malaria Vaccines - immunology | Malaria, Falciparum - immunology | CD8-Positive T-Lymphocytes - metabolism | Antibodies, Neutralizing - blood | Protozoan Proteins - immunology | Index Medicus | Abridged Index Medicus | Major and Brief Reports
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7. Full Text Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive Individuals
by Susanne H. Hodgson and Katie J. Ewer and Carly M. Bliss and Nick J. Edwards and Thomas Rampling and Nicholas A. Anagnostou and Eoghan de Barra and Tom Havelock and Georgina Bowyer and Ian D. Poulton and Simone de Cassan and Rhea Longley and Joseph J. Illingworth and Alexander D. Douglas and Pooja B. Mange and Katharine A. Collins and Rachel Roberts and Stephen Gerry and Eleanor Berrie and Sarah Moyle and Stefano Colloca and Riccardo Cortese and Robert E. Sinden and Sarah C. Gilbert and Philip Bejon and Alison M. Lawrie and Alfredo Nicosia and Saul N. Faust and Adrian V. S. Hill
The Journal of infectious diseases, ISSN 0022-1899, 4/2015, Volume 211, Issue 7, pp. 1076 - 1086
PARASITES | vaccine | P. falciparum | ChAd63 | MVA | malaria | ME-TRAP | CHMI | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Liver - virology | Adenoviruses, Simian - immunology | Malaria, Falciparum - prevention & control | Humans | Middle Aged | Male | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Antibodies, Protozoan - biosynthesis | Adenoviruses, Simian - genetics | Epitopes - immunology | Young Adult | Malaria, Falciparum - parasitology | Interferon-gamma - immunology | Plasmodium falciparum - genetics | Adolescent | Malaria Vaccines - immunology | Malaria, Falciparum - immunology | Adult | Female | Genetic Vectors | Protozoan Proteins - immunology | Dosage and administration | Vaccines | Malaria | Risk factors | Index Medicus | Abridged Index Medicus | CS | Major and Brief Reports
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8. Full Text Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
by Aley, Parvinder K and Clutterbuck, Elizabeth A and Dold, Christina and Heath, Paul and Makinson, Rebecca and Pollock, Katrina M and Ramasamy, Maheshi and Robinson, Hannah and Douglas, Alexander D and Lambe, Teresa and Aboagye, Jeremy and Allen, Elizabeth and Allison, Jennifer L and Anslow, Rachel and Arbe-Barnes, Edward H and Baker, Philip and Bates, Louise and Batten, Alexander and Berry, Lisa and Beveridge, Amy and Bingham, Tracey and Blundell, Caitlin L and Brunt, Emily and Burbage, Jamie and Cooper, Rachel and Damratoski, Brad E and Di Maso, Claudio and Dong, Tao and Donnellan, Francesca R and Douglas, Naomi and Downing, Charlotte and Fletcher, Clare and Fox, Polly and Frater, John and Galiza, Eva and Godwin, Kerry and Gorini, Giacomo and Goulston, Lyndsey and Gracie, Lara and Halwe, Sandro and Hamilton, Elizabeth and Harding, Irasha and Head, Ian and Hodgson, Susanne H.C and Howell, Nicola and Isitt, Catherine and Kailath, Reshma and Karampatsas, Konstantinos and Kerridge, Simon and Khan, Uzma and Kingham-Page, Lucy and Knott, Daniel and Koleva, Stanislava and Kupke, Alexandra and Larkworthy, Colin W and Lee, Arlene and Lees, Emily A and Linder, Aline and Lopez Ramon, Raquel and Marlow, Emma and Meddaugh, Gretchen and Moore, Maria and Moran, Edward and Morris, Susan Jane and Morshead, Gertraud and Muller, Jilly and Munro, Alasdair and Noé, Andrés and O'Brien, Katie and O'Connor, Daniel and Oguti, Blanché and Oliver, Jennifer L and Osborn, Mairead and Pacurar, Mihaela and Pearce, Jennifer and Pfafferott, Katja and Poulton, Ian and Riddell, Amy and Sajjad, Sara and Sanders, Helen and Sanders, Katherine and Selby, Beatrice and Sharpe, Hannah R and Shelton, Holly and Skelly, Donal T and Song, Rinn and Stefanova, Elena and Tait, Moira and Talbot, Helen and Themistocleous, Yrene and Thomas, Merin and Towner, James and Tree, Julia A and Turkentine, Kate and Turner, Sally and Veighey, Kristin and Verheul, Marije K and Vichos, Iason and Worth, Andrew T and Yau, Yasmine and Oxford COVID Vaccine Trial Group and Oxford COVID Vaccine Trial Grp
The Lancet (British edition), ISSN 0140-6736, 08/2020, Volume 396, Issue 10249, pp. 467 - 478
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Coronavirus Infections - prevention & control | Single-Blind Method | Genetic Vectors - administration & dosage | Immunoglobulin G - blood | Coronavirus Infections - drug therapy | Humans | Pandemics - prevention & control | Pneumonia, Viral - drug therapy | Male | Viral Vaccines - adverse effects | Antibodies, Viral - blood | Adenoviruses, Simian - genetics | Betacoronavirus - immunology | COVID-19 | SARS-CoV-2 | Immunization, Secondary | Adult | Female | Spike Glycoprotein, Coronavirus - immunology | Acetaminophen - therapeutic use | United Kingdom | Analgesics, Non-Narcotic - therapeutic use | Coronavirus Infections - immunology | Viral Vaccines - administration & dosage | Pneumonia, Viral - prevention & control | COVID-19 Vaccines | T-Lymphocytes - immunology | Viral Vaccines - immunology | Antibodies, Neutralizing - blood | Health aspects | Analysis | Vaccines | Epidemics | Headache | Immunoassay | Schedules | Pandemics | Laboratories | Immunoglobulin G | Vaccination | Viral diseases | Innovations | Antibodies | Research facilities | Clinical trials | Homology | Viruses | Leukocytes (mononuclear) | Lymphocytes T | Infections | Serology | Middle East respiratory syndrome | Chills | Proteins | Prevention | Paracetamol | Randomization | Pain | Older people | Peripheral blood mononuclear cells | Safety | Enzyme-linked immunosorbent assay | Spike protein | Severe acute respiratory syndrome | Muscles | Glycoproteins | Coronaviruses | Immune response (humoral) | Severe acute respiratory syndrome coronavirus 2 | Hospitals | Disease transmission | Immunogenicity | Correlation analysis | Respiratory diseases | γ-Interferon | Adenoviruses | Interferon | Index Medicus | Abridged Index Medicus
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