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Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7641, pp. 318 - 323
Spliceosome rearrangements facilitated by RNA helicase PRP16 before catalytic step two of splicing are poorly understood. Here we report a 3D cryo-electron... 
2ND STEP | I SPLICEOSOME | U4/U6.U5 TRI-SNRNP | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MOLECULAR ARCHITECTURE | CATALYTIC CORE | PRE-MESSENGER-RNA | PRP8 | INSIGHTS | Spliceosomes - chemistry | Humans | Cell Cycle Proteins - ultrastructure | RNA Splicing Factors - chemistry | RNA, Messenger - metabolism | RNA Splicing Factors - metabolism | Cell Cycle Proteins - chemistry | Spliceosomes - metabolism | RNA Splicing | Ribonucleoproteins, Small Nuclear - ultrastructure | Base Sequence | Protein Domains | Ribonucleoproteins, Small Nuclear - chemistry | DEAD-box RNA Helicases - metabolism | DEAD-box RNA Helicases - chemistry | Biocatalysis | Introns - genetics | Movement | RNA, Messenger - genetics | RNA-Binding Proteins - chemistry | Cell Cycle Proteins - metabolism | Models, Molecular | Exons - genetics | Spliceosomes - ultrastructure | RNA Stability | Saccharomyces cerevisiae - chemistry | Cryoelectron Microscopy | RNA-Binding Proteins - ultrastructure | RNA Splicing Factors - ultrastructure | Ribonuclease H - chemistry | Adenosine - metabolism | Saccharomyces cerevisiae - enzymology | RNA, Messenger - chemistry | DEAD-box RNA Helicases - ultrastructure | RNA-Binding Proteins - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | Ribonuclease H - metabolism | Genetic research | Genetic engineering | Research | Methods | RNA splicing | Proteins | Yeast | Catalysis | Molecular structure | Microscopy | Ribonucleic acid--RNA
Journal Article
Science, ISSN 0036-8075, 09/2016, Volume 353, Issue 6306, pp. 1399 - 1405
Journal Article
Cold Spring Harbor perspectives in biology, 02/2019, Volume 11, Issue 11
SUMMARYThe spliceosome is a highly complex, dynamic ribonucleoprotein molecular machine that undergoes numerous structural and compositional rearrangements... 
Molecular machines | Atomic force microscopy | Yeasts | Eukaryotes | Yeast | Splicing | mRNA | Catalysis | Structure-function relationships
Journal Article
Journal Article