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FASEB Journal, ISSN 0892-6638, 04/2012, Volume 26, Issue 4, pp. 1682 - 1693
Metabotropic glutamate (mGlu) receptors are promising targets to treat numerous brain disorders. So far, allosteric modulators are the only subtype selective... 
Drug development | mGluR | Parkinson's disease | POSITIVE ALLOSTERIC MODULATION | SITE | ACTIVATION | ACID | RECOGNITION | DOCKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | drug development | BINDING DOMAIN | MOLECULAR DETERMINANTS | CELL BIOLOGY | MGLUR4 | BIOLOGY | CHARMM | Antiparkinson Agents - pharmacology | Rats, Wistar | Humans | Male | Structure-Activity Relationship | Dose-Response Relationship, Drug | Receptors, Metabotropic Glutamate - genetics | HEK293 Cells | Antiparkinson Agents - chemistry | Synaptic Transmission - drug effects | Molecular Structure | Receptors, Metabotropic Glutamate - chemistry | Binding Sites | Recombinant Proteins - metabolism | Excitatory Amino Acid Agonists - metabolism | Mutagenesis, Site-Directed | Phosphinic Acids - chemistry | Rats | Excitatory Amino Acid Agonists - pharmacology | Recombinant Proteins - genetics | Mice, Knockout | Patch-Clamp Techniques | Animals | Phosphinic Acids - pharmacology | Phosphinic Acids - metabolism | Ligands | Mice | Receptors, Metabotropic Glutamate - agonists | Antiparkinson Agents - metabolism | Excitatory Amino Acid Agonists - chemistry | Excitatory Amino Acid Agonists | Neurons and Cognition | Neurobiology | Recombinant Proteins | Synaptic Transmission | Life Sciences | Phosphinic Acids | Psychology and behavior | Antiparkinson Agents | Receptors, Metabotropic Glutamate | Cognitive Sciences
Journal Article
Neuropharmacology, ISSN 0028-3908, 07/2017, Volume 121, p. 247
In cerebellar cortex, mGlu.sub.4 receptors located on parallel fibers play an essential role in normal motor function, but the molecular mechanisms involved... 
Proteins | Glutamate | Cells | Chromatography | Amino acids | Neurosciences | G proteins
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 5, pp. 1969 - 1989
A group III metabotropic glutamate (mGlu) receptor agonist (PCEP) was identified by virtual HTS. This orthosteric ligand is composed by an l-AP4-derived... 
Life Sciences | Neurons and Cognition
Journal Article
Neuropharmacology, ISSN 0028-3908, 07/2017, Volume 121, pp. 247 - 260
Journal Article
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