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Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2197 - 17
In colorectal cancer (CRC), aberrant Wnt signalling is essential for tumorigenesis and maintenance of cancer stem cells. However, how other oncogenic pathways... 
COLON-CANCER | LUNG | AXIN | APC | MULTIDISCIPLINARY SCIENCES | RESISTANCE | DIFFERENTIATION | BETA-CATENIN | ENDOCYTOSIS | PROMOTES | ERK | Cell Plasticity - drug effects | Neoplastic Stem Cells - drug effects | Humans | ras Proteins - metabolism | Male | Antineoplastic Agents - therapeutic use | Mitogen-Activated Protein Kinase Kinases - metabolism | Colorectal Neoplasms - drug therapy | HEK293 Cells | Female | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Adenomatous Polyposis Coli Protein - genetics | Intestines - pathology | Down-Regulation | Mice, Inbred C57BL | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Mice, SCID | CRISPR-Cas Systems - genetics | Carcinogenesis - drug effects | Xenograft Model Antitumor Assays | Animals | Wnt Signaling Pathway - drug effects | Biopsy | Protein Kinase Inhibitors - therapeutic use | Adenomatous Polyposis Coli Protein - metabolism | Proteomics | Cell Line, Tumor | Mice, Inbred NOD | Mice | Protein Kinase Inhibitors - pharmacology | Colorectal Neoplasms - pathology | Intestines - cytology | Wnt protein | Colorectal carcinoma | Colorectal cancer | Homeostasis | Stem cell transplantation | Synergism | β-catenin | Signal transduction | Organoids | Intestine | Plasticity | Tumorigenesis | Inhibition | CRISPR | MEK inhibitors | Embryos | Screens | Adenomatous polyposis coli | Signaling | Inhibitors | Cell lines | Stem cells | Plastic properties | Mutation | Cancer
Journal Article
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2019, Volume 37, Issue 4_suppl, pp. TPS174 - TPS174
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, pp. e0127146 - e0127146
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4112 - 16
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2017, Volume 35, Issue 15_suppl, pp. TPS10124 - TPS10124
Journal Article