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1. Full Text Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
by Dastani, Zari and Hivert, Marie-France and Timpson, Nicholas and Perry, John R. B and Yuan, Xin and Scott, Robert A and Henneman, Peter and Heid, Iris M and Kizer, Jorge R and Lyytikäinen, Leo-Pekka and Fuchsberger, Christian and Tanaka, Toshiko and Morris, Anew P and Small, Kerrin and Isaacs, Aaron and Beekman, Marian and Coassin, Stefan and Lohman, Kurt and Qi, Lu and Kanoni, Stavroula and Pankow, James S and Uh, Hae-Won and Wu, Ying and Bidulescu, Aurelian and Rasmussen-Torvik, Laura J and Greenwood, Celia M. T and Ladouceur, Martin and Grimsby, Jonna and Manning, Alisa K and Liu, Ching-Ti and Kooner, Jaspal and Mooser, Vincent E and Vollenweider, Peter and Kapur, Karen A and Chambers, John and Wareham, Nicholas J and Langenberg, Claudia and Frants, Rune and Willems-Vandijk, Ko and Oostra, Ben A and Willems, Sara M and Lamina, Claudia and Winkler, Thomas W and Psaty, Bruce M and Tracy, Russell P and Brody, Jennifer and Chen, Ida and Viikari, Jorma and Kähönen, Mika and Pramstaller, Peter P and Evans, David M and St Pourcain, Beate and Sattar, Naveed and Wood, Anew R and Bandinelli, Stefania and Carlson, Olga D and Egan, Josephine M and Böhringer, Stefan and van Heemst, Diana and Kedenko, Lyudmyla and Kristiansson, Kati and Nuotio, Marja-Liisa and Loo, Britt-Marie and Harris, Tamara and Garcia, Melissa and Kanaya, Alka and Haun, Margot and Klopp, Norman and Wichmann, H.-Erich and Deloukas, Panos and Katsareli, Efi and Couper, David J and Duncan, Bruce B and Kloppenburg, Margreet and Adair, Linda S and Borja, Judith B and Wilson, James G and Musani, Solomon and Guo, Xiuqing and Johnson, Toby and Semple, Robert and Teslovich, Tanya M and Allison, Matthew A and Redline, Susan and Buxbaum, Sarah G and Mohlke, Karen L and Meulenbelt, Ingrid and Ballantyne, Christie M and Dedoussis, George V and Hu, Frank B and Liu, Yongmei and Paulweber, Bernhard and Spector, Timothy D and Slagboom, P. Eline and Ferrucci, Luigi and Jula, Antti and Perola, Markus and Raitakari, Olli and Florez, Jose C and Salomaa, Veikko and ... and GLGC Investigators and DIAGRAM Consortium and MAGIC Consortium and MuTHER Consortium and Global B Pgen Consortium and MAGIC investigators and Procardis Consortium and DIAGRAM+ Consortium and GLGC Consortium and GIANT Consortium
PLoS genetics, ISSN 1553-7390, 2012, Volume 8, Issue 3, pp. e1002607 - e1002607
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes... 
POPULATION | GENETIC-BASIS | VARIANTS | INSULIN-RESISTANCE | LIPID CONCENTRATIONS | GENETICS & HEREDITY | RISK | RECEPTOR | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | ADIPOSE-TISSUE | Gene Expression | Genetic Predisposition to Disease | Genome-Wide Association Study | Glucose Tolerance Test | Diabetes Mellitus, Type 2 - genetics | Humans | African Americans | European Continental Ancestry Group | Male | Cholesterol, HDL - genetics | Adiponectin - blood | Asian Continental Ancestry Group | Metabolic Networks and Pathways | Adiponectin - genetics | Insulin Resistance - genetics | Female | Polymorphism, Single Nucleotide | Waist-Hip Ratio | Type 2 diabetes | Physiological aspects | Development and progression | Genetic aspects | Research | Metabolism | Health aspects | Blood proteins | Meta-analysis | Medical research | Cardiovascular disease | Drug therapy | Insulin | Metabolic disorders | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap
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2. Full Text A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans
by Palmer, N.D and McDonough, C.W and Hicks, P.J and Roh, B.H and Wing, M.R and Sandy An, S and Hester, J.M and Cooke, J.N and Bostrom, M.A and Rudock, M.E and Talbert, M.E and Lewis, J.P and Hottenga, J.J and Geus, de, E.J.C and Willemsen, G and Boomsma, D.I and Ferrara, A and Lu, L and Ziegler, J.T and Sale, M.M and Divers, J and Shriner, D and Adeyemo, A and Rotimi, C.N and Ng, M.C.Y and Langefeld, C.D and Freedman, B.I and Bowden, D.W and Posthuma, D and Penninx, B.W.J.H and Sladek, R and DIAGRAM Consortium and MAGIC Investigators and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Allmänmedicin and Näringsforskning and Umeå universitet and Medicin
PLoS ONE, ISSN 1932-6203, 2012, Volume 7, Issue 1, pp. e29202 - e29202
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this... 
FASTING GLUCOSE | COMMON VARIANTS | TCF7L2 GENE | LARGE-SCALE ASSOCIATION | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | LINKAGE ANALYSIS | STAGE RENAL-DISEASE | TISSUE FACTOR | HOMEODOMAIN PROTEIN | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | African Americans - genetics | Genotype | Male | Case-Control Studies | Diabetes Mellitus, Type 2 - ethnology | Validation Studies as Topic | Adult | Female | Aged | Polymorphism, Single Nucleotide | Cohort Studies | Type 2 diabetes | Chronic kidney failure | Analysis | Genes | Genomics | African Americans | Genetic aspects | Genomes | Haplotypes | End-stage renal disease | Physicians | Science | Biochemistry | Single-nucleotide polymorphism | Epidemiology | Population genetics | Consortia | Precision medicine | Atherosclerosis | Genetics | Diabetes mellitus (non-insulin dependent) | Lupus | Diabetes mellitus | Gene expression | Minority & ethnic groups | Disease control | Loci | Nephropathy | Genotyping | Insulin resistance | Replication | Diabetes | Kidney diseases | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap
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3. Full Text Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
by Voight, Benjamin and Scott, Laura and Steinthorsdottir, Valgerdur and Morris, Anew and Dina, Christian and Welch, Ryan and Zeggini, Eleftheria and Huth, Cornelia and Aulchenko, Yurii and Thorleifsson, Gudmar and McCulloch, Laura and Ferreira, Teresa and Grallert, Harald and Amin, Najaf and Wu, Guanming and Willer, Cristen and Raychaudhuri, Soumya and McCarroll, Steven and Langenberg, Claudia and Hofmann, Oliver and Dupuis, Josée and Qi, Lu and Segrè, Ayellet and Hoek, Mandy and Navarro, Pau and Ardlie, Kristin and Balkau, Beverley and Benediktsson, Rafn and Bennett, Amanda and Blagieva, Roza and Boerwinkle, Eric and Bonnycastle, Lori and Boström, Kristina Bengtsson and Bravenboer, Bert and Bumpstead, Suzannah and Burtt, Noël and Charpentier, Guillaume and Chines, Peter and Cornelis, Marilyn and Couper, David and Crawford, Gabe and Doney, Alex and Elliott, Katherine and Erdos, Michael and Fox, Caroline and Franklin, Christopher and Ganser, Martha and Gieger, Christian and Grarup, Niels and Green, Todd and Griffin, Simon and Groves, Christopher and Guiducci, Candace and Hadjadj, Samy and Hassanali, Neelam and Herder, Christian and Isomaa, Bo and Jackson, Anne and Johnson, Paul and Jørgensen, Torben and Kao, Wen and Klopp, Norman and Kong, Augustine and Kraft, Peter and Kuusisto, Johanna and Lauritzen, Torsten and Li, Man and Lieverse, Aloysius and Lindgren, Cecilia and Lyssenko, Valeriya and Marre, Michel and Meitinger, Thomas and Midthjell, Kristian and Morken, Mario and Narisu, Narisu and Nilsson, Peter and Owen, Katharine and Payne, Felicity and Perry, John and Petersen, A.K and Platou, Carl and Proença, Christine and Prokopenko, Inga and Rathmann, Wolfgang and Rayner, Nigel William and Robertson, Neil and Rocheleau, Ghislain and Roden, Michael and Sampson, Michael and Saxena, Richa and Shields, Beverley and Shrader, Peter and Sigurdsson, Gunnar and Sparsø, Thomas and Strassburger, Klaus and Stringham, Heather and Sun, Qi and Swift, Amy and Thorand, Barbara and Tichet, Jean and ... and GIANT Consortium and MAGIC Investigators and MAGIC investigators and The GIANT Consortium and The MAGIC investigators and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för genetik och patologi and Uppsala universitet
Nature Genetics, ISSN 1061-4036, 07/2010, Volume 42, Issue 7, pp. 579 - 589
textabstractBy combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following... 
C-REACTIVE PROTEIN | COMMON VARIANTS | FASTING PLASMA-GLUCOSE | CROHNS-DISEASE | INSULIN-RESISTANCE | HNF1-ALPHA GENE | GENETICS & HEREDITY | GENE-EXPRESSION | COMPLEX DISEASES | QT INTERVAL DURATION | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Meta-Analysis as Topic | KCNQ1 Potassium Channel - genetics | Hepatocyte Nuclear Factor 1-alpha - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Gene Dosage | Gene Expression Profiling | Mitogen-Activated Protein Kinase Phosphatases - genetics | Genetic Heterogeneity | Genome, Human - genetics | Diabetes Mellitus, Type 2 - blood | Fasting - blood | Dual-Specificity Phosphatases - genetics | Polymorphism, Single Nucleotide | Blood Glucose - metabolism | Type 2 diabetes | Genetic aspects | Research | Genetic susceptibility | Risk factors | Medical research | Diabetes | Meta-analysis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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4. Full Text Resistance to annexin A5 anticoagulant activity in women with histories for obstetric antiphospholipid syndrome
by Hunt, Beverley J., FRCPath and Wu, Xiao-Xuan, MD and de Laat, Bas, MD, PhD and Arslan, Alan A., MD and Stuart-Smith, Sara, FRCPath and Rand, Jacob H., MD
American Journal of Obstetrics and Gynecology, ISSN 0002-9378, 2011, Volume 205, Issue 5, pp. 485.e17 - 485.e23
Objective The objective of the study was to investigate whether resistance to annexin A5 anticoagulant activity (AnxA5) occurs in women with histories for... 
Obstetrics and Gynecology | antiphospholipid syndrome | annexin A5 | obstetric | pregnancy loss | β2-glycoprotein I | antiphospholipid antibodies | V BINDING | AUTOANTIBODIES | PROTEIN | ANTIBODY SYNDROME | ANXA5 GENE | PLASMAS | OBSTETRICS & GYNECOLOGY | SHIELD | REDUCTION | beta 2-glycoprotein I | HAPLOTYPE | Humans | Middle Aged | Antibodies, Antiphospholipid - immunology | Antibodies, Antiphospholipid - metabolism | Antiphospholipid Syndrome - immunology | Pregnancy | Annexin A5 - metabolism | Adult | Female | Aged | Pregnancy Complications - metabolism | Antiphospholipid Syndrome - metabolism | Pregnancy Complications - immunology | Women | Viral antibodies | Medical colleges | Antibodies | Anticoagulants (Medicine) | Annexins | Antiphospholipid syndrome | Index Medicus | Abridged Index Medicus | Annexin A5 | Antiphospholipid antibodies | annexin V | Pregnancy loss
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5. Full Text Towards a systematic nationwide screening strategy for MODY
by Shields, Beverley and Colclough, Kevin
Diabetologia, ISSN 0012-186X, 4/2017, Volume 60, Issue 4, pp. 609 - 612
MODY is an early-onset monogenic form of diabetes. Correctly identifying MODY is of considerable importance as diagnosing the specific genetic subtype can... 
Variants | Islet autoantibodies | MODY | Medicine & Public Health | Human Physiology | Metabolic Diseases | Monogenic diabetes | Internal Medicine | Maturity onset diabetes of the young | POPULATION | DIAGNOSIS | Maturityonset diabetes of the young | PREVALENCE | HNF1A | Isletautoantibodies | CHILDREN | YOUNG | HNF4A | ENDOCRINOLOGY & METABOLISM | MUTATIONS | Diabetes Mellitus, Type 1 - diagnosis | Diabetes Mellitus, Type 2 - diagnosis | Autoantibodies - immunology | Diabetes Mellitus, Type 2 - immunology | Humans | Diabetes Mellitus, Type 1 - immunology | Mass Screening - methods | Autoimmunity | Type 1 diabetes | Autoantibodies | Index Medicus
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6. Full Text A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function
by Porcu, E and Medici, M and Pistis, G and Volpato, C.B and Wilson, S.G and Cappola, A.R and Bos, S.D and Deelen, J and Heijer, M. den and Freathy, R.M and Lahti, J and Liu, C and Lopez, L.M and Nolte, I.M and O'Connell, J.R and Tanaka, T and Trompet, S and Arnold, A and Bandinelli, S and Beekman, M and Bohringer, S and Brown, S.J and Buckley, B.M and Camaschella, C and Craen, A.J. de and Davies, G and Visser, M.C.H. de and Ford, I and Forsen, T and Frayling, T.M and Fugazzola, L and Gogele, M and Hattersley, A.T and Hermus, A.R.M.M and Hofman, A and Houwing-Duistermaat, J.J and Jensen, R.A and Kajantie, E and Kloppenburg, M and Lim, E.M and Masciullo, C and Mariotti, S and Minelli, C and Mitchell, B.D and Nagaraja, R and Netea-Maier, R.T and Palotie, A and Persani, L and Piras, M.G and Psaty, B.M and Raikkonen, K and Richards, J.B and Rivadeneira, F and Sala, C and Sabra, M.M and Sattar, N and Shields, B.M and Soranzo, N and Starr, J.M and Stott, D.J and Sweep, F.C and Usala, G and Klauw, M.M. van der and Heemst, D. van and Mullem, A. van and Vermeulen, S and Visser, W.E and Walsh, J.P and Westendorp, R.G.J and Widen, E and Zhai, G and Cucca, F and Deary, I.J and Eriksson, J.G and Ferrucci, L and Fox, C.S and Jukema, J.W and Kiemeney, L.A.L.M and Pramstaller, P.P and Schlessinger, D and Shuldiner, A.R and Slagboom, E.P and Uitterlinden, A.G and Vaidya, B and Visser, T.J and Wolffenbuttel, B.H.R and Meulenbelt, I and Rotter, J.I and Spector, T.D and Hicks, A.A and Toniolo, D and Sanna, S and Peeters, R.P and Naitza, S
PLOS Genetics, ISSN 1553-7390, 2013, Volume 9, Issue 2, pp. e1003266 - e1003266
Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyroid function lead to common endocrine disorders affecting... 
CLEFT-PALATE | FACTOR BINDING PROTEIN-5 | GROWTH | GENETICS & HEREDITY | SERUM TSH | COMMON VARIATION | HORMONE PATHWAY GENES | EXPRESSION | HYPOTHYROIDISM | GENOME-WIDE ASSOCIATION | THYROTROPIN | Quantitative genetics | Physiological aspects | Genetic aspects | Research | Thyroid hormones | Health aspects | Meta-analysis | Studies | Older people | Thyroid gland | Genomes | Agreements | Hormones | Grants | Index Medicus
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7. Full Text Lower circulating b12 is associated with higher obesity and insulin resistance during pregnancy in a non-diabetic white british population
by Knight, Bridget Ann and Shields, Beverley M and Brook, Adam and Hill, Anita and Bhat, Dattatray S and Hattersley, Andrew T and Yajnik, Chittaranjan S
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, pp. e0135268 - e0135268
Objective Vitamin B12 and folate are critical micronutrients needed to support the increased metabolic demands of pregnancy. Recent studies from India have... 
VITAMIN-B-12 | MULTIDISCIPLINARY SCIENCES | MATERNAL NUTRITION | Life Style | Pregnancy Complications - blood | Cross-Sectional Studies | Lipoproteins, HDL - blood | Vitamin B 12 Deficiency - blood | Humans | European Continental Ancestry Group | Vitamin B 12 - blood | Obesity - blood | Pregnancy | Diet, Vegetarian | Diet | Insulin Resistance - physiology | Obesity - epidemiology | Folic Acid - blood | Triglycerides - blood | Female | Adiposity - physiology | Dietary Supplements | United Kingdom - epidemiology | Pregnant women | Analysis | Insulin resistance | Triglycerides | Research | Glucose | Dextrose | Folic acid | Adipose tissue | Fat metabolism | Multiple regression analysis | Body fat | Anthropometry | Biochemistry | Gestation | Vitamin B12 | Socioeconomics | Supplementation | Children | Lipoproteins (high density) | Obesity | Nutrition | Diabetes mellitus | Fetuses | Markers | Vegetarian diet | Dietary supplements | Socio-economic aspects | Metabolism | Insulin | Micronutrients | Body mass | Womens health | Biochemical markers | Index Medicus
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8. Full Text Prevalence of Vascular Complications Among Patients With Glucokinase Mutations and Prolonged, Mild Hyperglycemia
by Steele, Anna M and Shields, Beverley M and Wensley, Kirsty J and Colclough, Kevin and Ellard, Sian and Hattersley, Andrew T
JAMA, ISSN 0098-7484, 01/2014, Volume 311, Issue 3, pp. 279 - 286
IMPORTANCE Glycemic targets in diabetes have been developed to minimize complication risk. Patients with heterozygous, inactivating glucokinase (GCK) mutations... 
GLYCATED HEMOGLOBIN | POPULATION | MEDICINE, GENERAL & INTERNAL | GLUCOSE | MICROALBUMINURIA | DISEASE | MICROVASCULAR COMPLICATIONS | NONDIABETIC SUBJECTS | ASSOCIATION | MODY3 | Glycated Hemoglobin A - analysis | Severity of Illness Index | Diabetes Complications | Prevalence | Cross-Sectional Studies | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Hyperglycemia - complications | Glucokinase - genetics | Male | Case-Control Studies | Hyperglycemia - genetics | Time Factors | Adult | Female | Mutation | Diabetes Mellitus, Type 2 - complications | Complications and side effects | Blood circulation disorders | Hyperglycemia | Gene mutations | Glucokinase | Physiological aspects | Genetic aspects | Research | Risk factors | Medical research | Diabetes | Index Medicus | Abridged Index Medicus
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