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Journal Article
Nature Immunology, ISSN 1529-2908, 07/2017, Volume 18, Issue 8, pp. 861 - 869
A properly mounted immune response is indispensable for recognizing and eliminating danger arising from foreign invaders and tissue trauma. However, the... 
Transcription factors | Genetic aspects | Cellular signal transduction | Immune response | Health aspects | NF-κB protein | Pain perception | Homeostasis | Hazards | Inflammation | Trauma | Constraining | Immune systems | Molecular modelling | Restoration | Regulatory mechanisms (biology) | Cancer
Journal Article
Blood, ISSN 0006-4971, 04/2014, Volume 123, Issue 14, pp. 2131 - 2133
In this issue of Blood, Dubois et al show a catalytic-independent role of the linear ubiquitin chain assembly complex (LUBAC) in lymphocyte activation and... 
CELLS | ACTIVATION | HEMATOLOGY | NF-KAPPA-B | Lymphoma - metabolism | Receptors, Antigen, T-Cell - metabolism | Protein Interaction Domains and Motifs - physiology | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | NF-kappa B - chemistry | Index Medicus | Abridged Index Medicus
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 12/2014, Volume 92, Issue 4, p. 519
Journal Article
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 08/2011, Volume 12, Issue 8, pp. 725 - 727
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 512, Issue 1, pp. 69 - 73
Rheumatoid arthritis is a chronic autoinflammatory disease that affects 1-2% of the world's population and is characterized by widespread joint inflammation.... 
RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | ACTIVATION | 6Q23 | CASPASE-1 | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | MICE | INHIBITOR | NF-KAPPA-B | ASSOCIATION | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Arthritis, Rheumatoid - metabolism | Arthritis, Rheumatoid - prevention & control | Cysteine Endopeptidases - metabolism | Receptors, Interleukin-1 - deficiency | Cysteine Endopeptidases - deficiency | Female | Tumor Necrosis Factor alpha-Induced Protein 3 | DNA-Binding Proteins | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Interleukin-1 - metabolism | Signal Transduction | Nuclear Proteins - metabolism | Apoptosis Regulatory Proteins - metabolism | Arthritis, Rheumatoid - pathology | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Macrophages - metabolism | Phenotype | Animals | Carrier Proteins - metabolism | Caspase 1 - deficiency | Mice | Arthritis, Rheumatoid - immunology | Prevention | Rheumatoid arthritis | Physiological aspects | NLRP3 | Properties | Macrophages | Risk factors | Proteins | Pathology | Dehydrogenases | Histopathology | Pathogenesis | Rodents | Protein expression | Index Medicus | Nlrp3 | IL1R1 | caspase-1 | inflammasome | A20
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2016, Volume 17, Issue 3, pp. 227 - 228
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 03/2017, Volume 76, Issue Suppl 1, p. A11
BackgroundRheumatoid arthritis (RA) is characterised by the activation of auto-reactive T-cells and the development of auto-antibodies. Importantly, T-cells... 
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 07/2017, Volume 24, Issue 7, p. 1172
Polyubiquitination of proteins has a pivotal role in the regulation of numerous cellular functions such as protein degradation, DNA repair and cell signaling.... 
Ubiquitin | Deregulation | Gene regulation | Homeostasis | Cytokine receptors | Chains | Stimulation | DNA repair | Inflammatory diseases | Defects | Proteins | Receptors | Ubiquitination | Neurodegeneration | Rodents | Catalysis | Deoxyribonucleic acid--DNA | Enzymes | NF-κB protein | Pattern recognition | Gene expression | Substrates | Molecular modelling | Lymphocytes B | Tumor necrosis factor | Cell death | Apoptosis | Cancer
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 05/2011, Volume 30, Issue 9, pp. 1742 - 1752
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2016, Volume 116, p. 1
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 2005, Volume 30, Issue 1, pp. 1 - 4
Deregulation of the transcription factor NF-κB can mediate several inflammatory diseases in addition to cancer. Therefore, several proteins, including the zinc... 
TNF RECEPTOR | RECRUITMENT | FINGER PROTEIN A20 | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | RIP | DEPENDENT GENE-EXPRESSION | CYSTEINE PROTEASES
Journal Article
Immunity, ISSN 1074-7613, 2011, Volume 35, Issue 1, pp. 82 - 96
Dendritic cells (DCs) regulate both immunity and tolerance. Here we have shown that the ubiquitin editing enzyme A20 ( ) determines the activation threshold of... 
HOMEOSTASIS | MARGINAL ZONE | IMMUNE-RESPONSES | TOLERANCE | IN-VIVO | LUPUS-ERYTHEMATOSUS | ANTIGENS | DIFFERENTIATION | IMMUNOLOGY | NF-KAPPA-B | T-CELLS | Cell Proliferation | RANK Ligand - metabolism | Dendritic Cells - immunology | Humans | Autoimmunity - genetics | Dendritic Cells - pathology | Apoptosis - genetics | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Lupus Erythematosus, Systemic - blood | Interferon-gamma - metabolism | Plasma Cells - pathology | CD40 Ligand - metabolism | Cysteine Endopeptidases - metabolism | T-Lymphocytes - metabolism | Mice, Mutant Strains | Antibodies, Antinuclear - blood | Lupus Erythematosus, Systemic - immunology | Plasma Cells - metabolism | Tumor Necrosis Factor alpha-Induced Protein 3 | T-Lymphocytes - pathology | Intracellular Signaling Peptides and Proteins - genetics | Dendritic Cells - metabolism | Cells, Cultured | Mutation - genetics | Animals | Cysteine Endopeptidases - genetics | T-Lymphocytes - immunology | Mice | Cysteine Endopeptidases - immunology | Plasma Cells - immunology | Lupus | Autoimmunity | Ubiquitin | Enzymes | Dendritic cells | Respiratory agents | Biological response modifiers | T cells | Prevention | Kidney diseases | Universities and colleges | Apoptosis | Interferon gamma | Proteins | Antigens | Cytokines | Disease | Lymphocytes | Rodents | Grants | Autoimmune diseases | Gene expression | Immune system | Index Medicus
Journal Article