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Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2013, Volume 56, Issue 13, pp. 5562 - 5586
Journal Article
Journal Article
Journal Article
MedChemComm, ISSN 2040-2503, 12/2010, Volume 1, Issue 5, pp. 355 - 360
A new series of imidazo[2,1-b]pyridine/pyrimidine chalcone derivatives were synthesized and evaluated for their anticancer activity. These chalcone derivatives... 
APOPTOSIS | CHEMISTRY, MEDICINAL | ISOLIQUIRITIGENIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | NITRIC-OXIDE | CELL-CYCLE | INHIBITORS | ANTITUMOR | PROGRESSION | Antitumor activity
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 7/2013, Volume 56, Issue 13
A series of novel (E)-N-aryl-2-arylethenesulfonamides (6) were synthesized and evaluated for their anticancer activity. Some of the compounds in this series... 
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2008, Volume 49, Issue 2, pp. 348 - 353
A mild and efficient procedure has been developed for the monosulfonylation of various amines using mesyl or tosyl chlorides in water at room temperature to... 
Water | p-Toluenesulfonyl chloride | Methanesulfonyl chloride | Amines | Sulfonamides | ORGANIC-CHEMISTRY | amines | CHEMISTRY, ORGANIC | sulfonamides | DEPROTECTION | NUCLEOPHILIC-ADDITION | SOLUBLE PHOSPHINES | water | methanesuffonyl chloride | PHASE | p-toluenesulfonyl chloride | CHEMOENZYMATIC SYNTHESIS | LIPASE | FACILE
Journal Article
Anti-Cancer Agents in Medicinal Chemistry, ISSN 1871-5206, 2013, Volume 13, Issue 10, pp. 1590 - 1600
A series of new diaryl ether linked pyrrolobenzodiazepine (PBD) conjugates (4a-i, 5a-i and 6a-f) was synthesized and evaluated for their anticancer activity... 
Poly-(ADP-ribose) polymerase | Pyrrolobenzodiazepines | Diaryl ether | Anticancer activity | Caspase | Apoptosis | Mitochondrial membrane potential | diaryl ether | poly-(ADP-ribose) polymerase | DESIGN | CHEMISTRY, MEDICINAL | HUMAN BREAST | ANTICANCER AGENTS | mitochondrial membrane potential | APOPTOSIS-INDUCING ABILITY | TUBULIN-BINDING DRUG | apoptosis | CELL-PROLIFERATION | CANCER | caspase | ONCOLOGY | DNA | pyrrolobenzodiazepines | INHIBITORS | DERIVATIVES | Epithelial Cells - metabolism | Benzodiazepines - chemical synthesis | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Epithelial Cells - drug effects | Humans | Caspase 3 - metabolism | Gene Expression Regulation, Neoplastic | Structure-Activity Relationship | Mammary Glands, Human - metabolism | Membrane Potential, Mitochondrial - drug effects | Caspase 3 - genetics | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Molecular Structure | Ethers | Mammary Glands, Human - drug effects | Benzodiazepines - pharmacology | Signal Transduction | Epithelial Cells - pathology | Mammary Glands, Human - pathology | Mitochondria - metabolism | Mitochondria - drug effects | Poly(ADP-ribose) Polymerases - metabolism | Pyrroles - pharmacology | Poly(ADP-ribose) Polymerases - genetics | Pyrroles - chemical synthesis | Cell Line, Tumor | Resting Phase, Cell Cycle - drug effects | Cell Proliferation - drug effects | Drug Screening Assays, Antitumor
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2010, Volume 18, Issue 18, pp. 6666 - 6677
Journal Article
Mini reviews in medicinal chemistry, ISSN 1389-5575, 2010, Volume 10, Issue 5, pp. 405 - 435
Journal Article
MedChemComm, ISSN 2040-2503, 03/2013, Volume 4, Issue 3, pp. 575 - 581
A series of 3-diarylethyne quinazolinone compounds (4a-ad) were synthesized and evaluated for their cytotoxicity. They exhibited significant anticancer... 
POLY(ADP-RIBOSE) POLYMERASE | APOPTOSIS | CHEMISTRY, MEDICINAL | ANTICANCER | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INHIBITORS | ANTITUMOR-ACTIVITY | CELLULAR SENESCENCE | CANCER | TELOMERE LENGTH | P53
Journal Article
ISSN 2040-2503, 2/2013, Volume 4, Issue 3, pp. 575 - 581
A series of 3-diarylethyne quinazolinone compounds ( 4a-ad ) were synthesized and evaluated for their cytotoxicity. They exhibited significant anticancer... 
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2005, Volume 15, Issue 10, pp. 2621 - 2623
Synthesis of pyrrolo[2,1- ][1,4]benzodiazepines via azido reductive cyclization process employing FeCl –NaI reagent system. This methodology has been extended... 
CHEMISTRY, MEDICINAL | ASSAY | FACILE REDUCTION | AFFINITY | AMINES | CHEMISTRY, ORGANIC | DIMERS | Benzodiazepines - chemistry | DNA - metabolism | Benzodiazepines - chemical synthesis | Electrophoresis, Agar Gel | Azides - chemistry | Benzodiazepines - metabolism | Antianxiety agents | Benzodiazepines | Chemical properties | DNA | Food additives industry
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 01/2010, Volume 18, Issue 2, pp. 526 - 542
Journal Article
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