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1. Full Text Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial
by Le Tourneau, Christophe, Dr and Delord, Jean-Pierre, Prof and Gonçalves, Anthony, Prof and Gavoille, Céline, MD and Dubot, Coraline, MD and Isambert, Nicolas, MD and Campone, Mario, Prof and Trédan, Olivier, MD and Massiani, Marie-Ange, MD and Mauborgne, Cécile, MSc and Armanet, Sebastien, MSc and Servant, Nicolas, PhD and Bièche, Ivan, PhD and Bernard, Virginie, PhD and Gentien, David, PhD and Jezequel, Pascal, MD and Attignon, Valéry, PhD and Boyault, Sandrine, PhD and Vincent-Salomon, Anne, MD and Servois, Vincent, MD and Sablin, Marie-Paule, MD and Kamal, Maud, PhD and Paoletti, Xavier, PhD and SHIVA investigators and SHIVA Investigators
The lancet oncology, ISSN 1470-2045, 2015, Volume 16, Issue 13, pp. 1324 - 1334
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasms - metabolism | Predictive Value of Tests | Off-Label Use | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Patient Selection | Molecular Diagnostic Techniques | Neoplasm Metastasis | Neoplasms - genetics | Time Factors | Antineoplastic Agents - adverse effects | Biomarkers, Tumor - metabolism | Female | France | Precision Medicine | Genetic Predisposition to Disease | Molecular Targeted Therapy - adverse effects | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Neoplasms - mortality | Treatment Outcome | Disease Progression | Neoplasms - drug therapy | Disease-Free Survival | Phenotype | Signal Transduction - drug effects | Biopsy | Intention to Treat Analysis | Aged | Biomarkers, Tumor - genetics | Neoplasms - pathology | Care and treatment | Pharmacogenetics | Health aspects | Cancer | Index Medicus | Life Sciences
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2. Full Text ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS
by Pasmant, Eric and Sabbagh, Audrey and Vidaud, Michel and Bièche, Ivan
The FASEB journal, ISSN 0892-6638, 02/2011, Volume 25, Issue 2, pp. 444 - 448
p15/CDKN2B‐p16/CDKN2A‐p14/ARF gene cluster | long ncRNA | susceptibility locus | Long ncRNA | p15/CDKN2Bp-16/CDKN2A-p14/ARF gene cluster | Susceptibility locus | Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Gene Expression Regulation - physiology | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Animals | RNA, Untranslated - genetics | Humans | Index Medicus
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3. Full Text Tubulin glycylation controls primary cilia length
by Gadadhar, Sudarshan and Dadi, Hala and Bodakuntla, Satish and Schnitzler, Anne and Bièche, Ivan and Rusconi, Filippo and Janke, Carsten
The Journal of cell biology, ISSN 0021-9525, 09/2017, Volume 216, Issue 9, pp. 2701 - 2713
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Antibody Specificity | Axoneme - metabolism | Humans | Homeostasis | Cilia - immunology | Peptide Synthases - genetics | Tubulin - metabolism | Transfection | Time Factors | HEK293 Cells | Madin Darby Canine Kidney Cells | Antibodies - immunology | Flagella - immunology | Animals, Newborn | Tubulin - immunology | Movement | Mice, Inbred C57BL | Glycosylation | Cilia - metabolism | Peptide Synthases - metabolism | Axoneme - immunology | Animals | Flagella - metabolism | Dogs | Protein Processing, Post-Translational | HeLa Cells | Physiological aspects | Cell research | Research | Tubulins | Cilia and ciliary motion | Cellular control mechanisms | Enzymes | Antibodies | Organelles | Cells | Proteins | Eukaryotes | Tubulin | Microtubules | Cytoskeleton | Flagella | Cilia | Cancer | Index Medicus | Life Sciences | Cellular Biology | Subcellular Processes
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4. Full Text Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut
by Chanrion, Maia and Kuperstein, Inna and Barrière, Cédric and El Marjou, Fatima and Cohen, David and Vignjevic, Danijela and Stimmer, Lev and Paul-Gilloteaux, Perrine and Bièche, Ivan and Tavares, Silvina Dos Reis and Boccia, Giuseppe-Fulvio and Cacheux, Wulfran and Meseure, Didier and Fre, Silvia and Martignetti, Loredana and Legoix-Né, Patricia and Girard, Elodie and Fetler, Luc and Barillot, Emmanuel and Louvard, Daniel and Zinovyev, Andreï and Robine, Sylvie
Nature communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, pp. 5005 - 5005
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Immunohistochemistry | Green Fluorescent Proteins - metabolism | Epithelial-Mesenchymal Transition - physiology | Humans | Tumor Suppressor Protein p53 - metabolism | Molecular Sequence Data | Genotype | Mice, Transgenic | DNA Primers - genetics | Signal Transduction - genetics | Receptor, Notch1 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, DNA | Gastrointestinal Tract - metabolism | Cell Lineage | Exome - genetics | Animals | Image Processing, Computer-Assisted | Gastrointestinal Tract - physiology | Base Sequence | Neoplasm Metastasis - physiopathology | Signal Transduction - physiology | Mice | Disease Models, Animal | Index Medicus | Life Sciences
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5. Full Text Inhibitory signalling to the Arp2/3 complex steers cell migration
by Dang, Irene and Gorelik, Roman and Sousa-Blin, Carla and Derivery, Emmanuel and Guérin, Christophe and Linkner, Joern and Nemethova, Maria and Dumortier, Julien G and Giger, Florence A and Chipysheva, Tamara A and Ermilova, Valeria D and Vacher, Sophie and Campanacci, Valérie and Herrada, Isaline and Planson, Anne-Gaelle and Fetics, Susan and Henriot, Véronique and David, Violaine and Oguievetskaia, Ksenia and Lakisic, Goran and Pierre, Fabienne and Steffen, Anika and Boyreau, Adeline and Peyriéras, Nadine and Rottner, Klemens and Zinn-Justin, Sophie and Cherfils, Jacqueline and Bièche, Ivan and Alexandrova, Antonina Y and David, Nicolas B and Small, J. Victor and Faix, Jan and Blanchoin, Laurent and Gautreau, Alexis
Nature (London), ISSN 0028-0836, 2013, Volume 503, Issue 7475, pp. 281 - 284
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Line | Signal Transduction | Humans | Gene Knockout Techniques | Cell Movement - genetics | Zebrafish - genetics | Proteins - genetics | Carrier Proteins - genetics | Actin-Related Protein 2-3 Complex - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Pseudopodia - metabolism | Embryo, Nonmammalian | HEK293 Cells | Dictyostelium - genetics | Pseudopodia - genetics | Mice | Dictyostelium - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Cell research | Cellular signal transduction | Research | Cell migration | Proteins | Microscopy | Plasmids | Polymerization | Zebrafish | Binding sites | Cell adhesion & migration | Index Medicus | Neurons and Cognition | Pseudopodia | Actin-Related Protein 2-3 Complex | Proto-Oncogene Proteins c-akt | Life Sciences | Dictyostelium | Cell Movement
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6. Full Text Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: Identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF
by Pasmant, Eric and Laurendeau, Ingrid and Héron, Delphine and Vidaud, Michel and Vidaud, Dominique and Bièche, Ivan
Cancer research (Chicago, Ill.), ISSN 0008-5472, 04/2007, Volume 67, Issue 8, pp. 3963 - 3969
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the skin and soft tissue. Premalignant lesions | Dermatology | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | Melanoma - metabolism | Humans | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Male | Chromosome Mapping | Cyclin-Dependent Kinase Inhibitor p15 - biosynthesis | RNA, Untranslated - genetics | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Melanoma - genetics | Pedigree | Gene Deletion | Polymerase Chain Reaction | Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis | Female | Tumor Suppressor Protein p14ARF - biosynthesis | Nervous System Neoplasms - genetics | Tumor Suppressor Protein p14ARF - genetics | Nervous System Neoplasms - metabolism | RNA, Antisense - genetics | Index Medicus
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7. Full Text DNA methylation imprinting marks and DNA methyltransferase expression in human spermatogenic cell stages
by Marques, C. Joana and João Pinho, Maria and Carvalho, Filipa and Bièche, Ivan and Barros, Alberto and Sousa, Mário
Epigenetics, ISSN 1559-2294, 11/2011, Volume 6, Issue 11, pp. 1354 - 1361
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | H19 | Human spermatogenesis | MEST/PEG1 | DNA methyltransferases | Genomic imprinting | Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA (Cytosine-5-)-Methyltransferases - genetics | Genomic Imprinting | DNA Methylation | Spermatocytes - metabolism | Spermatogenesis - genetics | DNA (Cytosine-5-)-Methyltransferase 1 | Humans | Spermatocytes - cytology | Male | Spermatogonia - cytology | Spermatogonia - metabolism | Index Medicus
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8. Full Text Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function
by Castagnino, Alessia and Castro-Castro, Antonio and Irondelle, Marie and Guichard, Alan and Lodillinsky, Catalina and Fuhrmann, Laetitia and Vacher, Sophie and Agüera-González, Sonia and Zagryazhskaya-Masson, Anna and Romao, Maryse and El Kesrouani, Carole and Noegel, Angelika A and Dubois, Thierry and Raposo, Graça and Bear, James E and Clemen, Christoph S and Vincent-Salomon, Anne and Bièche, Ivan and Chavrier, Philippe
Oncogene, ISSN 0950-9232, 12/2018, Volume 37, Issue 50, pp. 6425 - 6441
Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Humans | Protein Transport - physiology | Matrix Metalloproteinase 14 - metabolism | Podosomes - metabolism | Podosomes - pathology | Animals | Heterografts | Neoplasm Invasiveness - pathology | Triple Negative Breast Neoplasms - metabolism | Triple Negative Breast Neoplasms - pathology | Cell Line, Tumor | Female | Mice | Microfilament Proteins - metabolism | Spheroids, Cellular | Research | Binding proteins | Gene expression | Cancer cells | Actin | Invasiveness | Collagen | Fibrils | Xenografts | Membrane trafficking | Breast cancer | Metalloproteinase | Matrix metalloproteinase | Spheroids | Metastases | Index Medicus | Life Sciences
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9. Full Text PIK3R1 underexpression is an independent prognostic marker in breast cancer
by Cizkova, Magdalena and Vacher, Sophie and Meseure, Didier and Trassard, Martine and Susini, Aurélie and Mlcuchova, Dana and Callens, Celine and Rouleau, Etienne and Spyratos, Frederique and Lidereau, Rosette and Bièche, Ivan
BMC cancer, ISSN 1471-2407, 11/2013, Volume 13, Issue 1, pp. 545 - 545
Prognostic value | Signaling pathways | Breast cancer | PIK3R1 | PIK3CA | Breast cancer subtypes | Prognosis | Signal Transduction | Humans | Middle Aged | RNA, Messenger - genetics | Gene Expression Regulation, Neoplastic | Phosphatidylinositol 3-Kinases - metabolism | RNA, Messenger - metabolism | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Aged, 80 and over | Adult | Breast Neoplasms - mortality | Female | Aged | Mutation | Proto-Oncogene Proteins c-akt - metabolism | Oncology, Experimental | Analysis | Protein tyrosine kinase | Genetic aspects | Metastasis | Research | Gene expression | Cancer | Index Medicus
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10. Full Text EHD2 is a Predictive Biomarker of Chemotherapy Efficacy in Triple Negative Breast Carcinoma
by Shen, Wei-Wei and Bieche, Ivan and Fuhrmann, Laetitia and Vacher, Sophie and Vincent-Salomon, Anne and Torrino, Stephanie and Lamaze, Christophe
Scientific reports, ISSN 2045-2322, 05/2020, Volume 10, Issue 1, pp. 7998 - 7998
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Immunohistochemistry | Prognosis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Treatment Outcome | Triple Negative Breast Neoplasms - drug therapy | Biomarkers, Tumor | Carrier Proteins - genetics | Neoplasm Metastasis | Carrier Proteins - metabolism | Neoplasm Grading | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Triple Negative Breast Neoplasms - metabolism | Triple Negative Breast Neoplasms - pathology | Adult | Female | Aged | Neoplasm Staging | Cell proliferation | Invaginations | Transcription | Caveolae | Breast cancer | Multivariate analysis | Metastases | Breast carcinoma | Chemotherapy | Medical prognosis | Cell migration | Adenosine triphosphatase | Interleukin 8 | Index Medicus | Life Sciences | Pharmacology | Molecular biology | Biochemistry, Molecular Biology | Pharmaceutical sciences | Cancer
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