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1. Full Text Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial
by Le Tourneau, Christophe, Dr and Delord, Jean-Pierre, Prof and Gonçalves, Anthony, Prof and Gavoille, Céline, MD and Dubot, Coraline, MD and Isambert, Nicolas, MD and Campone, Mario, Prof and Trédan, Olivier, MD and Massiani, Marie-Ange, MD and Mauborgne, Cécile, MSc and Armanet, Sebastien, MSc and Servant, Nicolas, PhD and Bièche, Ivan, PhD and Bernard, Virginie, PhD and Gentien, David, PhD and Jezequel, Pascal, MD and Attignon, Valéry, PhD and Boyault, Sandrine, PhD and Vincent-Salomon, Anne, MD and Servois, Vincent, MD and Sablin, Marie-Paule, MD and Kamal, Maud, PhD and Paoletti, Xavier, PhD and SHIVA Investigators and SHIVA investigators
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 13, pp. 1324 - 1334
Summary Background Molecularly targeted agents have been reported to have anti-tumour activity for patients whose tumours harbour the matching molecular... 
Hematology, Oncology and Palliative Medicine | LUNG-CANCER | MELANOMA | TRASTUZUMAB | EFFICACY | ONCOLOGY | VALIDATION | PERSONALIZED MEDICINE | HER2-POSITIVE BREAST-CANCER | CHEMOTHERAPY | PROGRAM | VEMURAFENIB | Neoplasms - metabolism | Predictive Value of Tests | Off-Label Use | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Patient Selection | Molecular Diagnostic Techniques | Neoplasm Metastasis | Neoplasms - genetics | Time Factors | Antineoplastic Agents - adverse effects | Biomarkers, Tumor - metabolism | Female | France | Precision Medicine | Genetic Predisposition to Disease | Molecular Targeted Therapy - adverse effects | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Neoplasms - mortality | Treatment Outcome | Disease Progression | Neoplasms - drug therapy | Disease-Free Survival | Phenotype | Signal Transduction - drug effects | Biopsy | Intention to Treat Analysis | Aged | Biomarkers, Tumor - genetics | Neoplasms - pathology | Care and treatment | Pharmacogenetics | Health aspects | Cancer
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2. Full Text Inhibitory signalling to the Arp2/3 complex steers cell migration
by Dang, Irene and Gorelik, Roman and Sousa-Blin, Carla and Derivery, Emmanuel and Guérin, Christophe and Linkner, Joern and Nemethova, Maria and Dumortier, Julien G and Giger, Florence A and Chipysheva, Tamara A and Ermilova, Valeria D and Vacher, Sophie and Campanacci, Valérie and Herrada, Isaline and Planson, Anne-Gaelle and Fetics, Susan and Henriot, Véronique and David, Violaine and Oguievetskaia, Ksenia and Lakisic, Goran and Pierre, Fabienne and Steffen, Anika and Boyreau, Adeline and Peyriéras, Nadine and Rottner, Klemens and Zinn-Justin, Sophie and Cherfils, Jacqueline and Bièche, Ivan and Alexandrova, Antonina Y and David, Nicolas B and Small, J. Victor and Faix, Jan and Blanchoin, Laurent and Gautreau, Alexis
Nature, ISSN 0028-0836, 2013, Volume 503, Issue 7475, pp. 281 - 284
Cell migration requires the generation of branched actin networks that power the protrusion of the plasma membrane inlamellipodia(1,2). The actin-related... 
DICTYOSTELIUM | WASP/SCAR PROTEINS | FILAMENTS | ACTIN POLYMERIZATION | LEADING-EDGE | MULTIDISCIPLINARY SCIENCES | DYNAMICS | LAMELLIPODIA | NETWORKS | ENDOCYTOSIS | MOTILITY | Cell Line | Signal Transduction | Humans | Gene Knockout Techniques | Cell Movement - genetics | Zebrafish - genetics | Proteins - genetics | Carrier Proteins - genetics | Actin-Related Protein 2-3 Complex - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Pseudopodia - metabolism | Embryo, Nonmammalian | HEK293 Cells | Dictyostelium - genetics | Pseudopodia - genetics | Mice | Dictyostelium - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Cell research | Cellular signal transduction | Research | Cell migration | Proteins | Microscopy | Plasmids | Polymerization | Zebrafish | Binding sites | Cell adhesion & migration | Neurons and Cognition | Pseudopodia | Actin-Related Protein 2-3 Complex | Proto-Oncogene Proteins c-akt | Life Sciences | Dictyostelium | Cell Movement
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3. Full Text Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer
by Liang, Xu and Vacher, Sophie and Boulai, Anais and Bernard, Virginie and Baulande, Sylvain and Bohec, Mylene and Bièche, Ivan and Lerebours, Florence and Callens, Céline
Breast Cancer Research, ISSN 1465-5411, 08/2018, Volume 20, Issue 1, pp. 88 - 12
Background: Inflammatory breast cancer (IBC) is the most aggressive form of primary breast cancer. Using a custom-made breast cancer gene sequencing panel, we... 
Somatic mutation | Inflammatory breast cancer | Targeted NGS | Prognosis | SURVIVAL | MULTICENTER | TRASTUZUMAB | PHENOTYPE | SUBGROUPS | TUMORS | DEFICIENCY | PIK3CA | ONCOLOGY | IMMUNOTHERAPY | REVEALS | Prospective Studies | Follow-Up Studies | Inflammatory Breast Neoplasms - pathology | Humans | Middle Aged | Kaplan-Meier Estimate | Inflammatory Breast Neoplasms - genetics | DNA Mutational Analysis - methods | Young Adult | Aged, 80 and over | Adult | Female | Aged | Biomarkers, Tumor - genetics | Mutation | High-Throughput Nucleotide Sequencing - methods | Breast - pathology | Inflammatory Breast Neoplasms - mortality | Gene mutations | Analysis | Breast cancer | Genetic aspects | Diagnosis | Nucleotide sequencing | Research | DNA sequencing
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4. Full Text PIK3R1 underexpression is an independent prognostic marker in breast cancer
by Cizkova, Magdalena and Vacher, Sophie and Meseure, Didier and Trassard, Martine and Susini, Aurélie and Mlcuchova, Dana and Callens, Celine and Rouleau, Etienne and Spyratos, Frederique and Lidereau, Rosette and Bièche, Ivan
BMC Cancer, ISSN 1471-2407, 11/2013, Volume 13, Issue 1, pp. 545 - 545
Background: The present study focused on the prognostic roles of PIK3CA and PIK3R1 genes and additional PI3K pathway-associated genes in breast cancer.... 
Prognostic value | Signaling pathways | Breast cancer | PIK3R1 | PIK3CA | Breast cancer subtypes | PTEN LOSS | ACTIVATION | P110-ALPHA | P85 REGULATORY SUBUNIT | TRASTUZUMAB | INHIBITION | ONCOLOGY | CELL-CYCLE | MUTATIONS | EXPRESSION | PROGRESSION | Prognosis | Signal Transduction | Humans | Middle Aged | RNA, Messenger - genetics | Gene Expression Regulation, Neoplastic | Phosphatidylinositol 3-Kinases - metabolism | RNA, Messenger - metabolism | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Aged, 80 and over | Adult | Breast Neoplasms - mortality | Female | Aged | Mutation | Proto-Oncogene Proteins c-akt - metabolism | Care and treatment | Protein tyrosine kinase | Physiological aspects | Genetic aspects | Research | Gene expression | RNA | Analysis | Oncology, Experimental | Genes | Metastasis | Cancer
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5. Full Text Tubulin glycylation controls primary cilia length
by Gadadhar, Sudarshan and Dadi, Hala and Bodakuntla, Satish and Schnitzler, Anne and Bièche, Ivan and Rusconi, Filippo and Janke, Carsten
Journal of Cell Biology, ISSN 0021-9525, 09/2017, Volume 216, Issue 9, pp. 2701 - 2713
As essential components of the eukaryotic cytoskeleton, microtubules fulfill a variety of functions that can be temporally and spatially controlled by tubulin... 
BETA-TUBULIN | ANTIBODIES | SEA-URCHIN SPERM | POLYGLYCYLATION | MICROTUBULES | ALPHA-TUBULIN | TETRAHYMENA | C-TERMINAL TAIL | POSTTRANSLATIONAL MODIFICATIONS | AXONEMAL TUBULIN | CELL BIOLOGY | Antibody Specificity | Axoneme - metabolism | Humans | Homeostasis | Cilia - immunology | Peptide Synthases - genetics | Tubulin - metabolism | Transfection | Time Factors | HEK293 Cells | Madin Darby Canine Kidney Cells | Antibodies - immunology | Flagella - immunology | Animals, Newborn | Tubulin - immunology | Movement | Mice, Inbred C57BL | Glycosylation | Cilia - metabolism | Peptide Synthases - metabolism | Axoneme - immunology | Animals | Flagella - metabolism | Dogs | Protein Processing, Post-Translational | HeLa Cells | Physiological aspects | Cell research | Research | Tubulins | Cilia and ciliary motion | Cellular control mechanisms
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6. Full Text Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: Identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF
by Pasmant, Eric and Laurendeau, Ingrid and Héron, Delphine and Vidaud, Michel and Vidaud, Dominique and Bièche, Ivan
Cancer Research, ISSN 0008-5472, 04/2007, Volume 67, Issue 8, pp. 3963 - 3969
We have previously detected a large germ-line deletion, which included the entire p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster, in the largest melanoma-neural... 
CUTANEOUS MALIGNANT-MELANOMA | NERVOUS-SYSTEM | PRONENESS | PROTEIN | P14(ARF) | ONCOLOGY | CDKN2A | GLIOMA | GENES | MUTATIONS | CANCER | Melanoma - metabolism | Humans | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Male | Chromosome Mapping | Cyclin-Dependent Kinase Inhibitor p15 - biosynthesis | RNA, Untranslated - genetics | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Melanoma - genetics | Pedigree | Gene Deletion | Polymerase Chain Reaction | Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis | Female | Tumor Suppressor Protein p14ARF - biosynthesis | Nervous System Neoplasms - genetics | Tumor Suppressor Protein p14ARF - genetics | Nervous System Neoplasms - metabolism | RNA, Antisense - genetics
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7. Full Text Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: Role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy
by Bièche, Ivan and Vacher, Sophie and Lallemand, François and Tozlu-Kara, Sengül and Bennani, Hind and Beuzelin, Michèle and Driouch, Keltouma and Rouleau, Etienne and Lerebours, Florence and Ripoche, Hugues and Cizeron-Clairac, Géraldine and Spyratos, Frédérique and Lidereau, Rosette
Molecular Cancer, ISSN 1476-4598, 02/2011, Volume 10, Issue 1, pp. 23 - 23
Background: Aneuploidy and chromosomal instability (CIN) are common abnormalities in human cancer. Alterations of the mitotic spindle checkpoint are likely to... 
GENOMIC INSTABILITY | ASSEMBLY CHECKPOINT | POTENT | AMPLIFICATION | MICROARRAY | ONCOLOGY | PROGNOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-PLOIDY | TETRAPLOIDY | CANCER | SMALL-MOLECULE INHIBITOR | Epithelial Cells - metabolism | Humans | Gene Expression Regulation, Neoplastic | Aneuploidy | Gene Expression Profiling | RNA, Messenger - metabolism | Breast - metabolism | Diploidy | Spindle Apparatus - genetics | Female | Precancerous Conditions - pathology | Nuclear Proteins - genetics | Breast - pathology | Genes, Neoplasm - genetics | Fibroblasts - metabolism | Reproducibility of Results | Neoplasm Invasiveness | RNA, Messenger - genetics | Nuclear Proteins - metabolism | Up-Regulation - genetics | Precancerous Conditions - genetics | Disease Progression | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | DNA, Neoplasm - genetics | Development and progression | Breast cancer | Genetic aspects | Research | Gene expression | Risk factors | Proteins | Statistical analysis | Chromosomes | Tumors | Life Sciences | Biochemistry, Molecular Biology | Genomics | Cancer
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8. Full Text Cytidine deaminase deficiency reveals new therapeutic opportunities against cancer
by Mameri, Hamza and Biéche, Ivan and Meseure, Didier and Marangoni, Elisabetta and Buhagiar-Labarchéde, Géraldine and Nicolas, André and Vacher, Sophie and Onclercq-Delic, Rosine and Rajapakse, Vinodh and Varma, Sudhir and Reinhold, William C and Pommier, Yves and Amor-Guéret, Mounira
Clinical Cancer Research, ISSN 1078-0432, 04/2017, Volume 23, Issue 8, pp. 2116 - 2126
Purpose: One of the main challenges in cancer therapy is the identification of molecular mechanisms mediating resistance or sensitivity to treatment. Cytidine... 
BREAST-CANCER | CYTOSINE-ARABINOSIDE | AMINOFLAVONE NSC-686288 | ONCOLOGY | ARYL-HYDROCARBON RECEPTOR | AID/APOBEC FAMILY | ANTICANCER AGENT | SINGLE-NUCLEOTIDE POLYMORPHISM | ACUTE MYELOID-LEUKEMIA | CONFERS RESISTANCE | GEMCITABINE | Immunohistochemistry | Xenograft Model Antitumor Assays | Animals | Biomarkers, Tumor - analysis | Humans | Cell Line, Tumor | Cytidine Deaminase - deficiency | Neoplasms - enzymology | Mice | Drug Resistance, Neoplasm - physiology | Real-Time Polymerase Chain Reaction | Blotting, Western | Drugs | Biotechnology | Tumor cells | Tumor cell lines | Drug development | Tissues | Cancer therapies | Subgroups | Western blotting | Molecular modelling | Bloom's syndrome | Experimental design | Cell lines | DNA methylation | Methylation | Deoxyribonucleic acid--DNA | Tumors | Cancer | Cytidine deaminase
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9. Full Text Gene expression profiling reveals new aspects of PIK3CA mutation in eralpha-positive breast cancer: Major implication of the Wnt signaling pathway
by Cizkova, Magdalena and Cizeron-Clairac, Géraldine and Vacher, Sophie and Susini, Aurélie and Andrieu, Catherine and Lidereau, Rosette and Bièche, Ivan
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 12, p. e15647
Background: The PI3K/AKT pathway plays a pivotal role in breast cancer development and maintenance. PIK3CA, encoding the PI3K catalytic subunit, is the... 
TRANSCRIPTION FACTORS | STEM-CELLS | BIOLOGY | CARCINOMAS | PTEN | CELL-GROWTH | DIFFERENTIATION | IDENTIFICATION | SIGNATURE | ESTROGEN-RECEPTOR | PROGRESSION | Catalytic Domain | Oligonucleotide Array Sequence Analysis | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | Gene Expression Profiling | Reverse Transcriptase Polymerase Chain Reaction | Wnt Proteins - metabolism | Breast Neoplasms - metabolism | Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases | DNA Mutational Analysis | Estrogen Receptor alpha - metabolism | Female | Catalysis | Mutation | Analysis | Genes | Cytochrome P-450 | Development and progression | Breast cancer | Genetic aspects | Genetic transcription | Cancer | Cytochrome | Transcription factors | Target recognition | Wnt protein | Transcription | Gene regulation | AKT protein | Activation | Genomes | Kinases | Osteoprotegerin | Proteins | Signal transduction | Msx2 protein | Tumorigenesis | Metal ions | Medical research | Enzymes | AP-2 protein | Gene expression | 1-Phosphatidylinositol 3-kinase | Polymerase chain reaction | Studies | Signaling | Overexpression | DNA microarrays | Breast | Aberration | Uterine cancer | Prostate cancer | Tumors
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10. Full Text Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile
by Ducray, François and Idbaih, Ahmed and de Reyniès, Aurélien and Bièche, Ivan and Thillet, Joëlle and Mokhtari, Karima and Lair, Séverine and Marie, Yannick and Paris, Sophie and Vidaud, Michel and Hoang-Xuan, Khê and Delattre, Olivier and Delattre, Jean-Yves and Sanson, Marc
Molecular Cancer, ISSN 1476-4598, 05/2008, Volume 7, Issue 1, pp. 41 - 41
Background: In high grade gliomas, 1p19q codeletion and EGFR amplification are mutually exclusive and predictive of dramatically different outcomes. We... 
PROGENITOR CELLS | GLIOMAS | ADULT BRAIN | ONCOLOGY | PROGNOSIS | GENOTYPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROGENESIS | CLASSIFICATION | IDENTIFICATION | OLIGODENDROCYTES | 1P | Chromosome Deletion | Immunohistochemistry | Reproducibility of Results | Oligodendroglioma - genetics | Genes, Neoplasm | Humans | Gene Expression Regulation, Neoplastic | Gene Expression Profiling | Reverse Transcriptase Polymerase Chain Reaction | Genome, Human - genetics | Receptor, Epidermal Growth Factor - metabolism | Oligodendroglioma - pathology | Neoplastic Stem Cells - pathology | Neurons - metabolism | Intermediate Filament Proteins - metabolism | Cluster Analysis | Polymerase chain reaction | Care and treatment | Usage | Prognosis | Gliomas | Genetic aspects | Research | Diagnosis | Gene expression | Health aspects | Methods | Risk factors
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11. Full Text Mutational analysis of anal cancers demonstrates frequent PIK3CA mutations associated with poor outcome after salvage abdominoperineal resection
by Cacheux, Wulfran and Rouleau, Etienne and Briaux, Adrien and Tsantoulis, Petros and Mariani, Pascale and Richard-Molard, Marion and Buecher, Bruno and Dangles-Marie, Virginie and Richon, Sophie and Lazartigues, Julien and Jeannot, Emmanuelle and Farkhondeh, Fereshteh and Sastre-Garau, Xavier and De La Rochefordière, Anne and Labib, Alain and Falcou, Marie-Christine and Stevens, Denise and Roth, Arnaud and Roman-Roman, Sergio and Mitry, Emmanuel and Bièche, Ivan and Lièvre, Astrid
British Journal of Cancer, ISSN 0007-0920, 06/2016, Volume 114, Issue 12, pp. 1387 - 1394
Background: A better understanding of the molecular profile of anal squamous cell carcinomas (ASCCs) is necessary to consider new therapeutic approaches, and... 
SURVIVAL | CHEMORADIATION THERAPY | prognostic factor | GROWTH-FACTOR-RECEPTOR | EPIDERMOID CARCINOMA | abdominoperineal resection | COMPREHENSIVE MOLECULAR CHARACTERIZATION | CHEMORADIOTHERAPY | therapeutic target | CERVICAL-CANCER | HUMAN-PAPILLOMAVIRUS | mutation status | anal squamous cell carcinoma | PIK3CA | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | EXPRESSION | Neoplasm Recurrence, Local - metabolism | Anus Neoplasms - metabolism | Humans | Middle Aged | Anus Neoplasms - surgery | Male | Anus Neoplasms - pathology | Phosphatidylinositol 3-Kinases - metabolism | Neoplasm Recurrence, Local - surgery | Neoplasm Recurrence, Local - pathology | Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases | DNA Mutational Analysis | Anus Neoplasms - genetics | Aged, 80 and over | Adult | Female | Neoplasm Recurrence, Local - genetics | Aged | Retrospective Studies | Mutation | Salvage Therapy - methods | Life Sciences | Genetics | Molecular Diagnostics
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12. Full Text ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS
by Pasmant, Eric and Sabbagh, Audrey and Vidaud, Michel and Bièche, Ivan
FASEB Journal, ISSN 0892-6638, 02/2011, Volume 25, Issue 2, pp. 444 - 448
A large noncoding RNA called ANRIL (for antisense noncoding RNA in the INK4 locus) has been identified within the p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster.... 
Long ncRNA | p15/CDKN2Bp-16/CDKN2A-p14/ARF gene cluster | Susceptibility locus | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUSCEPTIBILITY LOCI | RISK | long ncRNA | DELETION | CELL BIOLOGY | IDENTIFIES 3 | susceptibility locus | MELANOMA | p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster | BIOLOGY | INTRACRANIAL ANEURYSM | EXPRESSION | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | Gene Expression Regulation - physiology | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Animals | RNA, Untranslated - genetics | Humans
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13. Full Text Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut
by Chanrion, Maia and Kuperstein, Inna and Barrière, Cédric and El Marjou, Fatima and Cohen, David and Vignjevic, Danijela and Stimmer, Lev and Paul-Gilloteaux, Perrine and Bièche, Ivan and Tavares, Silvina Dos Reis and Boccia, Giuseppe-Fulvio and Cacheux, Wulfran and Meseure, Didier and Fre, Silvia and Martignetti, Loredana and Legoix-Né, Patricia and Girard, Elodie and Fetler, Luc and Barillot, Emmanuel and Louvard, Daniel and Zinovyev, Andreï and Robine, Sylvie
Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 5005
Epithelial-to-mesenchymal transition-like (EMT-like) is a critical process allowing initiation of metastases during tumour progression. Here, to investigate... 
COLON-CANCER | BREAST-CANCER | MOLECULAR CHARACTERIZATION | PROGENITOR CELLS | TUMOR-CELL MIGRATION | MICRORNA FAMILY | BIOLOGICAL NETWORKS | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | INTESTINAL TUMORIGENESIS | BETA-CATENIN | Immunohistochemistry | Green Fluorescent Proteins - metabolism | Epithelial-Mesenchymal Transition - physiology | Humans | Tumor Suppressor Protein p53 - metabolism | Molecular Sequence Data | Genotype | Mice, Transgenic | DNA Primers - genetics | Signal Transduction - genetics | Receptor, Notch1 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, DNA | Gastrointestinal Tract - metabolism | Cell Lineage | Exome - genetics | Animals | Image Processing, Computer-Assisted | Gastrointestinal Tract - physiology | Base Sequence | Neoplasm Metastasis - physiopathology | Signal Transduction - physiology | Mice | Disease Models, Animal | Life Sciences
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