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Surface Science, ISSN 0039-6028, 06/2019, Volume 684, pp. 52 - 57
The effect of different sulfur adsorption site on right Au electrodes in molecular device is investigated by using non-equilibrium Green’s function and density... 
Switching behavior | Molecular device | Electronic transport | Density functionals | Sulfur compounds | Adsorption | Sulfur | Isomerization | Electrodes | Asymmetry | Molecular orbitals | Density functional theory | Eigenvectors | Electrode polarization | Electron transport | Switching
Journal Article
Materials Chemistry and Physics, ISSN 0254-0584, 01/2020, Volume 239, p. 122048
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 10/2019, Volume 168, pp. 214 - 223
Targeting Trp-Kyn pathways has been identified as an attractive approach for the cancer immunotherapies. In this study, a novel phosphonamidate containing... 
Epacadostat | NSCLC | IDO1 inhibitors | Phosphonamidate | Trp-Kyn | Enzymes | Chemotherapy | Hydrogen | Analysis | Pharmacy | Immunotherapy | Tryptophan | Biological response modifiers | T cells | Interferon gamma | Cancer
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111629
Targeting indoleamine 2,3-dioxygenase 1 (IDO1) has been identified as an attractive approach for the development of cancer immunotherapy. In this study, a... 
Epacadostat | Phosphonamidate ester | IDO2 | IDO1 inhibitors | TDO
Journal Article
Scientific Reports, ISSN 2045-2322, 10/2016, Volume 6, Issue 1, p. 35771
Journal Article
Advances in Difference Equations, ISSN 1687-1839, 12/2019, Volume 2019, Issue 1, pp. 1 - 16
Journal Article
Current Cancer Drug Targets, ISSN 1568-0096, 2018, Volume 18, Issue 7, pp. 652 - 667
Prostate cancer is the most common carcinoma among aged males in western countries and more aggressive and lethal castration resistant prostate cancer often... 
Degradation | Small molecules | New strategies | Prostate cancer | Androgen receptor | Resistance mechanism | CHIMERIC MOLECULES | degradation | new strategies | prostate cancer | androgen receptor | ONCOLOGY | PROTEIN-DEGRADATION | GELDANAMYCIN | IN-VIVO | BIOLOGICAL EVALUATION | RESISTANCE | INCREASED SURVIVAL | INHIBITORS | PHASE-I | small molecules | ENZALUTAMIDE | Androgens | Deprivation | Castration | Males | Prostate | Cancer
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2019, Volume 34, Issue 1, pp. 250 - 263
With the aim of discovering novel IDO1 inhibitors, a combined similarity search and molecular docking approach was employed to the discovery of 32 hit... 
virtual screen | cyanopyridine scaffold | inhibitor | Indoleamine 2,3-dioxygenase 1 | hit optimisation | DESIGN | CHEMISTRY, MEDICINAL | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDOLEAMINE 2,3-DIOXYGENASE | CRYSTAL-STRUCTURES | POTENT INHIBITORS | MOLECULAR DOCKING | DETAILED ANALYSIS | TRYPTOPHAN DEGRADATION | DERIVATIVES | EXPRESSION
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, p. 828
NQO1 is a dimeric flavoprotein which intimately associated with cancer and overexpressed in the cytosol of numerous human tumor cells. Given that the cellular... 
Quinone | Investigations | Albumin | Lung cancer, Non-small cell | High performance liquid chromatography | Fluorescein
Journal Article
Organic Letters, ISSN 1523-7060, 07/2015, Volume 17, Issue 14, pp. 3410 - 3413
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2018, Volume 62, Issue 3, pp. 1096 - 1115
It has been demonstrated that glutamine metabolism has become the main energy and building blocks supply for the growth and viability of a potentially large... 
GLUTAMATE-DEHYDROGENASE | TARGETED INHIBITION | CHEMISTRY, MEDICINAL | ACID | KIDNEY-TYPE GLUTAMINASE | PHOSPHATE-DEPENDENT GLUTAMINASE | 6-DIAZO-5-OXO-L-NORLEUCINE DON | GROWTH | CANCER METABOLISM | GLUTAMINOLYSIS | PHASE-I
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 03/2019, Volume 27, Issue 5, pp. 677 - 685
Journal Article
Current Cancer Drug Targets, ISSN 1568-0096, 02/2017, Volume 17, Issue 2, pp. 122 - 136
Compared to normal cells, usually cancer cells are under higher oxidative stress. Elevating intracellular levels of reactive oxygen species (ROS) by... 
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 163, pp. 215 - 242
Cancer cells have been confirmed diverge significantly from normal cells on the metabolic properties. Energy production in cancer cells is abnormally dependent... 
Inhibitor | Synthesis | Cancer metabolism | Glutamine | CANCER-CELLS | NUCLEOTIDE-METABOLISM | L-ASPARAGINASE | CHEMISTRY, MEDICINAL | CYSTINE UPTAKE | KIDNEY-TYPE GLUTAMINASE | SYSTEM XC(-) | DEHYDROGENASE | AMINO-ACIDS | SULFASALAZINE | PHASE-I
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 143, pp. 656 - 669
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 01/2015, Volume 56, Issue 2, pp. 397 - 400
A regioselective biomimetic synthesis of bioactive natural products dunnione and nor- beta -lapachone is described. This cascade provides a new strategy of a... 
Lewis acid | Synthesis (chemistry) | Biomimetics | Natural products | Cascades | Tetrahedrons | Biocompatibility | Strategy
Journal Article
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