Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (24) 24
chemistry, medicinal (21) 21
humans (14) 14
chemistry, organic (13) 13
chemistry (12) 12
antineoplastic agents - pharmacology (11) 11
cell line, tumor (11) 11
metallurgy (11) 11
organic chemistry (11) 11
human necessities (10) 10
hygiene (10) 10
medical or veterinary science (10) 10
preparations for medical, dental, or toilet purposes (10) 10
specific therapeutic activity of chemical compounds ormedicinal preparations (10) 10
antineoplastic agents - chemistry (9) 9
antineoplastic agents - chemical synthesis (8) 8
antitumor (8) 8
cancer (8) 8
structure-activity relationship (8) 8
derivatives (7) 7
heterocyclic compounds (7) 7
molecular docking simulation (7) 7
nadh dehydrogenase (7) 7
beta-lapachone (6) 6
biochemistry & molecular biology (6) 6
drug screening assays, antitumor (6) 6
inhibitor (6) 6
activation (5) 5
cell proliferation - drug effects (5) 5
design (5) 5
identification (5) 5
nadh-quinone oxidoreductase-1 (5) 5
national demonstration areas for comprehensive prevention and control of non-communicable diseases (5) 5
quinone (5) 5
reactive oxygen species - metabolism (5) 5
analysis (4) 4
animals (4) 4
biological evaluation (4) 4
discovery (4) 4
drug design (4) 4
drug discovery (4) 4
inhibitors (4) 4
mechanism (4) 4
nqo1 (4) 4
potent (4) 4
synthesis (4) 4
wogonin (4) 4
β-lapachone (4) 4
androgen receptor (3) 3
antimitotic agents (3) 3
antineoplastic agents (3) 3
antitumor agents (3) 3
antitumor quinones (3) 3
apoptosis (3) 3
apoptosis - drug effects (3) 3
biomimetics (3) 3
cancer-cells (3) 3
cells (3) 3
degradation (3) 3
docking (3) 3
drugs (3) 3
enzyme inhibitors - chemical synthesis (3) 3
enzyme inhibitors - chemistry (3) 3
enzyme inhibitors - pharmacology (3) 3
expression (3) 3
flavanones - chemistry (3) 3
flavanones - pharmacology (3) 3
flavones (3) 3
ido1 inhibitors (3) 3
kidney-type glutaminase (3) 3
mice (3) 3
molecular structure (3) 3
naphthoquinones - chemical synthesis (3) 3
naphthoquinones - chemistry (3) 3
natural products (3) 3
non-communicable diseases (3) 3
nqo1 substrates (3) 3
nucleotides (3) 3
phase-i (3) 3
physics (3) 3
prostate cancer (3) 3
resistance (3) 3
ros (3) 3
tryptophan (3) 3
tumors (3) 3
acid (2) 2
antagonist (2) 2
binding sites (2) 2
bioflavonoids (2) 2
biological products - chemistry (2) 2
biological response modifiers (2) 2
cancer cells (2) 2
cancer metabolism (2) 2
care and treatment (2) 2
cascades (2) 2
catalysis (2) 2
cdk9 (2) 2
cell death - drug effects (2) 2
cell survival - drug effects (2) 2
chemistry, multidisciplinary (2) 2
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Electronic transport induced by asymmetric adsorption site of sulfur in molecular device
by Bian, Baoan and Yang, Jingjuan and Han, Xiaoxiao and Wei, Jinlei
Surface Science, ISSN 0039-6028, 06/2019, Volume 684, pp. 52 - 57
The effect of different sulfur adsorption site on right Au electrodes in molecular device is investigated by using non-equilibrium Green’s function and density... 
Switching behavior | Molecular device | Electronic transport | Density functionals | Sulfur compounds | Adsorption | Sulfur | Isomerization | Electrodes | Asymmetry | Molecular orbitals | Density functional theory | Eigenvectors | Electrode polarization | Electron transport | Switching
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Width dependent rectifying behavior in Schottky heterojunction based on black phosphorene
by Bian, Baoan and Yang, Jingjuan and Wei, Jinlei
Materials Chemistry and Physics, ISSN 0254-0584, 01/2020, Volume 239, p. 122048
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Synthesis and in vivo antitumor evaluation of an orally active potent phosphonamidate derivative targeting IDO1/IDO2/TDO
by Feng, Xi and Shen, Pei and Wang, Yinuo and Li, Zhiyu and Bian, Jinlei
Biochemical Pharmacology, ISSN 0006-2952, 10/2019, Volume 168, pp. 214 - 223
Targeting Trp-Kyn pathways has been identified as an attractive approach for the cancer immunotherapies. In this study, a novel phosphonamidate containing... 
Epacadostat | NSCLC | IDO1 inhibitors | Phosphonamidate | Trp-Kyn | Enzymes | Chemotherapy | Hydrogen | Analysis | Pharmacy | Immunotherapy | Tryptophan | Biological response modifiers | T cells | Interferon gamma | Cancer
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Bioactive modulators targeting STING adaptor in cGAS-STING pathway
by Feng, Xi and Liu, Dongyu and Li, Zhiyu and Bian, Jinlei
Drug Discovery Today, ISSN 1359-6446, 11/2019
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer
by Du, Qianming and Feng, Xi and Wang, Yinuo and Xu, Xi and Zhang, Yan and Qu, Xinliang and Li, Zhiyu and Bian, Jinlei
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111629
Targeting indoleamine 2,3-dioxygenase 1 (IDO1) has been identified as an attractive approach for the development of cancer immunotherapy. In this study, a... 
Epacadostat | Phosphonamidate ester | IDO2 | IDO1 inhibitors | TDO
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Current development of ROS-modulating agents as novel antitumor therapy
by Wang, Nan and Wu, Yue and Bian, Jinlei and Qian, Xue and Lin, Hongzhi and Sun, Haopeng and You, Qidong and Zhang, Xiaojin
Current Cancer Drug Targets, ISSN 1568-0096, 02/2017, Volume 17, Issue 2, pp. 122 - 136
Antioxidant system | Exogenous generating ROS agents | Mitochondrial respiratory chain | Redox homeostasis | ROS-modulating agents | Antitumor therapy
Journal Article
Details down arrow
7. Full Text Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo
by Xu, Xiaoli and Wu, Yue and Hu, Mingyang and Li, Xiang and Bao, Qichao and Bian, Jinlei and You, Qidong and Zhang, Xiaojin
Scientific Reports, ISSN 2045-2322, 10/2016, Volume 6, Issue 1, p. 35771
DDO-6101, a simplified structure obtained from the Garcinia natural product (NP) gambogic acid (GA), has been previously shown to possess high cytotoxicity to... 
CELLS | ZEBRAFISH | PROTEIN | GARCINIA XANTHONES | GAMBOGIC ACID | SIGNALING PATHWAY | INHIBITS ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | ACID INDUCES APOPTOSIS | BIOLOGICAL EVALUATION | CHEMIE DES GUMMIGUTTS | Apoptosis - drug effects | Humans | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Biological Products - pharmacology | Structure-Activity Relationship | Xanthones - pharmacology | Garcinia - chemistry | Drug Design | Female | Antineoplastic Agents - pharmacology | Xanthones - chemistry | Animals, Genetically Modified | HCT116 Cells | Angiogenesis Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Zebrafish | Antineoplastic Agents - chemistry | Hep G2 Cells | Xenograft Model Antitumor Assays | Biological Products - chemistry | Animals | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Mice, Nude | Cell Line, Tumor | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Angiogenesis Inhibitors - chemistry | Drug Screening Assays, Antitumor | Angiogenesis | Hsp90 protein | Hypoxia-inducible factor 1a | Natural products | Heat shock proteins | Cytotoxicity | Antitumor activity | Permeability | Tumor cell lines | Physicochemical properties | Adenosine triphosphatase | Tumors
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Dynamics analysis of stochastic epidemic models with standard incidence
by Zhao, Wencai and Liu, Jinlei and Chi, Mengnan and Bian, Feifei
Advances in Difference Equations, ISSN 1687-1839, 12/2019, Volume 2019, Issue 1, pp. 1 - 16
In this paper, two stochastic SIRS epidemic models with standard incidence were proposed and investigated. For the non-autonomous periodic model, the... 
Standard incidence | Stochastic SIRS epidemic model | Stationary distribution and ergodicity | Periodic solution | Extinction | ERGODICITY | POPULATION | MATHEMATICS, APPLIED | PERSISTENCE | BEHAVIOR | STATIONARY DISTRIBUTION | DIFFERENTIAL-EQUATIONS | GLOBAL ANALYSIS | MATHEMATICS | NUMERICAL SIMULATIONS | PHYTOPLANKTON | White noise | Liapunov functions | Epidemics | Dynamic tests | Incidence
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Degradation of androgen receptor through small molecules for prostate cancer
by Ge, Raoling and Xu, Xi and Xu, Pengfei and Li, Lei and Li, Zhiyu and Bian, Jinlei
Current Cancer Drug Targets, ISSN 1568-0096, 2018, Volume 18, Issue 7, pp. 652 - 667
Prostate cancer is the most common carcinoma among aged males in western countries and more aggressive and lethal castration resistant prostate cancer often... 
Degradation | Small molecules | New strategies | Prostate cancer | Androgen receptor | Resistance mechanism | CHIMERIC MOLECULES | degradation | new strategies | prostate cancer | androgen receptor | ONCOLOGY | PROTEIN-DEGRADATION | GELDANAMYCIN | IN-VIVO | BIOLOGICAL EVALUATION | RESISTANCE | INCREASED SURVIVAL | INHIBITORS | PHASE-I | small molecules | ENZALUTAMIDE | Androgens | Deprivation | Castration | Males | Prostate | Cancer
Journal Article
Details down arrow
10. Full Text Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation
by Xu, Xi and Ren, Jie and Ma, Yinghe and Liu, Hongting and Rong, Quanjin and Feng, Yifan and Wang, Yameng and Cheng, Yu and Ge, Ruijia and Li, Zhiyu and Bian, Jinlei
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2019, Volume 34, Issue 1, pp. 250 - 263
With the aim of discovering novel IDO1 inhibitors, a combined similarity search and molecular docking approach was employed to the discovery of 32 hit... 
virtual screen | cyanopyridine scaffold | inhibitor | Indoleamine 2,3-dioxygenase 1 | hit optimisation | DESIGN | CHEMISTRY, MEDICINAL | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDOLEAMINE 2,3-DIOXYGENASE | CRYSTAL-STRUCTURES | POTENT INHIBITORS | MOLECULAR DOCKING | DETAILED ANALYSIS | TRYPTOPHAN DEGRADATION | DERIVATIVES | EXPRESSION
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Affinity-based small fluorescent probe for NAD. Design, synthesis and pharmacological evaluation
by Bian, Jinlei and Li, Xiang and Xu, Lili and Wang, Nan and Qian, Xue and You, Qidong and Zhang, Xiaojin
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, p. 828
NQO1 is a dimeric flavoprotein which intimately associated with cancer and overexpressed in the cytosol of numerous human tumor cells. Given that the cellular... 
Quinone | Investigations | Albumin | Lung cancer, Non-small cell | High performance liquid chromatography | Fluorescein
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Palladium(II)-Catalyzed C-H Bond Activation/C-C Coupling/Intramolecular Tsuji-Trost Reaction Cascade: Facile Access to 2 H -Pyranonaphthoquinones
by Bian, Jinlei and Qian, Xue and Wang, Nan and Mu, Tong and Li, Xiang and Sun, Haopeng and Zhang, Lianshan and You, Qidong and Zhang, Xiaojin
Organic Letters, ISSN 1523-7060, 07/2015, Volume 17, Issue 14, pp. 3410 - 3413
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Overview of the Development of Glutaminase Inhibitors: Achievements and Future Directions
by Xu, Xi and Meng, Ying and Li, Lei and Xu, Pengfei and Wang, Jubo and Li, Zhiyu and Bian, Jinlei
Journal of Medicinal Chemistry, ISSN 0022-2623, 2018, Volume 62, Issue 3, pp. 1096 - 1115
It has been demonstrated that glutamine metabolism has become the main energy and building blocks supply for the growth and viability of a potentially large... 
GLUTAMATE-DEHYDROGENASE | TARGETED INHIBITION | CHEMISTRY, MEDICINAL | ACID | KIDNEY-TYPE GLUTAMINASE | PHOSPHATE-DEPENDENT GLUTAMINASE | 6-DIAZO-5-OXO-L-NORLEUCINE DON | GROWTH | CANCER METABOLISM | GLUTAMINOLYSIS | PHASE-I
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
14. Full Text A review on flavones targeting serine/threonine protein kinases for potential anticancer drugs
by Zhao, Lulu and Yuan, Xinyu and Wang, Jubo and Feng, Yifan and Ji, Fei and Li, Zhiyu and Bian, Jinlei
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 03/2019, Volume 27, Issue 5, pp. 677 - 685
Protein kinases have been important targets for antitumor targets due to their key roles in regulating multiple cell signaling pathways. Numerous compounds... 
Binding mode | Flavonoids | Protein kinase | Structure-activity relationship | Cancer | CLINICAL-PHARMACOLOGY | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | PHASE-II | CK2 | SMALL-MOLECULE INHIBITOR | P-TEFB | STRUCTURAL BASIS | CHRONIC LYMPHOCYTIC-LEUKEMIA | CELL CYCLES | CONTINUOUS-INFUSION | FLAVOPIRIDOL | Antimitotic agents | Flavones | Bioflavonoids | Cellular signal transduction | Antineoplastic agents | Protein kinases | Protein binding
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
15. Current Development of ROS-Modulating Agents as Novel Antitumor Therapy
by Wang, Nan and Wu, Yue and Bian, Jinlei and Qian, Xue and Lin, Hongzhi and Sun, Haopeng and You, Qidong and Zhang, Xiaojin
Current Cancer Drug Targets, ISSN 1568-0096, 02/2017, Volume 17, Issue 2, pp. 122 - 136
Compared to normal cells, usually cancer cells are under higher oxidative stress. Elevating intracellular levels of reactive oxygen species (ROS) by... 
Journal Article
Details down arrow
16. Full Text Recent discovery of indoleamine-2,3-dioxygenase 1 inhibitors targeting cancer immunotherapy
by Weng, Tianwei and Qiu, Xiaqiu and Wang, Jubo and Li, Zhiyu and Bian, Jinlei
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 143, pp. 656 - 669
There has been great attention on indoleamine-2,3-dioxygenase 1 (IDO1) around cancer immunotherapy because of its role in enabling cancers to evade the immune... 
Crystal structures | Cancer immunotherapy | IDO1 inhibitors | Immune escape | PHENYL BENZENESULFONYLHYDRAZIDES | CHEMISTRY, MEDICINAL | INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | DENDRITIC CELLS | CRYSTAL-STRUCTURES | POTENT INHIBITORS | CYTOSTATIC AGENTS | BIOLOGICAL EVALUATION | TRYPTOPHAN 2,3-DIOXYGENASE | DERIVATIVES | IDO1 | Care and treatment | Prostaglandins E | Immunotherapy | Crystals | Tryptophan | Interferon | Drug therapy | Structure | Biological response modifiers | T cells | Cancer
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
17. Full Text Discovery and development of small molecule modulators targeting glutamine metabolism
by Li, Zhiyu and Li, Lei and Meng, Ying and Dai, Wenhao and Xu, Xi and Bi, Xiaoling and Bian, Jinlei
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 163, pp. 215 - 242
Cancer cells have been confirmed diverge significantly from normal cells on the metabolic properties. Energy production in cancer cells is abnormally dependent... 
Inhibitor | Synthesis | Cancer metabolism | Glutamine | CANCER-CELLS | NUCLEOTIDE-METABOLISM | L-ASPARAGINASE | CHEMISTRY, MEDICINAL | CYSTINE UPTAKE | KIDNEY-TYPE GLUTAMINASE | SYSTEM XC(-) | DEHYDROGENASE | AMINO-ACIDS | SULFASALAZINE | PHASE-I
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
18. Full Text Discovery of quinone-directed antitumor agents selectively bioactivated by NQO1 over CPR with improved safety profile
by Bian, Jinlei and Li, Xiang and Wang, Nan and Wu, Xingsen and You, Qidong and Zhang, Xiaojin
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2017, Volume 129, pp. 27 - 40
In this work, we mainly focused on discovering compounds with good selectivity for NQO1 over CPR. The NQO1-mediated two-electron reduction of compounds would... 
NQO1 substrates | β-Lapachone | Ortho-quinones | ROS | Cancer cells | CANCER-CELLS | OXIDATIVE STRESS | NAD(P)H-QUINONE OXIDOREDUCTASE-1 | CHEMISTRY, MEDICINAL | ANTICANCER AGENT | DRUG DESIGN | REDOX ACTIVATION | IDENTIFICATION | beta-Lapachone | POTENT | NADPH-Ferrihemoprotein Reductase - metabolism | Reactive Oxygen Species - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Benzoquinones - chemistry | Structure-Activity Relationship | Drug Discovery | Patient Safety | NAD(P)H Dehydrogenase (Quinone) - metabolism | Antineoplastic Agents - pharmacology | Molecular Docking Simulation | Cell Death - drug effects | Binding Sites | Antimitotic agents | Safety and security measures | Antineoplastic agents | Quinone | Analysis | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
19. Full Text Design and synthesis of indoline thiohydantoin derivatives based on enzalutamide as antiproliferative agents against prostate cancer
by Zuo, Minzan and Xu, Xi and Xie, Zhouling and Ge, Raoling and Zhang, Ziyu and Li, Zhiyu and Bian, Jinlei
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2017, Volume 125, pp. 1002 - 1022
A novel scaffold of indoline thiohydantoin was discovered as potent androgen receptor (AR) antagonist through rational drug designation. Several compounds... 
Antagonist | Indoline thiohydantoin derivatives | Prostate cancer | Androgen receptor | CHEMISTRY, MEDICINAL | ANDROGEN RECEPTOR ANTAGONISTS | THERAPY | BIOLOGICAL EVALUATION | MECHANISMS | MUTATIONS | DISCOVERY | BICALUTAMIDE | Phenylthiohydantoin - chemistry | Thiohydantoins - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Receptors, Androgen - metabolism | Male | Thiohydantoins - chemical synthesis | Phenylthiohydantoin - analogs & derivatives | Receptors, Androgen - drug effects | Active Transport, Cell Nucleus - drug effects | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Docking Simulation | Indoles | Prostatic Neoplasms - drug therapy | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
20. Full Text NbCl.sub.5 mediated biomimetic cascade reaction: efficient and scalable one-pot synthesis of dunnione and nor-[beta]-lapachone
by Bian, Jinlei and Qian, Xue and Fan, Jun and Li, Xiang and Sun, Haopeng and You, Qidong and Zhang, Xiaojin
Tetrahedron Letters, ISSN 0040-4039, 01/2015, Volume 56, Issue 2, p. 397
Display Omitted 
Biomimetics
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.