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1. Full Text Electronic transport induced by asymmetric adsorption site of sulfur in molecular device
by Bian, Baoan and Yang, Jingjuan and Han, Xiaoxiao and Wei, Jinlei
Surface Science, ISSN 0039-6028, 06/2019, Volume 684, pp. 52 - 57
The effect of different sulfur adsorption site on right Au electrodes in molecular device is investigated by using non-equilibrium Green’s function and density... 
Switching behavior | Molecular device | Electronic transport | Density functionals | Sulfur compounds | Adsorption | Sulfur | Isomerization | Electrodes | Asymmetry | Molecular orbitals | Density functional theory | Eigenvectors | Electrode polarization | Electron transport | Switching
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2. Full Text Width dependent rectifying behavior in Schottky heterojunction based on black phosphorene
by Bian, Baoan and Yang, Jingjuan and Wei, Jinlei
Materials Chemistry and Physics, ISSN 0254-0584, 01/2020, Volume 239, p. 122048
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3. Full Text Synthesis and in vivo antitumor evaluation of an orally active potent phosphonamidate derivative targeting IDO1/IDO2/TDO
by Feng, Xi and Shen, Pei and Wang, Yinuo and Li, Zhiyu and Bian, Jinlei
Biochemical Pharmacology, ISSN 0006-2952, 10/2019, Volume 168, pp. 214 - 223
Targeting Trp-Kyn pathways has been identified as an attractive approach for the cancer immunotherapies. In this study, a novel phosphonamidate containing... 
Epacadostat | NSCLC | IDO1 inhibitors | Phosphonamidate | Trp-Kyn | Enzymes | Chemotherapy | Hydrogen | Analysis | Pharmacy | Immunotherapy | Tryptophan | Biological response modifiers | T cells | Interferon gamma | Cancer
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4. Full Text Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer
by Du, Qianming and Feng, Xi and Wang, Yinuo and Xu, Xi and Zhang, Yan and Qu, Xinliang and Li, Zhiyu and Bian, Jinlei
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111629
Targeting indoleamine 2,3-dioxygenase 1 (IDO1) has been identified as an attractive approach for the development of cancer immunotherapy. In this study, a... 
Epacadostat | Phosphonamidate ester | IDO2 | IDO1 inhibitors | TDO
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5. Current development of ROS-modulating agents as novel antitumor therapy
by Wang, Nan and Wu, Yue and Bian, Jinlei and Qian, Xue and Lin, Hongzhi and Sun, Haopeng and You, Qidong and Zhang, Xiaojin
Current Cancer Drug Targets, ISSN 1568-0096, 02/2017, Volume 17, Issue 2, pp. 122 - 136
Antioxidant system | Exogenous generating ROS agents | Mitochondrial respiratory chain | Redox homeostasis | ROS-modulating agents | Antitumor therapy
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6. Full Text Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo
by Xu, Xiaoli and Wu, Yue and Hu, Mingyang and Li, Xiang and Bao, Qichao and Bian, Jinlei and You, Qidong and Zhang, Xiaojin
Scientific Reports, ISSN 2045-2322, 10/2016, Volume 6, Issue 1, p. 35771
DDO-6101, a simplified structure obtained from the Garcinia natural product (NP) gambogic acid (GA), has been previously shown to possess high cytotoxicity to... 
CELLS | ZEBRAFISH | PROTEIN | GARCINIA XANTHONES | GAMBOGIC ACID | SIGNALING PATHWAY | INHIBITS ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | ACID INDUCES APOPTOSIS | BIOLOGICAL EVALUATION | CHEMIE DES GUMMIGUTTS | Apoptosis - drug effects | Humans | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Biological Products - pharmacology | Structure-Activity Relationship | Xanthones - pharmacology | Garcinia - chemistry | Drug Design | Female | Antineoplastic Agents - pharmacology | Xanthones - chemistry | Animals, Genetically Modified | HCT116 Cells | Angiogenesis Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Zebrafish | Antineoplastic Agents - chemistry | Hep G2 Cells | Xenograft Model Antitumor Assays | Biological Products - chemistry | Animals | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Mice, Nude | Cell Line, Tumor | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Angiogenesis Inhibitors - chemistry | Drug Screening Assays, Antitumor | Angiogenesis | Hsp90 protein | Hypoxia-inducible factor 1a | Natural products | Heat shock proteins | Cytotoxicity | Antitumor activity | Permeability | Tumor cell lines | Physicochemical properties | Adenosine triphosphatase | Tumors
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7. Full Text Dynamics analysis of stochastic epidemic models with standard incidence
by Zhao, Wencai and Liu, Jinlei and Chi, Mengnan and Bian, Feifei
Advances in Difference Equations, ISSN 1687-1839, 12/2019, Volume 2019, Issue 1, pp. 1 - 16
In this paper, two stochastic SIRS epidemic models with standard incidence were proposed and investigated. For the non-autonomous periodic model, the... 
Standard incidence | Stochastic SIRS epidemic model | Stationary distribution and ergodicity | Periodic solution | Extinction | ERGODICITY | POPULATION | MATHEMATICS, APPLIED | PERSISTENCE | BEHAVIOR | STATIONARY DISTRIBUTION | DIFFERENTIAL-EQUATIONS | GLOBAL ANALYSIS | MATHEMATICS | NUMERICAL SIMULATIONS | PHYTOPLANKTON | White noise | Liapunov functions | Epidemics | Dynamic tests | Incidence
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8. Degradation of androgen receptor through small molecules for prostate cancer
by Ge, Raoling and Xu, Xi and Xu, Pengfei and Li, Lei and Li, Zhiyu and Bian, Jinlei
Current Cancer Drug Targets, ISSN 1568-0096, 2018, Volume 18, Issue 7, pp. 652 - 667
Prostate cancer is the most common carcinoma among aged males in western countries and more aggressive and lethal castration resistant prostate cancer often... 
Degradation | Small molecules | New strategies | Prostate cancer | Androgen receptor | Resistance mechanism | CHIMERIC MOLECULES | degradation | new strategies | prostate cancer | androgen receptor | ONCOLOGY | PROTEIN-DEGRADATION | GELDANAMYCIN | IN-VIVO | BIOLOGICAL EVALUATION | RESISTANCE | INCREASED SURVIVAL | INHIBITORS | PHASE-I | small molecules | ENZALUTAMIDE | Androgens | Deprivation | Castration | Males | Prostate | Cancer
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9. Full Text Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation
by Xu, Xi and Ren, Jie and Ma, Yinghe and Liu, Hongting and Rong, Quanjin and Feng, Yifan and Wang, Yameng and Cheng, Yu and Ge, Ruijia and Li, Zhiyu and Bian, Jinlei
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2019, Volume 34, Issue 1, pp. 250 - 263
With the aim of discovering novel IDO1 inhibitors, a combined similarity search and molecular docking approach was employed to the discovery of 32 hit... 
virtual screen | cyanopyridine scaffold | inhibitor | Indoleamine 2,3-dioxygenase 1 | hit optimisation | DESIGN | CHEMISTRY, MEDICINAL | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDOLEAMINE 2,3-DIOXYGENASE | CRYSTAL-STRUCTURES | POTENT INHIBITORS | MOLECULAR DOCKING | DETAILED ANALYSIS | TRYPTOPHAN DEGRADATION | DERIVATIVES | EXPRESSION
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10. Full Text Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors
by Xu, Xi and Kuang, Zijian and Han, Jie and Meng, Ying and Li, Lei and Luan, Hongyu and Xu, Pengfei and Wang, Jubo and Luo, Cheng and Ding, Hong and Li, Zhiyu and Bian, Jinlei
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2019
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11. Full Text Affinity-based small fluorescent probe for NAD. Design, synthesis and pharmacological evaluation
by Bian, Jinlei and Li, Xiang and Xu, Lili and Wang, Nan and Qian, Xue and You, Qidong and Zhang, Xiaojin
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, p. 828
NQO1 is a dimeric flavoprotein which intimately associated with cancer and overexpressed in the cytosol of numerous human tumor cells. Given that the cellular... 
Quinone | Investigations | Albumin | Lung cancer, Non-small cell | High performance liquid chromatography | Fluorescein
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12. Full Text Palladium(II)-Catalyzed C-H Bond Activation/C-C Coupling/Intramolecular Tsuji-Trost Reaction Cascade: Facile Access to 2 H -Pyranonaphthoquinones
by Bian, Jinlei and Qian, Xue and Wang, Nan and Mu, Tong and Li, Xiang and Sun, Haopeng and Zhang, Lianshan and You, Qidong and Zhang, Xiaojin
Organic Letters, ISSN 1523-7060, 07/2015, Volume 17, Issue 14, pp. 3410 - 3413
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13. Full Text Overview of the Development of Glutaminase Inhibitors: Achievements and Future Directions
by Xu, Xi and Meng, Ying and Li, Lei and Xu, Pengfei and Wang, Jubo and Li, Zhiyu and Bian, Jinlei
Journal of Medicinal Chemistry, ISSN 0022-2623, 2018, Volume 62, Issue 3, pp. 1096 - 1115
It has been demonstrated that glutamine metabolism has become the main energy and building blocks supply for the growth and viability of a potentially large... 
GLUTAMATE-DEHYDROGENASE | TARGETED INHIBITION | CHEMISTRY, MEDICINAL | ACID | KIDNEY-TYPE GLUTAMINASE | PHOSPHATE-DEPENDENT GLUTAMINASE | 6-DIAZO-5-OXO-L-NORLEUCINE DON | GROWTH | CANCER METABOLISM | GLUTAMINOLYSIS | PHASE-I
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14. Full Text A review on flavones targeting serine/threonine protein kinases for potential anticancer drugs
by Zhao, Lulu and Yuan, Xinyu and Wang, Jubo and Feng, Yifan and Ji, Fei and Li, Zhiyu and Bian, Jinlei
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 03/2019, Volume 27, Issue 5, pp. 677 - 685
Protein kinases have been important targets for antitumor targets due to their key roles in regulating multiple cell signaling pathways. Numerous compounds... 
Binding mode | Flavonoids | Protein kinase | Structure-activity relationship | Cancer | CLINICAL-PHARMACOLOGY | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | PHASE-II | CK2 | SMALL-MOLECULE INHIBITOR | P-TEFB | STRUCTURAL BASIS | CHRONIC LYMPHOCYTIC-LEUKEMIA | CELL CYCLES | CONTINUOUS-INFUSION | FLAVOPIRIDOL | Antimitotic agents | Flavones | Bioflavonoids | Cellular signal transduction | Antineoplastic agents | Protein kinases | Protein binding
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15. Current Development of ROS-Modulating Agents as Novel Antitumor Therapy
by Wang, Nan and Wu, Yue and Bian, Jinlei and Qian, Xue and Lin, Hongzhi and Sun, Haopeng and You, Qidong and Zhang, Xiaojin
Current Cancer Drug Targets, ISSN 1568-0096, 02/2017, Volume 17, Issue 2, pp. 122 - 136
Compared to normal cells, usually cancer cells are under higher oxidative stress. Elevating intracellular levels of reactive oxygen species (ROS) by... 
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16. Full Text Discovery and development of small molecule modulators targeting glutamine metabolism
by Li, Zhiyu and Li, Lei and Meng, Ying and Dai, Wenhao and Xu, Xi and Bi, Xiaoling and Bian, Jinlei
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 163, pp. 215 - 242
Cancer cells have been confirmed diverge significantly from normal cells on the metabolic properties. Energy production in cancer cells is abnormally dependent... 
Inhibitor | Synthesis | Cancer metabolism | Glutamine | CANCER-CELLS | NUCLEOTIDE-METABOLISM | L-ASPARAGINASE | CHEMISTRY, MEDICINAL | CYSTINE UPTAKE | KIDNEY-TYPE GLUTAMINASE | SYSTEM XC(-) | DEHYDROGENASE | AMINO-ACIDS | SULFASALAZINE | PHASE-I
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17. Full Text Discovery of quinone-directed antitumor agents selectively bioactivated by NQO1 over CPR with improved safety profile
by Bian, Jinlei and Li, Xiang and Wang, Nan and Wu, Xingsen and You, Qidong and Zhang, Xiaojin
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2017, Volume 129, pp. 27 - 40
In this work, we mainly focused on discovering compounds with good selectivity for NQO1 over CPR. The NQO1-mediated two-electron reduction of compounds would... 
NQO1 substrates | β-Lapachone | Ortho-quinones | ROS | Cancer cells | CANCER-CELLS | OXIDATIVE STRESS | NAD(P)H-QUINONE OXIDOREDUCTASE-1 | CHEMISTRY, MEDICINAL | ANTICANCER AGENT | DRUG DESIGN | REDOX ACTIVATION | IDENTIFICATION | beta-Lapachone | POTENT | NADPH-Ferrihemoprotein Reductase - metabolism | Reactive Oxygen Species - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Benzoquinones - chemistry | Structure-Activity Relationship | Drug Discovery | Patient Safety | NAD(P)H Dehydrogenase (Quinone) - metabolism | Antineoplastic Agents - pharmacology | Molecular Docking Simulation | Cell Death - drug effects | Binding Sites | Antimitotic agents | Safety and security measures | Antineoplastic agents | Quinone | Analysis | Index Medicus
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18. Full Text Design and synthesis of indoline thiohydantoin derivatives based on enzalutamide as antiproliferative agents against prostate cancer
by Zuo, Minzan and Xu, Xi and Xie, Zhouling and Ge, Raoling and Zhang, Ziyu and Li, Zhiyu and Bian, Jinlei
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2017, Volume 125, pp. 1002 - 1022
A novel scaffold of indoline thiohydantoin was discovered as potent androgen receptor (AR) antagonist through rational drug designation. Several compounds... 
Antagonist | Indoline thiohydantoin derivatives | Prostate cancer | Androgen receptor | CHEMISTRY, MEDICINAL | ANDROGEN RECEPTOR ANTAGONISTS | THERAPY | BIOLOGICAL EVALUATION | MECHANISMS | MUTATIONS | DISCOVERY | BICALUTAMIDE | Phenylthiohydantoin - chemistry | Thiohydantoins - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Receptors, Androgen - metabolism | Male | Thiohydantoins - chemical synthesis | Phenylthiohydantoin - analogs & derivatives | Receptors, Androgen - drug effects | Active Transport, Cell Nucleus - drug effects | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Docking Simulation | Indoles | Prostatic Neoplasms - drug therapy | Index Medicus
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19. Full Text Recent discovery of indoleamine-2,3-dioxygenase 1 inhibitors targeting cancer immunotherapy
by Weng, Tianwei and Qiu, Xiaqiu and Wang, Jubo and Li, Zhiyu and Bian, Jinlei
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 143, pp. 656 - 669
There has been great attention on indoleamine-2,3-dioxygenase 1 (IDO1) around cancer immunotherapy because of its role in enabling cancers to evade the immune... 
Crystal structures | Cancer immunotherapy | IDO1 inhibitors | Immune escape | PHENYL BENZENESULFONYLHYDRAZIDES | CHEMISTRY, MEDICINAL | INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | DENDRITIC CELLS | CRYSTAL-STRUCTURES | POTENT INHIBITORS | CYTOSTATIC AGENTS | BIOLOGICAL EVALUATION | TRYPTOPHAN 2,3-DIOXYGENASE | DERIVATIVES | IDO1 | Care and treatment | Prostaglandins E | Immunotherapy | Crystals | Tryptophan | Interferon | Drug therapy | Structure | Biological response modifiers | T cells | Cancer
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20. NbCl sub(5) mediated biomimetic cascade reaction: efficient and scalable one-pot synthesis of dunnione and nor- beta -lapachone
by Bian, Jinlei and Qian, Xue and Fan, Jun and Li, Xiang and Sun, Haopeng and You, Qidong and Zhang, Xiaojin
Tetrahedron Letters, ISSN 0040-4039, 01/2015, Volume 56, Issue 2, pp. 397 - 400
A regioselective biomimetic synthesis of bioactive natural products dunnione and nor- beta -lapachone is described. This cascade provides a new strategy of a... 
Lewis acid | Synthesis (chemistry) | Biomimetics | Natural products | Cascades | Tetrahedrons | Biocompatibility | Strategy
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